Structural basis for promotion of duodenal iron absorption by enteric ferric reductase with ascorbate View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12

AUTHORS

Menega Ganasen, Hiromi Togashi, Hanae Takeda, Honami Asakura, Takehiko Tosha, Keitaro Yamashita, Kunio Hirata, Yuko Nariai, Takeshi Urano, Xiaojing Yuan, Iqbal Hamza, A. Grant Mauk, Yoshitsugu Shiro, Hiroshi Sugimoto, Hitomi Sawai

ABSTRACT

Dietary iron absorption is regulated by duodenal cytochrome b (Dcytb), an integral membrane protein that catalyzes reduction of nonheme Fe3+ by electron transfer from ascorbate across the membrane. This step is essential to enable iron uptake by the divalent metal transporter. Here we report the crystallographic structures of human Dcytb and its complex with ascorbate and Zn2+. Each monomer of the homodimeric protein possesses cytoplasmic and apical heme groups, as well as cytoplasmic and apical ascorbate-binding sites located adjacent to each heme. Zn2+ coordinates to two hydroxyl groups of the apical ascorbate and to a histidine residue. Biochemical analysis indicates that Fe3+ competes with Zn2+ for this binding site. These results provide a structural basis for the mechanism by which Fe3+ uptake is promoted by reducing agents and should facilitate structure-based development of improved agents for absorption of orally administered iron. More... »

PAGES

120

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s42003-018-0121-8

DOI

http://dx.doi.org/10.1038/s42003-018-0121-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106133620

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30272000


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