Heatstroke-induced late-onset neurological deficits in mice caused by white matter demyelination, Purkinje cell degeneration, and synaptic impairment in the cerebellum View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-06-22

AUTHORS

Kazuyuki Miyamoto, Motoyasu Nakamura, Hirokazu Ohtaki, Keisuke Suzuki, Hiroki Yamaga, Kaoru Yanagisawa, Atsuo Maeda, Masaharu Yagi, Munetaka Hayashi, Kazuho Honda, Kenji Dohi

ABSTRACT

Global warming increases heatstroke incidence. After heatstroke, patients exhibit neurological symptoms, suggesting cerebellar damage. However, the potential long-term adverse outcomes are poorly understood. We studied the cerebellum after heatstroke in mouse heatstroke models. In this study, motor coordination disorder significantly appeared 3 weeks after heatstroke and gradually improved to some extent. Although white matter demyelination was detected at 1 and 3 weeks after heatstroke in the cerebellum, it was not found in the corpus callosum. The Purkinje cell numbers significantly decreased at 1, 3, and 9 weeks after heatstroke. The intensity of synaptophysin and postsynaptic density-95 temporarily appeared to attenuate at 3 weeks after heatstroke; however, both appeared to intensify at 9 weeks after heatstroke. Motor coordination loss occurred a few weeks after heatstroke and recovered to some extent. Late-onset motor impairment was suggested to be caused by cerebellar dysfunctions morphologically assessed by myelin staining of cerebellar white matter and immunostaining of Purkinje cells with pre- and postsynaptic markers. Purkinje cell number did not recover for 9 weeks; other factors, including motor coordination, partially recovered, probably by synaptic reconstruction, residual Purkinje cells, and other cerebellar white matter remyelination. These phenomena were associated with late-onset neurological deficits and recovery after heatstroke. More... »

PAGES

10598

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-022-14849-9

DOI

http://dx.doi.org/10.1038/s41598-022-14849-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1148865388

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35732789


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24 schema:description Global warming increases heatstroke incidence. After heatstroke, patients exhibit neurological symptoms, suggesting cerebellar damage. However, the potential long-term adverse outcomes are poorly understood. We studied the cerebellum after heatstroke in mouse heatstroke models. In this study, motor coordination disorder significantly appeared 3 weeks after heatstroke and gradually improved to some extent. Although white matter demyelination was detected at 1 and 3 weeks after heatstroke in the cerebellum, it was not found in the corpus callosum. The Purkinje cell numbers significantly decreased at 1, 3, and 9 weeks after heatstroke. The intensity of synaptophysin and postsynaptic density-95 temporarily appeared to attenuate at 3 weeks after heatstroke; however, both appeared to intensify at 9 weeks after heatstroke. Motor coordination loss occurred a few weeks after heatstroke and recovered to some extent. Late-onset motor impairment was suggested to be caused by cerebellar dysfunctions morphologically assessed by myelin staining of cerebellar white matter and immunostaining of Purkinje cells with pre- and postsynaptic markers. Purkinje cell number did not recover for 9 weeks; other factors, including motor coordination, partially recovered, probably by synaptic reconstruction, residual Purkinje cells, and other cerebellar white matter remyelination. These phenomena were associated with late-onset neurological deficits and recovery after heatstroke.
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31 Purkinje cell number
32 Purkinje cells
33 adverse outcomes
34 callosum
35 cell degeneration
36 cell number
37 cells
38 cerebellar damage
39 cerebellar dysfunction
40 cerebellar white matter
41 cerebellum
42 coordination
43 coordination disorder
44 coordination loss
45 corpus callosum
46 damage
47 deficits
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49 demyelination
50 density-95
51 disorders
52 dysfunction
53 extent
54 factors
55 heatstroke
56 impairment
57 intensity
58 late-onset neurological deficits
59 long-term adverse outcomes
60 loss
61 markers
62 matter
63 mice
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65 motor coordination
66 motor coordination disorder
67 motor impairment
68 myelin staining
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73 patients
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75 postsynaptic density-95
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78 pre
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80 recovery
81 remyelination
82 residual Purkinje cells
83 staining
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85 symptoms
86 synaptic impairment
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