Intralobular distribution of ovarian-like stroma in pancreatic mucinous cystic neoplasms: a discussion on its tumorigenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-02-28

AUTHORS

Yuki Fukumura, Yuko Kinowaki, Yoko Matsuda, Masaru Takase, Momoko Tonosaki, Masaaki Minagawa, Akio Saiura, Minoru Tanabe, Keiichi Okano, Yasuyuki Suzuki, Kota Kato, Takashi Yao

ABSTRACT

Pancreatic mucinous cystic neoplasm (MCN) has two histological components: tumor epithelia and ovarian-like stroma (OLS). To examine the progression and changes in pancreatic MCNs, we analyzed the distribution, amount, immunohistochemical phenotype, presence of theca cells of OLS, and tumor epithelium in 45 surgically resected MCN cases, comparing them with tumor sizes. The OLS data of female MCN cases were also compared between those who were ≤ 51 years old and those > 51 years old to see the effect of menopause on MCN histology. Non-mucinous type epithelium was present in all low-grade MCNs, but its ratio decreased with tumor size (p < 0.001), suggesting that epithelial mucinous changes are a progression phenomenon. The intralobular distribution of OLS was observed in 28.8% of MCN cases and was related to smaller tumor size (p < 0.0001), suggesting intralobular involvement of early MCNs. The nuclear expression of β-catenin and the cytoplasmic expression of α-smooth muscle actin (SMA) was observed in almost all OLS. OLS tended to be lesser among female cases aged > 51 years than those ≤ 51 years old, however it did not reach statistical significance. This is the first study to show the intralobular distribution of OLS. More... »

PAGES

3326

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-022-07416-9

DOI

http://dx.doi.org/10.1038/s41598-022-07416-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1145889371

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35228647


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