Three-dimensional culture method enhances the therapeutic efficacies of tonsil-derived mesenchymal stem cells in murine chronic colitis model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-10-01

AUTHORS

Eun Mi Song, Yang Hee Joo, A. Reum Choe, Yehyun Park, Chung Hyun Tae, Ji Teak Hong, Chang Mo Moon, Seong-Eun Kim, Hye-Kyung Jung, Ki-Nam Shim, Kyung-Ah Cho, Inho Jo, Sung-Ae Jung

ABSTRACT

Tonsil-derived mesenchymal stem cells (TMSCs) showed therapeutic effects on acute and chronic murine colitis models, owing to their immunomodulatory properties; therefore, we evaluated enhanced therapeutic effects of TMSCs on a murine colitis model using three-dimensional (3D) culture method. The expression of angiogenic factors, VEGF, and anti-inflammatory cytokines, IL-10, TSG-6, TGF-β, and IDO-1, was significantly higher in the 3D-TMSC-treated group than in the 2D-TMSC-treated group (P < 0.05). At days 18 and 30 after inducing chronic colitis, disease activity index scores were estimated to be significantly lower in the 3D-TMSC-treated group than in the colitis control (P < 0.001 and P < 0.001, respectively) and 2D-TMSC-treated groups (P = 0.022 and P = 0.004, respectively). Body weight loss was significantly lower in the 3D-TMSC-treated group than in the colitis control (P < 0.001) and 2D-TMSC-treated groups (P = 0.005). Colon length shortening was significantly recovered in the 3D-TMSC-treated group compared to that in the 2D-TMSC-treated group (P = 0.001). Histological scoring index was significantly lower in the 3D-TMSC-treated group than in the 2D-TMSC-treated group (P = 0.002). These results indicate that 3D-cultured TMSCs showed considerably higher therapeutic effects in a chronic murine colitis model than those of 2D-cultured TMSCs via increased anti-inflammatory cytokine expression. More... »

PAGES

19589

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-021-98711-4

DOI

http://dx.doi.org/10.1038/s41598-021-98711-4

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34599237


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51 colitis
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53 colitis model
54 colon length shortening
55 control
56 culture method
57 cytokine expression
58 cytokines
59 day 18
60 effect
61 efficacy
62 expression
63 factors
64 group
65 high therapeutic effect
66 immunomodulatory properties
67 index
68 index score
69 length shortening
70 loss
71 mesenchymal stem cells
72 method
73 model
74 murine chronic colitis model
75 murine colitis model
76 properties
77 results
78 scores
79 scoring index
80 shortening
81 stem cells
82 therapeutic effect
83 therapeutic efficacy
84 three-dimensional culture method
85 tonsil-derived mesenchymal stem cells
86 tonsils
87 weight loss
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