Stigmasterol accumulation causes cardiac injury and promotes mortality View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-12

AUTHORS

Caroline Tao, Artem A. Shkumatov, Shawn T. Alexander, Brandon L. Ason, Mingyue Zhou

ABSTRACT

Cardiovascular disease is expected to remain the leading cause of death worldwide despite the introduction of proprotein convertase subtilisin/kexin type 9 inhibitors that effectively control cholesterol. Identifying residual risk factors for cardiovascular disease remains an important step for preventing and clinically managing the disease. Here we report cardiac injury and increased mortality occurring despite a 50% reduction in plasma cholesterol in a mouse model of phytosterolemia, a disease characterized by elevated levels of dietary plant sterols in the blood. Our studies show accumulation of stigmasterol, one of phytosterol species, leads to left ventricle dysfunction, cardiac interstitial fibrosis and macrophage infiltration without atherosclerosis, and increased mortality. A pharmacological inhibitor of sterol absorption prevents cardiac fibrogenesis. We propose that the pathological mechanism linking clinical sitosterolemia to the cardiovascular outcomes primarily involves phytosterols-induced cardiac fibrosis rather than cholesterol-driven atherosclerosis. Our studies suggest stigmasterol is a potent and independent risk factor for cardiovascular disease. More... »

PAGES

20

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s42003-018-0245-x

DOI

http://dx.doi.org/10.1038/s42003-018-0245-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111348304

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30675518


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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s42003-018-0245-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s42003-018-0245-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s42003-018-0245-x'


 

This table displays all metadata directly associated to this object as RDF triples.

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