DLEU1 promotes oral squamous cell carcinoma progression by activating interferon-stimulated genes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-10-14

AUTHORS

Yui Hatanaka, Takeshi Niinuma, Hiroshi Kitajima, Koyo Nishiyama, Reo Maruyama, Kazuya Ishiguro, Mutsumi Toyota, Eiichiro Yamamoto, Masahiro Kai, Akira Yorozu, Shohei Sekiguchi, Kazuhiro Ogi, Hironari Dehari, Masashi Idogawa, Yasushi Sasaki, Takashi Tokino, Akihiro Miyazaki, Hiromu Suzuki

ABSTRACT

Long noncoding RNAs (lncRNAs) are deeply involved in cancer development. We previously reported that DLEU1 (deleted in lymphocytic leukemia 1) is one of the lncRNAs overexpressed in oral squamous cell carcinoma (OSCC) cells, where it exhibits oncogenic activity. In the present study, we further clarified the molecular function of DLEU1 in the pathogenesis of OSCC. Chromatin immunoprecipitation-sequencing (ChIP-seq) analysis revealed that DLEU1 knockdown induced significant changes in the levels of histone H3 lysine 4 trimethylation (H3K4me3) and H3K27 acetylation (H3K27ac) in OSCC cells. Notably, DLEU1 knockdown suppressed levels of H3K4me3/ H3K27ac and expression of a number of interferon-stimulated genes (ISGs), including IFIT1, IFI6 and OAS1, while ectopic DLEU1 expression activated these genes. Western blot analysis and reporter assays suggested that DLEU1 upregulates ISGs through activation of JAK-STAT signaling in OSCC cells. Moreover, IFITM1, one of the ISGs induced by DLUE1, was frequently overexpressed in primary OSCC tumors, and its knockdown inhibited OSCC cell proliferation, migration and invasion. These findings suggest that DLEU1 exerts its oncogenic effects, at least in part, through activation of a series ISGs in OSCC cells. More... »

PAGES

20438

References to SciGraph publications

  • 2015-01-19. The landscape of long noncoding RNAs in the human transcriptome in NATURE GENETICS
  • 2018-08-01. Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1 in CELL DEATH & DISEASE
  • 2019-05-07. UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells in CLINICAL EPIGENETICS
  • 2012-12-14. The broad-spectrum antiviral functions of IFIT and IFITM proteins in NATURE REVIEWS IMMUNOLOGY
  • 2006-11. Interferons, immunity and cancer immunoediting in NATURE REVIEWS IMMUNOLOGY
  • 1997-11-13. Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia in ONCOGENE
  • 2020-11-04. IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells in NATURE
  • 2018-08-11. LncRNA DLEU1 contributes to colorectal cancer progression via activation of KPNA3 in MOLECULAR CANCER
  • 2019-01-09. IFIT1 and IFIT3 promote oral squamous cell carcinoma metastasis and contribute to the anti-tumor effect of gefitinib via enhancing p-EGFR recycling in ONCOGENE
  • 2005-05-01. Mechanisms of type-I- and type-II-interferon-mediated signalling in NATURE REVIEWS IMMUNOLOGY
  • 2019-07-04. IFITM3 promotes bone metastasis of prostate cancer cells by mediating activation of the TGF-β signaling pathway in CELL DEATH & DISEASE
  • 2017-12-27. Long non-coding RNA DLEU1 predicts poor prognosis of gastric cancer and contributes to cell proliferation by epigenetically suppressing KLF2 in CANCER GENE THERAPY
  • 2021-02-19. LncRNA CDKN2B-AS1 stabilized by IGF2BP3 drives the malignancy of renal clear cell carcinoma through epigenetically activating NUF2 transcription in CELL DEATH & DISEASE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-021-99736-5

    DOI

    http://dx.doi.org/10.1038/s41598-021-99736-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1141878347

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34650128


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antigens, Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma, Squamous Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genes, Neoplasm", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histone Code", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interferons", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mouth Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phosphorylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Long Noncoding", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Interferon", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "STAT1 Transcription Factor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Up-Regulation", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, 060-8556, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.263171.0", 
              "name": [
                "Department of Oral Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan", 
                "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, 060-8556, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hatanaka", 
            "givenName": "Yui", 
            "id": "sg:person.016164640770.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016164640770.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, 060-8556, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.263171.0", 
              "name": [
                "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, 060-8556, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Niinuma", 
            "givenName": "Takeshi", 
            "id": "sg:person.0765245215.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765245215.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, 060-8556, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.263171.0", 
              "name": [
                "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, 060-8556, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kitajima", 
            "givenName": "Hiroshi", 
            "id": "sg:person.01025415023.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025415023.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Oral Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.263171.0", 
              "name": [
                "Department of Oral Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nishiyama", 
            "givenName": "Koyo", 
            "id": "sg:person.010567305302.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010567305302.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Project for Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410807.a", 
              "name": [
                "Project for Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maruyama", 
            "givenName": "Reo", 
            "id": "sg:person.0774207002.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774207002.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.263171.0", 
              "name": [
                "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, 060-8556, Sapporo, Japan", 
                "Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ishiguro", 
            "givenName": "Kazuya", 
            "id": "sg:person.01260705133.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260705133.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, 060-8556, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.263171.0", 
              "name": [
                "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, 060-8556, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Toyota", 
            "givenName": "Mutsumi", 
            "id": "sg:person.010336230435.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010336230435.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, 060-8556, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.263171.0", 
              "name": [
                "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, 060-8556, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamamoto", 
            "givenName": "Eiichiro", 
            "id": "sg:person.01064102140.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064102140.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, 060-8556, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.263171.0", 
              "name": [
                "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, 060-8556, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kai", 
            "givenName": "Masahiro", 
            "id": "sg:person.0747516413.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747516413.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.263171.0", 
              "name": [
                "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, 060-8556, Sapporo, Japan", 
                "Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yorozu", 
            "givenName": "Akira", 
            "id": "sg:person.012451140051.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012451140051.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, 060-8556, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.263171.0", 
              "name": [
                "Department of Oral Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan", 
                "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, 060-8556, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sekiguchi", 
            "givenName": "Shohei", 
            "id": "sg:person.07436065274.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07436065274.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Oral Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.263171.0", 
              "name": [
                "Department of Oral Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ogi", 
            "givenName": "Kazuhiro", 
            "id": "sg:person.01371470771.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371470771.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Oral Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.263171.0", 
              "name": [
                "Department of Oral Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dehari", 
            "givenName": "Hironari", 
            "id": "sg:person.01365772160.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365772160.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Genome Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.263171.0", 
              "name": [
                "Department of Medical Genome Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Idogawa", 
            "givenName": "Masashi", 
            "id": "sg:person.0770307061.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770307061.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Biology Division, Department of Liberal Arts and Sciences, Center for Medical Education, Sapporo Medical University, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.263171.0", 
              "name": [
                "Biology Division, Department of Liberal Arts and Sciences, Center for Medical Education, Sapporo Medical University, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sasaki", 
            "givenName": "Yasushi", 
            "id": "sg:person.013060476532.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013060476532.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Genome Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.263171.0", 
              "name": [
                "Department of Medical Genome Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tokino", 
            "givenName": "Takashi", 
            "id": "sg:person.01272777202.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272777202.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Oral Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.263171.0", 
              "name": [
                "Department of Oral Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miyazaki", 
            "givenName": "Akihiro", 
            "id": "sg:person.01317656760.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317656760.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, 060-8556, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.263171.0", 
              "name": [
                "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, 060-8556, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suzuki", 
            "givenName": "Hiromu", 
            "id": "sg:person.014315602124.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014315602124.12"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nri1604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002731283", 
              "https://doi.org/10.1038/nri1604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-020-2884-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1132290147", 
              "https://doi.org/10.1038/s41586-020-2884-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41417-017-0007-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100078365", 
              "https://doi.org/10.1038/s41417-017-0007-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028060819", 
              "https://doi.org/10.1038/ng.3192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41419-021-03489-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1135441449", 
              "https://doi.org/10.1038/s41419-021-03489-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41419-018-0893-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105940437", 
              "https://doi.org/10.1038/s41419-018-0893-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13148-019-0668-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1113961027", 
              "https://doi.org/10.1186/s13148-019-0668-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1201643", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001074134", 
              "https://doi.org/10.1038/sj.onc.1201643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri3344", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038404776", 
              "https://doi.org/10.1038/nri3344"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1961", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034368267", 
              "https://doi.org/10.1038/nri1961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41419-019-1750-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1117737261", 
              "https://doi.org/10.1038/s41419-019-1750-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12943-018-0873-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106117677", 
              "https://doi.org/10.1186/s12943-018-0873-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41388-018-0662-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111258267", 
              "https://doi.org/10.1038/s41388-018-0662-9"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2021-10-14", 
        "datePublishedReg": "2021-10-14", 
        "description": "Long noncoding RNAs (lncRNAs) are deeply involved in cancer development. We previously reported that DLEU1 (deleted in lymphocytic leukemia 1) is one of the lncRNAs overexpressed in oral squamous cell carcinoma (OSCC) cells, where it exhibits oncogenic activity. In the present study, we further clarified the molecular function of DLEU1 in the pathogenesis of OSCC. Chromatin immunoprecipitation-sequencing (ChIP-seq) analysis revealed that DLEU1 knockdown induced significant changes in the levels of histone H3 lysine 4 trimethylation (H3K4me3) and H3K27 acetylation (H3K27ac) in OSCC cells. Notably, DLEU1 knockdown suppressed levels of H3K4me3/ H3K27ac and expression of a number of interferon-stimulated genes (ISGs), including IFIT1, IFI6 and OAS1, while ectopic DLEU1 expression activated these genes. Western blot analysis and reporter assays suggested that DLEU1 upregulates ISGs through activation of JAK-STAT signaling in OSCC cells. Moreover, IFITM1, one of the ISGs induced by DLUE1, was frequently overexpressed in primary OSCC tumors, and its knockdown inhibited OSCC cell proliferation, migration and invasion. These findings suggest that DLEU1 exerts its oncogenic effects, at least in part, through activation of a series ISGs in OSCC cells.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41598-021-99736-5", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.9692175", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8422600", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7534807", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "11"
          }
        ], 
        "keywords": [
          "interferon-stimulated genes", 
          "OSCC cells", 
          "oral squamous cell carcinoma progression", 
          "oral squamous cell carcinoma cells", 
          "squamous cell carcinoma progression", 
          "DLEU1 knockdown", 
          "pathogenesis of OSCC", 
          "primary OSCC tumors", 
          "squamous cell carcinoma cells", 
          "OSCC cell proliferation", 
          "Western blot analysis", 
          "OSCC tumors", 
          "carcinoma progression", 
          "DLEU1 expression", 
          "oncogenic effects", 
          "cancer development", 
          "carcinoma cells", 
          "cell proliferation", 
          "reporter assays", 
          "JAK-STAT", 
          "oncogenic activity", 
          "blot analysis", 
          "chromatin immunoprecipitation sequencing analyses", 
          "knockdown", 
          "DLEU1", 
          "present study", 
          "significant changes", 
          "H3K27 acetylation", 
          "cells", 
          "activation", 
          "OSCC", 
          "pathogenesis", 
          "expression", 
          "tumors", 
          "IFI6", 
          "IFIT1", 
          "histone H3 lysine 4 trimethylation", 
          "progression", 
          "IFITM1", 
          "genes", 
          "H3 lysine 4 trimethylation", 
          "OAS1", 
          "lysine 4 trimethylation", 
          "levels", 
          "invasion", 
          "proliferation", 
          "lncRNAs", 
          "assays", 
          "molecular functions", 
          "findings", 
          "RNA", 
          "acetylation", 
          "activity", 
          "study", 
          "analysis", 
          "effect", 
          "changes", 
          "H3K27ac", 
          "migration", 
          "function", 
          "development", 
          "trimethylation", 
          "number", 
          "part"
        ], 
        "name": "DLEU1 promotes oral squamous cell carcinoma progression by activating interferon-stimulated genes", 
        "pagination": "20438", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1141878347"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-021-99736-5"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "34650128"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-021-99736-5", 
          "https://app.dimensions.ai/details/publication/pub.1141878347"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:42", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_890.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41598-021-99736-5"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-99736-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-99736-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-99736-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-99736-5'


     

    This table displays all metadata directly associated to this object as RDF triples.

    370 TRIPLES      21 PREDICATES      116 URIs      95 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-021-99736-5 schema:about N03e9a0a146694680b8e1b9fb5a1bf194
    2 N5e92fea26b0a448f83b853881b7450fd
    3 N5fa5589dfc3c4f9baba50a281a4e762a
    4 N6726a0683bfe4c478e47bf7a7386413f
    5 N80092eed13c342c188f1becb240652c9
    6 N80d42b1c23df4f949fe9ef7b217a32f0
    7 N88d06d547931404184d65c215944a345
    8 N8f00d27e72904fec9f2ec38760f5232f
    9 N98a86676c6ce4207a1eb7c44919c4954
    10 Nb51d61e98973428dabb792b586b683e2
    11 Nd3f79aabde6c494d8b8a4239c8ace0f0
    12 Ne4572f70a75a493e9ce6202347414a63
    13 Ne476d33ab71e4f3f80a138245b24b1a1
    14 Nf4b3f6a9fc1a400d877f2ef063524eee
    15 anzsrc-for:11
    16 anzsrc-for:1112
    17 schema:author Ne6cd5124565146a2b9fa23eeb1a8d92c
    18 schema:citation sg:pub.10.1038/ng.3192
    19 sg:pub.10.1038/nri1604
    20 sg:pub.10.1038/nri1961
    21 sg:pub.10.1038/nri3344
    22 sg:pub.10.1038/s41388-018-0662-9
    23 sg:pub.10.1038/s41417-017-0007-9
    24 sg:pub.10.1038/s41419-018-0893-2
    25 sg:pub.10.1038/s41419-019-1750-7
    26 sg:pub.10.1038/s41419-021-03489-y
    27 sg:pub.10.1038/s41586-020-2884-6
    28 sg:pub.10.1038/sj.onc.1201643
    29 sg:pub.10.1186/s12943-018-0873-2
    30 sg:pub.10.1186/s13148-019-0668-3
    31 schema:datePublished 2021-10-14
    32 schema:datePublishedReg 2021-10-14
    33 schema:description Long noncoding RNAs (lncRNAs) are deeply involved in cancer development. We previously reported that DLEU1 (deleted in lymphocytic leukemia 1) is one of the lncRNAs overexpressed in oral squamous cell carcinoma (OSCC) cells, where it exhibits oncogenic activity. In the present study, we further clarified the molecular function of DLEU1 in the pathogenesis of OSCC. Chromatin immunoprecipitation-sequencing (ChIP-seq) analysis revealed that DLEU1 knockdown induced significant changes in the levels of histone H3 lysine 4 trimethylation (H3K4me3) and H3K27 acetylation (H3K27ac) in OSCC cells. Notably, DLEU1 knockdown suppressed levels of H3K4me3/ H3K27ac and expression of a number of interferon-stimulated genes (ISGs), including IFIT1, IFI6 and OAS1, while ectopic DLEU1 expression activated these genes. Western blot analysis and reporter assays suggested that DLEU1 upregulates ISGs through activation of JAK-STAT signaling in OSCC cells. Moreover, IFITM1, one of the ISGs induced by DLUE1, was frequently overexpressed in primary OSCC tumors, and its knockdown inhibited OSCC cell proliferation, migration and invasion. These findings suggest that DLEU1 exerts its oncogenic effects, at least in part, through activation of a series ISGs in OSCC cells.
    34 schema:genre article
    35 schema:isAccessibleForFree true
    36 schema:isPartOf Nb463068f2c254530948c868ca4c73f6d
    37 Nb77956a19d794c46afa4f3b5bf1d4088
    38 sg:journal.1045337
    39 schema:keywords DLEU1
    40 DLEU1 expression
    41 DLEU1 knockdown
    42 H3 lysine 4 trimethylation
    43 H3K27 acetylation
    44 H3K27ac
    45 IFI6
    46 IFIT1
    47 IFITM1
    48 JAK-STAT
    49 OAS1
    50 OSCC
    51 OSCC cell proliferation
    52 OSCC cells
    53 OSCC tumors
    54 RNA
    55 Western blot analysis
    56 acetylation
    57 activation
    58 activity
    59 analysis
    60 assays
    61 blot analysis
    62 cancer development
    63 carcinoma cells
    64 carcinoma progression
    65 cell proliferation
    66 cells
    67 changes
    68 chromatin immunoprecipitation sequencing analyses
    69 development
    70 effect
    71 expression
    72 findings
    73 function
    74 genes
    75 histone H3 lysine 4 trimethylation
    76 interferon-stimulated genes
    77 invasion
    78 knockdown
    79 levels
    80 lncRNAs
    81 lysine 4 trimethylation
    82 migration
    83 molecular functions
    84 number
    85 oncogenic activity
    86 oncogenic effects
    87 oral squamous cell carcinoma cells
    88 oral squamous cell carcinoma progression
    89 part
    90 pathogenesis
    91 pathogenesis of OSCC
    92 present study
    93 primary OSCC tumors
    94 progression
    95 proliferation
    96 reporter assays
    97 significant changes
    98 squamous cell carcinoma cells
    99 squamous cell carcinoma progression
    100 study
    101 trimethylation
    102 tumors
    103 schema:name DLEU1 promotes oral squamous cell carcinoma progression by activating interferon-stimulated genes
    104 schema:pagination 20438
    105 schema:productId N43bab673462c46ba844b6d091bf490f0
    106 N7ae9c38bc3d94940bdf6a683377dca8c
    107 N897f906411024f04aa7f92e7f058fb12
    108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1141878347
    109 https://doi.org/10.1038/s41598-021-99736-5
    110 schema:sdDatePublished 2022-12-01T06:42
    111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    112 schema:sdPublisher N5d821c2f8c074d989af83d50266bbbee
    113 schema:url https://doi.org/10.1038/s41598-021-99736-5
    114 sgo:license sg:explorer/license/
    115 sgo:sdDataset articles
    116 rdf:type schema:ScholarlyArticle
    117 N01fc15fb3fb240f1a5204d6a9defe2fd rdf:first sg:person.013060476532.17
    118 rdf:rest N54dcd4da8d7a46c5b01b136b501736e2
    119 N03e9a0a146694680b8e1b9fb5a1bf194 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name RNA, Long Noncoding
    121 rdf:type schema:DefinedTerm
    122 N18e2f84ff12944389d4d6476a1ede363 rdf:first sg:person.01260705133.41
    123 rdf:rest N2abcc0b6c2964e8a9f5523709d4c36a2
    124 N2abcc0b6c2964e8a9f5523709d4c36a2 rdf:first sg:person.010336230435.31
    125 rdf:rest Ne953d53ce43447b88a73dc98defa994e
    126 N33606045925948e085311399293e7bed rdf:first sg:person.01365772160.10
    127 rdf:rest N4e7f359659ec44d7928da914d704fe39
    128 N43bab673462c46ba844b6d091bf490f0 schema:name pubmed_id
    129 schema:value 34650128
    130 rdf:type schema:PropertyValue
    131 N4e7f359659ec44d7928da914d704fe39 rdf:first sg:person.0770307061.79
    132 rdf:rest N01fc15fb3fb240f1a5204d6a9defe2fd
    133 N54dcd4da8d7a46c5b01b136b501736e2 rdf:first sg:person.01272777202.67
    134 rdf:rest Ne383b72a3b6b413fbe54cfd2aca42d57
    135 N5d821c2f8c074d989af83d50266bbbee schema:name Springer Nature - SN SciGraph project
    136 rdf:type schema:Organization
    137 N5e92fea26b0a448f83b853881b7450fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Gene Expression Regulation, Neoplastic
    139 rdf:type schema:DefinedTerm
    140 N5fa5589dfc3c4f9baba50a281a4e762a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Up-Regulation
    142 rdf:type schema:DefinedTerm
    143 N65fdd212a6944933b6b696d9dafa59f1 rdf:first sg:person.01371470771.31
    144 rdf:rest N33606045925948e085311399293e7bed
    145 N6726a0683bfe4c478e47bf7a7386413f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name STAT1 Transcription Factor
    147 rdf:type schema:DefinedTerm
    148 N7163052e8ca647bdb3cf25cd3e8fb961 rdf:first sg:person.0774207002.15
    149 rdf:rest N18e2f84ff12944389d4d6476a1ede363
    150 N7354e6b6ae6f4b80bfeec02548258c37 rdf:first sg:person.014315602124.12
    151 rdf:rest rdf:nil
    152 N753b04a29e1c433b85177a0ae0d4187e rdf:first sg:person.01025415023.42
    153 rdf:rest Nf48204e38571469cb64f1be56a7409e4
    154 N7ae9c38bc3d94940bdf6a683377dca8c schema:name dimensions_id
    155 schema:value pub.1141878347
    156 rdf:type schema:PropertyValue
    157 N7b1759356cd84086880d95131711f8dd rdf:first sg:person.07436065274.31
    158 rdf:rest N65fdd212a6944933b6b696d9dafa59f1
    159 N80092eed13c342c188f1becb240652c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Cell Line, Tumor
    161 rdf:type schema:DefinedTerm
    162 N80d42b1c23df4f949fe9ef7b217a32f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Histone Code
    164 rdf:type schema:DefinedTerm
    165 N88d06d547931404184d65c215944a345 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Humans
    167 rdf:type schema:DefinedTerm
    168 N897f906411024f04aa7f92e7f058fb12 schema:name doi
    169 schema:value 10.1038/s41598-021-99736-5
    170 rdf:type schema:PropertyValue
    171 N8f00d27e72904fec9f2ec38760f5232f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Receptors, Interferon
    173 rdf:type schema:DefinedTerm
    174 N98a86676c6ce4207a1eb7c44919c4954 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Phosphorylation
    176 rdf:type schema:DefinedTerm
    177 Nb463068f2c254530948c868ca4c73f6d schema:volumeNumber 11
    178 rdf:type schema:PublicationVolume
    179 Nb51d61e98973428dabb792b586b683e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Carcinoma, Squamous Cell
    181 rdf:type schema:DefinedTerm
    182 Nb77956a19d794c46afa4f3b5bf1d4088 schema:issueNumber 1
    183 rdf:type schema:PublicationIssue
    184 Nc9bab4970a83431189088353ff14a1c0 rdf:first sg:person.0765245215.48
    185 rdf:rest N753b04a29e1c433b85177a0ae0d4187e
    186 Nca06985283eb4b0781c03dc51db6c70c rdf:first sg:person.012451140051.65
    187 rdf:rest N7b1759356cd84086880d95131711f8dd
    188 Nd3f79aabde6c494d8b8a4239c8ace0f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Antigens, Differentiation
    190 rdf:type schema:DefinedTerm
    191 Ne2d896d9dd3141a7b6777230a515e7e5 rdf:first sg:person.0747516413.06
    192 rdf:rest Nca06985283eb4b0781c03dc51db6c70c
    193 Ne383b72a3b6b413fbe54cfd2aca42d57 rdf:first sg:person.01317656760.00
    194 rdf:rest N7354e6b6ae6f4b80bfeec02548258c37
    195 Ne4572f70a75a493e9ce6202347414a63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Interferons
    197 rdf:type schema:DefinedTerm
    198 Ne476d33ab71e4f3f80a138245b24b1a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Genes, Neoplasm
    200 rdf:type schema:DefinedTerm
    201 Ne6cd5124565146a2b9fa23eeb1a8d92c rdf:first sg:person.016164640770.95
    202 rdf:rest Nc9bab4970a83431189088353ff14a1c0
    203 Ne953d53ce43447b88a73dc98defa994e rdf:first sg:person.01064102140.08
    204 rdf:rest Ne2d896d9dd3141a7b6777230a515e7e5
    205 Nf48204e38571469cb64f1be56a7409e4 rdf:first sg:person.010567305302.71
    206 rdf:rest N7163052e8ca647bdb3cf25cd3e8fb961
    207 Nf4b3f6a9fc1a400d877f2ef063524eee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Mouth Neoplasms
    209 rdf:type schema:DefinedTerm
    210 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    211 schema:name Medical and Health Sciences
    212 rdf:type schema:DefinedTerm
    213 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    214 schema:name Oncology and Carcinogenesis
    215 rdf:type schema:DefinedTerm
    216 sg:grant.7534807 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-021-99736-5
    217 rdf:type schema:MonetaryGrant
    218 sg:grant.8422600 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-021-99736-5
    219 rdf:type schema:MonetaryGrant
    220 sg:grant.9692175 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-021-99736-5
    221 rdf:type schema:MonetaryGrant
    222 sg:journal.1045337 schema:issn 2045-2322
    223 schema:name Scientific Reports
    224 schema:publisher Springer Nature
    225 rdf:type schema:Periodical
    226 sg:person.01025415023.42 schema:affiliation grid-institutes:grid.263171.0
    227 schema:familyName Kitajima
    228 schema:givenName Hiroshi
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025415023.42
    230 rdf:type schema:Person
    231 sg:person.010336230435.31 schema:affiliation grid-institutes:grid.263171.0
    232 schema:familyName Toyota
    233 schema:givenName Mutsumi
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010336230435.31
    235 rdf:type schema:Person
    236 sg:person.010567305302.71 schema:affiliation grid-institutes:grid.263171.0
    237 schema:familyName Nishiyama
    238 schema:givenName Koyo
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010567305302.71
    240 rdf:type schema:Person
    241 sg:person.01064102140.08 schema:affiliation grid-institutes:grid.263171.0
    242 schema:familyName Yamamoto
    243 schema:givenName Eiichiro
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064102140.08
    245 rdf:type schema:Person
    246 sg:person.012451140051.65 schema:affiliation grid-institutes:grid.263171.0
    247 schema:familyName Yorozu
    248 schema:givenName Akira
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012451140051.65
    250 rdf:type schema:Person
    251 sg:person.01260705133.41 schema:affiliation grid-institutes:grid.263171.0
    252 schema:familyName Ishiguro
    253 schema:givenName Kazuya
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260705133.41
    255 rdf:type schema:Person
    256 sg:person.01272777202.67 schema:affiliation grid-institutes:grid.263171.0
    257 schema:familyName Tokino
    258 schema:givenName Takashi
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272777202.67
    260 rdf:type schema:Person
    261 sg:person.013060476532.17 schema:affiliation grid-institutes:grid.263171.0
    262 schema:familyName Sasaki
    263 schema:givenName Yasushi
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013060476532.17
    265 rdf:type schema:Person
    266 sg:person.01317656760.00 schema:affiliation grid-institutes:grid.263171.0
    267 schema:familyName Miyazaki
    268 schema:givenName Akihiro
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317656760.00
    270 rdf:type schema:Person
    271 sg:person.01365772160.10 schema:affiliation grid-institutes:grid.263171.0
    272 schema:familyName Dehari
    273 schema:givenName Hironari
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365772160.10
    275 rdf:type schema:Person
    276 sg:person.01371470771.31 schema:affiliation grid-institutes:grid.263171.0
    277 schema:familyName Ogi
    278 schema:givenName Kazuhiro
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371470771.31
    280 rdf:type schema:Person
    281 sg:person.014315602124.12 schema:affiliation grid-institutes:grid.263171.0
    282 schema:familyName Suzuki
    283 schema:givenName Hiromu
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014315602124.12
    285 rdf:type schema:Person
    286 sg:person.016164640770.95 schema:affiliation grid-institutes:grid.263171.0
    287 schema:familyName Hatanaka
    288 schema:givenName Yui
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016164640770.95
    290 rdf:type schema:Person
    291 sg:person.07436065274.31 schema:affiliation grid-institutes:grid.263171.0
    292 schema:familyName Sekiguchi
    293 schema:givenName Shohei
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07436065274.31
    295 rdf:type schema:Person
    296 sg:person.0747516413.06 schema:affiliation grid-institutes:grid.263171.0
    297 schema:familyName Kai
    298 schema:givenName Masahiro
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747516413.06
    300 rdf:type schema:Person
    301 sg:person.0765245215.48 schema:affiliation grid-institutes:grid.263171.0
    302 schema:familyName Niinuma
    303 schema:givenName Takeshi
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765245215.48
    305 rdf:type schema:Person
    306 sg:person.0770307061.79 schema:affiliation grid-institutes:grid.263171.0
    307 schema:familyName Idogawa
    308 schema:givenName Masashi
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770307061.79
    310 rdf:type schema:Person
    311 sg:person.0774207002.15 schema:affiliation grid-institutes:grid.410807.a
    312 schema:familyName Maruyama
    313 schema:givenName Reo
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774207002.15
    315 rdf:type schema:Person
    316 sg:pub.10.1038/ng.3192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028060819
    317 https://doi.org/10.1038/ng.3192
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1038/nri1604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002731283
    320 https://doi.org/10.1038/nri1604
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1038/nri1961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034368267
    323 https://doi.org/10.1038/nri1961
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1038/nri3344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038404776
    326 https://doi.org/10.1038/nri3344
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1038/s41388-018-0662-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111258267
    329 https://doi.org/10.1038/s41388-018-0662-9
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1038/s41417-017-0007-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100078365
    332 https://doi.org/10.1038/s41417-017-0007-9
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1038/s41419-018-0893-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105940437
    335 https://doi.org/10.1038/s41419-018-0893-2
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1038/s41419-019-1750-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1117737261
    338 https://doi.org/10.1038/s41419-019-1750-7
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1038/s41419-021-03489-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1135441449
    341 https://doi.org/10.1038/s41419-021-03489-y
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1038/s41586-020-2884-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132290147
    344 https://doi.org/10.1038/s41586-020-2884-6
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1038/sj.onc.1201643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001074134
    347 https://doi.org/10.1038/sj.onc.1201643
    348 rdf:type schema:CreativeWork
    349 sg:pub.10.1186/s12943-018-0873-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106117677
    350 https://doi.org/10.1186/s12943-018-0873-2
    351 rdf:type schema:CreativeWork
    352 sg:pub.10.1186/s13148-019-0668-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113961027
    353 https://doi.org/10.1186/s13148-019-0668-3
    354 rdf:type schema:CreativeWork
    355 grid-institutes:grid.263171.0 schema:alternateName Biology Division, Department of Liberal Arts and Sciences, Center for Medical Education, Sapporo Medical University, Sapporo, Japan
    356 Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan
    357 Department of Medical Genome Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    358 Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, 060-8556, Sapporo, Japan
    359 Department of Oral Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    360 Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    361 schema:name Biology Division, Department of Liberal Arts and Sciences, Center for Medical Education, Sapporo Medical University, Sapporo, Japan
    362 Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan
    363 Department of Medical Genome Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    364 Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, 060-8556, Sapporo, Japan
    365 Department of Oral Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    366 Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    367 rdf:type schema:Organization
    368 grid-institutes:grid.410807.a schema:alternateName Project for Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    369 schema:name Project for Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    370 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...