Bracing copper for the catalytic oxidation of C–H bonds View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-08-10

AUTHORS

Luisa Ciano, Gideon J. Davies, William B. Tolman, Paul H. Walton

ABSTRACT

A structural unit found in the active site of some copper proteins, the histidine brace, is comprised of an N-terminal histidine that chelates a single copper ion through its amino terminus NH2 and the π–N of its imidazole side chain. Coordination is completed by the τ-N of a further histidine side chain, to give an overall N3 T-shaped coordination at the copper ion. The histidine brace appears in several proteins, including lytic polysaccharide monooxygenases LPMOs and particulate methane monooxygenases pMMOs, both of which catalyse the oxidation of substrates with strong C–H bonds (bond dissociation enthalpies ~100 kcal mol–1). As such, the copper histidine brace is the focus of research aimed at understanding how nature catalyses the oxidation of unactivated C–H bonds. In this Perspective, we evaluate these studies, which further give bioinspired direction to coordination chemists in the design and preparation of small molecule copper oxidation catalysts. More... »

PAGES

571-577

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41929-018-0110-9

DOI

http://dx.doi.org/10.1038/s41929-018-0110-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106062693


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0302", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Inorganic Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Chemistry, University of York, Heslington, York, UK", 
          "id": "http://www.grid.ac/institutes/grid.5685.e", 
          "name": [
            "Department of Chemistry, University of York, Heslington, York, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ciano", 
        "givenName": "Luisa", 
        "id": "sg:person.01256427425.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256427425.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemistry, University of York, Heslington, York, UK", 
          "id": "http://www.grid.ac/institutes/grid.5685.e", 
          "name": [
            "Department of Chemistry, University of York, Heslington, York, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Davies", 
        "givenName": "Gideon J.", 
        "id": "sg:person.01211607401.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211607401.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemistry, One Brookings Hall, Washington University in St. Louis, St. Louis, MO, USA", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Chemistry, One Brookings Hall, Washington University in St. Louis, St. Louis, MO, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tolman", 
        "givenName": "William B.", 
        "id": "sg:person.01065133100.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065133100.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemistry, University of York, Heslington, York, UK", 
          "id": "http://www.grid.ac/institutes/grid.5685.e", 
          "name": [
            "Department of Chemistry, University of York, Heslington, York, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walton", 
        "givenName": "Paul H.", 
        "id": "sg:person.01203045742.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203045742.72"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nchembio.2029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036828541", 
          "https://doi.org/10.1038/nchembio.2029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms6961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012380337", 
          "https://doi.org/10.1038/ncomms6961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08992", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000713870", 
          "https://doi.org/10.1038/nature08992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.2470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091431912", 
          "https://doi.org/10.1038/nchembio.2470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00775-017-1480-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090597180", 
          "https://doi.org/10.1007/s00775-017-1480-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-018-03142-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101086623", 
          "https://doi.org/10.1038/s41467-018-03142-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.1417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034339977", 
          "https://doi.org/10.1038/nchembio.1417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1754-6834-6-41", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000812569", 
          "https://doi.org/10.1186/1754-6834-6-41"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045219943", 
          "https://doi.org/10.1038/nature03311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.2558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100684488", 
          "https://doi.org/10.1038/nchembio.2558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00775-016-1415-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027192508", 
          "https://doi.org/10.1007/s00775-016-1415-2"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-08-10", 
    "datePublishedReg": "2018-08-10", 
    "description": "A structural unit found in the active site of some copper proteins, the histidine brace, is comprised of an N-terminal histidine that chelates a single copper ion through its amino terminus NH2 and the \u03c0\u2013N of its imidazole side chain. Coordination is completed by the \u03c4-N of a further histidine side chain, to give an overall N3 T-shaped coordination at the copper ion. The histidine brace appears in several proteins, including lytic polysaccharide monooxygenases LPMOs and particulate methane monooxygenases pMMOs, both of which catalyse the oxidation of substrates with strong C\u2013H bonds (bond dissociation enthalpies ~100 kcal mol\u20131). As such, the copper histidine brace is the focus of research aimed at understanding how nature catalyses the oxidation of unactivated C\u2013H bonds. In this Perspective, we evaluate these studies, which further give bioinspired direction to coordination chemists in the design and preparation of small molecule copper oxidation catalysts.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41929-018-0110-9", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2635312", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3863693", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3865701", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7389087", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1299977", 
        "issn": [
          "2520-1158"
        ], 
        "name": "Nature Catalysis", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "1"
      }
    ], 
    "keywords": [
      "histidine brace", 
      "copper ions", 
      "single copper ion", 
      "side chains", 
      "coordination chemists", 
      "imidazole side chain", 
      "histidine side chain", 
      "catalytic oxidation", 
      "oxidation of substrates", 
      "copper oxidation", 
      "copper proteins", 
      "oxidation", 
      "active site", 
      "structural units", 
      "bonds", 
      "N3T", 
      "ions", 
      "terminal histidine", 
      "chemists", 
      "chain", 
      "coordination", 
      "NH2", 
      "copper", 
      "preparation", 
      "LPMO", 
      "substrate", 
      "histidine", 
      "focus of research", 
      "nature", 
      "units", 
      "sites", 
      "protein", 
      "study", 
      "design", 
      "direction", 
      "focus", 
      "research", 
      "perspective", 
      "brace", 
      "amino terminus NH2", 
      "terminus NH2", 
      "further histidine side chain", 
      "overall N3 T", 
      "lytic polysaccharide monooxygenases LPMOs", 
      "polysaccharide monooxygenases LPMOs", 
      "monooxygenases LPMOs", 
      "particulate methane monooxygenases pMMOs", 
      "methane monooxygenases pMMOs", 
      "monooxygenases pMMOs", 
      "pMMOs", 
      "copper histidine brace", 
      "bioinspired direction", 
      "small molecule copper oxidation", 
      "molecule copper oxidation"
    ], 
    "name": "Bracing copper for the catalytic oxidation of C\u2013H bonds", 
    "pagination": "571-577", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1106062693"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41929-018-0110-9"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41929-018-0110-9", 
      "https://app.dimensions.ai/details/publication/pub.1106062693"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:33", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_787.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41929-018-0110-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41929-018-0110-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41929-018-0110-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41929-018-0110-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41929-018-0110-9'


 

This table displays all metadata directly associated to this object as RDF triples.

195 TRIPLES      22 PREDICATES      92 URIs      71 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41929-018-0110-9 schema:about anzsrc-for:03
2 anzsrc-for:0302
3 anzsrc-for:06
4 anzsrc-for:0601
5 schema:author N838b5abc568341ea9f83ed7842595fa7
6 schema:citation sg:pub.10.1007/s00775-016-1415-2
7 sg:pub.10.1007/s00775-017-1480-1
8 sg:pub.10.1038/nature03311
9 sg:pub.10.1038/nature08992
10 sg:pub.10.1038/nchembio.1417
11 sg:pub.10.1038/nchembio.2029
12 sg:pub.10.1038/nchembio.2470
13 sg:pub.10.1038/nchembio.2558
14 sg:pub.10.1038/ncomms6961
15 sg:pub.10.1038/s41467-018-03142-x
16 sg:pub.10.1186/1754-6834-6-41
17 schema:datePublished 2018-08-10
18 schema:datePublishedReg 2018-08-10
19 schema:description A structural unit found in the active site of some copper proteins, the histidine brace, is comprised of an N-terminal histidine that chelates a single copper ion through its amino terminus NH2 and the π–N of its imidazole side chain. Coordination is completed by the τ-N of a further histidine side chain, to give an overall N3 T-shaped coordination at the copper ion. The histidine brace appears in several proteins, including lytic polysaccharide monooxygenases LPMOs and particulate methane monooxygenases pMMOs, both of which catalyse the oxidation of substrates with strong C–H bonds (bond dissociation enthalpies ~100 kcal mol–1). As such, the copper histidine brace is the focus of research aimed at understanding how nature catalyses the oxidation of unactivated C–H bonds. In this Perspective, we evaluate these studies, which further give bioinspired direction to coordination chemists in the design and preparation of small molecule copper oxidation catalysts.
20 schema:genre article
21 schema:inLanguage en
22 schema:isAccessibleForFree true
23 schema:isPartOf N9903ee0def1f447785f79716390be76c
24 Ncfcd3b483cd84544947a761f5371b283
25 sg:journal.1299977
26 schema:keywords LPMO
27 N3T
28 NH2
29 active site
30 amino terminus NH2
31 bioinspired direction
32 bonds
33 brace
34 catalytic oxidation
35 chain
36 chemists
37 coordination
38 coordination chemists
39 copper
40 copper histidine brace
41 copper ions
42 copper oxidation
43 copper proteins
44 design
45 direction
46 focus
47 focus of research
48 further histidine side chain
49 histidine
50 histidine brace
51 histidine side chain
52 imidazole side chain
53 ions
54 lytic polysaccharide monooxygenases LPMOs
55 methane monooxygenases pMMOs
56 molecule copper oxidation
57 monooxygenases LPMOs
58 monooxygenases pMMOs
59 nature
60 overall N3 T
61 oxidation
62 oxidation of substrates
63 pMMOs
64 particulate methane monooxygenases pMMOs
65 perspective
66 polysaccharide monooxygenases LPMOs
67 preparation
68 protein
69 research
70 side chains
71 single copper ion
72 sites
73 small molecule copper oxidation
74 structural units
75 study
76 substrate
77 terminal histidine
78 terminus NH2
79 units
80 schema:name Bracing copper for the catalytic oxidation of C–H bonds
81 schema:pagination 571-577
82 schema:productId N293058f058f34b0b8b3c844a642010ac
83 N90800e5f8c7e4c2f802f74e697199d80
84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106062693
85 https://doi.org/10.1038/s41929-018-0110-9
86 schema:sdDatePublished 2021-11-01T18:33
87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
88 schema:sdPublisher N6e9592046c49435a8b48885e30da1fd1
89 schema:url https://doi.org/10.1038/s41929-018-0110-9
90 sgo:license sg:explorer/license/
91 sgo:sdDataset articles
92 rdf:type schema:ScholarlyArticle
93 N293058f058f34b0b8b3c844a642010ac schema:name dimensions_id
94 schema:value pub.1106062693
95 rdf:type schema:PropertyValue
96 N6132bcca7c5143e9a00b063490354189 rdf:first sg:person.01065133100.53
97 rdf:rest N8ec07e11451b498cbc097f13d2964b33
98 N6e9592046c49435a8b48885e30da1fd1 schema:name Springer Nature - SN SciGraph project
99 rdf:type schema:Organization
100 N838b5abc568341ea9f83ed7842595fa7 rdf:first sg:person.01256427425.72
101 rdf:rest N935d09554593438f908b99abf79ab3a5
102 N8ec07e11451b498cbc097f13d2964b33 rdf:first sg:person.01203045742.72
103 rdf:rest rdf:nil
104 N90800e5f8c7e4c2f802f74e697199d80 schema:name doi
105 schema:value 10.1038/s41929-018-0110-9
106 rdf:type schema:PropertyValue
107 N935d09554593438f908b99abf79ab3a5 rdf:first sg:person.01211607401.09
108 rdf:rest N6132bcca7c5143e9a00b063490354189
109 N9903ee0def1f447785f79716390be76c schema:volumeNumber 1
110 rdf:type schema:PublicationVolume
111 Ncfcd3b483cd84544947a761f5371b283 schema:issueNumber 8
112 rdf:type schema:PublicationIssue
113 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
114 schema:name Chemical Sciences
115 rdf:type schema:DefinedTerm
116 anzsrc-for:0302 schema:inDefinedTermSet anzsrc-for:
117 schema:name Inorganic Chemistry
118 rdf:type schema:DefinedTerm
119 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
120 schema:name Biological Sciences
121 rdf:type schema:DefinedTerm
122 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
123 schema:name Biochemistry and Cell Biology
124 rdf:type schema:DefinedTerm
125 sg:grant.2635312 http://pending.schema.org/fundedItem sg:pub.10.1038/s41929-018-0110-9
126 rdf:type schema:MonetaryGrant
127 sg:grant.3863693 http://pending.schema.org/fundedItem sg:pub.10.1038/s41929-018-0110-9
128 rdf:type schema:MonetaryGrant
129 sg:grant.3865701 http://pending.schema.org/fundedItem sg:pub.10.1038/s41929-018-0110-9
130 rdf:type schema:MonetaryGrant
131 sg:grant.7389087 http://pending.schema.org/fundedItem sg:pub.10.1038/s41929-018-0110-9
132 rdf:type schema:MonetaryGrant
133 sg:journal.1299977 schema:issn 2520-1158
134 schema:name Nature Catalysis
135 schema:publisher Springer Nature
136 rdf:type schema:Periodical
137 sg:person.01065133100.53 schema:affiliation grid-institutes:grid.4367.6
138 schema:familyName Tolman
139 schema:givenName William B.
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065133100.53
141 rdf:type schema:Person
142 sg:person.01203045742.72 schema:affiliation grid-institutes:grid.5685.e
143 schema:familyName Walton
144 schema:givenName Paul H.
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203045742.72
146 rdf:type schema:Person
147 sg:person.01211607401.09 schema:affiliation grid-institutes:grid.5685.e
148 schema:familyName Davies
149 schema:givenName Gideon J.
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211607401.09
151 rdf:type schema:Person
152 sg:person.01256427425.72 schema:affiliation grid-institutes:grid.5685.e
153 schema:familyName Ciano
154 schema:givenName Luisa
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256427425.72
156 rdf:type schema:Person
157 sg:pub.10.1007/s00775-016-1415-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027192508
158 https://doi.org/10.1007/s00775-016-1415-2
159 rdf:type schema:CreativeWork
160 sg:pub.10.1007/s00775-017-1480-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090597180
161 https://doi.org/10.1007/s00775-017-1480-1
162 rdf:type schema:CreativeWork
163 sg:pub.10.1038/nature03311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045219943
164 https://doi.org/10.1038/nature03311
165 rdf:type schema:CreativeWork
166 sg:pub.10.1038/nature08992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000713870
167 https://doi.org/10.1038/nature08992
168 rdf:type schema:CreativeWork
169 sg:pub.10.1038/nchembio.1417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034339977
170 https://doi.org/10.1038/nchembio.1417
171 rdf:type schema:CreativeWork
172 sg:pub.10.1038/nchembio.2029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036828541
173 https://doi.org/10.1038/nchembio.2029
174 rdf:type schema:CreativeWork
175 sg:pub.10.1038/nchembio.2470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091431912
176 https://doi.org/10.1038/nchembio.2470
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/nchembio.2558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100684488
179 https://doi.org/10.1038/nchembio.2558
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/ncomms6961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012380337
182 https://doi.org/10.1038/ncomms6961
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/s41467-018-03142-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1101086623
185 https://doi.org/10.1038/s41467-018-03142-x
186 rdf:type schema:CreativeWork
187 sg:pub.10.1186/1754-6834-6-41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000812569
188 https://doi.org/10.1186/1754-6834-6-41
189 rdf:type schema:CreativeWork
190 grid-institutes:grid.4367.6 schema:alternateName Department of Chemistry, One Brookings Hall, Washington University in St. Louis, St. Louis, MO, USA
191 schema:name Department of Chemistry, One Brookings Hall, Washington University in St. Louis, St. Louis, MO, USA
192 rdf:type schema:Organization
193 grid-institutes:grid.5685.e schema:alternateName Department of Chemistry, University of York, Heslington, York, UK
194 schema:name Department of Chemistry, University of York, Heslington, York, UK
195 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...