Ontology type: schema:ScholarlyArticle Open Access: True
2021-08-26
AUTHORSJ. Wohlschlegel, M. Argentini, C. Michiels, C. Letellier, V. Forster, C. Condroyer, Z. He, G. Thuret, C. Zeitz, T. Léger, I. Audo
ABSTRACTIntegral Membrane Protein 2 B (ITM2B) is a type II ubiquitous transmembrane protein which role remains unclear. ITM2B mutations have been associated with different disorders: mutations leading to longer mutant proteins have been reported in two distinct Alzheimer-like autosomal dominant disorders with early-onset progressive dementia and cerebellar ataxia. Both disorders share neurological features including severe cerebral amyloid angiopathy, non-neuritic plaques, and fibrillary tangles as in Alzheimer disease. Our group reported a missense mutation in ITM2B, in an unusual retinal dystrophy with no dementia. This finding suggests a specific role of ITM2B in the retina. As the identification of retinal-specific ITM2B partners could bring new insights into the cellular functions of ITM2B, we performed quantitative proteomics of ITM2B interactome of the human retina. Overall, 457 ITM2B partners were identified with 8 of them involved in visual transduction. In addition, bulk Gene Ontology analyses showed that many ITM2B partners are involved in several other biological functions, such as microtubule organization, protein translation and interestingly, mitochondrial homeostasis. These data represent the first report of the ITM2B interactome in the human retina and may serve as a valuable inventory of new potential ITM2B partners for future investigations of ITM2B physiological functions and dysfunctions. More... »
PAGES17210
http://scigraph.springernature.com/pub.10.1038/s41598-021-96571-6
DOIhttp://dx.doi.org/10.1038/s41598-021-96571-6
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1140661016
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/34446781
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Neurosciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adaptor Proteins, Signal Transducing",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Amyloid beta-Peptides",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carrier Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cerebellar Ataxia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Dementia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genetic Predisposition to Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "HEK293 Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mutation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Protein Binding",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proteome",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proteomics",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retina",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sequence Analysis, DNA",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012, Paris, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012, Paris, France"
],
"type": "Organization"
},
"familyName": "Wohlschlegel",
"givenName": "J.",
"id": "sg:person.010642370063.11",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010642370063.11"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012, Paris, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012, Paris, France"
],
"type": "Organization"
},
"familyName": "Argentini",
"givenName": "M.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012, Paris, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012, Paris, France"
],
"type": "Organization"
},
"familyName": "Michiels",
"givenName": "C.",
"id": "sg:person.01004210007.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004210007.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012, Paris, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012, Paris, France"
],
"type": "Organization"
},
"familyName": "Letellier",
"givenName": "C.",
"id": "sg:person.013472037367.59",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013472037367.59"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012, Paris, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012, Paris, France"
],
"type": "Organization"
},
"familyName": "Forster",
"givenName": "V.",
"id": "sg:person.0627750275.79",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627750275.79"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012, Paris, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012, Paris, France"
],
"type": "Organization"
},
"familyName": "Condroyer",
"givenName": "C.",
"id": "sg:person.01236601243.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236601243.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Corneal Graft Biology, Engineering and Imaging Laboratory, Health Innovation Campus, Faculty of Medicine, Jean Monnet University, Saint-Etienne, France",
"id": "http://www.grid.ac/institutes/grid.6279.a",
"name": [
"Corneal Graft Biology, Engineering and Imaging Laboratory, Health Innovation Campus, Faculty of Medicine, Jean Monnet University, Saint-Etienne, France"
],
"type": "Organization"
},
"familyName": "He",
"givenName": "Z.",
"id": "sg:person.0655600650.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655600650.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Ophthalmology, University Hospital, Saint-Etienne, France",
"id": "http://www.grid.ac/institutes/grid.412954.f",
"name": [
"Corneal Graft Biology, Engineering and Imaging Laboratory, Health Innovation Campus, Faculty of Medicine, Jean Monnet University, Saint-Etienne, France",
"Department of Ophthalmology, University Hospital, Saint-Etienne, France"
],
"type": "Organization"
},
"familyName": "Thuret",
"givenName": "G.",
"id": "sg:person.01366453064.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366453064.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012, Paris, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012, Paris, France"
],
"type": "Organization"
},
"familyName": "Zeitz",
"givenName": "C.",
"id": "sg:person.01144502661.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144502661.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Sant\u00e9, environnement et travail)-UMR_S 1085, 35000, Rennes, France",
"id": "http://www.grid.ac/institutes/grid.410368.8",
"name": [
"Mass Spectrometry Laboratory, Institut Jacques Monod, UMR 7592, Universit\u00e9 Paris Diderot, CNRS, Sorbonne Paris Cit\u00e9, 75205, Paris, France",
"Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Sant\u00e9, environnement et travail)-UMR_S 1085, 35000, Rennes, France"
],
"type": "Organization"
},
"familyName": "L\u00e9ger",
"givenName": "T.",
"id": "sg:person.0634765440.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634765440.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Genetics, UCL-Institute of Ophthalmology, 11-43 Bath Street, EC1V 9EL, London, UK",
"id": "http://www.grid.ac/institutes/grid.83440.3b",
"name": [
"Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012, Paris, France",
"CHNO des Quinze-Vingts, INSERM-DGOS CIC 1423, 28 rue de Charenton, 75012, Paris, France",
"Department of Genetics, UCL-Institute of Ophthalmology, 11-43 Bath Street, EC1V 9EL, London, UK"
],
"type": "Organization"
},
"familyName": "Audo",
"givenName": "I.",
"id": "sg:person.01162710507.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162710507.23"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/s41467-019-09164-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1112947985",
"https://doi.org/10.1038/s41467-019-09164-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41564-019-0575-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1121785927",
"https://doi.org/10.1038/s41564-019-0575-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/14783",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006022144",
"https://doi.org/10.1038/14783"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41598-020-66092-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1128523021",
"https://doi.org/10.1038/s41598-020-66092-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00401-003-0783-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037622698",
"https://doi.org/10.1007/s00401-003-0783-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1205464",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013100127",
"https://doi.org/10.1038/sj.onc.1205464"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41598-018-21453-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1101113721",
"https://doi.org/10.1038/s41598-018-21453-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13041-016-0245-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028802033",
"https://doi.org/10.1186/s13041-016-0245-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/21637",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025199978",
"https://doi.org/10.1038/21637"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41598-019-41340-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1112856573",
"https://doi.org/10.1038/s41598-019-41340-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nn.4198",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003177086",
"https://doi.org/10.1038/nn.4198"
],
"type": "CreativeWork"
}
],
"datePublished": "2021-08-26",
"datePublishedReg": "2021-08-26",
"description": "Integral Membrane Protein 2 B (ITM2B) is a type II ubiquitous transmembrane protein which role remains unclear. ITM2B mutations have been associated with different disorders: mutations leading to longer mutant proteins have been reported in two distinct Alzheimer-like autosomal dominant disorders with early-onset progressive dementia and cerebellar ataxia. Both disorders share neurological features including severe cerebral amyloid angiopathy, non-neuritic plaques, and fibrillary tangles as in Alzheimer disease. Our group reported a missense mutation in ITM2B, in an unusual retinal dystrophy with no dementia. This finding suggests a specific role of ITM2B in the retina. As the identification of retinal-specific ITM2B partners could bring new insights into the cellular functions of ITM2B, we performed quantitative proteomics of ITM2B interactome of the human retina. Overall, 457 ITM2B partners were identified with 8 of them involved in visual transduction. In addition, bulk Gene Ontology analyses showed that many ITM2B partners are involved in several other biological functions, such as microtubule organization, protein translation and interestingly, mitochondrial homeostasis. These data represent the first report of the ITM2B interactome in the human retina and may serve as a valuable inventory of new potential ITM2B partners for future investigations of ITM2B physiological functions and dysfunctions.",
"genre": "article",
"id": "sg:pub.10.1038/s41598-021-96571-6",
"inLanguage": "en",
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.100080795",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1045337",
"issn": [
"2045-2322"
],
"name": "Scientific Reports",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "11"
}
],
"keywords": [
"human retina",
"early-onset progressive dementia",
"severe cerebral amyloid",
"non-neuritic plaques",
"unusual retinal dystrophy",
"autosomal dominant disorder",
"progressive dementia",
"cerebral amyloid",
"neurological features",
"retinal dystrophy",
"Alzheimer's disease",
"cerebellar ataxia",
"different disorders",
"retina",
"dominant disorder",
"disorders",
"dementia",
"missense mutations",
"mitochondrial homeostasis",
"physiological functions",
"Gene ontology analysis",
"specific role",
"first report",
"future investigations",
"mutations",
"visual transduction",
"ITM2B",
"ubiquitous transmembrane proteins",
"ontology analysis",
"dysfunction",
"plaques",
"protein translation",
"ataxia",
"disease",
"first identification",
"dystrophy",
"biological functions",
"amyloid",
"quantitative proteomics",
"cellular functions",
"transmembrane protein",
"protein",
"homeostasis",
"role",
"report",
"partners",
"group",
"function",
"microtubule organization",
"findings",
"new insights",
"identification",
"interactome",
"mutant proteins",
"transduction",
"proteomics",
"data",
"addition",
"Inventory",
"investigation",
"analysis",
"features",
"translation",
"insights",
"organization",
"valuable inventory"
],
"name": "First identification of ITM2B interactome in the human retina",
"pagination": "17210",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1140661016"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41598-021-96571-6"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"34446781"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41598-021-96571-6",
"https://app.dimensions.ai/details/publication/pub.1140661016"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T10:32",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_919.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/s41598-021-96571-6"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-96571-6'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-96571-6'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-96571-6'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-96571-6'
This table displays all metadata directly associated to this object as RDF triples.
334 TRIPLES
22 PREDICATES
122 URIs
101 LITERALS
24 BLANK NODES