Metformin combined with local irradiation provokes abscopal effects in a murine rectal cancer model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-05-04

AUTHORS

Mineyuki Tojo, Hideyo Miyato, Koji Koinuma, Hisanaga Horie, Hidenori Tsukui, Yuki Kimura, Yuki Kaneko, Hideyuki Ohzawa, Hironori Yamaguchi, Kotaro Yoshimura, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama

ABSTRACT

Although preoperative chemoradiation therapy can down-stage locally advanced rectal cancer (LARC), it has little effect on distant metastases. Metformin exerts an anti-cancer effect partly through the activation of host immunity. LuM1, a highly lung metastatic subclone of colon 26, was injected subcutaneously (sc) in BALB/c mice and treated with metformin and/or local radiation (RT). Lung metastases and the primary tumors were evaluated and the phenotypes of immune cells in the spleen and lung metastases were examined with flow cytometry and immunohistochemistry. Local RT, but not metformin, partially delayed the growth of sc tumor which was augmented with metformin. Lung metastases were unchanged in metformin or RT alone, but significantly reduced in the combined therapy. The ratios of splenic T cells tended to be low in the RT group, which were increased by the addition of metformin. IFN-γ production of the splenic CD4(+) and CD8(+) T cells was enhanced and CD49b (+) CD335(+) activated NK cells was increased after combined treatment group. Density of NK cells infiltrating in lung metastases was increased after combination treatment. Metformin effectively enhances local and abscopal effects of RT though the activation of cell-mediated immunity and might be clinically useful for LARC. More... »

PAGES

7290

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-022-11236-2

DOI

http://dx.doi.org/10.1038/s41598-022-11236-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1147569863

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35508498


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD8-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metformin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rectal Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tojo", 
        "givenName": "Mineyuki", 
        "id": "sg:person.015347513503.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015347513503.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyato", 
        "givenName": "Hideyo", 
        "id": "sg:person.01025624363.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025624363.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koinuma", 
        "givenName": "Koji", 
        "id": "sg:person.0726142141.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726142141.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horie", 
        "givenName": "Hisanaga", 
        "id": "sg:person.0760333502.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760333502.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsukui", 
        "givenName": "Hidenori", 
        "id": "sg:person.01112460451.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112460451.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kimura", 
        "givenName": "Yuki", 
        "id": "sg:person.013410730721.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013410730721.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaneko", 
        "givenName": "Yuki", 
        "id": "sg:person.015304266513.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015304266513.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohzawa", 
        "givenName": "Hideyuki", 
        "id": "sg:person.01247734520.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247734520.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Oncology, Jichi Medical University, Shimotsuke, Tochigi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Clinical Oncology, Jichi Medical University, Shimotsuke, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamaguchi", 
        "givenName": "Hironori", 
        "id": "sg:person.01262743167.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262743167.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Plastic Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Plastic Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshimura", 
        "givenName": "Kotaro", 
        "id": "sg:person.01242345470.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242345470.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lefor", 
        "givenName": "Alan Kawarai", 
        "id": "sg:person.07506353527.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07506353527.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sata", 
        "givenName": "Naohiro", 
        "id": "sg:person.01312270004.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312270004.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kitayama", 
        "givenName": "Joji", 
        "id": "sg:person.01131725253.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131725253.77"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/s12885-020-06893-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1127548151", 
          "https://doi.org/10.1186/s12885-020-06893-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014349523", 
          "https://doi.org/10.1038/nrc1735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-016-2148-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001505790", 
          "https://doi.org/10.1007/s00432-016-2148-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2022-05-04", 
    "datePublishedReg": "2022-05-04", 
    "description": "Although preoperative chemoradiation therapy can down-stage locally advanced rectal cancer (LARC), it has little effect on distant metastases. Metformin exerts an anti-cancer effect partly through the activation of host immunity. LuM1, a highly lung metastatic subclone of colon 26, was injected subcutaneously (sc) in BALB/c mice and treated with metformin and/or local radiation (RT). Lung metastases and the primary tumors were evaluated and the phenotypes of immune cells in the spleen and lung metastases were examined with flow cytometry and immunohistochemistry. Local RT, but not metformin, partially delayed the growth of sc tumor which was augmented with metformin. Lung metastases were unchanged in metformin or RT alone, but significantly reduced in the combined therapy. The ratios of splenic T cells tended to be low in the RT group, which were increased by the addition of metformin. IFN-\u03b3 production of the splenic CD4(+) and CD8(+) T cells was enhanced and CD49b (+) CD335(+) activated NK cells was increased after combined treatment group. Density of NK cells infiltrating in lung metastases was increased after combination treatment. Metformin effectively enhances local and abscopal effects of RT though the activation of cell-mediated immunity and might be clinically useful for LARC.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-022-11236-2", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6836127", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8439620", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "keywords": [
      "lung metastases", 
      "NK cells", 
      "abscopal effect", 
      "T cells", 
      "BALB/c mice", 
      "local radiation", 
      "preoperative chemoradiation therapy", 
      "advanced rectal cancer", 
      "cell-mediated immunity", 
      "IFN-\u03b3 production", 
      "addition of metformin", 
      "splenic T cells", 
      "anti-cancer effects", 
      "chemoradiation therapy", 
      "rectal cancer", 
      "RT group", 
      "distant metastasis", 
      "SC tumors", 
      "c mice", 
      "primary tumor", 
      "immune cells", 
      "colon 26", 
      "treatment groups", 
      "local irradiation", 
      "combination treatment", 
      "host immunity", 
      "metformin", 
      "cancer model", 
      "metastasis", 
      "flow cytometry", 
      "therapy", 
      "tumors", 
      "immunity", 
      "metastatic subclones", 
      "cells", 
      "activation", 
      "CD49b", 
      "group", 
      "immunohistochemistry", 
      "spleen", 
      "cancer", 
      "LARC", 
      "mice", 
      "cytometry", 
      "effect", 
      "treatment", 
      "little effect", 
      "phenotype", 
      "subclones", 
      "radiation", 
      "addition", 
      "ratio", 
      "irradiation", 
      "production", 
      "growth", 
      "model", 
      "density"
    ], 
    "name": "Metformin combined with local irradiation provokes abscopal effects in a murine rectal cancer model", 
    "pagination": "7290", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1147569863"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-022-11236-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "35508498"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-022-11236-2", 
      "https://app.dimensions.ai/details/publication/pub.1147569863"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T17:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_938.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-022-11236-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-022-11236-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-022-11236-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-022-11236-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-022-11236-2'


 

This table displays all metadata directly associated to this object as RDF triples.

252 TRIPLES      21 PREDICATES      93 URIs      81 LITERALS      14 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-022-11236-2 schema:about N124512acf5d14c8a826ddf306c11e557
2 N27bd93732a374235b8ed02bf5b8c5853
3 N37da8bb60b91439e9897cd4c9ee5f8af
4 N44fd6d0c46a544bb8aba11827f309622
5 Naec974c6e4e84ea48aba5d64ae5ef309
6 Nba78ba99471b42339931b41a0912ce13
7 Nf94d538bf57843feb9ff4457e23badda
8 anzsrc-for:11
9 anzsrc-for:1107
10 anzsrc-for:1112
11 schema:author N88c2e08af1104800b5f9638690c3c4b4
12 schema:citation sg:pub.10.1007/s00432-016-2148-x
13 sg:pub.10.1038/nrc1735
14 sg:pub.10.1186/s12885-020-06893-3
15 schema:datePublished 2022-05-04
16 schema:datePublishedReg 2022-05-04
17 schema:description Although preoperative chemoradiation therapy can down-stage locally advanced rectal cancer (LARC), it has little effect on distant metastases. Metformin exerts an anti-cancer effect partly through the activation of host immunity. LuM1, a highly lung metastatic subclone of colon 26, was injected subcutaneously (sc) in BALB/c mice and treated with metformin and/or local radiation (RT). Lung metastases and the primary tumors were evaluated and the phenotypes of immune cells in the spleen and lung metastases were examined with flow cytometry and immunohistochemistry. Local RT, but not metformin, partially delayed the growth of sc tumor which was augmented with metformin. Lung metastases were unchanged in metformin or RT alone, but significantly reduced in the combined therapy. The ratios of splenic T cells tended to be low in the RT group, which were increased by the addition of metformin. IFN-γ production of the splenic CD4(+) and CD8(+) T cells was enhanced and CD49b (+) CD335(+) activated NK cells was increased after combined treatment group. Density of NK cells infiltrating in lung metastases was increased after combination treatment. Metformin effectively enhances local and abscopal effects of RT though the activation of cell-mediated immunity and might be clinically useful for LARC.
18 schema:genre article
19 schema:isAccessibleForFree true
20 schema:isPartOf N37f9d93df4184377a788d7b5a915c0f7
21 N43d86098e3c541f9b641518b06976479
22 sg:journal.1045337
23 schema:keywords BALB/c mice
24 CD49b
25 IFN-γ production
26 LARC
27 NK cells
28 RT group
29 SC tumors
30 T cells
31 abscopal effect
32 activation
33 addition
34 addition of metformin
35 advanced rectal cancer
36 anti-cancer effects
37 c mice
38 cancer
39 cancer model
40 cell-mediated immunity
41 cells
42 chemoradiation therapy
43 colon 26
44 combination treatment
45 cytometry
46 density
47 distant metastasis
48 effect
49 flow cytometry
50 group
51 growth
52 host immunity
53 immune cells
54 immunity
55 immunohistochemistry
56 irradiation
57 little effect
58 local irradiation
59 local radiation
60 lung metastases
61 metastasis
62 metastatic subclones
63 metformin
64 mice
65 model
66 phenotype
67 preoperative chemoradiation therapy
68 primary tumor
69 production
70 radiation
71 ratio
72 rectal cancer
73 spleen
74 splenic T cells
75 subclones
76 therapy
77 treatment
78 treatment groups
79 tumors
80 schema:name Metformin combined with local irradiation provokes abscopal effects in a murine rectal cancer model
81 schema:pagination 7290
82 schema:productId N115c65d43171438baea8ecf3fd54676f
83 Nc3960e4416a848a984abe362e9f866b4
84 Neffd3344477e4543ba962a082346821e
85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1147569863
86 https://doi.org/10.1038/s41598-022-11236-2
87 schema:sdDatePublished 2022-08-04T17:12
88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
89 schema:sdPublisher N21ae1210a7734d4696761b8ffc8fdab9
90 schema:url https://doi.org/10.1038/s41598-022-11236-2
91 sgo:license sg:explorer/license/
92 sgo:sdDataset articles
93 rdf:type schema:ScholarlyArticle
94 N0e8ccaae2ebd48cdb469e9325eb05764 rdf:first sg:person.01247734520.20
95 rdf:rest N387d71ae42f44f10a17cf6fdecf9b02c
96 N115c65d43171438baea8ecf3fd54676f schema:name dimensions_id
97 schema:value pub.1147569863
98 rdf:type schema:PropertyValue
99 N11dc60c4f81a4b01a127bb5fe3ba2a0c rdf:first sg:person.01242345470.74
100 rdf:rest N4e8cbd52b0484ddc80afa9140e4079bf
101 N124512acf5d14c8a826ddf306c11e557 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Mice, Inbred BALB C
103 rdf:type schema:DefinedTerm
104 N1acfbdc202d740d5b3642f2281552ead rdf:first sg:person.013410730721.72
105 rdf:rest Nccac5a70dc5e4d14aef8d7d784a8d167
106 N21ae1210a7734d4696761b8ffc8fdab9 schema:name Springer Nature - SN SciGraph project
107 rdf:type schema:Organization
108 N27bd93732a374235b8ed02bf5b8c5853 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Metformin
110 rdf:type schema:DefinedTerm
111 N37da8bb60b91439e9897cd4c9ee5f8af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Lung Neoplasms
113 rdf:type schema:DefinedTerm
114 N37f9d93df4184377a788d7b5a915c0f7 schema:volumeNumber 12
115 rdf:type schema:PublicationVolume
116 N387d71ae42f44f10a17cf6fdecf9b02c rdf:first sg:person.01262743167.40
117 rdf:rest N11dc60c4f81a4b01a127bb5fe3ba2a0c
118 N42c5fdf314e349dda6146cd719e822e1 rdf:first sg:person.01112460451.19
119 rdf:rest N1acfbdc202d740d5b3642f2281552ead
120 N43d86098e3c541f9b641518b06976479 schema:issueNumber 1
121 rdf:type schema:PublicationIssue
122 N44fd6d0c46a544bb8aba11827f309622 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Mice
124 rdf:type schema:DefinedTerm
125 N4e8cbd52b0484ddc80afa9140e4079bf rdf:first sg:person.07506353527.40
126 rdf:rest Ne9e4782f76524b75a5eded6f967e1988
127 N88c2e08af1104800b5f9638690c3c4b4 rdf:first sg:person.015347513503.14
128 rdf:rest Nef92b8d66b554615a59994a853512caf
129 Na1a9aa880d7948b8ae5f687796f86c36 rdf:first sg:person.01131725253.77
130 rdf:rest rdf:nil
131 Naec974c6e4e84ea48aba5d64ae5ef309 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name CD8-Positive T-Lymphocytes
133 rdf:type schema:DefinedTerm
134 Nb2f79ae439ae4489a0ffb183a837f3e0 rdf:first sg:person.0726142141.15
135 rdf:rest Nc8c90aaf996c4783b2387661afe0804d
136 Nba78ba99471b42339931b41a0912ce13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Animals
138 rdf:type schema:DefinedTerm
139 Nc3960e4416a848a984abe362e9f866b4 schema:name pubmed_id
140 schema:value 35508498
141 rdf:type schema:PropertyValue
142 Nc8c90aaf996c4783b2387661afe0804d rdf:first sg:person.0760333502.93
143 rdf:rest N42c5fdf314e349dda6146cd719e822e1
144 Nccac5a70dc5e4d14aef8d7d784a8d167 rdf:first sg:person.015304266513.18
145 rdf:rest N0e8ccaae2ebd48cdb469e9325eb05764
146 Ne9e4782f76524b75a5eded6f967e1988 rdf:first sg:person.01312270004.83
147 rdf:rest Na1a9aa880d7948b8ae5f687796f86c36
148 Nef92b8d66b554615a59994a853512caf rdf:first sg:person.01025624363.28
149 rdf:rest Nb2f79ae439ae4489a0ffb183a837f3e0
150 Neffd3344477e4543ba962a082346821e schema:name doi
151 schema:value 10.1038/s41598-022-11236-2
152 rdf:type schema:PropertyValue
153 Nf94d538bf57843feb9ff4457e23badda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Rectal Neoplasms
155 rdf:type schema:DefinedTerm
156 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
157 schema:name Medical and Health Sciences
158 rdf:type schema:DefinedTerm
159 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
160 schema:name Immunology
161 rdf:type schema:DefinedTerm
162 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
163 schema:name Oncology and Carcinogenesis
164 rdf:type schema:DefinedTerm
165 sg:grant.6836127 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-022-11236-2
166 rdf:type schema:MonetaryGrant
167 sg:grant.8439620 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-022-11236-2
168 rdf:type schema:MonetaryGrant
169 sg:journal.1045337 schema:issn 2045-2322
170 schema:name Scientific Reports
171 rdf:type schema:Periodical
172 sg:person.01025624363.28 schema:affiliation grid-institutes:grid.410804.9
173 schema:familyName Miyato
174 schema:givenName Hideyo
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025624363.28
176 rdf:type schema:Person
177 sg:person.01112460451.19 schema:affiliation grid-institutes:grid.410804.9
178 schema:familyName Tsukui
179 schema:givenName Hidenori
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112460451.19
181 rdf:type schema:Person
182 sg:person.01131725253.77 schema:affiliation grid-institutes:grid.410804.9
183 schema:familyName Kitayama
184 schema:givenName Joji
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131725253.77
186 rdf:type schema:Person
187 sg:person.01242345470.74 schema:affiliation grid-institutes:grid.410804.9
188 schema:familyName Yoshimura
189 schema:givenName Kotaro
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242345470.74
191 rdf:type schema:Person
192 sg:person.01247734520.20 schema:affiliation grid-institutes:grid.410804.9
193 schema:familyName Ohzawa
194 schema:givenName Hideyuki
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247734520.20
196 rdf:type schema:Person
197 sg:person.01262743167.40 schema:affiliation grid-institutes:grid.410804.9
198 schema:familyName Yamaguchi
199 schema:givenName Hironori
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262743167.40
201 rdf:type schema:Person
202 sg:person.01312270004.83 schema:affiliation grid-institutes:grid.410804.9
203 schema:familyName Sata
204 schema:givenName Naohiro
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312270004.83
206 rdf:type schema:Person
207 sg:person.013410730721.72 schema:affiliation grid-institutes:grid.410804.9
208 schema:familyName Kimura
209 schema:givenName Yuki
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013410730721.72
211 rdf:type schema:Person
212 sg:person.015304266513.18 schema:affiliation grid-institutes:grid.410804.9
213 schema:familyName Kaneko
214 schema:givenName Yuki
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015304266513.18
216 rdf:type schema:Person
217 sg:person.015347513503.14 schema:affiliation grid-institutes:grid.410804.9
218 schema:familyName Tojo
219 schema:givenName Mineyuki
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015347513503.14
221 rdf:type schema:Person
222 sg:person.0726142141.15 schema:affiliation grid-institutes:grid.410804.9
223 schema:familyName Koinuma
224 schema:givenName Koji
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726142141.15
226 rdf:type schema:Person
227 sg:person.07506353527.40 schema:affiliation grid-institutes:grid.410804.9
228 schema:familyName Lefor
229 schema:givenName Alan Kawarai
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07506353527.40
231 rdf:type schema:Person
232 sg:person.0760333502.93 schema:affiliation grid-institutes:grid.410804.9
233 schema:familyName Horie
234 schema:givenName Hisanaga
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760333502.93
236 rdf:type schema:Person
237 sg:pub.10.1007/s00432-016-2148-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001505790
238 https://doi.org/10.1007/s00432-016-2148-x
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/nrc1735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014349523
241 https://doi.org/10.1038/nrc1735
242 rdf:type schema:CreativeWork
243 sg:pub.10.1186/s12885-020-06893-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1127548151
244 https://doi.org/10.1186/s12885-020-06893-3
245 rdf:type schema:CreativeWork
246 grid-institutes:grid.410804.9 schema:alternateName Department of Clinical Oncology, Jichi Medical University, Shimotsuke, Tochigi, Japan
247 Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan
248 Department of Plastic Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan
249 schema:name Department of Clinical Oncology, Jichi Medical University, Shimotsuke, Tochigi, Japan
250 Department of Gastrointestinal Surgery, Jichi Medical University, Yakushiji 3311-1, 329-0498, Shimotsuke, Tochigi, Japan
251 Department of Plastic Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan
252 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...