Expression of LGR5 in mammary myoepithelial cells and in triple-negative breast cancers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-09-07

AUTHORS

Hyun Ju Lee, Jae Kyung Myung, Hye Sung Kim, Dong Hui Lee, Hyun Su Go, Jae Hyuck Choi, Hyun Min Koh, Su-Jae Lee, Bogun Jang

ABSTRACT

Lineage tracing in mice indicates that LGR5 is an adult stem cell marker in multiple organs, such as the intestine, stomach, hair follicles, ovary, and mammary glands. Despite many studies exploring the presence of LGR5 cells in human tissues, little is known about its expression profile in either human mammary tissue or pathological lesions. In this study we aim to investigate LGR5 expression in normal, benign, and malignant lesions of the human breast using RNA in situ hybridization. LGR5 expression has not been observed in normal lactiferous ducts and terminal duct lobular units, whereas LGR5-positive cells have been specifically observed in the basal myoepithelium of ducts in the regenerative tissues, ductal carcinoma in situ, and in ducts surrounded by invasive cancer cells. These findings suggest LGR5 marks facultative stem cells that are involved in post injury regeneration instead of homeostatic stem cells. LGR5 positivity was found in 3% (9 of 278 cases) of invasive breast cancers (BC), and it showed positive associations with higher histologic grades (P = 0.001) and T stages (P < 0.001), while having negative correlations with estrogen receptor (P < 0.001) and progesterone receptor (P < 0.001) expression. Remarkably, all LGR5-positive BC, except one, belong to triple-negative BC (TNBC), representing 24% (9 of 38 cases) of all of them. LGR5 histoscores have no correlations with EGFR, CK5/6, Ki-67, or P53 expression. Additionally, no β-catenin nuclear localization was observed in LGR5-positive BC, indicating that canonical Wnt pathway activation is less likely involved in LGR5 expression in BC. Our results demonstrate that LGR5 expression is induced in regenerative conditions in the myoepithelium of human mammary ducts and that its expression is only observed in TNBC subtype among all invasive BC. Further studies regarding the functional and prognostic impact of LGR5 in TNBC are warranted. More... »

PAGES

17750

References to SciGraph publications

  • 2017-02-13. Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive in NATURE CELL BIOLOGY
  • 2014-10-19. Identification of multipotent mammary stem cells by protein C receptor expression in NATURE
  • 2011-10-09. Distinct stem cells contribute to mammary gland development and maintenance in NATURE
  • 2000-08. Molecular portraits of human breast tumours in NATURE
  • 2007-10-14. Identification of stem cells in small intestine and colon by marker gene Lgr5 in NATURE
  • 2014-07-06. Lgr5 marks stem/progenitor cells in ovary and tubal epithelia in NATURE CELL BIOLOGY
  • 2010-11-12. β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation in MODERN PATHOLOGY
  • 2008-12-17. Crypt stem cells as the cells-of-origin of intestinal cancer in NATURE
  • 2008-10-12. Lgr5 marks cycling, yet long-lived, hair follicle stem cells in NATURE GENETICS
  • 2017-06-05. Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach in NATURE CELL BIOLOGY
  • 2020-06-10. LGR5 in breast cancer and ductal carcinoma in situ: a diagnostic and prognostic biomarker and a therapeutic target in BMC CANCER
  • 2013-01-27. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration in NATURE
  • 2016-04-19. Gastric Lgr5+ stem cells are the cellular origin of invasive intestinal-type gastric cancer in mice in CELL RESEARCH
  • 2017-03-30. A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer in NATURE
  • 2017-09-25. Cell plasticity in epithelial homeostasis and tumorigenesis in NATURE CELL BIOLOGY
  • 2017-09-25. Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma in NATURE GENETICS
  • 2012-01-06. Prognostic value of proliferation assay in the luminal, HER2-positive, and triple-negative biologic classes of breast cancer in BREAST CANCER RESEARCH
  • 2015-09-19. Prognostic significance of leucine-rich-repeat-containing G-protein-coupled receptor 5, an intestinal stem cell marker, in gastric carcinomas in GASTRIC CANCER
  • 2017-03-29. Visualization and targeting of LGR5+ human colon cancer stem cells in NATURE
  • 2018-02-22. LGR5 overexpression confers poor relapse-free survival in breast cancer patients in BMC CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-021-97351-y

    DOI

    http://dx.doi.org/10.1038/s41598-021-97351-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1140936476

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34493772


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Breast", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Breast Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma, Ductal, Breast", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma, Intraductal, Noninfiltrating", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epithelial Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fibroadenoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "In Situ Hybridization", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Papilloma, Intraductal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phyllodes Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Messenger", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Neoplasm", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, G-Protein-Coupled", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Regeneration", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Triple Negative Breast Neoplasms", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Soonchunhyang University College of Medicine and Soonchunhyang University Cheonan Hospital, Cheonan, Korea", 
              "id": "http://www.grid.ac/institutes/grid.412677.1", 
              "name": [
                "Department of Pathology, Soonchunhyang University College of Medicine and Soonchunhyang University Cheonan Hospital, Cheonan, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Hyun Ju", 
            "id": "sg:person.07562435745.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07562435745.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Hanyang University College of Medicine, Seoul, Korea", 
              "id": "http://www.grid.ac/institutes/grid.49606.3d", 
              "name": [
                "Department of Pathology, Hanyang University College of Medicine, Seoul, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Myung", 
            "givenName": "Jae Kyung", 
            "id": "sg:person.0701520567.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701520567.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Jeju National University School of Medicine, Jeju, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.411277.6", 
              "name": [
                "Department of Pathology, Jeju National University School of Medicine, Jeju, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Hye Sung", 
            "id": "sg:person.0771453563.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771453563.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Jeju National University School of Medicine and Jeju National University Hospital, Aran 13 gil 15, 63241, Jeju city, Jeju, Korea", 
              "id": "http://www.grid.ac/institutes/grid.411277.6", 
              "name": [
                "Department of Pathology, Jeju National University School of Medicine and Jeju National University Hospital, Aran 13 gil 15, 63241, Jeju city, Jeju, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Dong Hui", 
            "id": "sg:person.010725430255.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010725430255.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Jeju National University School of Medicine, Jeju, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.411277.6", 
              "name": [
                "Department of Pathology, Jeju National University School of Medicine, Jeju, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Go", 
            "givenName": "Hyun Su", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Jeju National University School of Medicine and Jeju National University Hospital, Jeju, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.411277.6", 
              "name": [
                "Department of Surgery, Jeju National University School of Medicine and Jeju National University Hospital, Jeju, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Choi", 
            "givenName": "Jae Hyuck", 
            "id": "sg:person.0651672565.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651672565.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.256681.e", 
              "name": [
                "Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koh", 
            "givenName": "Hyun Min", 
            "id": "sg:person.01165545573.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165545573.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Life Science, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea", 
              "id": "http://www.grid.ac/institutes/grid.49606.3d", 
              "name": [
                "Department of Life Science, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Su-Jae", 
            "id": "sg:person.01122425732.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122425732.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Jeju National University School of Medicine and Jeju National University Hospital, Aran 13 gil 15, 63241, Jeju city, Jeju, Korea", 
              "id": "http://www.grid.ac/institutes/grid.411277.6", 
              "name": [
                "Department of Pathology, Jeju National University School of Medicine and Jeju National University Hospital, Aran 13 gil 15, 63241, Jeju city, Jeju, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jang", 
            "givenName": "Bogun", 
            "id": "sg:person.0640426775.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640426775.09"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature10573", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009808673", 
              "https://doi.org/10.1038/nature10573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2010.205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002473292", 
              "https://doi.org/10.1038/modpathol.2010.205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12885-020-06986-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1128385627", 
              "https://doi.org/10.1186/s12885-020-06986-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35021093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033846543", 
              "https://doi.org/10.1038/35021093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature21713", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084128603", 
              "https://doi.org/10.1038/nature21713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3611", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091913431", 
              "https://doi.org/10.1038/ncb3611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr3084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007429235", 
              "https://doi.org/10.1186/bcr3084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11826", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009532460", 
              "https://doi.org/10.1038/nature11826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13851", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017721211", 
              "https://doi.org/10.1038/nature13851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085861655", 
              "https://doi.org/10.1038/ncb3541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10120-015-0543-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000289507", 
              "https://doi.org/10.1007/s10120-015-0543-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3471", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083802253", 
              "https://doi.org/10.1038/ncb3471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036627687", 
              "https://doi.org/10.1038/ncb3000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature22081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084128635", 
              "https://doi.org/10.1038/nature22081"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2016.47", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040434522", 
              "https://doi.org/10.1038/cr.2016.47"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3957", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091911785", 
              "https://doi.org/10.1038/ng.3957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12885-018-4018-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101179530", 
              "https://doi.org/10.1186/s12885-018-4018-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020963310", 
              "https://doi.org/10.1038/nature07602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023194186", 
              "https://doi.org/10.1038/ng.239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06196", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050225537", 
              "https://doi.org/10.1038/nature06196"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2021-09-07", 
        "datePublishedReg": "2021-09-07", 
        "description": "Lineage tracing in mice indicates that LGR5 is an adult stem cell marker in multiple organs, such as the intestine, stomach, hair follicles, ovary, and mammary glands. Despite many studies exploring the presence of LGR5 cells in human tissues, little is known about its expression profile in either human mammary tissue or pathological lesions. In this study we aim to investigate LGR5 expression in normal, benign, and malignant lesions of the human breast using RNA in situ hybridization. LGR5 expression has not been observed in normal lactiferous ducts and terminal duct lobular units, whereas LGR5-positive cells have been specifically observed in the basal myoepithelium of ducts in the regenerative tissues, ductal carcinoma in situ, and in ducts surrounded by invasive cancer cells. These findings suggest LGR5 marks facultative stem cells that are involved in post injury regeneration instead of homeostatic stem cells. LGR5 positivity was found in 3% (9 of 278 cases) of invasive breast cancers (BC), and it showed positive associations with higher histologic grades (P\u2009=\u20090.001) and T stages (P\u2009<\u20090.001), while having negative correlations with estrogen receptor (P\u2009<\u20090.001) and progesterone receptor (P\u2009<\u20090.001) expression. Remarkably, all LGR5-positive BC, except one, belong to triple-negative BC (TNBC), representing 24% (9 of 38 cases) of all of them. LGR5 histoscores have no correlations with EGFR, CK5/6, Ki-67, or P53 expression. Additionally, no \u03b2-catenin nuclear localization was observed in LGR5-positive BC, indicating that canonical Wnt pathway activation is less likely involved in LGR5 expression in BC. Our results demonstrate that LGR5 expression is induced in regenerative conditions in the myoepithelium of human mammary ducts and that its expression is only observed in TNBC subtype among all invasive BC. Further studies regarding the functional and prognostic impact of LGR5 in TNBC are warranted.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41598-021-97351-y", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "11"
          }
        ], 
        "keywords": [
          "triple-negative breast cancer", 
          "invasive breast cancer", 
          "triple-negative BC", 
          "breast cancer", 
          "LGR5 expression", 
          "normal lactiferous ducts", 
          "terminal duct lobular units", 
          "high histologic grade", 
          "expression of LGR5", 
          "Lgr5-positive cells", 
          "mammary myoepithelial cells", 
          "human mammary tissue", 
          "\u03b2-catenin nuclear localization", 
          "human mammary ducts", 
          "stem cells", 
          "Wnt pathway activation", 
          "post-injury regeneration", 
          "stem cell markers", 
          "canonical Wnt pathway activation", 
          "Lgr5 cells", 
          "LGR5 positivity", 
          "prognostic impact", 
          "T stage", 
          "ductal carcinoma", 
          "TNBC subtypes", 
          "histologic grade", 
          "facultative stem cells", 
          "invasive cancer cells", 
          "estrogen receptor", 
          "Ki-67", 
          "pathological lesions", 
          "malignant lesions", 
          "lobular units", 
          "lactiferous ducts", 
          "multiple organs", 
          "p53 expression", 
          "mammary ducts", 
          "mammary tissue", 
          "cell markers", 
          "pathway activation", 
          "myoepithelial cells", 
          "mammary gland", 
          "hair follicles", 
          "human breast", 
          "cancer cells", 
          "Lgr5", 
          "Further studies", 
          "positive association", 
          "adult stem cell markers", 
          "lesions", 
          "cancer", 
          "duct", 
          "regenerative conditions", 
          "tissue", 
          "myoepithelium", 
          "situ hybridization", 
          "human tissues", 
          "cells", 
          "negative correlation", 
          "expression profiles", 
          "expression", 
          "regenerative tissue", 
          "nuclear localization", 
          "histoscores", 
          "CK5/6", 
          "carcinoma", 
          "EGFR", 
          "breast", 
          "stomach", 
          "subtypes", 
          "mice", 
          "follicles", 
          "intestine", 
          "positivity", 
          "receptors", 
          "study", 
          "gland", 
          "organs", 
          "markers", 
          "association", 
          "activation", 
          "correlation", 
          "grade", 
          "findings", 
          "RNA", 
          "regeneration", 
          "localization", 
          "presence", 
          "profile", 
          "hybridization", 
          "stage", 
          "lineages", 
          "units", 
          "impact", 
          "results", 
          "situ", 
          "conditions"
        ], 
        "name": "Expression of LGR5 in mammary myoepithelial cells and in triple-negative breast cancers", 
        "pagination": "17750", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1140936476"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-021-97351-y"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "34493772"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-021-97351-y", 
          "https://app.dimensions.ai/details/publication/pub.1140936476"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-20T07:39", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_900.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41598-021-97351-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-97351-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-97351-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-97351-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-97351-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    392 TRIPLES      22 PREDICATES      164 URIs      136 LITERALS      28 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-021-97351-y schema:about N031b9d3a024245e8afb172af3588d84e
    2 N07ea31f76aa44e0d9e32e4bfea4c2d68
    3 N0d822fc3ad784b92a5acf620e3c8c0b6
    4 N1d763924d1394790bfd5adbbd7da616e
    5 N44de197cb1ca4125bc66c05d7dd81d42
    6 N58f1fbf06f814b67b0e4e3a38b9dc93e
    7 N6675103e9e814f5e8111d2ab8f73eb75
    8 N67a20cf881734860a2564734659187b0
    9 N6cc02aa5b3404634b7e9c7e70ded1ab4
    10 N6ec5ab856fe043b2915ac6ea1aa7eccc
    11 N70f0fbf9939e441d94eaa4198bc0263d
    12 N73cfe6710f974532a141a7473a3e1bcc
    13 N77f11c5400c647c7a9a42896f6cfef06
    14 N93ba77a8b85f4302b4db7356e16a19d9
    15 Na2e6a79802964676aebec32f1a68d749
    16 Naaae852eece34429bc818cf23c271ee1
    17 Nca74ccd9bd9642e8814e4783ce639bad
    18 Nd20fb120ffe742a89b56e24ed9c38939
    19 Ne1c5820d397d4f409f1685c9a05c74b5
    20 Ne44e04653fb54b4daece6fed20d834eb
    21 Nf3a7476b27b94dc4a2d2bfaf56a24b42
    22 anzsrc-for:11
    23 anzsrc-for:1112
    24 schema:author N3b82a16be69141ef9ba9d65d113ac4a1
    25 schema:citation sg:pub.10.1007/s10120-015-0543-7
    26 sg:pub.10.1038/35021093
    27 sg:pub.10.1038/cr.2016.47
    28 sg:pub.10.1038/modpathol.2010.205
    29 sg:pub.10.1038/nature06196
    30 sg:pub.10.1038/nature07602
    31 sg:pub.10.1038/nature10573
    32 sg:pub.10.1038/nature11826
    33 sg:pub.10.1038/nature13851
    34 sg:pub.10.1038/nature21713
    35 sg:pub.10.1038/nature22081
    36 sg:pub.10.1038/ncb3000
    37 sg:pub.10.1038/ncb3471
    38 sg:pub.10.1038/ncb3541
    39 sg:pub.10.1038/ncb3611
    40 sg:pub.10.1038/ng.239
    41 sg:pub.10.1038/ng.3957
    42 sg:pub.10.1186/bcr3084
    43 sg:pub.10.1186/s12885-018-4018-1
    44 sg:pub.10.1186/s12885-020-06986-z
    45 schema:datePublished 2021-09-07
    46 schema:datePublishedReg 2021-09-07
    47 schema:description Lineage tracing in mice indicates that LGR5 is an adult stem cell marker in multiple organs, such as the intestine, stomach, hair follicles, ovary, and mammary glands. Despite many studies exploring the presence of LGR5 cells in human tissues, little is known about its expression profile in either human mammary tissue or pathological lesions. In this study we aim to investigate LGR5 expression in normal, benign, and malignant lesions of the human breast using RNA in situ hybridization. LGR5 expression has not been observed in normal lactiferous ducts and terminal duct lobular units, whereas LGR5-positive cells have been specifically observed in the basal myoepithelium of ducts in the regenerative tissues, ductal carcinoma in situ, and in ducts surrounded by invasive cancer cells. These findings suggest LGR5 marks facultative stem cells that are involved in post injury regeneration instead of homeostatic stem cells. LGR5 positivity was found in 3% (9 of 278 cases) of invasive breast cancers (BC), and it showed positive associations with higher histologic grades (P = 0.001) and T stages (P < 0.001), while having negative correlations with estrogen receptor (P < 0.001) and progesterone receptor (P < 0.001) expression. Remarkably, all LGR5-positive BC, except one, belong to triple-negative BC (TNBC), representing 24% (9 of 38 cases) of all of them. LGR5 histoscores have no correlations with EGFR, CK5/6, Ki-67, or P53 expression. Additionally, no β-catenin nuclear localization was observed in LGR5-positive BC, indicating that canonical Wnt pathway activation is less likely involved in LGR5 expression in BC. Our results demonstrate that LGR5 expression is induced in regenerative conditions in the myoepithelium of human mammary ducts and that its expression is only observed in TNBC subtype among all invasive BC. Further studies regarding the functional and prognostic impact of LGR5 in TNBC are warranted.
    48 schema:genre article
    49 schema:inLanguage en
    50 schema:isAccessibleForFree true
    51 schema:isPartOf N5ffe2132a4284174ab4d1ff3f405ad35
    52 Nd2a112f2959848e182b9f4d420051df5
    53 sg:journal.1045337
    54 schema:keywords CK5/6
    55 EGFR
    56 Further studies
    57 Ki-67
    58 LGR5 expression
    59 LGR5 positivity
    60 Lgr5
    61 Lgr5 cells
    62 Lgr5-positive cells
    63 RNA
    64 T stage
    65 TNBC subtypes
    66 Wnt pathway activation
    67 activation
    68 adult stem cell markers
    69 association
    70 breast
    71 breast cancer
    72 cancer
    73 cancer cells
    74 canonical Wnt pathway activation
    75 carcinoma
    76 cell markers
    77 cells
    78 conditions
    79 correlation
    80 duct
    81 ductal carcinoma
    82 estrogen receptor
    83 expression
    84 expression of LGR5
    85 expression profiles
    86 facultative stem cells
    87 findings
    88 follicles
    89 gland
    90 grade
    91 hair follicles
    92 high histologic grade
    93 histologic grade
    94 histoscores
    95 human breast
    96 human mammary ducts
    97 human mammary tissue
    98 human tissues
    99 hybridization
    100 impact
    101 intestine
    102 invasive breast cancer
    103 invasive cancer cells
    104 lactiferous ducts
    105 lesions
    106 lineages
    107 lobular units
    108 localization
    109 malignant lesions
    110 mammary ducts
    111 mammary gland
    112 mammary myoepithelial cells
    113 mammary tissue
    114 markers
    115 mice
    116 multiple organs
    117 myoepithelial cells
    118 myoepithelium
    119 negative correlation
    120 normal lactiferous ducts
    121 nuclear localization
    122 organs
    123 p53 expression
    124 pathological lesions
    125 pathway activation
    126 positive association
    127 positivity
    128 post-injury regeneration
    129 presence
    130 profile
    131 prognostic impact
    132 receptors
    133 regeneration
    134 regenerative conditions
    135 regenerative tissue
    136 results
    137 situ
    138 situ hybridization
    139 stage
    140 stem cell markers
    141 stem cells
    142 stomach
    143 study
    144 subtypes
    145 terminal duct lobular units
    146 tissue
    147 triple-negative BC
    148 triple-negative breast cancer
    149 units
    150 β-catenin nuclear localization
    151 schema:name Expression of LGR5 in mammary myoepithelial cells and in triple-negative breast cancers
    152 schema:pagination 17750
    153 schema:productId N072b7bc810774bbb8568db464c5a3448
    154 N1e97ebb48b9840c9aaa652033ab544e6
    155 N3c2004bd8e5e476a96673f6cbbddf526
    156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1140936476
    157 https://doi.org/10.1038/s41598-021-97351-y
    158 schema:sdDatePublished 2022-05-20T07:39
    159 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    160 schema:sdPublisher Nd0d5ea98f25b4cc6a6bf60650563dc2b
    161 schema:url https://doi.org/10.1038/s41598-021-97351-y
    162 sgo:license sg:explorer/license/
    163 sgo:sdDataset articles
    164 rdf:type schema:ScholarlyArticle
    165 N031b9d3a024245e8afb172af3588d84e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Regeneration
    167 rdf:type schema:DefinedTerm
    168 N072b7bc810774bbb8568db464c5a3448 schema:name pubmed_id
    169 schema:value 34493772
    170 rdf:type schema:PropertyValue
    171 N0761ddaf66ca4867b68ed8afa39bbc19 rdf:first N36cd7ab649424da7b063af569a6269cf
    172 rdf:rest Neabd33fae0a943eca684029dcb49e6ef
    173 N07ea31f76aa44e0d9e32e4bfea4c2d68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Breast
    175 rdf:type schema:DefinedTerm
    176 N093773c14f5b4232bd4794bf1cba2456 rdf:first sg:person.0771453563.33
    177 rdf:rest N466c7320f2b3467a8c6522d82151e4c2
    178 N0d822fc3ad784b92a5acf620e3c8c0b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Carcinoma
    180 rdf:type schema:DefinedTerm
    181 N1d763924d1394790bfd5adbbd7da616e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Papilloma, Intraductal
    183 rdf:type schema:DefinedTerm
    184 N1e97ebb48b9840c9aaa652033ab544e6 schema:name doi
    185 schema:value 10.1038/s41598-021-97351-y
    186 rdf:type schema:PropertyValue
    187 N36cd7ab649424da7b063af569a6269cf schema:affiliation grid-institutes:grid.411277.6
    188 schema:familyName Go
    189 schema:givenName Hyun Su
    190 rdf:type schema:Person
    191 N3b82a16be69141ef9ba9d65d113ac4a1 rdf:first sg:person.07562435745.39
    192 rdf:rest Ndf766a61cf654b7eaff61cf4bef123bc
    193 N3c2004bd8e5e476a96673f6cbbddf526 schema:name dimensions_id
    194 schema:value pub.1140936476
    195 rdf:type schema:PropertyValue
    196 N44de197cb1ca4125bc66c05d7dd81d42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Fibroadenoma
    198 rdf:type schema:DefinedTerm
    199 N466c7320f2b3467a8c6522d82151e4c2 rdf:first sg:person.010725430255.89
    200 rdf:rest N0761ddaf66ca4867b68ed8afa39bbc19
    201 N519b7b860b9e4dcbbbebd7b331ecf7d9 rdf:first sg:person.01122425732.33
    202 rdf:rest Nd034951fa6074a50ae411151262ae83e
    203 N58f1fbf06f814b67b0e4e3a38b9dc93e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    204 schema:name Carcinoma, Intraductal, Noninfiltrating
    205 rdf:type schema:DefinedTerm
    206 N5ffe2132a4284174ab4d1ff3f405ad35 schema:issueNumber 1
    207 rdf:type schema:PublicationIssue
    208 N6675103e9e814f5e8111d2ab8f73eb75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name RNA, Neoplasm
    210 rdf:type schema:DefinedTerm
    211 N67a20cf881734860a2564734659187b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name RNA, Messenger
    213 rdf:type schema:DefinedTerm
    214 N6cc02aa5b3404634b7e9c7e70ded1ab4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Triple Negative Breast Neoplasms
    216 rdf:type schema:DefinedTerm
    217 N6ec5ab856fe043b2915ac6ea1aa7eccc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    218 schema:name Neoplasm Proteins
    219 rdf:type schema:DefinedTerm
    220 N70f0fbf9939e441d94eaa4198bc0263d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    221 schema:name Female
    222 rdf:type schema:DefinedTerm
    223 N73cfe6710f974532a141a7473a3e1bcc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    224 schema:name In Situ Hybridization
    225 rdf:type schema:DefinedTerm
    226 N77f11c5400c647c7a9a42896f6cfef06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    227 schema:name Adult
    228 rdf:type schema:DefinedTerm
    229 N7a577c3247a24d1185e397c7d5ac6cf8 rdf:first sg:person.01165545573.57
    230 rdf:rest N519b7b860b9e4dcbbbebd7b331ecf7d9
    231 N93ba77a8b85f4302b4db7356e16a19d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    232 schema:name Middle Aged
    233 rdf:type schema:DefinedTerm
    234 Na2e6a79802964676aebec32f1a68d749 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    235 schema:name Aged
    236 rdf:type schema:DefinedTerm
    237 Naaae852eece34429bc818cf23c271ee1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    238 schema:name Phyllodes Tumor
    239 rdf:type schema:DefinedTerm
    240 Nca74ccd9bd9642e8814e4783ce639bad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    241 schema:name Carcinoma, Ductal, Breast
    242 rdf:type schema:DefinedTerm
    243 Nd034951fa6074a50ae411151262ae83e rdf:first sg:person.0640426775.09
    244 rdf:rest rdf:nil
    245 Nd0d5ea98f25b4cc6a6bf60650563dc2b schema:name Springer Nature - SN SciGraph project
    246 rdf:type schema:Organization
    247 Nd20fb120ffe742a89b56e24ed9c38939 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    248 schema:name Receptors, G-Protein-Coupled
    249 rdf:type schema:DefinedTerm
    250 Nd2a112f2959848e182b9f4d420051df5 schema:volumeNumber 11
    251 rdf:type schema:PublicationVolume
    252 Ndf766a61cf654b7eaff61cf4bef123bc rdf:first sg:person.0701520567.75
    253 rdf:rest N093773c14f5b4232bd4794bf1cba2456
    254 Ne1c5820d397d4f409f1685c9a05c74b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    255 schema:name Breast Diseases
    256 rdf:type schema:DefinedTerm
    257 Ne44e04653fb54b4daece6fed20d834eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    258 schema:name Humans
    259 rdf:type schema:DefinedTerm
    260 Neabd33fae0a943eca684029dcb49e6ef rdf:first sg:person.0651672565.45
    261 rdf:rest N7a577c3247a24d1185e397c7d5ac6cf8
    262 Nf3a7476b27b94dc4a2d2bfaf56a24b42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    263 schema:name Epithelial Cells
    264 rdf:type schema:DefinedTerm
    265 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    266 schema:name Medical and Health Sciences
    267 rdf:type schema:DefinedTerm
    268 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    269 schema:name Oncology and Carcinogenesis
    270 rdf:type schema:DefinedTerm
    271 sg:journal.1045337 schema:issn 2045-2322
    272 schema:name Scientific Reports
    273 schema:publisher Springer Nature
    274 rdf:type schema:Periodical
    275 sg:person.010725430255.89 schema:affiliation grid-institutes:grid.411277.6
    276 schema:familyName Lee
    277 schema:givenName Dong Hui
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010725430255.89
    279 rdf:type schema:Person
    280 sg:person.01122425732.33 schema:affiliation grid-institutes:grid.49606.3d
    281 schema:familyName Lee
    282 schema:givenName Su-Jae
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122425732.33
    284 rdf:type schema:Person
    285 sg:person.01165545573.57 schema:affiliation grid-institutes:grid.256681.e
    286 schema:familyName Koh
    287 schema:givenName Hyun Min
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165545573.57
    289 rdf:type schema:Person
    290 sg:person.0640426775.09 schema:affiliation grid-institutes:grid.411277.6
    291 schema:familyName Jang
    292 schema:givenName Bogun
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640426775.09
    294 rdf:type schema:Person
    295 sg:person.0651672565.45 schema:affiliation grid-institutes:grid.411277.6
    296 schema:familyName Choi
    297 schema:givenName Jae Hyuck
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651672565.45
    299 rdf:type schema:Person
    300 sg:person.0701520567.75 schema:affiliation grid-institutes:grid.49606.3d
    301 schema:familyName Myung
    302 schema:givenName Jae Kyung
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701520567.75
    304 rdf:type schema:Person
    305 sg:person.07562435745.39 schema:affiliation grid-institutes:grid.412677.1
    306 schema:familyName Lee
    307 schema:givenName Hyun Ju
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07562435745.39
    309 rdf:type schema:Person
    310 sg:person.0771453563.33 schema:affiliation grid-institutes:grid.411277.6
    311 schema:familyName Kim
    312 schema:givenName Hye Sung
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771453563.33
    314 rdf:type schema:Person
    315 sg:pub.10.1007/s10120-015-0543-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000289507
    316 https://doi.org/10.1007/s10120-015-0543-7
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/35021093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033846543
    319 https://doi.org/10.1038/35021093
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/cr.2016.47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040434522
    322 https://doi.org/10.1038/cr.2016.47
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1038/modpathol.2010.205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002473292
    325 https://doi.org/10.1038/modpathol.2010.205
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/nature06196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050225537
    328 https://doi.org/10.1038/nature06196
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/nature07602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020963310
    331 https://doi.org/10.1038/nature07602
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/nature10573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009808673
    334 https://doi.org/10.1038/nature10573
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/nature11826 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009532460
    337 https://doi.org/10.1038/nature11826
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/nature13851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017721211
    340 https://doi.org/10.1038/nature13851
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/nature21713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084128603
    343 https://doi.org/10.1038/nature21713
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/nature22081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084128635
    346 https://doi.org/10.1038/nature22081
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1038/ncb3000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036627687
    349 https://doi.org/10.1038/ncb3000
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1038/ncb3471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083802253
    352 https://doi.org/10.1038/ncb3471
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1038/ncb3541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085861655
    355 https://doi.org/10.1038/ncb3541
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1038/ncb3611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091913431
    358 https://doi.org/10.1038/ncb3611
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1038/ng.239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023194186
    361 https://doi.org/10.1038/ng.239
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1038/ng.3957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091911785
    364 https://doi.org/10.1038/ng.3957
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1186/bcr3084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007429235
    367 https://doi.org/10.1186/bcr3084
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1186/s12885-018-4018-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101179530
    370 https://doi.org/10.1186/s12885-018-4018-1
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1186/s12885-020-06986-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1128385627
    373 https://doi.org/10.1186/s12885-020-06986-z
    374 rdf:type schema:CreativeWork
    375 grid-institutes:grid.256681.e schema:alternateName Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, South Korea
    376 schema:name Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, South Korea
    377 rdf:type schema:Organization
    378 grid-institutes:grid.411277.6 schema:alternateName Department of Pathology, Jeju National University School of Medicine and Jeju National University Hospital, Aran 13 gil 15, 63241, Jeju city, Jeju, Korea
    379 Department of Pathology, Jeju National University School of Medicine, Jeju, South Korea
    380 Department of Surgery, Jeju National University School of Medicine and Jeju National University Hospital, Jeju, South Korea
    381 schema:name Department of Pathology, Jeju National University School of Medicine and Jeju National University Hospital, Aran 13 gil 15, 63241, Jeju city, Jeju, Korea
    382 Department of Pathology, Jeju National University School of Medicine, Jeju, South Korea
    383 Department of Surgery, Jeju National University School of Medicine and Jeju National University Hospital, Jeju, South Korea
    384 rdf:type schema:Organization
    385 grid-institutes:grid.412677.1 schema:alternateName Department of Pathology, Soonchunhyang University College of Medicine and Soonchunhyang University Cheonan Hospital, Cheonan, Korea
    386 schema:name Department of Pathology, Soonchunhyang University College of Medicine and Soonchunhyang University Cheonan Hospital, Cheonan, Korea
    387 rdf:type schema:Organization
    388 grid-institutes:grid.49606.3d schema:alternateName Department of Life Science, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea
    389 Department of Pathology, Hanyang University College of Medicine, Seoul, Korea
    390 schema:name Department of Life Science, Research Institute for Natural Sciences, Hanyang University, Seoul, South Korea
    391 Department of Pathology, Hanyang University College of Medicine, Seoul, Korea
    392 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...