Cytoskeletal actin patterns shape mast cell activation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-12

AUTHORS

Huw Colin-York, Dong Li, Kseniya Korobchevskaya, Veronica T. Chang, Eric Betzig, Christian Eggeling, Marco Fritzsche

ABSTRACT

Activation of immune cells relies on a dynamic actin cytoskeleton. Despite detailed knowledge of molecular actin assembly, the exact processes governing actin organization during activation remain elusive. Using advanced microscopy, we here show that Rat Basophilic Leukemia (RBL) cells, a model mast cell line, employ an orchestrated series of reorganization events within the cortical actin network during activation. In response to IgE antigen-stimulation of FCε receptors (FCεR) at the RBL cell surface, we observed symmetry breaking of the F-actin network and subsequent rapid disassembly of the actin cortex. This was followed by a reassembly process that may be driven by the coordinated transformation of distinct nanoscale F-actin architectures, reminiscent of self-organizing actin patterns. Actin patterns co-localized with zones of Arp2/3 nucleation, while network reassembly was accompanied by myosin-II activity. Strikingly, cortical actin disassembly coincided with zones of granule secretion, suggesting that cytoskeletal actin patterns contribute to orchestrate RBL cell activation. More... »

PAGES

93

References to SciGraph publications

  • 2015-12. The Airyscan detector from ZEISS: confocal imaging with improved signal-to-noise ratio and super-resolution in NATURE METHODS
  • 2011-12. Spindles and active vortices in a model of confined filament-motor mixtures in BMC BIOPHYSICS
  • 2017-04. Dissection of mechanical force in living cells by super-resolved traction force microscopy in NATURE PROTOCOLS
  • 2011-05. Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2017-02-13. Self-organizing actin patterns shape membrane architecture but not cell mechanics in NATURE COMMUNICATIONS
  • 2013-01. Conformational states of the kinase Lck regulate clustering in early T cell signaling in NATURE IMMUNOLOGY
  • 2010-01. TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation in NATURE IMMUNOLOGY
  • 2014-12. Molecular regulation of effector and memory T cell differentiation in NATURE IMMUNOLOGY
  • 2014-03. Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse in NATURE
  • 2008-03. Self-organization in cell biology: a brief history in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2013-09. Molecular motors robustly drive active gels to a critically connected state in NATURE PHYSICS
  • 2012-12. Coordinated oscillations in cortical actin and Ca2+ correlate with cycles of vesicle secretion in NATURE CELL BIOLOGY
  • 2015-12. Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence in NATURE COMMUNICATIONS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s42003-019-0322-9

    DOI

    http://dx.doi.org/10.1038/s42003-019-0322-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112602991

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30854485


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Oxford", 
              "id": "https://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, OX3 9DS, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Colin-York", 
            "givenName": "Huw", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Biophysics", 
              "id": "https://www.grid.ac/institutes/grid.418856.6", 
              "name": [
                "Howard Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, 20147, Ashburn, VA, USA", 
                "National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Dong", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Oxford", 
              "id": "https://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Kennedy Institute for Rheumatology, University of Oxford, Roosevelt Drive, OX3 7LF, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Korobchevskaya", 
            "givenName": "Kseniya", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Cambridge", 
              "id": "https://www.grid.ac/institutes/grid.5335.0", 
              "name": [
                "MRC Laboratory of Molecular Biology, University of Cambridge, CB2 0QH, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chang", 
            "givenName": "Veronica T.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Howard Hughes Medical Institute", 
              "id": "https://www.grid.ac/institutes/grid.413575.1", 
              "name": [
                "Howard Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, 20147, Ashburn, VA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Betzig", 
            "givenName": "Eric", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Oxford", 
              "id": "https://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, OX3 9DS, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eggeling", 
            "givenName": "Christian", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Oxford", 
              "id": "https://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, OX3 9DS, Oxford, UK", 
                "Kennedy Institute for Rheumatology, University of Oxford, Roosevelt Drive, OX3 7LF, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fritzsche", 
            "givenName": "Marco", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1126/science.1059758", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000770172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1103/physrevlett.92.078101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000950540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1103/physrevlett.92.078101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000950540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0320(19990801)36:4<340::aid-cyto9>3.0.co;2-c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001688938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bies.201500111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001968978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.098210", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004415121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.275.13.9664", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006150973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.201201018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006661542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.nanolett.6b00273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011419211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2818.2006.01706.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011935284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.biophys.32.110601.141704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012325406"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1103/physrevlett.97.038102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012739578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1103/physrevlett.97.038102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012739578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.8.4293", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014145182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12951", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014791196", 
              "https://doi.org/10.1038/nature12951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1088/1478-3975/3/4/004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016143166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2614", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016668494", 
              "https://doi.org/10.1038/ncb2614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200108110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017197513"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.201210123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018116389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.f.388", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018861370", 
              "https://doi.org/10.1038/nmeth.f.388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.138.2.375", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018944717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nphys2715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019034898", 
              "https://doi.org/10.1038/nphys2715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aac8167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019100713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1529/biophysj.107.120345", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019425310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0502121102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019601168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1832", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019926285", 
              "https://doi.org/10.1038/ni.1832"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1832", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019926285", 
              "https://doi.org/10.1038/ni.1832"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/sciadv.1501337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020333468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms7174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020682158", 
              "https://doi.org/10.1038/ncomms7174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.05.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020763454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(01)00112-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022775935"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tcb.2012.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024836750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.01433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030466370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2357", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030631416", 
              "https://doi.org/10.1038/nrm2357"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.04.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036292363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.04.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036292363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.11.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036376810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tcb.2012.08.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036779401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037616905", 
              "https://doi.org/10.1038/ni.2488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2009.12.980", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039398665"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2046-1682-4-18", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041236202", 
              "https://doi.org/10.1186/2046-1682-4-18"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2015.04.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041862725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1504762112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044152058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1016616108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045069477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200203043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047281557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047835195", 
              "https://doi.org/10.1038/nsmb.2044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.3031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048090828", 
              "https://doi.org/10.1038/ni.3031"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.201603080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050264641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2004-04-1392", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050381507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aab3500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051440627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1103/physrevlett.95.198101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051850662"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1103/physrevlett.95.198101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051850662"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1221538110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052754526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1103/physrevlett.89.268101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060825803"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1103/physrevlett.89.268101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060825803"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1364/ol.19.000780", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1065215090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080667371", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms14347", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083804284", 
              "https://doi.org/10.1038/ncomms14347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2017.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084129547", 
              "https://doi.org/10.1038/nprot.2017.009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/sciadv.1603032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090321538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/photonics4030041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090371287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2017.12.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100775039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2017.12.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100775039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/sciadv.aar2847", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104431607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acsnano.8b04080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105711890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acsnano.8b04080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105711890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.aat0756", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110751645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.aat0756", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110751645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.aat0756", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110751645"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "Activation of immune cells relies on a dynamic actin cytoskeleton. Despite detailed knowledge of molecular actin assembly, the exact processes governing actin organization during activation remain elusive. Using advanced microscopy, we here show that Rat Basophilic Leukemia (RBL) cells, a model mast cell line, employ an orchestrated series of reorganization events within the cortical actin network during activation. In response to IgE antigen-stimulation of FC\u03b5 receptors (FC\u03b5R) at the RBL cell surface, we observed symmetry breaking of the F-actin network and subsequent rapid disassembly of the actin cortex. This was followed by a reassembly process that may be driven by the coordinated transformation of distinct nanoscale F-actin architectures, reminiscent of self-organizing actin patterns. Actin patterns co-localized with zones of Arp2/3 nucleation, while network reassembly was accompanied by myosin-II activity. Strikingly, cortical actin disassembly coincided with zones of granule secretion, suggesting that cytoskeletal actin patterns contribute to orchestrate RBL cell activation.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s42003-019-0322-9", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3643662", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7747809", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2778032", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1300829", 
            "issn": [
              "2399-3642"
            ], 
            "name": "Communications Biology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "2"
          }
        ], 
        "name": "Cytoskeletal actin patterns shape mast cell activation", 
        "pagination": "93", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "2816fd2069cbd71ddbdb6f8686e9939549e4062bac77f06a00b4d1d11d3dd047"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30854485"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101719179"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s42003-019-0322-9"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1112602991"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s42003-019-0322-9", 
          "https://app.dimensions.ai/details/publication/pub.1112602991"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:20", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78965_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s42003-019-0322-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s42003-019-0322-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s42003-019-0322-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s42003-019-0322-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s42003-019-0322-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    309 TRIPLES      21 PREDICATES      88 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s42003-019-0322-9 schema:about anzsrc-for:11
    2 anzsrc-for:1107
    3 schema:author Nddaaea60d4cb4aa78bfe1747a82fc855
    4 schema:citation sg:pub.10.1038/nature12951
    5 sg:pub.10.1038/ncb2614
    6 sg:pub.10.1038/ncomms14347
    7 sg:pub.10.1038/ncomms7174
    8 sg:pub.10.1038/ni.1832
    9 sg:pub.10.1038/ni.2488
    10 sg:pub.10.1038/ni.3031
    11 sg:pub.10.1038/nmeth.f.388
    12 sg:pub.10.1038/nphys2715
    13 sg:pub.10.1038/nprot.2017.009
    14 sg:pub.10.1038/nrm2357
    15 sg:pub.10.1038/nsmb.2044
    16 sg:pub.10.1186/2046-1682-4-18
    17 https://app.dimensions.ai/details/publication/pub.1080667371
    18 https://doi.org/10.1002/(sici)1097-0320(19990801)36:4<340::aid-cyto9>3.0.co;2-c
    19 https://doi.org/10.1002/bies.201500111
    20 https://doi.org/10.1016/j.cell.2005.04.009
    21 https://doi.org/10.1016/j.cell.2012.05.008
    22 https://doi.org/10.1016/j.cell.2012.11.011
    23 https://doi.org/10.1016/j.cub.2017.12.044
    24 https://doi.org/10.1016/j.immuni.2015.04.013
    25 https://doi.org/10.1016/j.jaci.2009.12.980
    26 https://doi.org/10.1016/j.tcb.2012.03.003
    27 https://doi.org/10.1016/j.tcb.2012.08.012
    28 https://doi.org/10.1016/s1074-7613(01)00112-1
    29 https://doi.org/10.1021/acs.nanolett.6b00273
    30 https://doi.org/10.1021/acsnano.8b04080
    31 https://doi.org/10.1073/pnas.0502121102
    32 https://doi.org/10.1073/pnas.1016616108
    33 https://doi.org/10.1073/pnas.1221538110
    34 https://doi.org/10.1073/pnas.1504762112
    35 https://doi.org/10.1073/pnas.95.8.4293
    36 https://doi.org/10.1074/jbc.275.13.9664
    37 https://doi.org/10.1083/jcb.138.2.375
    38 https://doi.org/10.1083/jcb.200108110
    39 https://doi.org/10.1083/jcb.200203043
    40 https://doi.org/10.1083/jcb.201201018
    41 https://doi.org/10.1083/jcb.201210123
    42 https://doi.org/10.1083/jcb.201603080
    43 https://doi.org/10.1088/1478-3975/3/4/004
    44 https://doi.org/10.1103/physrevlett.89.268101
    45 https://doi.org/10.1103/physrevlett.92.078101
    46 https://doi.org/10.1103/physrevlett.95.198101
    47 https://doi.org/10.1103/physrevlett.97.038102
    48 https://doi.org/10.1111/j.1365-2818.2006.01706.x
    49 https://doi.org/10.1126/sciadv.1501337
    50 https://doi.org/10.1126/sciadv.1603032
    51 https://doi.org/10.1126/sciadv.aar2847
    52 https://doi.org/10.1126/science.1059758
    53 https://doi.org/10.1126/science.aab3500
    54 https://doi.org/10.1126/science.aac8167
    55 https://doi.org/10.1126/scisignal.aat0756
    56 https://doi.org/10.1146/annurev.biophys.32.110601.141704
    57 https://doi.org/10.1182/blood-2004-04-1392
    58 https://doi.org/10.1242/jcs.098210
    59 https://doi.org/10.1364/ol.19.000780
    60 https://doi.org/10.1529/biophysj.107.120345
    61 https://doi.org/10.3390/photonics4030041
    62 https://doi.org/10.7554/elife.01433
    63 schema:datePublished 2019-12
    64 schema:datePublishedReg 2019-12-01
    65 schema:description Activation of immune cells relies on a dynamic actin cytoskeleton. Despite detailed knowledge of molecular actin assembly, the exact processes governing actin organization during activation remain elusive. Using advanced microscopy, we here show that Rat Basophilic Leukemia (RBL) cells, a model mast cell line, employ an orchestrated series of reorganization events within the cortical actin network during activation. In response to IgE antigen-stimulation of FCε receptors (FCεR) at the RBL cell surface, we observed symmetry breaking of the F-actin network and subsequent rapid disassembly of the actin cortex. This was followed by a reassembly process that may be driven by the coordinated transformation of distinct nanoscale F-actin architectures, reminiscent of self-organizing actin patterns. Actin patterns co-localized with zones of Arp2/3 nucleation, while network reassembly was accompanied by myosin-II activity. Strikingly, cortical actin disassembly coincided with zones of granule secretion, suggesting that cytoskeletal actin patterns contribute to orchestrate RBL cell activation.
    66 schema:genre research_article
    67 schema:inLanguage en
    68 schema:isAccessibleForFree false
    69 schema:isPartOf N90fc185e04724d8a88c22f0c840784c4
    70 N978ce523e30e4be8a51f61b3167ce581
    71 sg:journal.1300829
    72 schema:name Cytoskeletal actin patterns shape mast cell activation
    73 schema:pagination 93
    74 schema:productId N173961ecaade4c32a8b9da857c464692
    75 N2994b3ac4062473ca4a5c8dc9fbc6b7b
    76 N5bfbca6b4ed74d8986fc1fc232f82851
    77 Nc240cb2e67d8494badfd7ada9c7f3c31
    78 Nde3369b65c434efc8bd5988df58047ed
    79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112602991
    80 https://doi.org/10.1038/s42003-019-0322-9
    81 schema:sdDatePublished 2019-04-11T13:20
    82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    83 schema:sdPublisher Na5184383a9724d6987191f89a81fc81b
    84 schema:url https://www.nature.com/articles/s42003-019-0322-9
    85 sgo:license sg:explorer/license/
    86 sgo:sdDataset articles
    87 rdf:type schema:ScholarlyArticle
    88 N007b581194c948d9babd8746aafa139c schema:affiliation https://www.grid.ac/institutes/grid.4991.5
    89 schema:familyName Eggeling
    90 schema:givenName Christian
    91 rdf:type schema:Person
    92 N03f6bd6024ff4216be4bee386a5a8bcc rdf:first Nc013181559b04cbbaf0594238c89aa98
    93 rdf:rest N8083107fe3684417bb8dce3d5360d2ed
    94 N12f03e9cf3bc43afa7a42ea5f66e3abb rdf:first Nf14470c0ff90439984369d25ef24f945
    95 rdf:rest N03f6bd6024ff4216be4bee386a5a8bcc
    96 N173961ecaade4c32a8b9da857c464692 schema:name doi
    97 schema:value 10.1038/s42003-019-0322-9
    98 rdf:type schema:PropertyValue
    99 N2167270b5abe4f6fbd37075db610c3ac rdf:first N007b581194c948d9babd8746aafa139c
    100 rdf:rest Nbf81c33f5ace4ca098585bf26479cd76
    101 N2994b3ac4062473ca4a5c8dc9fbc6b7b schema:name nlm_unique_id
    102 schema:value 101719179
    103 rdf:type schema:PropertyValue
    104 N3a816c16b7e34e3f9c70e7eeeb8d44dd schema:affiliation https://www.grid.ac/institutes/grid.4991.5
    105 schema:familyName Colin-York
    106 schema:givenName Huw
    107 rdf:type schema:Person
    108 N46e9c4c570e547c585b0e91cc3e96d85 schema:affiliation https://www.grid.ac/institutes/grid.418856.6
    109 schema:familyName Li
    110 schema:givenName Dong
    111 rdf:type schema:Person
    112 N5bfbca6b4ed74d8986fc1fc232f82851 schema:name dimensions_id
    113 schema:value pub.1112602991
    114 rdf:type schema:PropertyValue
    115 N76cef74b3770442880f5326c936b276f schema:affiliation https://www.grid.ac/institutes/grid.413575.1
    116 schema:familyName Betzig
    117 schema:givenName Eric
    118 rdf:type schema:Person
    119 N8083107fe3684417bb8dce3d5360d2ed rdf:first N76cef74b3770442880f5326c936b276f
    120 rdf:rest N2167270b5abe4f6fbd37075db610c3ac
    121 N90fc185e04724d8a88c22f0c840784c4 schema:issueNumber 1
    122 rdf:type schema:PublicationIssue
    123 N978ce523e30e4be8a51f61b3167ce581 schema:volumeNumber 2
    124 rdf:type schema:PublicationVolume
    125 Na5184383a9724d6987191f89a81fc81b schema:name Springer Nature - SN SciGraph project
    126 rdf:type schema:Organization
    127 Nb1d8888a429e4c9e87ff5f8de657dc82 rdf:first N46e9c4c570e547c585b0e91cc3e96d85
    128 rdf:rest N12f03e9cf3bc43afa7a42ea5f66e3abb
    129 Nbf81c33f5ace4ca098585bf26479cd76 rdf:first Ne16031afaa944a8b90199a6a7e3e36bf
    130 rdf:rest rdf:nil
    131 Nc013181559b04cbbaf0594238c89aa98 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
    132 schema:familyName Chang
    133 schema:givenName Veronica T.
    134 rdf:type schema:Person
    135 Nc240cb2e67d8494badfd7ada9c7f3c31 schema:name readcube_id
    136 schema:value 2816fd2069cbd71ddbdb6f8686e9939549e4062bac77f06a00b4d1d11d3dd047
    137 rdf:type schema:PropertyValue
    138 Nddaaea60d4cb4aa78bfe1747a82fc855 rdf:first N3a816c16b7e34e3f9c70e7eeeb8d44dd
    139 rdf:rest Nb1d8888a429e4c9e87ff5f8de657dc82
    140 Nde3369b65c434efc8bd5988df58047ed schema:name pubmed_id
    141 schema:value 30854485
    142 rdf:type schema:PropertyValue
    143 Ne16031afaa944a8b90199a6a7e3e36bf schema:affiliation https://www.grid.ac/institutes/grid.4991.5
    144 schema:familyName Fritzsche
    145 schema:givenName Marco
    146 rdf:type schema:Person
    147 Nf14470c0ff90439984369d25ef24f945 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
    148 schema:familyName Korobchevskaya
    149 schema:givenName Kseniya
    150 rdf:type schema:Person
    151 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    152 schema:name Medical and Health Sciences
    153 rdf:type schema:DefinedTerm
    154 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    155 schema:name Immunology
    156 rdf:type schema:DefinedTerm
    157 sg:grant.2778032 http://pending.schema.org/fundedItem sg:pub.10.1038/s42003-019-0322-9
    158 rdf:type schema:MonetaryGrant
    159 sg:grant.3643662 http://pending.schema.org/fundedItem sg:pub.10.1038/s42003-019-0322-9
    160 rdf:type schema:MonetaryGrant
    161 sg:grant.7747809 http://pending.schema.org/fundedItem sg:pub.10.1038/s42003-019-0322-9
    162 rdf:type schema:MonetaryGrant
    163 sg:journal.1300829 schema:issn 2399-3642
    164 schema:name Communications Biology
    165 rdf:type schema:Periodical
    166 sg:pub.10.1038/nature12951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014791196
    167 https://doi.org/10.1038/nature12951
    168 rdf:type schema:CreativeWork
    169 sg:pub.10.1038/ncb2614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016668494
    170 https://doi.org/10.1038/ncb2614
    171 rdf:type schema:CreativeWork
    172 sg:pub.10.1038/ncomms14347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083804284
    173 https://doi.org/10.1038/ncomms14347
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1038/ncomms7174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020682158
    176 https://doi.org/10.1038/ncomms7174
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1038/ni.1832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019926285
    179 https://doi.org/10.1038/ni.1832
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1038/ni.2488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037616905
    182 https://doi.org/10.1038/ni.2488
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1038/ni.3031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048090828
    185 https://doi.org/10.1038/ni.3031
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1038/nmeth.f.388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018861370
    188 https://doi.org/10.1038/nmeth.f.388
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/nphys2715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019034898
    191 https://doi.org/10.1038/nphys2715
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/nprot.2017.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129547
    194 https://doi.org/10.1038/nprot.2017.009
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/nrm2357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030631416
    197 https://doi.org/10.1038/nrm2357
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/nsmb.2044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047835195
    200 https://doi.org/10.1038/nsmb.2044
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1186/2046-1682-4-18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041236202
    203 https://doi.org/10.1186/2046-1682-4-18
    204 rdf:type schema:CreativeWork
    205 https://app.dimensions.ai/details/publication/pub.1080667371 schema:CreativeWork
    206 https://doi.org/10.1002/(sici)1097-0320(19990801)36:4<340::aid-cyto9>3.0.co;2-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1001688938
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1002/bies.201500111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001968978
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1016/j.cell.2005.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036292363
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1016/j.cell.2012.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020763454
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1016/j.cell.2012.11.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036376810
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1016/j.cub.2017.12.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100775039
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1016/j.immuni.2015.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041862725
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1016/j.jaci.2009.12.980 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039398665
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1016/j.tcb.2012.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024836750
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1016/j.tcb.2012.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036779401
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1016/s1074-7613(01)00112-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022775935
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1021/acs.nanolett.6b00273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011419211
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1021/acsnano.8b04080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105711890
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1073/pnas.0502121102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019601168
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1073/pnas.1016616108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045069477
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1073/pnas.1221538110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052754526
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1073/pnas.1504762112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044152058
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1073/pnas.95.8.4293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014145182
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1074/jbc.275.13.9664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006150973
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1083/jcb.138.2.375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018944717
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1083/jcb.200108110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017197513
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1083/jcb.200203043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047281557
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1083/jcb.201201018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006661542
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1083/jcb.201210123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018116389
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1083/jcb.201603080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050264641
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1088/1478-3975/3/4/004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016143166
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1103/physrevlett.89.268101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060825803
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1103/physrevlett.92.078101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000950540
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1103/physrevlett.95.198101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051850662
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1103/physrevlett.97.038102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012739578
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1111/j.1365-2818.2006.01706.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011935284
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1126/sciadv.1501337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020333468
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1126/sciadv.1603032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090321538
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1126/sciadv.aar2847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104431607
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1126/science.1059758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000770172
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1126/science.aab3500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051440627
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1126/science.aac8167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019100713
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1126/scisignal.aat0756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110751645
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1146/annurev.biophys.32.110601.141704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012325406
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1182/blood-2004-04-1392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050381507
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1242/jcs.098210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004415121
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1364/ol.19.000780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1065215090
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1529/biophysj.107.120345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019425310
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.3390/photonics4030041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090371287
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.7554/elife.01433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030466370
    295 rdf:type schema:CreativeWork
    296 https://www.grid.ac/institutes/grid.413575.1 schema:alternateName Howard Hughes Medical Institute
    297 schema:name Howard Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, 20147, Ashburn, VA, USA
    298 rdf:type schema:Organization
    299 https://www.grid.ac/institutes/grid.418856.6 schema:alternateName Institute of Biophysics
    300 schema:name Howard Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, 20147, Ashburn, VA, USA
    301 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China
    302 rdf:type schema:Organization
    303 https://www.grid.ac/institutes/grid.4991.5 schema:alternateName University of Oxford
    304 schema:name Kennedy Institute for Rheumatology, University of Oxford, Roosevelt Drive, OX3 7LF, Oxford, UK
    305 MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, OX3 9DS, Oxford, UK
    306 rdf:type schema:Organization
    307 https://www.grid.ac/institutes/grid.5335.0 schema:alternateName University of Cambridge
    308 schema:name MRC Laboratory of Molecular Biology, University of Cambridge, CB2 0QH, Cambridge, UK
    309 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...