NapM enhances the survival of Mycobacterium tuberculosis under stress and in macrophages View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-12

AUTHORS

Yu Liu, Zhiwei Xie, Xiling Zhou, Weihui Li, Hua Zhang, Zheng-Guo He

ABSTRACT

Hostile environmental cues cause Mycobacterium tuberculosis to enter a state of slow growth for survival. However, the underlying regulatory mechanism remains unclear. DnaA is essential for DNA replication initiation and represents an efficient target for growth regulation in bacteria. Here, we show that the nucleoid-associated protein NapM is a DnaA antagonist, protecting M. tuberculosis from stress-mediated killing. NapM can be induced by diverse stressful signals. It binds to DnaA to inhibit both its DNA replication origin-binding and ATP hydrolysis activity. As a DnaA antagonist, NapM inhibits the mycobacterial DNA synthesis in vitro and in vivo in M. tuberculosis. Furthermore, we show that NapM contributes to the survival of M. tuberculosis under stress and within macrophages during infection. Our findings provide a previously unidentified mechanism of mycobacterial survival under stress and also suggest NapM as a potential drug target for tuberculosis control. More... »

PAGES

65

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s42003-019-0314-9

DOI

http://dx.doi.org/10.1038/s42003-019-0314-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112165562

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30793043


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Huazhong Agricultural University", 
          "id": "https://www.grid.ac/institutes/grid.35155.37", 
          "name": [
            "College of Life Science and Technology, Huazhong Agricultural University, 430070, Wuhan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Yu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Huazhong Agricultural University", 
          "id": "https://www.grid.ac/institutes/grid.35155.37", 
          "name": [
            "College of Life Science and Technology, Huazhong Agricultural University, 430070, Wuhan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xie", 
        "givenName": "Zhiwei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Huazhong Agricultural University", 
          "id": "https://www.grid.ac/institutes/grid.35155.37", 
          "name": [
            "College of Life Science and Technology, Huazhong Agricultural University, 430070, Wuhan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Xiling", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Huazhong Agricultural University", 
          "id": "https://www.grid.ac/institutes/grid.35155.37", 
          "name": [
            "College of Life Science and Technology, Huazhong Agricultural University, 430070, Wuhan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Weihui", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Huazhong Agricultural University", 
          "id": "https://www.grid.ac/institutes/grid.35155.37", 
          "name": [
            "College of Life Science and Technology, Huazhong Agricultural University, 430070, Wuhan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Hua", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Huazhong Agricultural University", 
          "id": "https://www.grid.ac/institutes/grid.35155.37", 
          "name": [
            "College of Life Science and Technology, Huazhong Agricultural University, 430070, Wuhan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "He", 
        "givenName": "Zheng-Guo", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0092-8674(84)90284-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007557380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.06.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010697497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro749", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011605641", 
          "https://doi.org/10.1038/nrmicro749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro749", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011605641", 
          "https://doi.org/10.1038/nrmicro749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro1445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011907049", 
          "https://doi.org/10.1038/nrmicro1445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro1445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011907049", 
          "https://doi.org/10.1038/nrmicro1445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1574-6976.2007.00070.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012728162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0810126106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016695967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2180-6-35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018935179", 
          "https://doi.org/10.1186/1471-2180-6-35"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/mmi.13383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019291450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/mmi.13144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021455869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1212753109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023006294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2014.11.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025055340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-4658.2007.06241.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026933064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0908966106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027686299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(87)90221-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028090340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro1557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028266555", 
          "https://doi.org/10.1038/nrmicro1557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro1557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028266555", 
          "https://doi.org/10.1038/nrmicro1557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkq737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030781296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2014.02.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030895700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.micro.60.080805.142111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030916519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2011.05.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035421407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1574-6976.2012.00331.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038760313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro2314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039350804", 
          "https://doi.org/10.1038/nrmicro2314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro2314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039350804", 
          "https://doi.org/10.1038/nrmicro2314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.1781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039392762", 
          "https://doi.org/10.1038/ni.1781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1561207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040356407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041601361", 
          "https://doi.org/10.1038/ni981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041601361", 
          "https://doi.org/10.1038/ni981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0004139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042077207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro1640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043068639", 
          "https://doi.org/10.1038/nrmicro1640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro1640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043068639", 
          "https://doi.org/10.1038/nrmicro1640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.2006.05068.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046052926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.2006.05068.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046052926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mib.2014.02.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046291651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gks923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046304836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.micro.112408.134306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052721858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1007115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093037820"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Hostile environmental cues cause Mycobacterium tuberculosis to enter a state of slow growth for survival. However, the underlying regulatory mechanism remains unclear. DnaA is essential for DNA replication initiation and represents an efficient target for growth regulation in bacteria. Here, we show that the nucleoid-associated protein NapM is a DnaA antagonist, protecting M. tuberculosis from stress-mediated killing. NapM can be induced by diverse stressful signals. It binds to DnaA to inhibit both its DNA replication origin-binding and ATP hydrolysis activity. As a DnaA antagonist, NapM inhibits the mycobacterial DNA synthesis in vitro and in vivo in M. tuberculosis. Furthermore, we show that NapM contributes to the survival of M. tuberculosis under stress and within macrophages during infection. Our findings provide a previously unidentified mechanism of mycobacterial survival under stress and also suggest NapM as a potential drug target for tuberculosis control.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s42003-019-0314-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1300829", 
        "issn": [
          "2399-3642"
        ], 
        "name": "Communications Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "name": "NapM enhances the survival of Mycobacterium tuberculosis under stress and in macrophages", 
    "pagination": "65", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "137f33fd3780a7fd0161e898f7fa38737a436aeaef4552bcc36a89e3b087b8bb"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30793043"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101719179"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s42003-019-0314-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112165562"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s42003-019-0314-9", 
      "https://app.dimensions.ai/details/publication/pub.1112165562"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113667_00000005.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s42003-019-0314-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s42003-019-0314-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s42003-019-0314-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s42003-019-0314-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s42003-019-0314-9'


 

This table displays all metadata directly associated to this object as RDF triples.

198 TRIPLES      21 PREDICATES      60 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s42003-019-0314-9 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author Nb2f816b323c445cc8e9322837299972c
4 schema:citation sg:pub.10.1038/ni.1781
5 sg:pub.10.1038/ni981
6 sg:pub.10.1038/nrmicro1445
7 sg:pub.10.1038/nrmicro1557
8 sg:pub.10.1038/nrmicro1640
9 sg:pub.10.1038/nrmicro2314
10 sg:pub.10.1038/nrmicro749
11 sg:pub.10.1186/1471-2180-6-35
12 https://doi.org/10.1016/0092-8674(84)90284-8
13 https://doi.org/10.1016/0092-8674(87)90221-2
14 https://doi.org/10.1016/j.cell.2013.06.034
15 https://doi.org/10.1016/j.cell.2014.02.050
16 https://doi.org/10.1016/j.cell.2014.11.024
17 https://doi.org/10.1016/j.cub.2011.05.040
18 https://doi.org/10.1016/j.mib.2014.02.006
19 https://doi.org/10.1073/pnas.0810126106
20 https://doi.org/10.1073/pnas.0908966106
21 https://doi.org/10.1073/pnas.1212753109
22 https://doi.org/10.1093/nar/gkq737
23 https://doi.org/10.1093/nar/gks923
24 https://doi.org/10.1101/gad.1561207
25 https://doi.org/10.1111/j.1365-2958.2006.05068.x
26 https://doi.org/10.1111/j.1574-6976.2007.00070.x
27 https://doi.org/10.1111/j.1574-6976.2012.00331.x
28 https://doi.org/10.1111/j.1742-4658.2007.06241.x
29 https://doi.org/10.1111/mmi.13144
30 https://doi.org/10.1111/mmi.13383
31 https://doi.org/10.1146/annurev.micro.112408.134306
32 https://doi.org/10.1146/annurev.micro.60.080805.142111
33 https://doi.org/10.1371/journal.pgen.1007115
34 https://doi.org/10.1371/journal.pone.0004139
35 schema:datePublished 2019-12
36 schema:datePublishedReg 2019-12-01
37 schema:description Hostile environmental cues cause <i>Mycobacterium tuberculosis</i> to enter a state of slow growth for survival. However, the underlying regulatory mechanism remains unclear. DnaA is essential for DNA replication initiation and represents an efficient target for growth regulation in bacteria. Here, we show that the nucleoid-associated protein NapM is a DnaA antagonist, protecting <i>M. tuberculosis</i> from stress-mediated killing. NapM can be induced by diverse stressful signals. It binds to DnaA to inhibit both its DNA replication origin-binding and ATP hydrolysis activity. As a DnaA antagonist, NapM inhibits the mycobacterial DNA synthesis in vitro and in vivo in <i>M. tuberculosis</i>. Furthermore, we show that NapM contributes to the survival of <i>M. tuberculosis</i> under stress and within macrophages during infection. Our findings provide a previously unidentified mechanism of mycobacterial survival under stress and also suggest NapM as a potential drug target for tuberculosis control.
38 schema:genre research_article
39 schema:inLanguage en
40 schema:isAccessibleForFree false
41 schema:isPartOf Na37eac3cbff44f03a615bbe599949cbb
42 Ne0fce814223544e0be749e42083c4db8
43 sg:journal.1300829
44 schema:name NapM enhances the survival of Mycobacterium tuberculosis under stress and in macrophages
45 schema:pagination 65
46 schema:productId N1bdbb01be60b4fa9a0736800a3f8e758
47 N38f3826e2f68424a9d23a745e621442b
48 N4950fa66bbb64f9792b1b022e003c2da
49 N6988a47f6ba84ff49a5ef3cd35acc37a
50 Nfe54df251c8e4051afa389e7d26bf89a
51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112165562
52 https://doi.org/10.1038/s42003-019-0314-9
53 schema:sdDatePublished 2019-04-11T10:35
54 schema:sdLicense https://scigraph.springernature.com/explorer/license/
55 schema:sdPublisher N924d67c8f4b04fdcbd1389b30bb1c00b
56 schema:url https://www.nature.com/articles/s42003-019-0314-9
57 sgo:license sg:explorer/license/
58 sgo:sdDataset articles
59 rdf:type schema:ScholarlyArticle
60 N0cfedd3241f64b1dac0632a20c8d6ba4 rdf:first N7b8db8ed612c45628a6437317ffe17b0
61 rdf:rest rdf:nil
62 N1bdbb01be60b4fa9a0736800a3f8e758 schema:name dimensions_id
63 schema:value pub.1112165562
64 rdf:type schema:PropertyValue
65 N30fa58e00a614a109c61428e28263b56 schema:affiliation https://www.grid.ac/institutes/grid.35155.37
66 schema:familyName Li
67 schema:givenName Weihui
68 rdf:type schema:Person
69 N38f3826e2f68424a9d23a745e621442b schema:name doi
70 schema:value 10.1038/s42003-019-0314-9
71 rdf:type schema:PropertyValue
72 N4950fa66bbb64f9792b1b022e003c2da schema:name nlm_unique_id
73 schema:value 101719179
74 rdf:type schema:PropertyValue
75 N4e76ce0de42e42098c01b1c243df9184 schema:affiliation https://www.grid.ac/institutes/grid.35155.37
76 schema:familyName Zhang
77 schema:givenName Hua
78 rdf:type schema:Person
79 N6988a47f6ba84ff49a5ef3cd35acc37a schema:name pubmed_id
80 schema:value 30793043
81 rdf:type schema:PropertyValue
82 N7476972d86df4c64a90b87a9e74a697f schema:affiliation https://www.grid.ac/institutes/grid.35155.37
83 schema:familyName Zhou
84 schema:givenName Xiling
85 rdf:type schema:Person
86 N7b8db8ed612c45628a6437317ffe17b0 schema:affiliation https://www.grid.ac/institutes/grid.35155.37
87 schema:familyName He
88 schema:givenName Zheng-Guo
89 rdf:type schema:Person
90 N7cf2fe4fd4e745b9a6940edb3d1aeb8c schema:affiliation https://www.grid.ac/institutes/grid.35155.37
91 schema:familyName Xie
92 schema:givenName Zhiwei
93 rdf:type schema:Person
94 N8f5bf0f0d92d419ebc8646a259e23026 rdf:first N4e76ce0de42e42098c01b1c243df9184
95 rdf:rest N0cfedd3241f64b1dac0632a20c8d6ba4
96 N924d67c8f4b04fdcbd1389b30bb1c00b schema:name Springer Nature - SN SciGraph project
97 rdf:type schema:Organization
98 N98f4fbab67884b2395b68f05930ad887 schema:affiliation https://www.grid.ac/institutes/grid.35155.37
99 schema:familyName Liu
100 schema:givenName Yu
101 rdf:type schema:Person
102 Na37eac3cbff44f03a615bbe599949cbb schema:volumeNumber 2
103 rdf:type schema:PublicationVolume
104 Nb2f816b323c445cc8e9322837299972c rdf:first N98f4fbab67884b2395b68f05930ad887
105 rdf:rest Nd1130bb27d6749d5891cfec366b3f74b
106 Nd1130bb27d6749d5891cfec366b3f74b rdf:first N7cf2fe4fd4e745b9a6940edb3d1aeb8c
107 rdf:rest Nf08d9318747748448e25d6939666ad21
108 Ndd22e61df2744aab8e403da21271e602 rdf:first N30fa58e00a614a109c61428e28263b56
109 rdf:rest N8f5bf0f0d92d419ebc8646a259e23026
110 Ne0fce814223544e0be749e42083c4db8 schema:issueNumber 1
111 rdf:type schema:PublicationIssue
112 Nf08d9318747748448e25d6939666ad21 rdf:first N7476972d86df4c64a90b87a9e74a697f
113 rdf:rest Ndd22e61df2744aab8e403da21271e602
114 Nfe54df251c8e4051afa389e7d26bf89a schema:name readcube_id
115 schema:value 137f33fd3780a7fd0161e898f7fa38737a436aeaef4552bcc36a89e3b087b8bb
116 rdf:type schema:PropertyValue
117 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
118 schema:name Biological Sciences
119 rdf:type schema:DefinedTerm
120 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
121 schema:name Biochemistry and Cell Biology
122 rdf:type schema:DefinedTerm
123 sg:journal.1300829 schema:issn 2399-3642
124 schema:name Communications Biology
125 rdf:type schema:Periodical
126 sg:pub.10.1038/ni.1781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039392762
127 https://doi.org/10.1038/ni.1781
128 rdf:type schema:CreativeWork
129 sg:pub.10.1038/ni981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041601361
130 https://doi.org/10.1038/ni981
131 rdf:type schema:CreativeWork
132 sg:pub.10.1038/nrmicro1445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011907049
133 https://doi.org/10.1038/nrmicro1445
134 rdf:type schema:CreativeWork
135 sg:pub.10.1038/nrmicro1557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028266555
136 https://doi.org/10.1038/nrmicro1557
137 rdf:type schema:CreativeWork
138 sg:pub.10.1038/nrmicro1640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043068639
139 https://doi.org/10.1038/nrmicro1640
140 rdf:type schema:CreativeWork
141 sg:pub.10.1038/nrmicro2314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039350804
142 https://doi.org/10.1038/nrmicro2314
143 rdf:type schema:CreativeWork
144 sg:pub.10.1038/nrmicro749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011605641
145 https://doi.org/10.1038/nrmicro749
146 rdf:type schema:CreativeWork
147 sg:pub.10.1186/1471-2180-6-35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018935179
148 https://doi.org/10.1186/1471-2180-6-35
149 rdf:type schema:CreativeWork
150 https://doi.org/10.1016/0092-8674(84)90284-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007557380
151 rdf:type schema:CreativeWork
152 https://doi.org/10.1016/0092-8674(87)90221-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028090340
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1016/j.cell.2013.06.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010697497
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1016/j.cell.2014.02.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030895700
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1016/j.cell.2014.11.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025055340
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/j.cub.2011.05.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035421407
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/j.mib.2014.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046291651
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1073/pnas.0810126106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016695967
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1073/pnas.0908966106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027686299
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1073/pnas.1212753109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023006294
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1093/nar/gkq737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030781296
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1093/nar/gks923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046304836
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1101/gad.1561207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040356407
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1111/j.1365-2958.2006.05068.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046052926
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1111/j.1574-6976.2007.00070.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012728162
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1111/j.1574-6976.2012.00331.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038760313
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1111/j.1742-4658.2007.06241.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026933064
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1111/mmi.13144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021455869
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1111/mmi.13383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019291450
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1146/annurev.micro.112408.134306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052721858
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1146/annurev.micro.60.080805.142111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030916519
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1371/journal.pgen.1007115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093037820
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1371/journal.pone.0004139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042077207
195 rdf:type schema:CreativeWork
196 https://www.grid.ac/institutes/grid.35155.37 schema:alternateName Huazhong Agricultural University
197 schema:name College of Life Science and Technology, Huazhong Agricultural University, 430070, Wuhan, China
198 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...