Regulation of RNA editing by RNA-binding proteins in human cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-12

AUTHORS

Giovanni Quinones-Valdez, Stephen S. Tran, Hyun-Ik Jun, Jae Hoon Bahn, Ei-Wen Yang, Lijun Zhan, Anneke Brümmer, Xintao Wei, Eric L. Van Nostrand, Gabriel A. Pratt, Gene W. Yeo, Brenton R. Graveley, Xinshu Xiao

ABSTRACT

Adenosine-to-inosine (A-to-I) editing, mediated by the ADAR enzymes, diversifies the transcriptome by altering RNA sequences. Recent studies reported global changes in RNA editing in disease and development. Such widespread editing variations necessitate an improved understanding of the regulatory mechanisms of RNA editing. Here, we study the roles of >200 RNA-binding proteins (RBPs) in mediating RNA editing in two human cell lines. Using RNA-sequencing and global protein-RNA binding data, we identify a number of RBPs as key regulators of A-to-I editing. These RBPs, such as TDP-43, DROSHA, NF45/90 and Ro60, mediate editing through various mechanisms including regulation of ADAR1 expression, interaction with ADAR1, and binding to Alu elements. We highlight that editing regulation by Ro60 is consistent with the global up-regulation of RNA editing in systemic lupus erythematosus. Additionally, most key editing regulators act in a cell type-specific manner. Together, our work provides insights for the regulatory mechanisms of RNA editing. More... »

PAGES

19

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s42003-018-0271-8

DOI

http://dx.doi.org/10.1038/s42003-018-0271-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111273983

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30652130


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