Ontology type: schema:ScholarlyArticle Open Access: True
2021-09-02
AUTHORSIrene Cimino, Debra Rimmington, Y. C. Loraine Tung, Katherine Lawler, Pierre Larraufie, Richard G. Kay, Samuel Virtue, Brian Y. H. Lam, Luca Fagnocchi, Marcella K. L. Ma, Vladimir Saudek, Ilona Zvetkova, Antonio Vidal-Puig, Giles S. H. Yeo, I. Sadaf Farooqi, J. Andrew Pospisilik, Fiona M. Gribble, Frank Reimann, Stephen O’Rahilly, Anthony P. Coll
ABSTRACTNeuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype of a bimodal body weight. To better characterise this variability, we examined the key contributors to energy balance in Nnat+/−p mice that carry a paternal null allele and do not express Nnat. Consistent with our previous studies, Nnat deficient mice on chow diet displayed a bimodal body weight phenotype with more than 30% of Nnat+/−p mice developing obesity. In response to both a 45% high fat diet and exposure to thermoneutrality (30 °C) Nnat deficient mice maintained the hypervariable body weight phenotype. Within a calorimetry system, food intake in Nnat+/−p mice was hypervariable, with some mice consuming more than twice the intake seen in wild type littermates. A hyperphagic response was also seen in Nnat+/−p mice in a second, non-home cage environment. An expected correlation between body weight and energy expenditure was seen, but corrections for the effects of positive energy balance and body weight greatly diminished the effect of neuronatin deficiency on energy expenditure. Male and female Nnat+/−p mice displayed subtle distinctions in the degree of variance body weight phenotype and food intake and further sexual dimorphism was reflected in different patterns of hypothalamic gene expression in Nnat+/−p mice. Loss of the imprinted gene Nnat is associated with a highly variable food intake, with the impact of this phenotype varying between genetically identical individuals. More... »
PAGES17571
http://scigraph.springernature.com/pub.10.1038/s41598-021-96278-8
DOIhttp://dx.doi.org/10.1038/s41598-021-96278-8
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1140836614
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/34475432
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1111",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Nutrition and Dietetics",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biomarkers",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Body Weight",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Diet, High-Fat",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Eating",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Energy Metabolism",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Profiling",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Membrane Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred C57BL",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Knockout",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Nerve Tissue Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Obesity",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.5335.0",
"name": [
"MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Cimino",
"givenName": "Irene",
"id": "sg:person.012627067243.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012627067243.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.5335.0",
"name": [
"MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Rimmington",
"givenName": "Debra",
"id": "sg:person.01177257654.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177257654.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.5335.0",
"name": [
"MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Tung",
"givenName": "Y. C. Loraine",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust\u2011MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.120073.7",
"name": [
"University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust\u2011MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Lawler",
"givenName": "Katherine",
"id": "sg:person.011517226430.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011517226430.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Universit\u00e9 Paris-Saclay, AgroParisTech, INRAE, UMR PNCA, 75005, Paris, France",
"id": "http://www.grid.ac/institutes/grid.417885.7",
"name": [
"MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK",
"Universit\u00e9 Paris-Saclay, AgroParisTech, INRAE, UMR PNCA, 75005, Paris, France"
],
"type": "Organization"
},
"familyName": "Larraufie",
"givenName": "Pierre",
"id": "sg:person.011726766221.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011726766221.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.5335.0",
"name": [
"MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Kay",
"givenName": "Richard G.",
"id": "sg:person.01341630244.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341630244.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.5335.0",
"name": [
"MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Virtue",
"givenName": "Samuel",
"id": "sg:person.015537336047.86",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015537336047.86"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.5335.0",
"name": [
"MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Lam",
"givenName": "Brian Y. H.",
"id": "sg:person.011167132472.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011167132472.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Epigenetics, Van Andel Institute, 49503, Grand Rapids, MI, USA",
"id": "http://www.grid.ac/institutes/grid.251017.0",
"name": [
"Department of Epigenetics, Van Andel Institute, 49503, Grand Rapids, MI, USA"
],
"type": "Organization"
},
"familyName": "Fagnocchi",
"givenName": "Luca",
"id": "sg:person.01313026263.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313026263.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.5335.0",
"name": [
"MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Ma",
"givenName": "Marcella K. L.",
"id": "sg:person.01174243661.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174243661.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.5335.0",
"name": [
"MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Saudek",
"givenName": "Vladimir",
"id": "sg:person.0735210650.57",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735210650.57"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.5335.0",
"name": [
"MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Zvetkova",
"givenName": "Ilona",
"id": "sg:person.0720051327.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720051327.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.5335.0",
"name": [
"MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Vidal-Puig",
"givenName": "Antonio",
"id": "sg:person.015024501017.64",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015024501017.64"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.5335.0",
"name": [
"MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Yeo",
"givenName": "Giles S. H.",
"id": "sg:person.0672333020.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672333020.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust\u2011MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.120073.7",
"name": [
"University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust\u2011MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Farooqi",
"givenName": "I. Sadaf",
"id": "sg:person.01056713204.62",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056713204.62"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Epigenetics, Van Andel Institute, 49503, Grand Rapids, MI, USA",
"id": "http://www.grid.ac/institutes/grid.251017.0",
"name": [
"Department of Epigenetics, Van Andel Institute, 49503, Grand Rapids, MI, USA"
],
"type": "Organization"
},
"familyName": "Pospisilik",
"givenName": "J. Andrew",
"id": "sg:person.01276760410.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276760410.78"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.5335.0",
"name": [
"MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Gribble",
"givenName": "Fiona M.",
"id": "sg:person.0656362133.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656362133.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.5335.0",
"name": [
"MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Reimann",
"givenName": "Frank",
"id": "sg:person.01100200445.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100200445.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.5335.0",
"name": [
"MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "O\u2019Rahilly",
"givenName": "Stephen",
"id": "sg:person.07711435224.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07711435224.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.5335.0",
"name": [
"MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Coll",
"givenName": "Anthony P.",
"id": "sg:person.01002656510.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002656510.36"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1186/s13059-014-0550-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015222646",
"https://doi.org/10.1186/s13059-014-0550-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1471-2105-9-559",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020312314",
"https://doi.org/10.1186/1471-2105-9-559"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00441-015-2325-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046771375",
"https://doi.org/10.1007/s00441-015-2325-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmeth.1806",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042536830",
"https://doi.org/10.1038/nmeth.1806"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00018-019-03197-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1117735071",
"https://doi.org/10.1007/s00018-019-03197-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s42255-018-0028-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1111675771",
"https://doi.org/10.1038/s42255-018-0028-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature07181",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047418703",
"https://doi.org/10.1038/nature07181"
],
"type": "CreativeWork"
}
],
"datePublished": "2021-09-02",
"datePublishedReg": "2021-09-02",
"description": "Neuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype of a bimodal body weight. To better characterise this variability, we examined the key contributors to energy balance in Nnat+/\u2212p mice that carry a paternal null allele and do not express Nnat. Consistent with our previous studies, Nnat deficient mice on chow diet displayed a bimodal body weight phenotype with more than 30% of Nnat+/\u2212p mice developing obesity. In response to both a 45% high fat diet and exposure to thermoneutrality (30\u00a0\u00b0C) Nnat deficient mice maintained the hypervariable body weight phenotype. Within a calorimetry system, food intake in Nnat+/\u2212p mice was hypervariable, with some mice consuming more than twice the intake seen in wild type littermates. A hyperphagic response was also seen in Nnat+/\u2212p mice in a second, non-home cage environment. An expected correlation between body weight and energy expenditure was seen, but corrections for the effects of positive energy balance and body weight greatly diminished the effect of neuronatin\u00a0deficiency on energy expenditure. Male and female Nnat+/\u2212p mice displayed subtle distinctions in the degree of variance body weight\u00a0phenotype and food intake and further sexual dimorphism was reflected in different patterns of hypothalamic gene expression in Nnat+/\u2212p mice. Loss of the imprinted gene Nnat is associated with a highly variable food intake, with the impact of this phenotype varying between genetically identical individuals.",
"genre": "article",
"id": "sg:pub.10.1038/s41598-021-96278-8",
"inLanguage": "en",
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2752738",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.3559965",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.3560056",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2762296",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.8470215",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2783446",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.8469512",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.3560141",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.7159916",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.8470218",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.8470187",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.5141564",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.9462536",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1045337",
"issn": [
"2045-2322"
],
"name": "Scientific Reports",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "11"
}
],
"keywords": [
"food intake",
"body weight phenotype",
"body weight",
"deficient mice",
"variable food intake",
"weight phenotype",
"high-fat diet",
"energy expenditure",
"wild-type littermates",
"hypothalamic gene expression",
"chow diet",
"positive energy balance",
"fat diet",
"hyperphagic response",
"mice",
"intake",
"imprinted gene Nnat",
"obesity",
"unusual phenotype",
"neuronatin",
"phenotype",
"diet",
"deficiency",
"gene expression",
"energy balance",
"different patterns",
"key contributor",
"cage environment",
"previous studies",
"weight",
"littermates",
"response",
"calorimetry system",
"Nnat",
"sexual dimorphism",
"TRIM28",
"exposure",
"expenditure",
"effect",
"thermoneutrality",
"null alleles",
"expression",
"individuals",
"disruption",
"alleles",
"identical individuals",
"balance",
"genes",
"study",
"correlation",
"loss",
"contributor",
"patterns",
"members",
"dimorphism",
"correction",
"impact",
"degree",
"variability",
"part",
"subtle distinctions",
"distinction",
"system",
"environment",
"network"
],
"name": "Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity",
"pagination": "17571",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1140836614"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41598-021-96278-8"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"34475432"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41598-021-96278-8",
"https://app.dimensions.ai/details/publication/pub.1140836614"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:38",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_882.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/s41598-021-96278-8"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-96278-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-96278-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-96278-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-96278-8'
This table displays all metadata directly associated to this object as RDF triples.
382 TRIPLES
22 PREDICATES
113 URIs
98 LITERALS
22 BLANK NODES