Biochemical and reproductive biomarker analysis to study the consequences of heavy metal burden on health profile of male brick kiln ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-05-03

AUTHORS

Mehwish David, Sarwat Jahan, Javaid Hussain, Humaira Rehman, Karen J. Cloete, Tayyaba Afsar, Ali Almajwal, Nawaf W. Alruwaili, Suhail Razak

ABSTRACT

The present study aims to assess the effect of a heavy metal burden on general health, biochemical parameters, an antioxidant enzyme, and reproductive hormone parameters in adult male brick kiln workers from Pakistan. The study participants (n = 546) provided demographic data including general health as well as body mass index. Blood was collected to quantitatively assess hematological, biochemical, and reproductive hormone parameters as well as heavy metal concentrations using both atomic absorption spectroscopy (AAS) and particle-induced X-ray emission (PIXE). The data showed that 10% of the brick kiln workers were underweight and 10% obese (P = 0.059), with workers also reporting multiple health issues. Heavy metal concentrations utilizing AAS revealed significantly (p = 0.000) higher levels of cadmium, chromium, and nickel, while PIXE detected more than permissible levels of Si, P, S, Cl, K, Ca, Zn, Ti (p = 0.052), Mn (p = 0.017), Fe (p = 0.055), Co (p = 0.011), Ni (p = 0.045), and Cu (p = 0.003), in the blood of kiln workers. Moreover, a significant increase in platelet count (P = 0.010), a decrease in sodium dismutase levels (p = 0.006), a major increase in reactive oxygen species (p = 0.001), and a reduction in protein content (p = 0.013) were evident. A significant increase in cortisol levels (p = 0.000) among the workers group was also observed. The concentration of LH and FSH increased significantly (p = 0.000), while that of testosterone decreased (p = 0.000) in the worker group compared with controls. A significant inverse relationship was found between cortisol, LH (r = − 0.380), and FSH (r = − 0.946), while a positive correlation between cortisol and testosterone was also evident (r = 0.164). The study concludes that increased heavy metal burden in the blood of brick kiln workers exposes them to the development of general and reproductive health problems due to compromised antioxidant enzyme levels, increased oxidative stress conditions, and a disturbing reproductive axis. More... »

PAGES

7172

References to SciGraph publications

  • 2013-04-28. Blood nickel and chromium levels in association with smoking and occupational exposure among head and neck cancer patients in Tunisia in ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • 2021-07-15. Evaluation of respiratory function and biomarkers of exposure to mixtures of pollutants in brick-kilns workers from a marginalized urban area in Mexico in ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • 2012-11-20. Respiratory symptoms and illnesses among brick kiln workers: a cross sectional study from rural districts of Pakistan in BMC PUBLIC HEALTH
  • 2019-04-13. Effects of Titanium Dioxide Nanoparticles Exposure on Human Health—a Review in BIOLOGICAL TRACE ELEMENT RESEARCH
  • 2018-05-12. Ecological and Human Health Risk Assessment of Heavy Metal Content of Atmospheric Dry Deposition, a Case Study: Kermanshah, Iran in BIOLOGICAL TRACE ELEMENT RESEARCH
  • 2020-01-08. Re-epithelialization and immune cell behaviour in an ex vivo human skin model in SCIENTIFIC REPORTS
  • 2013-01-13. Analysis of blood serum of lung cancer patients using particle induced X-ray emission in JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • 2016-03-29. Particle induced X-ray emission study of blood samples of Indian Kala-azar patients in JOURNAL OF PARASITIC DISEASES
  • 2020-08-14. Otorhinolaryngologic Evaluation of Brick Kiln Workers in INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
  • 2016-03-21. Antioxidant enzymes status and reproductive health of adult male workers exposed to brick kiln pollutants in Pakistan in ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • 2020-03-23. Human health risk assessment of elevated and variable iron and manganese intake with arsenic-safe groundwater in Jashore, Bangladesh in SCIENTIFIC REPORTS
  • 2020-08-04. Study of occupational exposure to brick kiln emissions on heavy metal burden, biochemical profile, cortisol level and reproductive health risks among female workers at Rawat, Pakistan in ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-022-11304-7

    DOI

    http://dx.doi.org/10.1038/s41598-022-11304-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1147570782

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35504976


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Public Health and Health Services", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antioxidants", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Follicle Stimulating Hormone", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hydrocortisone", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Metals, Heavy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Occupational Exposure", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Testosterone", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Reproductive Physiology Laboratory, Department of Zoology, Quaid-I-Azam University, Islamabad, Pakistan", 
              "id": "http://www.grid.ac/institutes/grid.412621.2", 
              "name": [
                "Reproductive Physiology Laboratory, Department of Zoology, Quaid-I-Azam University, Islamabad, Pakistan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "David", 
            "givenName": "Mehwish", 
            "id": "sg:person.07704157734.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07704157734.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Reproductive Physiology Laboratory, Department of Zoology, Quaid-I-Azam University, Islamabad, Pakistan", 
              "id": "http://www.grid.ac/institutes/grid.412621.2", 
              "name": [
                "Reproductive Physiology Laboratory, Department of Zoology, Quaid-I-Azam University, Islamabad, Pakistan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jahan", 
            "givenName": "Sarwat", 
            "id": "sg:person.01145161315.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145161315.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Centre for Physics, Quaid-I-Azam University Campus, 44000, Islamabad, Pakistan", 
              "id": "http://www.grid.ac/institutes/grid.412621.2", 
              "name": [
                "National Centre for Physics, Quaid-I-Azam University Campus, 44000, Islamabad, Pakistan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hussain", 
            "givenName": "Javaid", 
            "id": "sg:person.010727014427.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010727014427.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Biomedical Center, Uppsala University, Husargatan 3, 752 37, Uppsala, Sweden", 
              "id": "http://www.grid.ac/institutes/grid.8993.b", 
              "name": [
                "Biomedical Center, Uppsala University, Husargatan 3, 752 37, Uppsala, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rehman", 
            "givenName": "Humaira", 
            "id": "sg:person.015507213730.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015507213730.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nanoscience\u2019s African Network (NANOAFNET), iThemba LABS-National Research Foundation, 1 Old Faure RoadWestern Cape Province, PO Box 722, 7129, Somerset West, South Africa", 
              "id": "http://www.grid.ac/institutes/grid.462638.d", 
              "name": [
                "College of Graduate Studies, UNESCO-UNISA Africa Chair in Nanosciences-Nanotechnology, University of South Africa, Muckleneuk Ridge, PO Box 392, Pretoria, South Africa", 
                "Nanoscience\u2019s African Network (NANOAFNET), iThemba LABS-National Research Foundation, 1 Old Faure RoadWestern Cape Province, PO Box 722, 7129, Somerset West, South Africa"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cloete", 
            "givenName": "Karen J.", 
            "id": "sg:person.01326673471.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326673471.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia", 
              "id": "http://www.grid.ac/institutes/grid.56302.32", 
              "name": [
                "Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Afsar", 
            "givenName": "Tayyaba", 
            "id": "sg:person.01243457111.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243457111.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia", 
              "id": "http://www.grid.ac/institutes/grid.56302.32", 
              "name": [
                "Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Almajwal", 
            "givenName": "Ali", 
            "id": "sg:person.0760740725.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760740725.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia", 
              "id": "http://www.grid.ac/institutes/grid.56302.32", 
              "name": [
                "Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alruwaili", 
            "givenName": "Nawaf W.", 
            "id": "sg:person.013770466307.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013770466307.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia", 
              "id": "http://www.grid.ac/institutes/grid.56302.32", 
              "name": [
                "Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Razak", 
            "givenName": "Suhail", 
            "id": "sg:person.01357705511.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357705511.88"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s11356-016-6454-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035525829", 
              "https://doi.org/10.1007/s11356-016-6454-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12011-018-1383-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103962996", 
              "https://doi.org/10.1007/s12011-018-1383-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10967-012-2398-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038119470", 
              "https://doi.org/10.1007/s10967-012-2398-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11356-020-10275-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1129879856", 
              "https://doi.org/10.1007/s11356-020-10275-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11356-021-15375-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1139704965", 
              "https://doi.org/10.1007/s11356-021-15375-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11356-013-1466-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016769064", 
              "https://doi.org/10.1007/s11356-013-1466-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-019-56847-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1123950493", 
              "https://doi.org/10.1038/s41598-019-56847-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12070-020-02031-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1130119420", 
              "https://doi.org/10.1007/s12070-020-02031-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-020-62187-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1125823978", 
              "https://doi.org/10.1038/s41598-020-62187-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12639-016-0775-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034848427", 
              "https://doi.org/10.1007/s12639-016-0775-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2458-12-999", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045601084", 
              "https://doi.org/10.1186/1471-2458-12-999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12011-019-01706-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1113461938", 
              "https://doi.org/10.1007/s12011-019-01706-6"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2022-05-03", 
        "datePublishedReg": "2022-05-03", 
        "description": "The present study aims to assess the effect of a heavy metal burden on general health, biochemical parameters, an antioxidant enzyme, and reproductive hormone parameters in adult male brick kiln workers from Pakistan. The study participants (n\u2009=\u2009546) provided demographic data including general health as well as body mass index. Blood was collected to quantitatively assess hematological, biochemical, and reproductive hormone parameters as well as heavy metal concentrations using both atomic absorption spectroscopy (AAS) and particle-induced X-ray emission (PIXE). The data showed that 10% of the brick kiln workers were underweight and 10% obese (P\u2009=\u20090.059), with workers also reporting multiple health issues. Heavy metal concentrations utilizing AAS revealed significantly (p\u2009=\u20090.000) higher levels of cadmium, chromium, and nickel, while PIXE detected more than permissible levels of Si, P, S, Cl, K, Ca, Zn, Ti (p\u2009=\u20090.052), Mn (p\u2009=\u20090.017), Fe (p\u2009=\u20090.055), Co (p\u2009=\u20090.011), Ni (p\u2009=\u20090.045), and Cu (p\u2009=\u20090.003), in the blood of kiln workers. Moreover, a significant increase in platelet count (P\u2009=\u20090.010), a decrease in sodium dismutase levels (p\u2009=\u20090.006), a major increase in reactive oxygen species (p\u2009=\u20090.001), and a reduction in protein content (p\u2009=\u20090.013) were evident. A significant increase in cortisol levels (p\u2009=\u20090.000) among the workers group was also observed. The concentration of LH and FSH increased significantly (p\u2009=\u20090.000), while that of testosterone decreased (p\u2009=\u20090.000) in the worker group compared with controls. A significant inverse relationship was found between cortisol, LH (r\u2009=\u2009\u2009\u2212\u20090.380), and FSH (r\u2009=\u2009\u2009\u2212\u20090.946), while a positive correlation between cortisol and testosterone was also evident (r\u2009=\u20090.164). The study concludes that increased heavy metal burden in the blood of brick kiln workers exposes them to the development of general and reproductive health problems due to compromised antioxidant enzyme levels, increased oxidative stress conditions, and a disturbing reproductive axis.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41598-022-11304-7", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "12"
          }
        ], 
        "keywords": [
          "brick kiln workers", 
          "kiln workers", 
          "hormone parameters", 
          "general health", 
          "body mass index", 
          "concentrations of LH", 
          "reproductive health problems", 
          "antioxidant enzyme levels", 
          "significant increase", 
          "multiple health issues", 
          "mass index", 
          "worker groups", 
          "platelet count", 
          "significant inverse relationship", 
          "dismutase levels", 
          "reproductive axis", 
          "health profile", 
          "cortisol levels", 
          "health problems", 
          "demographic data", 
          "study participants", 
          "biochemical parameters", 
          "health issues", 
          "enzyme levels", 
          "reactive oxygen species", 
          "blood", 
          "FSH", 
          "antioxidant enzymes", 
          "LH", 
          "testosterone", 
          "biomarker analysis", 
          "cortisol", 
          "burden", 
          "oxidative stress conditions", 
          "present study", 
          "oxygen species", 
          "inverse relationship", 
          "positive correlation", 
          "health", 
          "high levels", 
          "levels", 
          "group", 
          "major increase", 
          "workers", 
          "heavy metal burden", 
          "increase", 
          "metal burden", 
          "study", 
          "protein content", 
          "count", 
          "concentration", 
          "participants", 
          "biochemical", 
          "index", 
          "data", 
          "decrease", 
          "control", 
          "atomic absorption spectroscopy", 
          "correlation", 
          "reduction", 
          "effect", 
          "enzyme", 
          "profile", 
          "axis", 
          "permissible levels", 
          "consequences", 
          "development", 
          "relationship", 
          "Pakistan", 
          "analysis", 
          "parameters", 
          "cadmium", 
          "stress conditions", 
          "Cl", 
          "conditions", 
          "content", 
          "Ca", 
          "issues", 
          "particle-induced X-ray emission", 
          "species", 
          "problem", 
          "heavy metal concentrations", 
          "metal concentrations", 
          "chromium", 
          "Zn", 
          "Mn", 
          "CO", 
          "nickel", 
          "Cu", 
          "spectroscopy", 
          "emission", 
          "Fe", 
          "Ti", 
          "absorption spectroscopy", 
          "Si", 
          "Ni", 
          "X-ray emission"
        ], 
        "name": "Biochemical and reproductive biomarker analysis to study the consequences of heavy metal burden on health profile of male brick kiln workers", 
        "pagination": "7172", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1147570782"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-022-11304-7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "35504976"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-022-11304-7", 
          "https://app.dimensions.ai/details/publication/pub.1147570782"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T17:10", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_943.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41598-022-11304-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-022-11304-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-022-11304-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-022-11304-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-022-11304-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    313 TRIPLES      21 PREDICATES      144 URIs      124 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-022-11304-7 schema:about N07986fc690964adb889e9ea35836e33f
    2 N0da8fc80e8f3444cb5cf602fe7b453f2
    3 N1ec053129ff846489c99a399940c39b7
    4 N3bb363058b1e4296aa737972dc851c65
    5 N40a4d0746bb74ede8ca66c017a642862
    6 N79ecbd9fd5ec4475b9c4b18192afcdf5
    7 Ncc0cb1ec1e8a4aed98006b4af7aab87c
    8 Nf135d109c275425a8c2f37b2690ab5da
    9 Nf196bd2b6c1a4e8a8a06f738ba9157cb
    10 Nf6241963ae0d4656ae5a0d6da878a793
    11 anzsrc-for:11
    12 anzsrc-for:1117
    13 schema:author Nd1d7a14a37ad4f318aa620536d76f9f0
    14 schema:citation sg:pub.10.1007/s10967-012-2398-2
    15 sg:pub.10.1007/s11356-013-1466-7
    16 sg:pub.10.1007/s11356-016-6454-2
    17 sg:pub.10.1007/s11356-020-10275-4
    18 sg:pub.10.1007/s11356-021-15375-3
    19 sg:pub.10.1007/s12011-018-1383-1
    20 sg:pub.10.1007/s12011-019-01706-6
    21 sg:pub.10.1007/s12070-020-02031-4
    22 sg:pub.10.1007/s12639-016-0775-4
    23 sg:pub.10.1038/s41598-019-56847-4
    24 sg:pub.10.1038/s41598-020-62187-5
    25 sg:pub.10.1186/1471-2458-12-999
    26 schema:datePublished 2022-05-03
    27 schema:datePublishedReg 2022-05-03
    28 schema:description The present study aims to assess the effect of a heavy metal burden on general health, biochemical parameters, an antioxidant enzyme, and reproductive hormone parameters in adult male brick kiln workers from Pakistan. The study participants (n = 546) provided demographic data including general health as well as body mass index. Blood was collected to quantitatively assess hematological, biochemical, and reproductive hormone parameters as well as heavy metal concentrations using both atomic absorption spectroscopy (AAS) and particle-induced X-ray emission (PIXE). The data showed that 10% of the brick kiln workers were underweight and 10% obese (P = 0.059), with workers also reporting multiple health issues. Heavy metal concentrations utilizing AAS revealed significantly (p = 0.000) higher levels of cadmium, chromium, and nickel, while PIXE detected more than permissible levels of Si, P, S, Cl, K, Ca, Zn, Ti (p = 0.052), Mn (p = 0.017), Fe (p = 0.055), Co (p = 0.011), Ni (p = 0.045), and Cu (p = 0.003), in the blood of kiln workers. Moreover, a significant increase in platelet count (P = 0.010), a decrease in sodium dismutase levels (p = 0.006), a major increase in reactive oxygen species (p = 0.001), and a reduction in protein content (p = 0.013) were evident. A significant increase in cortisol levels (p = 0.000) among the workers group was also observed. The concentration of LH and FSH increased significantly (p = 0.000), while that of testosterone decreased (p = 0.000) in the worker group compared with controls. A significant inverse relationship was found between cortisol, LH (r =  − 0.380), and FSH (r =  − 0.946), while a positive correlation between cortisol and testosterone was also evident (r = 0.164). The study concludes that increased heavy metal burden in the blood of brick kiln workers exposes them to the development of general and reproductive health problems due to compromised antioxidant enzyme levels, increased oxidative stress conditions, and a disturbing reproductive axis.
    29 schema:genre article
    30 schema:isAccessibleForFree true
    31 schema:isPartOf N9d4ed0770877474dba0599b755c786e7
    32 Nce22e202ed3540218c3b9cd5000db93e
    33 sg:journal.1045337
    34 schema:keywords CO
    35 Ca
    36 Cl
    37 Cu
    38 FSH
    39 Fe
    40 LH
    41 Mn
    42 Ni
    43 Pakistan
    44 Si
    45 Ti
    46 X-ray emission
    47 Zn
    48 absorption spectroscopy
    49 analysis
    50 antioxidant enzyme levels
    51 antioxidant enzymes
    52 atomic absorption spectroscopy
    53 axis
    54 biochemical
    55 biochemical parameters
    56 biomarker analysis
    57 blood
    58 body mass index
    59 brick kiln workers
    60 burden
    61 cadmium
    62 chromium
    63 concentration
    64 concentrations of LH
    65 conditions
    66 consequences
    67 content
    68 control
    69 correlation
    70 cortisol
    71 cortisol levels
    72 count
    73 data
    74 decrease
    75 demographic data
    76 development
    77 dismutase levels
    78 effect
    79 emission
    80 enzyme
    81 enzyme levels
    82 general health
    83 group
    84 health
    85 health issues
    86 health problems
    87 health profile
    88 heavy metal burden
    89 heavy metal concentrations
    90 high levels
    91 hormone parameters
    92 increase
    93 index
    94 inverse relationship
    95 issues
    96 kiln workers
    97 levels
    98 major increase
    99 mass index
    100 metal burden
    101 metal concentrations
    102 multiple health issues
    103 nickel
    104 oxidative stress conditions
    105 oxygen species
    106 parameters
    107 participants
    108 particle-induced X-ray emission
    109 permissible levels
    110 platelet count
    111 positive correlation
    112 present study
    113 problem
    114 profile
    115 protein content
    116 reactive oxygen species
    117 reduction
    118 relationship
    119 reproductive axis
    120 reproductive health problems
    121 significant increase
    122 significant inverse relationship
    123 species
    124 spectroscopy
    125 stress conditions
    126 study
    127 study participants
    128 testosterone
    129 worker groups
    130 workers
    131 schema:name Biochemical and reproductive biomarker analysis to study the consequences of heavy metal burden on health profile of male brick kiln workers
    132 schema:pagination 7172
    133 schema:productId N9be14c09751c48b093a67721de0353e5
    134 Naba293341cad4cb8855e12daf21cd313
    135 Nff0fda4ef7be4226ba122ea4cb639420
    136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1147570782
    137 https://doi.org/10.1038/s41598-022-11304-7
    138 schema:sdDatePublished 2022-08-04T17:10
    139 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    140 schema:sdPublisher N182af5f465944a21aef4d3c976b5aea0
    141 schema:url https://doi.org/10.1038/s41598-022-11304-7
    142 sgo:license sg:explorer/license/
    143 sgo:sdDataset articles
    144 rdf:type schema:ScholarlyArticle
    145 N02a1f57dad7b4c41a312ad4bb0dba443 rdf:first sg:person.015507213730.52
    146 rdf:rest N86b7fcbd57de4d1091cb27d845dc7031
    147 N07986fc690964adb889e9ea35836e33f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Antioxidants
    149 rdf:type schema:DefinedTerm
    150 N0914083b5e6f45fe84a4b7613a4c5515 rdf:first sg:person.0760740725.04
    151 rdf:rest N93115aa2edf443a780ec7d6836f6e09f
    152 N0da8fc80e8f3444cb5cf602fe7b453f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Biomarkers
    154 rdf:type schema:DefinedTerm
    155 N182af5f465944a21aef4d3c976b5aea0 schema:name Springer Nature - SN SciGraph project
    156 rdf:type schema:Organization
    157 N1ec053129ff846489c99a399940c39b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Occupational Exposure
    159 rdf:type schema:DefinedTerm
    160 N3bb363058b1e4296aa737972dc851c65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Testosterone
    162 rdf:type schema:DefinedTerm
    163 N40a4d0746bb74ede8ca66c017a642862 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Humans
    165 rdf:type schema:DefinedTerm
    166 N681d879411394d7f92a4de23ed045258 rdf:first sg:person.010727014427.92
    167 rdf:rest N02a1f57dad7b4c41a312ad4bb0dba443
    168 N79ecbd9fd5ec4475b9c4b18192afcdf5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Male
    170 rdf:type schema:DefinedTerm
    171 N86b7fcbd57de4d1091cb27d845dc7031 rdf:first sg:person.01326673471.76
    172 rdf:rest Na03202f9e6b548ea9df4f294ce7a6dd4
    173 N8ed86f763051412490ca6fbe896336f7 rdf:first sg:person.01357705511.88
    174 rdf:rest rdf:nil
    175 N93115aa2edf443a780ec7d6836f6e09f rdf:first sg:person.013770466307.45
    176 rdf:rest N8ed86f763051412490ca6fbe896336f7
    177 N9be14c09751c48b093a67721de0353e5 schema:name pubmed_id
    178 schema:value 35504976
    179 rdf:type schema:PropertyValue
    180 N9d4ed0770877474dba0599b755c786e7 schema:issueNumber 1
    181 rdf:type schema:PublicationIssue
    182 Na03202f9e6b548ea9df4f294ce7a6dd4 rdf:first sg:person.01243457111.54
    183 rdf:rest N0914083b5e6f45fe84a4b7613a4c5515
    184 Naba293341cad4cb8855e12daf21cd313 schema:name doi
    185 schema:value 10.1038/s41598-022-11304-7
    186 rdf:type schema:PropertyValue
    187 Ncc0cb1ec1e8a4aed98006b4af7aab87c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Adult
    189 rdf:type schema:DefinedTerm
    190 Nce22e202ed3540218c3b9cd5000db93e schema:volumeNumber 12
    191 rdf:type schema:PublicationVolume
    192 Nd1d7a14a37ad4f318aa620536d76f9f0 rdf:first sg:person.07704157734.67
    193 rdf:rest Ndc96ba269dfe4ea8b3677b9d99f1aab1
    194 Ndc96ba269dfe4ea8b3677b9d99f1aab1 rdf:first sg:person.01145161315.83
    195 rdf:rest N681d879411394d7f92a4de23ed045258
    196 Nf135d109c275425a8c2f37b2690ab5da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Follicle Stimulating Hormone
    198 rdf:type schema:DefinedTerm
    199 Nf196bd2b6c1a4e8a8a06f738ba9157cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Hydrocortisone
    201 rdf:type schema:DefinedTerm
    202 Nf6241963ae0d4656ae5a0d6da878a793 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Metals, Heavy
    204 rdf:type schema:DefinedTerm
    205 Nff0fda4ef7be4226ba122ea4cb639420 schema:name dimensions_id
    206 schema:value pub.1147570782
    207 rdf:type schema:PropertyValue
    208 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    209 schema:name Medical and Health Sciences
    210 rdf:type schema:DefinedTerm
    211 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
    212 schema:name Public Health and Health Services
    213 rdf:type schema:DefinedTerm
    214 sg:journal.1045337 schema:issn 2045-2322
    215 schema:name Scientific Reports
    216 schema:publisher Springer Nature
    217 rdf:type schema:Periodical
    218 sg:person.010727014427.92 schema:affiliation grid-institutes:grid.412621.2
    219 schema:familyName Hussain
    220 schema:givenName Javaid
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010727014427.92
    222 rdf:type schema:Person
    223 sg:person.01145161315.83 schema:affiliation grid-institutes:grid.412621.2
    224 schema:familyName Jahan
    225 schema:givenName Sarwat
    226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145161315.83
    227 rdf:type schema:Person
    228 sg:person.01243457111.54 schema:affiliation grid-institutes:grid.56302.32
    229 schema:familyName Afsar
    230 schema:givenName Tayyaba
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243457111.54
    232 rdf:type schema:Person
    233 sg:person.01326673471.76 schema:affiliation grid-institutes:grid.462638.d
    234 schema:familyName Cloete
    235 schema:givenName Karen J.
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326673471.76
    237 rdf:type schema:Person
    238 sg:person.01357705511.88 schema:affiliation grid-institutes:grid.56302.32
    239 schema:familyName Razak
    240 schema:givenName Suhail
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357705511.88
    242 rdf:type schema:Person
    243 sg:person.013770466307.45 schema:affiliation grid-institutes:grid.56302.32
    244 schema:familyName Alruwaili
    245 schema:givenName Nawaf W.
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013770466307.45
    247 rdf:type schema:Person
    248 sg:person.015507213730.52 schema:affiliation grid-institutes:grid.8993.b
    249 schema:familyName Rehman
    250 schema:givenName Humaira
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015507213730.52
    252 rdf:type schema:Person
    253 sg:person.0760740725.04 schema:affiliation grid-institutes:grid.56302.32
    254 schema:familyName Almajwal
    255 schema:givenName Ali
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760740725.04
    257 rdf:type schema:Person
    258 sg:person.07704157734.67 schema:affiliation grid-institutes:grid.412621.2
    259 schema:familyName David
    260 schema:givenName Mehwish
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07704157734.67
    262 rdf:type schema:Person
    263 sg:pub.10.1007/s10967-012-2398-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038119470
    264 https://doi.org/10.1007/s10967-012-2398-2
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1007/s11356-013-1466-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016769064
    267 https://doi.org/10.1007/s11356-013-1466-7
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1007/s11356-016-6454-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035525829
    270 https://doi.org/10.1007/s11356-016-6454-2
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1007/s11356-020-10275-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1129879856
    273 https://doi.org/10.1007/s11356-020-10275-4
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1007/s11356-021-15375-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1139704965
    276 https://doi.org/10.1007/s11356-021-15375-3
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1007/s12011-018-1383-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103962996
    279 https://doi.org/10.1007/s12011-018-1383-1
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1007/s12011-019-01706-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113461938
    282 https://doi.org/10.1007/s12011-019-01706-6
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1007/s12070-020-02031-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1130119420
    285 https://doi.org/10.1007/s12070-020-02031-4
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1007/s12639-016-0775-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034848427
    288 https://doi.org/10.1007/s12639-016-0775-4
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/s41598-019-56847-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1123950493
    291 https://doi.org/10.1038/s41598-019-56847-4
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/s41598-020-62187-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1125823978
    294 https://doi.org/10.1038/s41598-020-62187-5
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1186/1471-2458-12-999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045601084
    297 https://doi.org/10.1186/1471-2458-12-999
    298 rdf:type schema:CreativeWork
    299 grid-institutes:grid.412621.2 schema:alternateName National Centre for Physics, Quaid-I-Azam University Campus, 44000, Islamabad, Pakistan
    300 Reproductive Physiology Laboratory, Department of Zoology, Quaid-I-Azam University, Islamabad, Pakistan
    301 schema:name National Centre for Physics, Quaid-I-Azam University Campus, 44000, Islamabad, Pakistan
    302 Reproductive Physiology Laboratory, Department of Zoology, Quaid-I-Azam University, Islamabad, Pakistan
    303 rdf:type schema:Organization
    304 grid-institutes:grid.462638.d schema:alternateName Nanoscience’s African Network (NANOAFNET), iThemba LABS-National Research Foundation, 1 Old Faure RoadWestern Cape Province, PO Box 722, 7129, Somerset West, South Africa
    305 schema:name College of Graduate Studies, UNESCO-UNISA Africa Chair in Nanosciences-Nanotechnology, University of South Africa, Muckleneuk Ridge, PO Box 392, Pretoria, South Africa
    306 Nanoscience’s African Network (NANOAFNET), iThemba LABS-National Research Foundation, 1 Old Faure RoadWestern Cape Province, PO Box 722, 7129, Somerset West, South Africa
    307 rdf:type schema:Organization
    308 grid-institutes:grid.56302.32 schema:alternateName Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia
    309 schema:name Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia
    310 rdf:type schema:Organization
    311 grid-institutes:grid.8993.b schema:alternateName Biomedical Center, Uppsala University, Husargatan 3, 752 37, Uppsala, Sweden
    312 schema:name Biomedical Center, Uppsala University, Husargatan 3, 752 37, Uppsala, Sweden
    313 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...