Targeted cleavage of nad6 mRNA induced by a modified pentatricopeptide repeat protein in plant mitochondria View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12

AUTHORS

Catherine Colas des Francs-Small, Lilian Vincis Pereira Sanglard, Ian Small

ABSTRACT

Mitochondrial genes encode key components of the cellular energy machinery, but their genetic analysis is difficult or impossible in most organisms (including plants) because of the lack of viable transformation approaches. We report here a method to block the expression of the mitochondrial nad6 gene encoding a subunit of respiratory complex I in Arabidopsis tha liana, via the modification of the specificity of the RNA-binding protein RNA PROCESSING FACTOR 2 (RPF2). We show that the modified RPF2 binds and specifically induces cleavage of nad6 RNA, almost eliminating expression of the Nad6 protein and consequently complex I accumulation and activity. To our knowledge, this is the first example of a targeted block in expression of a specific mitochondrial transcript by a custom-designed RNA-binding protein. This opens the path to reverse genetics studies on mitochondrial gene functions and leads to potential applications in agriculture. More... »

PAGES

166

Journal

TITLE

Communications Biology

ISSUE

1

VOLUME

1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s42003-018-0166-8

DOI

http://dx.doi.org/10.1038/s42003-018-0166-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107455985

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30320233


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Australian Research Council Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, The University of Western Australia, Crawley, WA 6009 Australia."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Colas des Francs-Small", 
        "givenName": "Catherine", 
        "id": "sg:person.01202307534.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202307534.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Australian Research Council Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, The University of Western Australia, Crawley, WA 6009 Australia."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vincis Pereira Sanglard", 
        "givenName": "Lilian", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Australian Research Council Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, The University of Western Australia, Crawley, WA 6009 Australia."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Small", 
        "givenName": "Ian", 
        "id": "sg:person.01313604274.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313604274.41"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1074/jbc.m110.147603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000204878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkt337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003519520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.121202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004486460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fpls.2012.00106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005770113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/tpj.13185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006865528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/tpj.13121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007703049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mito.2014.02.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011808551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tig.2006.12.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013031177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1993.tb18311.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013285112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-313x.1998.00343.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013777935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014404364", 
          "https://doi.org/10.1038/nsmb.1812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014404364", 
          "https://doi.org/10.1038/nsmb.1812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-014-0550-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015222646", 
          "https://doi.org/10.1186/s13059-014-0550-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-014-0550-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015222646", 
          "https://doi.org/10.1186/s13059-014-0550-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-313x.2010.04460.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019031304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1007667108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019058570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1104/pp.89.4.1311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020970935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/tpj.12377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021236082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2006.09.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022563087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/nph.12282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025840798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1105/tpc.109.066944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026979217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/tpj.12756", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029623500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1360-1385(98)01235-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031025333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/tpj.13111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032368598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11103-015-0400-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032923909", 
          "https://doi.org/10.1007/s11103-015-0400-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11103-015-0400-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032923909", 
          "https://doi.org/10.1007/s11103-015-0400-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms6729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033173742", 
          "https://doi.org/10.1038/ncomms6729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fpls.2016.01816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033641616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkm270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033866073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms2358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034631739", 
          "https://doi.org/10.1038/ncomms2358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mito.2007.10.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035121468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkw466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038692841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/tpj.12466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038851429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2008.07.061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042458153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1104/pp.114.244616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046623957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1002910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046871778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.26.7.2869-2876.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047601637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2005.04.062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048379604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2005.04.062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048379604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1104/pp.109.141770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048939245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms11285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050889558", 
          "https://doi.org/10.1038/ncomms11285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1104/pp.111.181552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050917262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.209601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052151675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-arplant-050213-040159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052324539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-313x.2008.03581.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053021110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/12.22.8711", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053487532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1105/tpc.16.00398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060842282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/rna.25568", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072310175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/rna.26129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072310190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1261/rna.059568.116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079397708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.4197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084129290", 
          "https://doi.org/10.1038/nmeth.4197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkx162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084186664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/nph.14528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084216562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkx1288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099877422"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "Mitochondrial genes encode key components of the cellular energy machinery, but their genetic analysis is difficult or impossible in most organisms (including plants) because of the lack of viable transformation approaches. We report here a method to block the expression of the mitochondrial nad6 gene encoding a subunit of respiratory complex I\u00a0in Arabidopsis tha liana, via the modification of the specificity of the RNA-binding protein RNA PROCESSING FACTOR 2 (RPF2). We show that the modified RPF2 binds and specifically induces cleavage of nad6 RNA, almost eliminating expression of the Nad6 protein and consequently complex I accumulation and activity. To our knowledge, this is the first example of a targeted block in expression of a specific mitochondrial transcript by a custom-designed RNA-binding protein. This opens the path to reverse genetics studies on mitochondrial gene functions and leads to potential applications in agriculture.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s42003-018-0166-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1300829", 
        "issn": [
          "2399-3642"
        ], 
        "name": "Communications Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "1"
      }
    ], 
    "name": "Targeted cleavage of nad6 mRNA induced by a modified pentatricopeptide repeat protein in plant mitochondria", 
    "pagination": "166", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e1de1f1253b31c1c63775028d559b22d170bdb55e96825bcd354e390bceb1277"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30320233"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101719179"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s42003-018-0166-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1107455985"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s42003-018-0166-8", 
      "https://app.dimensions.ai/details/publication/pub.1107455985"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000566.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s42003-018-0166-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s42003-018-0166-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s42003-018-0166-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s42003-018-0166-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s42003-018-0166-8'


 

This table displays all metadata directly associated to this object as RDF triples.

241 TRIPLES      21 PREDICATES      79 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s42003-018-0166-8 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author N6cdd534edd4f4e12a6a1f5a712689fba
4 schema:citation sg:pub.10.1007/s11103-015-0400-4
5 sg:pub.10.1038/ncomms11285
6 sg:pub.10.1038/ncomms2358
7 sg:pub.10.1038/ncomms6729
8 sg:pub.10.1038/nmeth.4197
9 sg:pub.10.1038/nsmb.1812
10 sg:pub.10.1186/s13059-014-0550-8
11 https://doi.org/10.1016/j.febslet.2006.09.010
12 https://doi.org/10.1016/j.febslet.2008.07.061
13 https://doi.org/10.1016/j.jmb.2005.04.062
14 https://doi.org/10.1016/j.mito.2007.10.006
15 https://doi.org/10.1016/j.mito.2014.02.006
16 https://doi.org/10.1016/j.tig.2006.12.004
17 https://doi.org/10.1016/s1360-1385(98)01235-7
18 https://doi.org/10.1046/j.1365-313x.1998.00343.x
19 https://doi.org/10.1073/pnas.1007667108
20 https://doi.org/10.1074/jbc.m110.121202
21 https://doi.org/10.1074/jbc.m110.147603
22 https://doi.org/10.1074/jbc.m110.209601
23 https://doi.org/10.1093/nar/12.22.8711
24 https://doi.org/10.1093/nar/gkm270
25 https://doi.org/10.1093/nar/gkt337
26 https://doi.org/10.1093/nar/gkw466
27 https://doi.org/10.1093/nar/gkx1288
28 https://doi.org/10.1093/nar/gkx162
29 https://doi.org/10.1104/pp.109.141770
30 https://doi.org/10.1104/pp.111.181552
31 https://doi.org/10.1104/pp.114.244616
32 https://doi.org/10.1104/pp.89.4.1311
33 https://doi.org/10.1105/tpc.109.066944
34 https://doi.org/10.1105/tpc.16.00398
35 https://doi.org/10.1111/j.1365-313x.2008.03581.x
36 https://doi.org/10.1111/j.1365-313x.2010.04460.x
37 https://doi.org/10.1111/j.1432-1033.1993.tb18311.x
38 https://doi.org/10.1111/nph.12282
39 https://doi.org/10.1111/nph.14528
40 https://doi.org/10.1111/tpj.12377
41 https://doi.org/10.1111/tpj.12466
42 https://doi.org/10.1111/tpj.12756
43 https://doi.org/10.1111/tpj.13111
44 https://doi.org/10.1111/tpj.13121
45 https://doi.org/10.1111/tpj.13185
46 https://doi.org/10.1128/mcb.26.7.2869-2876.2006
47 https://doi.org/10.1146/annurev-arplant-050213-040159
48 https://doi.org/10.1261/rna.059568.116
49 https://doi.org/10.1371/journal.pgen.1002910
50 https://doi.org/10.3389/fpls.2012.00106
51 https://doi.org/10.3389/fpls.2016.01816
52 https://doi.org/10.4161/rna.25568
53 https://doi.org/10.4161/rna.26129
54 schema:datePublished 2018-12
55 schema:datePublishedReg 2018-12-01
56 schema:description Mitochondrial genes encode key components of the cellular energy machinery, but their genetic analysis is difficult or impossible in most organisms (including plants) because of the lack of viable transformation approaches. We report here a method to block the expression of the mitochondrial <i>nad6</i> gene encoding a subunit of respiratory complex I in <i>Arabidopsis tha</i> <i>liana</i>, via the modification of the specificity of the RNA-binding protein RNA PROCESSING FACTOR 2 (RPF2). We show that the modified RPF2 binds and specifically induces cleavage of <i>nad6</i> RNA, almost eliminating expression of the Nad6 protein and consequently complex I accumulation and activity. To our knowledge, this is the first example of a targeted block in expression of a specific mitochondrial transcript by a custom-designed RNA-binding protein. This opens the path to reverse genetics studies on mitochondrial gene functions and leads to potential applications in agriculture.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree false
60 schema:isPartOf Nbec3bdc07f5548908f9ff6ffa11577d1
61 Nd5c7e31721a145b883227562b1d7205b
62 sg:journal.1300829
63 schema:name Targeted cleavage of nad6 mRNA induced by a modified pentatricopeptide repeat protein in plant mitochondria
64 schema:pagination 166
65 schema:productId N27e3d638b4f44efb9075cf6445108b96
66 N5f07540653374af28f34b85a69086555
67 N6e19f9c275e14d869e71807ab9cd5943
68 N78ba80fde22849a7956d5c31e896db30
69 Ncb0957782da84a0fa04224096134eb1d
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107455985
71 https://doi.org/10.1038/s42003-018-0166-8
72 schema:sdDatePublished 2019-04-10T20:06
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Ne708dc79b797472ea058c5c810d681c8
75 schema:url https://www.nature.com/articles/s42003-018-0166-8
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N048dca4b38da40c2ad6392a4070e9be8 schema:name Australian Research Council Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, The University of Western Australia, Crawley, WA 6009 Australia.
80 rdf:type schema:Organization
81 N27e3d638b4f44efb9075cf6445108b96 schema:name nlm_unique_id
82 schema:value 101719179
83 rdf:type schema:PropertyValue
84 N2bbeb074716b43839314360bbac0baa6 rdf:first sg:person.01313604274.41
85 rdf:rest rdf:nil
86 N3ad574da127a4ed885f6cf23ab5a3d35 rdf:first Nae09c32d5db64f32b3f2e65cd280470f
87 rdf:rest N2bbeb074716b43839314360bbac0baa6
88 N5f07540653374af28f34b85a69086555 schema:name dimensions_id
89 schema:value pub.1107455985
90 rdf:type schema:PropertyValue
91 N6cdd534edd4f4e12a6a1f5a712689fba rdf:first sg:person.01202307534.14
92 rdf:rest N3ad574da127a4ed885f6cf23ab5a3d35
93 N6e19f9c275e14d869e71807ab9cd5943 schema:name doi
94 schema:value 10.1038/s42003-018-0166-8
95 rdf:type schema:PropertyValue
96 N78ba80fde22849a7956d5c31e896db30 schema:name pubmed_id
97 schema:value 30320233
98 rdf:type schema:PropertyValue
99 Nae09c32d5db64f32b3f2e65cd280470f schema:affiliation N048dca4b38da40c2ad6392a4070e9be8
100 schema:familyName Vincis Pereira Sanglard
101 schema:givenName Lilian
102 rdf:type schema:Person
103 Nbec3bdc07f5548908f9ff6ffa11577d1 schema:issueNumber 1
104 rdf:type schema:PublicationIssue
105 Ncae649b9e0bc4088b8006bc53d519e7c schema:name Australian Research Council Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, The University of Western Australia, Crawley, WA 6009 Australia.
106 rdf:type schema:Organization
107 Ncb0957782da84a0fa04224096134eb1d schema:name readcube_id
108 schema:value e1de1f1253b31c1c63775028d559b22d170bdb55e96825bcd354e390bceb1277
109 rdf:type schema:PropertyValue
110 Nce110fbe5a9840c89c0639bf89a5d00f schema:name Australian Research Council Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, The University of Western Australia, Crawley, WA 6009 Australia.
111 rdf:type schema:Organization
112 Nd5c7e31721a145b883227562b1d7205b schema:volumeNumber 1
113 rdf:type schema:PublicationVolume
114 Ne708dc79b797472ea058c5c810d681c8 schema:name Springer Nature - SN SciGraph project
115 rdf:type schema:Organization
116 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
117 schema:name Biological Sciences
118 rdf:type schema:DefinedTerm
119 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
120 schema:name Genetics
121 rdf:type schema:DefinedTerm
122 sg:journal.1300829 schema:issn 2399-3642
123 schema:name Communications Biology
124 rdf:type schema:Periodical
125 sg:person.01202307534.14 schema:affiliation Ncae649b9e0bc4088b8006bc53d519e7c
126 schema:familyName Colas des Francs-Small
127 schema:givenName Catherine
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202307534.14
129 rdf:type schema:Person
130 sg:person.01313604274.41 schema:affiliation Nce110fbe5a9840c89c0639bf89a5d00f
131 schema:familyName Small
132 schema:givenName Ian
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313604274.41
134 rdf:type schema:Person
135 sg:pub.10.1007/s11103-015-0400-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032923909
136 https://doi.org/10.1007/s11103-015-0400-4
137 rdf:type schema:CreativeWork
138 sg:pub.10.1038/ncomms11285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050889558
139 https://doi.org/10.1038/ncomms11285
140 rdf:type schema:CreativeWork
141 sg:pub.10.1038/ncomms2358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034631739
142 https://doi.org/10.1038/ncomms2358
143 rdf:type schema:CreativeWork
144 sg:pub.10.1038/ncomms6729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033173742
145 https://doi.org/10.1038/ncomms6729
146 rdf:type schema:CreativeWork
147 sg:pub.10.1038/nmeth.4197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129290
148 https://doi.org/10.1038/nmeth.4197
149 rdf:type schema:CreativeWork
150 sg:pub.10.1038/nsmb.1812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014404364
151 https://doi.org/10.1038/nsmb.1812
152 rdf:type schema:CreativeWork
153 sg:pub.10.1186/s13059-014-0550-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015222646
154 https://doi.org/10.1186/s13059-014-0550-8
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1016/j.febslet.2006.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022563087
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1016/j.febslet.2008.07.061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042458153
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/j.jmb.2005.04.062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048379604
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/j.mito.2007.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035121468
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/j.mito.2014.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011808551
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/j.tig.2006.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013031177
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/s1360-1385(98)01235-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031025333
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1046/j.1365-313x.1998.00343.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013777935
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1073/pnas.1007667108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019058570
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1074/jbc.m110.121202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004486460
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1074/jbc.m110.147603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000204878
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1074/jbc.m110.209601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052151675
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1093/nar/12.22.8711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053487532
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1093/nar/gkm270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033866073
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1093/nar/gkt337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003519520
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1093/nar/gkw466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038692841
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1093/nar/gkx1288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099877422
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1093/nar/gkx162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084186664
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1104/pp.109.141770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048939245
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1104/pp.111.181552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050917262
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1104/pp.114.244616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046623957
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1104/pp.89.4.1311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020970935
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1105/tpc.109.066944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026979217
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1105/tpc.16.00398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060842282
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1111/j.1365-313x.2008.03581.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053021110
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1111/j.1365-313x.2010.04460.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019031304
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1111/j.1432-1033.1993.tb18311.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013285112
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1111/nph.12282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025840798
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1111/nph.14528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084216562
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1111/tpj.12377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021236082
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1111/tpj.12466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038851429
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1111/tpj.12756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029623500
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1111/tpj.13111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032368598
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1111/tpj.13121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007703049
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1111/tpj.13185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006865528
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1128/mcb.26.7.2869-2876.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047601637
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1146/annurev-arplant-050213-040159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052324539
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1261/rna.059568.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079397708
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1371/journal.pgen.1002910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046871778
233 rdf:type schema:CreativeWork
234 https://doi.org/10.3389/fpls.2012.00106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005770113
235 rdf:type schema:CreativeWork
236 https://doi.org/10.3389/fpls.2016.01816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033641616
237 rdf:type schema:CreativeWork
238 https://doi.org/10.4161/rna.25568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072310175
239 rdf:type schema:CreativeWork
240 https://doi.org/10.4161/rna.26129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072310190
241 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...