Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-27

AUTHORS

Eirini Marouli, M. Fabiola Del Greco, Christina M. Astley, Jian Yang, Shafqat Ahmad, Sonja I. Berndt, Mark J. Caulfield, Evangelos Evangelou, Barbara McKnight, Carolina Medina-Gomez, Jana V. van Vliet-Ostaptchouk, Helen R. Warren, Zhihong Zhu, Joel N. Hirschhorn, Ruth J. F. Loos, Zoltan Kutalik, Panos Deloukas

ABSTRACT

There is evidence that lower height is associated with a higher risk of coronary artery disease (CAD) and increased risk of type 2 diabetes (T2D). It is not clear though whether these associations are causal, direct or mediated by other factors. Here we show that one standard deviation higher genetically determined height (~6.5 cm) is causally associated with a 16% decrease in CAD risk (OR = 0.84, 95% CI 0.80-0.87). This causal association remains after performing sensitivity analyses relaxing pleiotropy assumptions. The causal effect of height on CAD risk is reduced by 1-3% after adjustment for potential mediators (lipids, blood pressure, glycaemic traits, body mass index, socio-economic status). In contrast, our data suggest that lung function (measured by forced expiratory volume [FEV1] and forced vital capacity [FVC]) is a mediator of the effect of height on CAD. We observe no direct causal effect of height on the risk of T2D. More... »

PAGES

119

References to SciGraph publications

  • 2002-08. The association between components of adult height and Type II diabetes and insulin resistance: British Women's Heart and Health Study in DIABETOLOGIA
  • 2007-02. Angiographic Segment Size in Patients Referred for Coronary Intervention is Influenced by Constitutional, Anatomical, and Clinical Features in THE INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
  • 2014-11. Defining the role of common variation in the genomic and biological architecture of adult human height in NATURE GENETICS
  • 2018-10. Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits in NATURE GENETICS
  • 2018-05. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases in NATURE GENETICS
  • 1999-08. Coronary atherosclerosis associated with body structure and obesity in 599 women aged between 15 and 50 years in INTERNATIONAL JOURNAL OF OBESITY
  • 2017-02-01. Rare and low-frequency coding variants alter human adult height in NATURE
  • 2017-09. Association analyses based on false discovery rate implicate new loci for coronary artery disease in NATURE GENETICS
  • 2012-12. Associations of hip circumference and height with incidence of type 2 diabetes: the Isfahan diabetes prevention study in ACTA DIABETOLOGICA
  • 2018-12. Causal associations between risk factors and common diseases inferred from GWAS summary data in NATURE COMMUNICATIONS
  • 2018-12. Adult height and risk of 50 diseases: a combined epidemiological and genetic analysis in BMC MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s42003-019-0361-2

    DOI

    http://dx.doi.org/10.1038/s42003-019-0361-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113004301

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30937401


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Public Health and Health Services", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Queen Mary University of London", 
              "id": "https://www.grid.ac/institutes/grid.4868.2", 
              "name": [
                "William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ, London, UK", 
                "Centre for Genomic Health, Life Sciences, Queen Mary University of London, EC1M 6BQ, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Marouli", 
            "givenName": "Eirini", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck, 39100, Bolzano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Del Greco", 
            "givenName": "M. Fabiola", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Boston Children\u2019s Hospital, 02115, Boston, MA, USA", 
                "Broad Institute of Harvard and MIT, 02142, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Astley", 
            "givenName": "Christina M.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Queensland", 
              "id": "https://www.grid.ac/institutes/grid.1003.2", 
              "name": [
                "Institute for Molecular Bioscience, University of Queensland, 4072, Brisbane, QLD, Australia", 
                "Queensland Brain Institute, The University of Queensland, 4072, Brisbane, QLD, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Jian", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Uppsala University", 
              "id": "https://www.grid.ac/institutes/grid.8993.b", 
              "name": [
                "Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, 02115, Boston, MA, USA", 
                "Division of Preventive Medicine, Harvard Medical School, Department of Medicine, Brigham and Women\u2019s Hospital, 02215, Boston, MA, USA", 
                "Department of Medical Sciences, Molecular Epidemiology, Uppsala University, 751 41, Uppsala, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ahmad", 
            "givenName": "Shafqat", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 20892, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Berndt", 
            "givenName": "Sonja I.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Queen Mary University of London", 
              "id": "https://www.grid.ac/institutes/grid.4868.2", 
              "name": [
                "William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ, London, UK", 
                "National Institute for Health Research, Barts Cardiovascular Biomedical Research Center, Queen Mary University of London, EC1M 6BQ, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Caulfield", 
            "givenName": "Mark J.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Ioannina", 
              "id": "https://www.grid.ac/institutes/grid.9594.1", 
              "name": [
                "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, W2 1PG, London, UK", 
                "Department of Hygiene and Epidemiology, University of Ioannina Medical School, 45110, Ioannina, Greece"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Evangelou", 
            "givenName": "Evangelos", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Biostatistics, University of Washington, 98101, Seattle, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McKnight", 
            "givenName": "Barbara", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Erasmus University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.5645.2", 
              "name": [
                "Department of Internal Medicine, Erasmus Medical Center, 3015 GE, Rotterdam, The Netherlands", 
                "Department of Epidemiology, Erasmus Medical Center, 3015 GE, Rotterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Medina-Gomez", 
            "givenName": "Carolina", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Medical Center Groningen", 
              "id": "https://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9713, Groningen, GZ, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van Vliet-Ostaptchouk", 
            "givenName": "Jana V.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Queen Mary University of London", 
              "id": "https://www.grid.ac/institutes/grid.4868.2", 
              "name": [
                "William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ, London, UK", 
                "National Institute for Health Research, Barts Cardiovascular Biomedical Research Center, Queen Mary University of London, EC1M 6BQ, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Warren", 
            "givenName": "Helen R.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Queensland", 
              "id": "https://www.grid.ac/institutes/grid.1003.2", 
              "name": [
                "Institute for Molecular Bioscience, University of Queensland, 4072, Brisbane, QLD, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhu", 
            "givenName": "Zhihong", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Boston Children\u2019s Hospital, 02115, Boston, MA, USA", 
                "Broad Institute of Harvard and MIT, 02142, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hirschhorn", 
            "givenName": "Joel N.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Icahn School of Medicine at Mount Sinai", 
              "id": "https://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Loos", 
            "givenName": "Ruth J. F.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Swiss Institute of Bioinformatics", 
              "id": "https://www.grid.ac/institutes/grid.419765.8", 
              "name": [
                "Institute of Social and Preventive Medicine, Lausanne University Hospital, 1010, Lausanne, Switzerland", 
                "Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kutalik", 
            "givenName": "Zoltan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "King Abdulaziz University", 
              "id": "https://www.grid.ac/institutes/grid.412125.1", 
              "name": [
                "William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ, London, UK", 
                "Centre for Genomic Health, Life Sciences, Queen Mary University of London, EC1M 6BQ, London, UK", 
                "Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, 21589, Jeddah, Saudi Arabia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Deloukas", 
            "givenName": "Panos", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1136/jech.54.2.97", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000282257"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.05.047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004362994"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0735-1097(98)00056-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005495116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/aje/kwu283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005694128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006357119", 
              "https://doi.org/10.1038/ng.3097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ije/dyv074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006713257"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/sim.5659", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007651270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ije/dys086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007841271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.0000116750.63158.94", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008308911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.i582", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013318110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/aje/kwr026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014375355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/519795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019061180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001648-199901000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019676192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001648-199901000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019676192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0609301103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020126176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s2213-8587(15)00474-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022291443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(11)70154-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024268708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(11)70154-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024268708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0167-9473(01)00097-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027048055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(12)60404-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027246737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00592-011-0351-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027345298", 
              "https://doi.org/10.1007/s00592-011-0351-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/aje/kwj081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032727228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10554-006-9119-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034695936", 
              "https://doi.org/10.1007/s10554-006-9119-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db10-0839", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034913309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1404881", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036410069"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/sim.3034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037075298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-002-0887-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039592813", 
              "https://doi.org/10.1007/s00125-002-0887-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-002-0887-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039592813", 
              "https://doi.org/10.1007/s00125-002-0887-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0962280210394459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040186326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0962280210394459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040186326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gepi.21965", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041410024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ije/dyu176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042470692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ije/dyv080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042843395"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ije/dyt179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045144996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jech.57.2.141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049556440"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gepi.21758", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050596269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0800960", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053339522", 
              "https://doi.org/10.1038/sj.ijo.0800960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0800960", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053339522", 
              "https://doi.org/10.1038/sj.ijo.0800960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/sim.6522", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053494248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0962280215597579", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054004639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0962280215597579", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054004639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/285356", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058595479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/sim.7221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074197080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076814301", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/oxfordjournals.aje.a112044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1080335705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature21039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083401652", 
              "https://doi.org/10.1038/nature21039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ije/dyx034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083932280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/hjh.0000000000001300", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083934859"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/hjh.0000000000001300", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083934859"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ije/dyx102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085641416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db16-1253", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085730555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3913", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090747969", 
              "https://doi.org/10.1038/ng.3913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3913", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090747969", 
              "https://doi.org/10.1038/ng.3913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3913", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090747969", 
              "https://doi.org/10.1038/ng.3913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(17)30572-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090914167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.117.300191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091329993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.j3542", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091435027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.j3542", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091435027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ije/dyx206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091472608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-017-02317-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100275573", 
              "https://doi.org/10.1038/s41467-017-02317-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0099-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103565841", 
              "https://doi.org/10.1038/s41588-018-0099-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1707388115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103602655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ije/dyy177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106071203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ije/dyy177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106071203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0205-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107041202", 
              "https://doi.org/10.1038/s41588-018-0205-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0205-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107041202", 
              "https://doi.org/10.1038/s41588-018-0205-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0205-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107041202", 
              "https://doi.org/10.1038/s41588-018-0205-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12916-018-1175-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107417733", 
              "https://doi.org/10.1186/s12916-018-1175-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12916-018-1175-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107417733", 
              "https://doi.org/10.1186/s12916-018-1175-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ije/dyy258", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1109975731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ije/dyy258", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1109975731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ije/dyy258", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1109975731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ije/dyy258", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1109975731"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-03-27", 
        "datePublishedReg": "2019-03-27", 
        "description": "There is evidence that lower height is associated with a higher risk of coronary artery disease (CAD) and increased risk of type 2 diabetes (T2D). It is not clear though whether these associations are causal, direct or mediated by other factors. Here we show that one standard deviation higher genetically determined height (~6.5\u2009cm) is causally associated with a 16% decrease in CAD risk (OR\u2009=\u20090.84, 95% CI 0.80-0.87). This causal association remains after performing sensitivity analyses relaxing pleiotropy assumptions. The causal effect of height on CAD risk is reduced by 1-3% after adjustment for potential mediators (lipids, blood pressure, glycaemic traits, body mass index, socio-economic status). In contrast, our data suggest that lung function (measured by forced expiratory volume [FEV1] and forced vital capacity [FVC]) is a mediator of the effect of height on CAD. We observe no direct causal effect of height on the risk of T2D.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s42003-019-0361-2", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5138169", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2416501", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1300829", 
            "issn": [
              "2399-3642"
            ], 
            "name": "Communications Biology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "2"
          }
        ], 
        "name": "Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease", 
        "pagination": "119", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s42003-019-0361-2"
            ]
          }, 
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "1c12dfc0106d482f5b4ba858020a045f82a51386a849fc3e4f45dd8e6cc29344"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113004301"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101719179"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30937401"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s42003-019-0361-2", 
          "https://app.dimensions.ai/details/publication/pub.1113004301"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-15T09:04", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91469_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s42003-019-0361-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s42003-019-0361-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s42003-019-0361-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s42003-019-0361-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s42003-019-0361-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    391 TRIPLES      21 PREDICATES      84 URIs      20 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s42003-019-0361-2 schema:about anzsrc-for:11
    2 anzsrc-for:1117
    3 schema:author N742d9ee7c0994a5489a7afeee9ca3b75
    4 schema:citation sg:pub.10.1007/s00125-002-0887-5
    5 sg:pub.10.1007/s00592-011-0351-4
    6 sg:pub.10.1007/s10554-006-9119-2
    7 sg:pub.10.1038/nature21039
    8 sg:pub.10.1038/ng.3097
    9 sg:pub.10.1038/ng.3913
    10 sg:pub.10.1038/s41467-017-02317-2
    11 sg:pub.10.1038/s41588-018-0099-7
    12 sg:pub.10.1038/s41588-018-0205-x
    13 sg:pub.10.1038/sj.ijo.0800960
    14 sg:pub.10.1186/s12916-018-1175-7
    15 https://app.dimensions.ai/details/publication/pub.1076814301
    16 https://doi.org/10.1002/gepi.21758
    17 https://doi.org/10.1002/gepi.21965
    18 https://doi.org/10.1002/sim.3034
    19 https://doi.org/10.1002/sim.5659
    20 https://doi.org/10.1002/sim.6522
    21 https://doi.org/10.1002/sim.7221
    22 https://doi.org/10.1016/j.cell.2007.05.047
    23 https://doi.org/10.1016/s0140-6736(12)60404-8
    24 https://doi.org/10.1016/s0140-6736(17)30572-x
    25 https://doi.org/10.1016/s0167-9473(01)00097-4
    26 https://doi.org/10.1016/s0735-1097(98)00056-4
    27 https://doi.org/10.1016/s1470-2045(11)70154-1
    28 https://doi.org/10.1016/s2213-8587(15)00474-x
    29 https://doi.org/10.1056/nejmoa1404881
    30 https://doi.org/10.1073/pnas.0609301103
    31 https://doi.org/10.1073/pnas.1707388115
    32 https://doi.org/10.1086/285356
    33 https://doi.org/10.1086/519795
    34 https://doi.org/10.1093/aje/kwj081
    35 https://doi.org/10.1093/aje/kwr026
    36 https://doi.org/10.1093/aje/kwu283
    37 https://doi.org/10.1093/ije/dys086
    38 https://doi.org/10.1093/ije/dyt179
    39 https://doi.org/10.1093/ije/dyu176
    40 https://doi.org/10.1093/ije/dyv074
    41 https://doi.org/10.1093/ije/dyv080
    42 https://doi.org/10.1093/ije/dyx034
    43 https://doi.org/10.1093/ije/dyx102
    44 https://doi.org/10.1093/ije/dyx206
    45 https://doi.org/10.1093/ije/dyy177
    46 https://doi.org/10.1093/ije/dyy258
    47 https://doi.org/10.1093/oxfordjournals.aje.a112044
    48 https://doi.org/10.1097/00001648-199901000-00008
    49 https://doi.org/10.1097/hjh.0000000000001300
    50 https://doi.org/10.1136/bmj.i582
    51 https://doi.org/10.1136/bmj.j3542
    52 https://doi.org/10.1136/jech.54.2.97
    53 https://doi.org/10.1136/jech.57.2.141
    54 https://doi.org/10.1161/01.cir.0000116750.63158.94
    55 https://doi.org/10.1177/0962280210394459
    56 https://doi.org/10.1177/0962280215597579
    57 https://doi.org/10.1534/genetics.117.300191
    58 https://doi.org/10.2337/db10-0839
    59 https://doi.org/10.2337/db16-1253
    60 schema:datePublished 2019-03-27
    61 schema:datePublishedReg 2019-03-27
    62 schema:description There is evidence that lower height is associated with a higher risk of coronary artery disease (CAD) and increased risk of type 2 diabetes (T2D). It is not clear though whether these associations are causal, direct or mediated by other factors. Here we show that one standard deviation higher genetically determined height (~6.5 cm) is causally associated with a 16% decrease in CAD risk (OR = 0.84, 95% CI 0.80-0.87). This causal association remains after performing sensitivity analyses relaxing pleiotropy assumptions. The causal effect of height on CAD risk is reduced by 1-3% after adjustment for potential mediators (lipids, blood pressure, glycaemic traits, body mass index, socio-economic status). In contrast, our data suggest that lung function (measured by forced expiratory volume [FEV1] and forced vital capacity [FVC]) is a mediator of the effect of height on CAD. We observe no direct causal effect of height on the risk of T2D.
    63 schema:genre research_article
    64 schema:inLanguage en
    65 schema:isAccessibleForFree false
    66 schema:isPartOf N2659777983994adb8f8a90df6e7532cb
    67 Nad47db31d2e04905b8a37a8eb3c5a796
    68 sg:journal.1300829
    69 schema:name Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease
    70 schema:pagination 119
    71 schema:productId N38b7984fe8514a57a0908aec4a32878b
    72 N4ed9bb6bbe9f4c898e3a748ac107c3d5
    73 N81a6218f2576496fb4648f9a6cbde5aa
    74 Nd8e436f7edf549bb9118e06f8994993b
    75 Ne18db9e316e94fbea484dc4dc50900c7
    76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113004301
    77 https://doi.org/10.1038/s42003-019-0361-2
    78 schema:sdDatePublished 2019-04-15T09:04
    79 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    80 schema:sdPublisher Nbb4c956a1ff84ee69e6113a0a8b25461
    81 schema:url https://www.nature.com/articles/s42003-019-0361-2
    82 sgo:license sg:explorer/license/
    83 sgo:sdDataset articles
    84 rdf:type schema:ScholarlyArticle
    85 N078915e101dc4cce8cabac90424b21fb rdf:first N3881bff0ddcf44a0a923f440a6594994
    86 rdf:rest rdf:nil
    87 N0944d9401092458d95c5a9587ca52fdd schema:affiliation https://www.grid.ac/institutes/grid.1003.2
    88 schema:familyName Zhu
    89 schema:givenName Zhihong
    90 rdf:type schema:Person
    91 N102719d7876b4bfbaf43d39c3f087e0a schema:affiliation https://www.grid.ac/institutes/grid.1003.2
    92 schema:familyName Yang
    93 schema:givenName Jian
    94 rdf:type schema:Person
    95 N1bc80811c3594539b9cb76e0cb312f39 rdf:first N9f61ce6a897345909458bf11e02c7e4c
    96 rdf:rest Ne498c8e0d8e244768661f1f329cb9ce7
    97 N25f6d1229621419b8387384313131c0b rdf:first N102719d7876b4bfbaf43d39c3f087e0a
    98 rdf:rest Nebd1499c63264fd38ff425267d381dd8
    99 N2605144822854fe2b5f7bd582e8d9e9e rdf:first N4ab79670b92242bbb083f293fcef1ac6
    100 rdf:rest N75c25d56991f4bf4b852f1dd92ffb4e0
    101 N2659777983994adb8f8a90df6e7532cb schema:volumeNumber 2
    102 rdf:type schema:PublicationVolume
    103 N26a7d6b5629045df94819c760f4712ec schema:affiliation https://www.grid.ac/institutes/grid.8993.b
    104 schema:familyName Ahmad
    105 schema:givenName Shafqat
    106 rdf:type schema:Person
    107 N335f13c775a842fb8f171ad159087bed rdf:first Nddbbf28d6b204f449d7c3cd4d1520b59
    108 rdf:rest Ne5b3f45293714dd09cca9da5637fc1ce
    109 N3881bff0ddcf44a0a923f440a6594994 schema:affiliation https://www.grid.ac/institutes/grid.412125.1
    110 schema:familyName Deloukas
    111 schema:givenName Panos
    112 rdf:type schema:Person
    113 N38b7984fe8514a57a0908aec4a32878b schema:name doi
    114 schema:value 10.1038/s42003-019-0361-2
    115 rdf:type schema:PropertyValue
    116 N4ab79670b92242bbb083f293fcef1ac6 schema:affiliation Nfa9b0fd58e4d41ddbed74e6a7fe7ccf5
    117 schema:familyName Del Greco
    118 schema:givenName M. Fabiola
    119 rdf:type schema:Person
    120 N4ed9bb6bbe9f4c898e3a748ac107c3d5 schema:name nlm_unique_id
    121 schema:value 101719179
    122 rdf:type schema:PropertyValue
    123 N622a93a225d14dd5a570ddc53c2b0c34 schema:affiliation https://www.grid.ac/institutes/grid.4868.2
    124 schema:familyName Warren
    125 schema:givenName Helen R.
    126 rdf:type schema:Person
    127 N6d4bbe6f52104765ac8f57f073cbb2a7 rdf:first Ne9c4a8d29bd04fa6aa1e388011e98974
    128 rdf:rest N078915e101dc4cce8cabac90424b21fb
    129 N742d9ee7c0994a5489a7afeee9ca3b75 rdf:first N8bc4e547195f48d49f1291429bca762d
    130 rdf:rest N2605144822854fe2b5f7bd582e8d9e9e
    131 N75c25d56991f4bf4b852f1dd92ffb4e0 rdf:first Nc724cacae15c4632a150960413988f5b
    132 rdf:rest N25f6d1229621419b8387384313131c0b
    133 N81a6218f2576496fb4648f9a6cbde5aa schema:name pubmed_id
    134 schema:value 30937401
    135 rdf:type schema:PropertyValue
    136 N8bc4e547195f48d49f1291429bca762d schema:affiliation https://www.grid.ac/institutes/grid.4868.2
    137 schema:familyName Marouli
    138 schema:givenName Eirini
    139 rdf:type schema:Person
    140 N8feacf1c92cc4442bf3a72571de338e5 rdf:first Nf06d3fa513964e4ab5a99e6bb9900ef0
    141 rdf:rest N335f13c775a842fb8f171ad159087bed
    142 N948a228828c14ce09b1cc3afb2bdf8ef schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    143 schema:familyName Berndt
    144 schema:givenName Sonja I.
    145 rdf:type schema:Person
    146 N96e7c782f9334235ad528cb3486db311 schema:affiliation https://www.grid.ac/institutes/grid.4494.d
    147 schema:familyName van Vliet-Ostaptchouk
    148 schema:givenName Jana V.
    149 rdf:type schema:Person
    150 N9f61ce6a897345909458bf11e02c7e4c schema:affiliation https://www.grid.ac/institutes/grid.5645.2
    151 schema:familyName Medina-Gomez
    152 schema:givenName Carolina
    153 rdf:type schema:Person
    154 Nad47db31d2e04905b8a37a8eb3c5a796 schema:issueNumber 1
    155 rdf:type schema:PublicationIssue
    156 Nbb4c956a1ff84ee69e6113a0a8b25461 schema:name Springer Nature - SN SciGraph project
    157 rdf:type schema:Organization
    158 Nbb739c58d0de43b5b18e6343681aaff0 rdf:first Nd58d00fc122a463b99704fb363b2dc32
    159 rdf:rest N6d4bbe6f52104765ac8f57f073cbb2a7
    160 Nbf476ded91d74acd979c3d5e76ebf405 rdf:first N948a228828c14ce09b1cc3afb2bdf8ef
    161 rdf:rest N8feacf1c92cc4442bf3a72571de338e5
    162 Nc724cacae15c4632a150960413988f5b schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    163 schema:familyName Astley
    164 schema:givenName Christina M.
    165 rdf:type schema:Person
    166 Nc766e8be385a423394eacf0a59a8d42e rdf:first Ne331be8fbb2749f99171bee096cb78f7
    167 rdf:rest Nbb739c58d0de43b5b18e6343681aaff0
    168 Nd4051b6f5a0f403e8e38ccaed1cf1a6f schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    169 schema:familyName McKnight
    170 schema:givenName Barbara
    171 rdf:type schema:Person
    172 Nd58d00fc122a463b99704fb363b2dc32 schema:affiliation https://www.grid.ac/institutes/grid.59734.3c
    173 schema:familyName Loos
    174 schema:givenName Ruth J. F.
    175 rdf:type schema:Person
    176 Nd8e436f7edf549bb9118e06f8994993b schema:name dimensions_id
    177 schema:value pub.1113004301
    178 rdf:type schema:PropertyValue
    179 Nddbbf28d6b204f449d7c3cd4d1520b59 schema:affiliation https://www.grid.ac/institutes/grid.9594.1
    180 schema:familyName Evangelou
    181 schema:givenName Evangelos
    182 rdf:type schema:Person
    183 Ne18db9e316e94fbea484dc4dc50900c7 schema:name readcube_id
    184 schema:value 1c12dfc0106d482f5b4ba858020a045f82a51386a849fc3e4f45dd8e6cc29344
    185 rdf:type schema:PropertyValue
    186 Ne331be8fbb2749f99171bee096cb78f7 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    187 schema:familyName Hirschhorn
    188 schema:givenName Joel N.
    189 rdf:type schema:Person
    190 Ne498c8e0d8e244768661f1f329cb9ce7 rdf:first N96e7c782f9334235ad528cb3486db311
    191 rdf:rest Nf663c51383d44a859f922b52d51122ad
    192 Ne5b3f45293714dd09cca9da5637fc1ce rdf:first Nd4051b6f5a0f403e8e38ccaed1cf1a6f
    193 rdf:rest N1bc80811c3594539b9cb76e0cb312f39
    194 Ne9c4a8d29bd04fa6aa1e388011e98974 schema:affiliation https://www.grid.ac/institutes/grid.419765.8
    195 schema:familyName Kutalik
    196 schema:givenName Zoltan
    197 rdf:type schema:Person
    198 Nebd1499c63264fd38ff425267d381dd8 rdf:first N26a7d6b5629045df94819c760f4712ec
    199 rdf:rest Nbf476ded91d74acd979c3d5e76ebf405
    200 Nf06d3fa513964e4ab5a99e6bb9900ef0 schema:affiliation https://www.grid.ac/institutes/grid.4868.2
    201 schema:familyName Caulfield
    202 schema:givenName Mark J.
    203 rdf:type schema:Person
    204 Nf663c51383d44a859f922b52d51122ad rdf:first N622a93a225d14dd5a570ddc53c2b0c34
    205 rdf:rest Nf7d270a10b8a4f2494d2e1e11bfd5ce8
    206 Nf7d270a10b8a4f2494d2e1e11bfd5ce8 rdf:first N0944d9401092458d95c5a9587ca52fdd
    207 rdf:rest Nc766e8be385a423394eacf0a59a8d42e
    208 Nfa9b0fd58e4d41ddbed74e6a7fe7ccf5 schema:name Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck, 39100, Bolzano, Italy
    209 rdf:type schema:Organization
    210 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    211 schema:name Medical and Health Sciences
    212 rdf:type schema:DefinedTerm
    213 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
    214 schema:name Public Health and Health Services
    215 rdf:type schema:DefinedTerm
    216 sg:grant.2416501 http://pending.schema.org/fundedItem sg:pub.10.1038/s42003-019-0361-2
    217 rdf:type schema:MonetaryGrant
    218 sg:grant.5138169 http://pending.schema.org/fundedItem sg:pub.10.1038/s42003-019-0361-2
    219 rdf:type schema:MonetaryGrant
    220 sg:journal.1300829 schema:issn 2399-3642
    221 schema:name Communications Biology
    222 rdf:type schema:Periodical
    223 sg:pub.10.1007/s00125-002-0887-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039592813
    224 https://doi.org/10.1007/s00125-002-0887-5
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1007/s00592-011-0351-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027345298
    227 https://doi.org/10.1007/s00592-011-0351-4
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1007/s10554-006-9119-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034695936
    230 https://doi.org/10.1007/s10554-006-9119-2
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/nature21039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083401652
    233 https://doi.org/10.1038/nature21039
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/ng.3097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006357119
    236 https://doi.org/10.1038/ng.3097
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/ng.3913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090747969
    239 https://doi.org/10.1038/ng.3913
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/s41467-017-02317-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100275573
    242 https://doi.org/10.1038/s41467-017-02317-2
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/s41588-018-0099-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103565841
    245 https://doi.org/10.1038/s41588-018-0099-7
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/s41588-018-0205-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1107041202
    248 https://doi.org/10.1038/s41588-018-0205-x
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/sj.ijo.0800960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053339522
    251 https://doi.org/10.1038/sj.ijo.0800960
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1186/s12916-018-1175-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107417733
    254 https://doi.org/10.1186/s12916-018-1175-7
    255 rdf:type schema:CreativeWork
    256 https://app.dimensions.ai/details/publication/pub.1076814301 schema:CreativeWork
    257 https://doi.org/10.1002/gepi.21758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050596269
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1002/gepi.21965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041410024
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1002/sim.3034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037075298
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1002/sim.5659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007651270
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1002/sim.6522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053494248
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1002/sim.7221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074197080
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/j.cell.2007.05.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004362994
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/s0140-6736(12)60404-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027246737
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/s0140-6736(17)30572-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1090914167
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/s0167-9473(01)00097-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027048055
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/s0735-1097(98)00056-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005495116
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/s1470-2045(11)70154-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024268708
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/s2213-8587(15)00474-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022291443
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1056/nejmoa1404881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036410069
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1073/pnas.0609301103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020126176
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1073/pnas.1707388115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103602655
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1086/285356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058595479
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1086/519795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019061180
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1093/aje/kwj081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032727228
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1093/aje/kwr026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014375355
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1093/aje/kwu283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005694128
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1093/ije/dys086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007841271
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1093/ije/dyt179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045144996
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1093/ije/dyu176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042470692
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1093/ije/dyv074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006713257
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1093/ije/dyv080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042843395
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1093/ije/dyx034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083932280
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1093/ije/dyx102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085641416
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1093/ije/dyx206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091472608
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1093/ije/dyy177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106071203
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1093/ije/dyy258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1109975731
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1093/oxfordjournals.aje.a112044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080335705
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1097/00001648-199901000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019676192
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1097/hjh.0000000000001300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083934859
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1136/bmj.i582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013318110
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1136/bmj.j3542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091435027
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1136/jech.54.2.97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000282257
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1136/jech.57.2.141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049556440
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1161/01.cir.0000116750.63158.94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008308911
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1177/0962280210394459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040186326
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1177/0962280215597579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054004639
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1534/genetics.117.300191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091329993
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.2337/db10-0839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034913309
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.2337/db16-1253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085730555
    344 rdf:type schema:CreativeWork
    345 https://www.grid.ac/institutes/grid.1003.2 schema:alternateName University of Queensland
    346 schema:name Institute for Molecular Bioscience, University of Queensland, 4072, Brisbane, QLD, Australia
    347 Queensland Brain Institute, The University of Queensland, 4072, Brisbane, QLD, Australia
    348 rdf:type schema:Organization
    349 https://www.grid.ac/institutes/grid.34477.33 schema:alternateName University of Washington
    350 schema:name Department of Biostatistics, University of Washington, 98101, Seattle, WA, USA
    351 rdf:type schema:Organization
    352 https://www.grid.ac/institutes/grid.412125.1 schema:alternateName King Abdulaziz University
    353 schema:name Centre for Genomic Health, Life Sciences, Queen Mary University of London, EC1M 6BQ, London, UK
    354 Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, 21589, Jeddah, Saudi Arabia
    355 William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ, London, UK
    356 rdf:type schema:Organization
    357 https://www.grid.ac/institutes/grid.419765.8 schema:alternateName Swiss Institute of Bioinformatics
    358 schema:name Institute of Social and Preventive Medicine, Lausanne University Hospital, 1010, Lausanne, Switzerland
    359 Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland
    360 rdf:type schema:Organization
    361 https://www.grid.ac/institutes/grid.4494.d schema:alternateName University Medical Center Groningen
    362 schema:name Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9713, Groningen, GZ, The Netherlands
    363 rdf:type schema:Organization
    364 https://www.grid.ac/institutes/grid.4868.2 schema:alternateName Queen Mary University of London
    365 schema:name Centre for Genomic Health, Life Sciences, Queen Mary University of London, EC1M 6BQ, London, UK
    366 National Institute for Health Research, Barts Cardiovascular Biomedical Research Center, Queen Mary University of London, EC1M 6BQ, London, UK
    367 William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ, London, UK
    368 rdf:type schema:Organization
    369 https://www.grid.ac/institutes/grid.5645.2 schema:alternateName Erasmus University Medical Center
    370 schema:name Department of Epidemiology, Erasmus Medical Center, 3015 GE, Rotterdam, The Netherlands
    371 Department of Internal Medicine, Erasmus Medical Center, 3015 GE, Rotterdam, The Netherlands
    372 rdf:type schema:Organization
    373 https://www.grid.ac/institutes/grid.59734.3c schema:alternateName Icahn School of Medicine at Mount Sinai
    374 schema:name The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA
    375 rdf:type schema:Organization
    376 https://www.grid.ac/institutes/grid.66859.34 schema:alternateName Broad Institute
    377 schema:name Boston Children’s Hospital, 02115, Boston, MA, USA
    378 Broad Institute of Harvard and MIT, 02142, Cambridge, MA, USA
    379 rdf:type schema:Organization
    380 https://www.grid.ac/institutes/grid.8993.b schema:alternateName Uppsala University
    381 schema:name Department of Medical Sciences, Molecular Epidemiology, Uppsala University, 751 41, Uppsala, Sweden
    382 Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, 02115, Boston, MA, USA
    383 Division of Preventive Medicine, Harvard Medical School, Department of Medicine, Brigham and Women’s Hospital, 02215, Boston, MA, USA
    384 rdf:type schema:Organization
    385 https://www.grid.ac/institutes/grid.94365.3d schema:alternateName National Institutes of Health
    386 schema:name Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 20892, Bethesda, MD, USA
    387 rdf:type schema:Organization
    388 https://www.grid.ac/institutes/grid.9594.1 schema:alternateName University of Ioannina
    389 schema:name Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, W2 1PG, London, UK
    390 Department of Hygiene and Epidemiology, University of Ioannina Medical School, 45110, Ioannina, Greece
    391 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...