Screening and identification of a non-peptide antagonist for the peptide hormone receptor in Arabidopsis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-12

AUTHORS

Hidefumi Shinohara, Naoko Yasue, Tetsuo Onuki, Yasumitsu Kondoh, Minoru Yoshida, Yoshikatsu Matsubayashi

ABSTRACT

Intercellular signaling mediated by peptide hormones and membrane-localized receptor kinases plays crucial roles in plant developmental processes. Because of their diverse functions, agonistic or antagonistic modulation of peptide signaling holds enormous promise for agricultural applications. Here we established a high-throughput screening system using a bead-immobilized receptor kinase and fluorescent-labeled peptide ligand to identify small molecules that bind peptide hormone receptors in competition with natural ligands. We used the Arabidopsis CLE9-BAM1 ligand-receptor pair to screen a library of ≈30,000 chemicals and identified NPD12704 as an antagonist for BAM1. NPD12704 also inhibited CLV3 binding to BAM1 but only minimally interfered with CLV3 binding to CLV1, the closest homolog of BAM1, demonstrating preferential receptor specificity. Treatment of clv1-101 mutant seedlings with NPD12704 enhanced the enlarged shoot apical meristem phenotype. Our results provide a technological framework enabling high-throughput identification of small non-peptide chemicals that specifically control receptor kinase-mediated peptide hormone signaling in plants. More... »

PAGES

61

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s42003-019-0307-8

DOI

http://dx.doi.org/10.1038/s42003-019-0307-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112165560

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30793040


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, 464-8602, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shinohara", 
        "givenName": "Hidefumi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Basic Biology", 
          "id": "https://www.grid.ac/institutes/grid.419396.0", 
          "name": [
            "National Institute for Basic Biology, Myodaiji, 444-8585, Okazaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yasue", 
        "givenName": "Naoko", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RIKEN", 
          "id": "https://www.grid.ac/institutes/grid.7597.c", 
          "name": [
            "RIKEN Center for Sustainable Resource Science, Hirosawa 2-1, 351-0198, Wako, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Onuki", 
        "givenName": "Tetsuo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RIKEN", 
          "id": "https://www.grid.ac/institutes/grid.7597.c", 
          "name": [
            "RIKEN Center for Sustainable Resource Science, Hirosawa 2-1, 351-0198, Wako, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kondoh", 
        "givenName": "Yasumitsu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RIKEN", 
          "id": "https://www.grid.ac/institutes/grid.7597.c", 
          "name": [
            "RIKEN Center for Sustainable Resource Science, Hirosawa 2-1, 351-0198, Wako, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshida", 
        "givenName": "Minoru", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, 464-8602, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsubayashi", 
        "givenName": "Yoshikatsu", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.cbpa.2012.02.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001918078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-arplant-050312-120122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003984765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-313x.2005.02592.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006091430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/tpj.12817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006322105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/pbi.12313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009902903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80239-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010751872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd4336", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012699339", 
          "https://doi.org/10.1038/nrd4336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.copbio.2005.10.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013248636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1150083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014409766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/pcp/pcs174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015617233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cr.2016.45", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020688538", 
          "https://doi.org/10.1038/cr.2016.45"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.124800", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024595509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-313x.2012.04934.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027261503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029683194", 
          "https://doi.org/10.1038/nchembio.182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029683194", 
          "https://doi.org/10.1038/nchembio.182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-313x.2007.03204.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030775165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fpls.2014.00373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034555997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pbi.2014.09.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038505454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jxb/err002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038693703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-9063(199901)55:1<69::aid-ps860>3.0.co;2-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038772918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.108.091108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048959940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.108.091108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048959940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms12383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049360435", 
          "https://doi.org/10.1038/ncomms12383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/nph.13520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052504111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.283.5409.1911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062564567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd.2017.178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092403570", 
          "https://doi.org/10.1038/nrd.2017.178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules22122188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099645978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules22122188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099645978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tplants.2017.12.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100623992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tplants.2017.12.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100623992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms19061648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104372120"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Intercellular signaling mediated by peptide hormones and membrane-localized receptor kinases plays crucial roles in plant developmental processes. Because of their diverse functions, agonistic or antagonistic modulation of peptide signaling holds enormous promise for agricultural applications. Here we established a high-throughput screening system using a bead-immobilized receptor kinase and fluorescent-labeled peptide ligand to identify small molecules that bind peptide hormone receptors in competition with natural ligands. We used the Arabidopsis CLE9-BAM1 ligand-receptor pair to screen a library of \u224830,000 chemicals and identified NPD12704 as an antagonist for BAM1. NPD12704 also inhibited CLV3 binding to BAM1 but only minimally interfered with CLV3 binding to CLV1, the closest homolog of BAM1, demonstrating preferential receptor specificity. Treatment of clv1-101 mutant seedlings with NPD12704 enhanced the enlarged shoot apical meristem phenotype. Our results provide a technological framework enabling high-throughput identification of small non-peptide chemicals that specifically control receptor kinase-mediated peptide hormone signaling in plants.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s42003-019-0307-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5857218", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6130980", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6107384", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7610870", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5903483", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1300829", 
        "issn": [
          "2399-3642"
        ], 
        "name": "Communications Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "name": "Screening and identification of a non-peptide antagonist for the peptide hormone receptor in Arabidopsis", 
    "pagination": "61", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a22814a59362afb740f8320f2abeb57083eaf1fdf72aef1851b516d044edf968"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30793040"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101719179"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s42003-019-0307-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112165560"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s42003-019-0307-8", 
      "https://app.dimensions.ai/details/publication/pub.1112165560"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113676_00000005.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s42003-019-0307-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s42003-019-0307-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s42003-019-0307-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s42003-019-0307-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s42003-019-0307-8'


 

This table displays all metadata directly associated to this object as RDF triples.

199 TRIPLES      21 PREDICATES      56 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s42003-019-0307-8 schema:about anzsrc-for:11
2 anzsrc-for:1115
3 schema:author N7c24b37ab83543769ef494dea4b3da3b
4 schema:citation sg:pub.10.1038/cr.2016.45
5 sg:pub.10.1038/nchembio.182
6 sg:pub.10.1038/ncomms12383
7 sg:pub.10.1038/nrd.2017.178
8 sg:pub.10.1038/nrd4336
9 https://doi.org/10.1002/(sici)1096-9063(199901)55:1<69::aid-ps860>3.0.co;2-h
10 https://doi.org/10.1016/j.cbpa.2012.02.016
11 https://doi.org/10.1016/j.copbio.2005.10.008
12 https://doi.org/10.1016/j.pbi.2014.09.013
13 https://doi.org/10.1016/j.tplants.2017.12.007
14 https://doi.org/10.1016/s0092-8674(00)80239-1
15 https://doi.org/10.1074/jbc.m110.124800
16 https://doi.org/10.1093/jxb/err002
17 https://doi.org/10.1093/pcp/pcs174
18 https://doi.org/10.1111/j.1365-313x.2005.02592.x
19 https://doi.org/10.1111/j.1365-313x.2007.03204.x
20 https://doi.org/10.1111/j.1365-313x.2012.04934.x
21 https://doi.org/10.1111/nph.13520
22 https://doi.org/10.1111/pbi.12313
23 https://doi.org/10.1111/tpj.12817
24 https://doi.org/10.1126/science.1150083
25 https://doi.org/10.1126/science.283.5409.1911
26 https://doi.org/10.1146/annurev-arplant-050312-120122
27 https://doi.org/10.1534/genetics.108.091108
28 https://doi.org/10.3389/fpls.2014.00373
29 https://doi.org/10.3390/ijms19061648
30 https://doi.org/10.3390/molecules22122188
31 schema:datePublished 2019-12
32 schema:datePublishedReg 2019-12-01
33 schema:description Intercellular signaling mediated by peptide hormones and membrane-localized receptor kinases plays crucial roles in plant developmental processes. Because of their diverse functions, agonistic or antagonistic modulation of peptide signaling holds enormous promise for agricultural applications. Here we established a high-throughput screening system using a bead-immobilized receptor kinase and fluorescent-labeled peptide ligand to identify small molecules that bind peptide hormone receptors in competition with natural ligands. We used the <i>Arabidopsis</i> CLE9-BAM1 ligand-receptor pair to screen a library of ≈30,000 chemicals and identified NPD12704 as an antagonist for BAM1. NPD12704 also inhibited CLV3 binding to BAM1 but only minimally interfered with CLV3 binding to CLV1, the closest homolog of BAM1, demonstrating preferential receptor specificity. Treatment of <i>clv1-101</i> mutant seedlings with NPD12704 enhanced the enlarged shoot apical meristem phenotype. Our results provide a technological framework enabling high-throughput identification of small non-peptide chemicals that specifically control receptor kinase-mediated peptide hormone signaling in plants.
34 schema:genre research_article
35 schema:inLanguage en
36 schema:isAccessibleForFree false
37 schema:isPartOf N81ad188da56d46b4a472ccb2eeabe963
38 Nea4c9b11c2c846119eb868d3a2d3c966
39 sg:journal.1300829
40 schema:name Screening and identification of a non-peptide antagonist for the peptide hormone receptor in Arabidopsis
41 schema:pagination 61
42 schema:productId N73af08a8d45b41a99a6a9a705a87523c
43 N74a7c01a33904d22aaa39a03c1a2ff01
44 N955385cf8e444ba69ad2bbb6b4982424
45 N966226e1e2d542079203093b20434a9c
46 Na56fcb1c70614648964e0dad30826027
47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112165560
48 https://doi.org/10.1038/s42003-019-0307-8
49 schema:sdDatePublished 2019-04-11T10:38
50 schema:sdLicense https://scigraph.springernature.com/explorer/license/
51 schema:sdPublisher N794a2c46088f40d29f3ff8116c252078
52 schema:url https://www.nature.com/articles/s42003-019-0307-8
53 sgo:license sg:explorer/license/
54 sgo:sdDataset articles
55 rdf:type schema:ScholarlyArticle
56 N1f12b92fb2be477b8bcddf6fd64d811d rdf:first N5c8193a718f74742843b2b9ed14d1a06
57 rdf:rest N26fa6487d48047c18fb522f3a23ca7d5
58 N26fa6487d48047c18fb522f3a23ca7d5 rdf:first N89181aa74cd54d21b28294efc26971e8
59 rdf:rest rdf:nil
60 N2b1c65c762ba4bcd9dbcc5b7720087cf rdf:first Nb94e7a07337d4c219cec8717b3eaa6b2
61 rdf:rest N1f12b92fb2be477b8bcddf6fd64d811d
62 N5c8193a718f74742843b2b9ed14d1a06 schema:affiliation https://www.grid.ac/institutes/grid.7597.c
63 schema:familyName Yoshida
64 schema:givenName Minoru
65 rdf:type schema:Person
66 N69e9c134e4be4a0abdd992f19302b28d schema:affiliation https://www.grid.ac/institutes/grid.7597.c
67 schema:familyName Onuki
68 schema:givenName Tetsuo
69 rdf:type schema:Person
70 N73af08a8d45b41a99a6a9a705a87523c schema:name dimensions_id
71 schema:value pub.1112165560
72 rdf:type schema:PropertyValue
73 N74a7c01a33904d22aaa39a03c1a2ff01 schema:name doi
74 schema:value 10.1038/s42003-019-0307-8
75 rdf:type schema:PropertyValue
76 N794a2c46088f40d29f3ff8116c252078 schema:name Springer Nature - SN SciGraph project
77 rdf:type schema:Organization
78 N79575a045c9b4f659c372a6a6b450f3c schema:affiliation https://www.grid.ac/institutes/grid.27476.30
79 schema:familyName Shinohara
80 schema:givenName Hidefumi
81 rdf:type schema:Person
82 N7c24b37ab83543769ef494dea4b3da3b rdf:first N79575a045c9b4f659c372a6a6b450f3c
83 rdf:rest Nbfcdcd36a00846638c4857f26cc32bdc
84 N81ad188da56d46b4a472ccb2eeabe963 schema:issueNumber 1
85 rdf:type schema:PublicationIssue
86 N89181aa74cd54d21b28294efc26971e8 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
87 schema:familyName Matsubayashi
88 schema:givenName Yoshikatsu
89 rdf:type schema:Person
90 N9379651547b1424196cdc64100558941 schema:affiliation https://www.grid.ac/institutes/grid.419396.0
91 schema:familyName Yasue
92 schema:givenName Naoko
93 rdf:type schema:Person
94 N94aaac08ecbb4f4495fc12546a9f00de rdf:first N69e9c134e4be4a0abdd992f19302b28d
95 rdf:rest N2b1c65c762ba4bcd9dbcc5b7720087cf
96 N955385cf8e444ba69ad2bbb6b4982424 schema:name nlm_unique_id
97 schema:value 101719179
98 rdf:type schema:PropertyValue
99 N966226e1e2d542079203093b20434a9c schema:name readcube_id
100 schema:value a22814a59362afb740f8320f2abeb57083eaf1fdf72aef1851b516d044edf968
101 rdf:type schema:PropertyValue
102 Na56fcb1c70614648964e0dad30826027 schema:name pubmed_id
103 schema:value 30793040
104 rdf:type schema:PropertyValue
105 Nb94e7a07337d4c219cec8717b3eaa6b2 schema:affiliation https://www.grid.ac/institutes/grid.7597.c
106 schema:familyName Kondoh
107 schema:givenName Yasumitsu
108 rdf:type schema:Person
109 Nbfcdcd36a00846638c4857f26cc32bdc rdf:first N9379651547b1424196cdc64100558941
110 rdf:rest N94aaac08ecbb4f4495fc12546a9f00de
111 Nea4c9b11c2c846119eb868d3a2d3c966 schema:volumeNumber 2
112 rdf:type schema:PublicationVolume
113 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
114 schema:name Medical and Health Sciences
115 rdf:type schema:DefinedTerm
116 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
117 schema:name Pharmacology and Pharmaceutical Sciences
118 rdf:type schema:DefinedTerm
119 sg:grant.5857218 http://pending.schema.org/fundedItem sg:pub.10.1038/s42003-019-0307-8
120 rdf:type schema:MonetaryGrant
121 sg:grant.5903483 http://pending.schema.org/fundedItem sg:pub.10.1038/s42003-019-0307-8
122 rdf:type schema:MonetaryGrant
123 sg:grant.6107384 http://pending.schema.org/fundedItem sg:pub.10.1038/s42003-019-0307-8
124 rdf:type schema:MonetaryGrant
125 sg:grant.6130980 http://pending.schema.org/fundedItem sg:pub.10.1038/s42003-019-0307-8
126 rdf:type schema:MonetaryGrant
127 sg:grant.7610870 http://pending.schema.org/fundedItem sg:pub.10.1038/s42003-019-0307-8
128 rdf:type schema:MonetaryGrant
129 sg:journal.1300829 schema:issn 2399-3642
130 schema:name Communications Biology
131 rdf:type schema:Periodical
132 sg:pub.10.1038/cr.2016.45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020688538
133 https://doi.org/10.1038/cr.2016.45
134 rdf:type schema:CreativeWork
135 sg:pub.10.1038/nchembio.182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029683194
136 https://doi.org/10.1038/nchembio.182
137 rdf:type schema:CreativeWork
138 sg:pub.10.1038/ncomms12383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049360435
139 https://doi.org/10.1038/ncomms12383
140 rdf:type schema:CreativeWork
141 sg:pub.10.1038/nrd.2017.178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092403570
142 https://doi.org/10.1038/nrd.2017.178
143 rdf:type schema:CreativeWork
144 sg:pub.10.1038/nrd4336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012699339
145 https://doi.org/10.1038/nrd4336
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1002/(sici)1096-9063(199901)55:1<69::aid-ps860>3.0.co;2-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1038772918
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1016/j.cbpa.2012.02.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001918078
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1016/j.copbio.2005.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013248636
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1016/j.pbi.2014.09.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038505454
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1016/j.tplants.2017.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100623992
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1016/s0092-8674(00)80239-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010751872
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1074/jbc.m110.124800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024595509
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1093/jxb/err002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038693703
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1093/pcp/pcs174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015617233
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1111/j.1365-313x.2005.02592.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006091430
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1111/j.1365-313x.2007.03204.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030775165
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1111/j.1365-313x.2012.04934.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027261503
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1111/nph.13520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052504111
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1111/pbi.12313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009902903
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1111/tpj.12817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006322105
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1126/science.1150083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014409766
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1126/science.283.5409.1911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062564567
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1146/annurev-arplant-050312-120122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003984765
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1534/genetics.108.091108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048959940
184 rdf:type schema:CreativeWork
185 https://doi.org/10.3389/fpls.2014.00373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034555997
186 rdf:type schema:CreativeWork
187 https://doi.org/10.3390/ijms19061648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104372120
188 rdf:type schema:CreativeWork
189 https://doi.org/10.3390/molecules22122188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099645978
190 rdf:type schema:CreativeWork
191 https://www.grid.ac/institutes/grid.27476.30 schema:alternateName Nagoya University
192 schema:name Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, 464-8602, Nagoya, Japan
193 rdf:type schema:Organization
194 https://www.grid.ac/institutes/grid.419396.0 schema:alternateName National Institute for Basic Biology
195 schema:name National Institute for Basic Biology, Myodaiji, 444-8585, Okazaki, Japan
196 rdf:type schema:Organization
197 https://www.grid.ac/institutes/grid.7597.c schema:alternateName RIKEN
198 schema:name RIKEN Center for Sustainable Resource Science, Hirosawa 2-1, 351-0198, Wako, Japan
199 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...