Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-09-02

AUTHORS

Irene Cimino, Debra Rimmington, Y. C. Loraine Tung, Katherine Lawler, Pierre Larraufie, Richard G. Kay, Samuel Virtue, Brian Y. H. Lam, Luca Fagnocchi, Marcella K. L. Ma, Vladimir Saudek, Ilona Zvetkova, Antonio Vidal-Puig, Giles S. H. Yeo, I. Sadaf Farooqi, J. Andrew Pospisilik, Fiona M. Gribble, Frank Reimann, Stephen O’Rahilly, Anthony P. Coll

ABSTRACT

Neuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype of a bimodal body weight. To better characterise this variability, we examined the key contributors to energy balance in Nnat+/−p mice that carry a paternal null allele and do not express Nnat. Consistent with our previous studies, Nnat deficient mice on chow diet displayed a bimodal body weight phenotype with more than 30% of Nnat+/−p mice developing obesity. In response to both a 45% high fat diet and exposure to thermoneutrality (30 °C) Nnat deficient mice maintained the hypervariable body weight phenotype. Within a calorimetry system, food intake in Nnat+/−p mice was hypervariable, with some mice consuming more than twice the intake seen in wild type littermates. A hyperphagic response was also seen in Nnat+/−p mice in a second, non-home cage environment. An expected correlation between body weight and energy expenditure was seen, but corrections for the effects of positive energy balance and body weight greatly diminished the effect of neuronatin deficiency on energy expenditure. Male and female Nnat+/−p mice displayed subtle distinctions in the degree of variance body weight phenotype and food intake and further sexual dimorphism was reflected in different patterns of hypothalamic gene expression in Nnat+/−p mice. Loss of the imprinted gene Nnat is associated with a highly variable food intake, with the impact of this phenotype varying between genetically identical individuals. More... »

PAGES

17571

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-021-96278-8

DOI

http://dx.doi.org/10.1038/s41598-021-96278-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1140836614

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34475432


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1111", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Nutrition and Dietetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diet, High-Fat", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Eating", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Energy Metabolism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Tissue Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Obesity", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cimino", 
        "givenName": "Irene", 
        "id": "sg:person.012627067243.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012627067243.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rimmington", 
        "givenName": "Debra", 
        "id": "sg:person.01177257654.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177257654.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tung", 
        "givenName": "Y. C. Loraine", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust\u2011MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.120073.7", 
          "name": [
            "University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust\u2011MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lawler", 
        "givenName": "Katherine", 
        "id": "sg:person.011517226430.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011517226430.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Paris-Saclay, AgroParisTech, INRAE, UMR PNCA, 75005, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.417885.7", 
          "name": [
            "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK", 
            "Universit\u00e9 Paris-Saclay, AgroParisTech, INRAE, UMR PNCA, 75005, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Larraufie", 
        "givenName": "Pierre", 
        "id": "sg:person.011726766221.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011726766221.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kay", 
        "givenName": "Richard G.", 
        "id": "sg:person.01341630244.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341630244.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Virtue", 
        "givenName": "Samuel", 
        "id": "sg:person.015537336047.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015537336047.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lam", 
        "givenName": "Brian Y. H.", 
        "id": "sg:person.011167132472.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011167132472.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Epigenetics, Van Andel Institute, 49503, Grand Rapids, MI, USA", 
          "id": "http://www.grid.ac/institutes/grid.251017.0", 
          "name": [
            "Department of Epigenetics, Van Andel Institute, 49503, Grand Rapids, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fagnocchi", 
        "givenName": "Luca", 
        "id": "sg:person.01313026263.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313026263.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ma", 
        "givenName": "Marcella K. L.", 
        "id": "sg:person.01174243661.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174243661.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saudek", 
        "givenName": "Vladimir", 
        "id": "sg:person.0735210650.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735210650.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zvetkova", 
        "givenName": "Ilona", 
        "id": "sg:person.0720051327.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720051327.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vidal-Puig", 
        "givenName": "Antonio", 
        "id": "sg:person.015024501017.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015024501017.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yeo", 
        "givenName": "Giles S. H.", 
        "id": "sg:person.0672333020.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672333020.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust\u2011MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.120073.7", 
          "name": [
            "University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust\u2011MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Farooqi", 
        "givenName": "I. Sadaf", 
        "id": "sg:person.01056713204.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056713204.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Epigenetics, Van Andel Institute, 49503, Grand Rapids, MI, USA", 
          "id": "http://www.grid.ac/institutes/grid.251017.0", 
          "name": [
            "Department of Epigenetics, Van Andel Institute, 49503, Grand Rapids, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pospisilik", 
        "givenName": "J. Andrew", 
        "id": "sg:person.01276760410.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276760410.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gribble", 
        "givenName": "Fiona M.", 
        "id": "sg:person.0656362133.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656362133.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reimann", 
        "givenName": "Frank", 
        "id": "sg:person.01100200445.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100200445.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O\u2019Rahilly", 
        "givenName": "Stephen", 
        "id": "sg:person.07711435224.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07711435224.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, CB2 0SL, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coll", 
        "givenName": "Anthony P.", 
        "id": "sg:person.01002656510.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002656510.36"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/s13059-014-0550-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015222646", 
          "https://doi.org/10.1186/s13059-014-0550-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-9-559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020312314", 
          "https://doi.org/10.1186/1471-2105-9-559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00441-015-2325-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046771375", 
          "https://doi.org/10.1007/s00441-015-2325-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.1806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042536830", 
          "https://doi.org/10.1038/nmeth.1806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-019-03197-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1117735071", 
          "https://doi.org/10.1007/s00018-019-03197-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s42255-018-0028-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1111675771", 
          "https://doi.org/10.1038/s42255-018-0028-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047418703", 
          "https://doi.org/10.1038/nature07181"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-09-02", 
    "datePublishedReg": "2021-09-02", 
    "description": "Neuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype of a bimodal body weight. To better characterise this variability, we examined the key contributors to energy balance in Nnat+/\u2212p mice that carry a paternal null allele and do not express Nnat. Consistent with our previous studies, Nnat deficient mice on chow diet displayed a bimodal body weight phenotype with more than 30% of Nnat+/\u2212p mice developing obesity. In response to both a 45% high fat diet and exposure to thermoneutrality (30\u00a0\u00b0C) Nnat deficient mice maintained the hypervariable body weight phenotype. Within a calorimetry system, food intake in Nnat+/\u2212p mice was hypervariable, with some mice consuming more than twice the intake seen in wild type littermates. A hyperphagic response was also seen in Nnat+/\u2212p mice in a second, non-home cage environment. An expected correlation between body weight and energy expenditure was seen, but corrections for the effects of positive energy balance and body weight greatly diminished the effect of neuronatin\u00a0deficiency on energy expenditure. Male and female Nnat+/\u2212p mice displayed subtle distinctions in the degree of variance body weight\u00a0phenotype and food intake and further sexual dimorphism was reflected in different patterns of hypothalamic gene expression in Nnat+/\u2212p mice. Loss of the imprinted gene Nnat is associated with a highly variable food intake, with the impact of this phenotype varying between genetically identical individuals.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-021-96278-8", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2752738", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3559965", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3560056", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2762296", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8470215", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2783446", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8469512", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3560141", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7159916", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8470218", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8470187", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5141564", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.9462536", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "keywords": [
      "food intake", 
      "body weight phenotype", 
      "body weight", 
      "deficient mice", 
      "variable food intake", 
      "weight phenotype", 
      "high-fat diet", 
      "energy expenditure", 
      "wild-type littermates", 
      "hypothalamic gene expression", 
      "chow diet", 
      "positive energy balance", 
      "fat diet", 
      "hyperphagic response", 
      "mice", 
      "intake", 
      "imprinted gene Nnat", 
      "obesity", 
      "unusual phenotype", 
      "neuronatin", 
      "phenotype", 
      "diet", 
      "deficiency", 
      "gene expression", 
      "energy balance", 
      "different patterns", 
      "key contributor", 
      "cage environment", 
      "previous studies", 
      "weight", 
      "littermates", 
      "response", 
      "calorimetry system", 
      "Nnat", 
      "sexual dimorphism", 
      "TRIM28", 
      "exposure", 
      "expenditure", 
      "effect", 
      "thermoneutrality", 
      "null alleles", 
      "expression", 
      "individuals", 
      "disruption", 
      "alleles", 
      "identical individuals", 
      "balance", 
      "genes", 
      "study", 
      "correlation", 
      "loss", 
      "contributor", 
      "patterns", 
      "members", 
      "dimorphism", 
      "correction", 
      "impact", 
      "degree", 
      "variability", 
      "part", 
      "subtle distinctions", 
      "distinction", 
      "system", 
      "environment", 
      "network"
    ], 
    "name": "Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity", 
    "pagination": "17571", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1140836614"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-021-96278-8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "34475432"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-021-96278-8", 
      "https://app.dimensions.ai/details/publication/pub.1140836614"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_882.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-021-96278-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-96278-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-96278-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-96278-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-96278-8'


 

This table displays all metadata directly associated to this object as RDF triples.

382 TRIPLES      22 PREDICATES      113 URIs      98 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-021-96278-8 schema:about N00b300601f1d46d5a2d616911070917d
2 N01cb7b50a17e41a99cffea168a09796e
3 N323aa1ef79124d55a3dcb73697bec806
4 N333391f87dc64b56bb9356dcaa9ca5c8
5 N617cd1f8d19e447db54e45b1afb69cf5
6 N646baf335a0e4c9f9f26e47092cfa7d8
7 N69e1d8847b0446fcac2de12d09809433
8 N779298dba2ed4f65afdb342de6032462
9 N78d0477970094cd18c7bf18eaa8db992
10 N885b665d7b564b3984b19a157f9b17ad
11 N96b9277541d34ac9af6d2cf119c09a9d
12 Nd06f9c004a444b74b5ed159c7b8c688b
13 Ne1747708702842d59ad59d96a039b219
14 Ne645e8bb5abc4980a424f681b6551342
15 Nfd6cb97e72a04abf883d0444041f0018
16 anzsrc-for:11
17 anzsrc-for:1111
18 schema:author N5d91fe1c5f7a4ca498e8fedb83bfe52d
19 schema:citation sg:pub.10.1007/s00018-019-03197-z
20 sg:pub.10.1007/s00441-015-2325-2
21 sg:pub.10.1038/nature07181
22 sg:pub.10.1038/nmeth.1806
23 sg:pub.10.1038/s42255-018-0028-1
24 sg:pub.10.1186/1471-2105-9-559
25 sg:pub.10.1186/s13059-014-0550-8
26 schema:datePublished 2021-09-02
27 schema:datePublishedReg 2021-09-02
28 schema:description Neuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype of a bimodal body weight. To better characterise this variability, we examined the key contributors to energy balance in Nnat+/−p mice that carry a paternal null allele and do not express Nnat. Consistent with our previous studies, Nnat deficient mice on chow diet displayed a bimodal body weight phenotype with more than 30% of Nnat+/−p mice developing obesity. In response to both a 45% high fat diet and exposure to thermoneutrality (30 °C) Nnat deficient mice maintained the hypervariable body weight phenotype. Within a calorimetry system, food intake in Nnat+/−p mice was hypervariable, with some mice consuming more than twice the intake seen in wild type littermates. A hyperphagic response was also seen in Nnat+/−p mice in a second, non-home cage environment. An expected correlation between body weight and energy expenditure was seen, but corrections for the effects of positive energy balance and body weight greatly diminished the effect of neuronatin deficiency on energy expenditure. Male and female Nnat+/−p mice displayed subtle distinctions in the degree of variance body weight phenotype and food intake and further sexual dimorphism was reflected in different patterns of hypothalamic gene expression in Nnat+/−p mice. Loss of the imprinted gene Nnat is associated with a highly variable food intake, with the impact of this phenotype varying between genetically identical individuals.
29 schema:genre article
30 schema:inLanguage en
31 schema:isAccessibleForFree true
32 schema:isPartOf N25828b62031844cb800cd00b3dd5efae
33 N66bee9fe054b4c2980539e548aab353a
34 sg:journal.1045337
35 schema:keywords Nnat
36 TRIM28
37 alleles
38 balance
39 body weight
40 body weight phenotype
41 cage environment
42 calorimetry system
43 chow diet
44 contributor
45 correction
46 correlation
47 deficiency
48 deficient mice
49 degree
50 diet
51 different patterns
52 dimorphism
53 disruption
54 distinction
55 effect
56 energy balance
57 energy expenditure
58 environment
59 expenditure
60 exposure
61 expression
62 fat diet
63 food intake
64 gene expression
65 genes
66 high-fat diet
67 hyperphagic response
68 hypothalamic gene expression
69 identical individuals
70 impact
71 imprinted gene Nnat
72 individuals
73 intake
74 key contributor
75 littermates
76 loss
77 members
78 mice
79 network
80 neuronatin
81 null alleles
82 obesity
83 part
84 patterns
85 phenotype
86 positive energy balance
87 previous studies
88 response
89 sexual dimorphism
90 study
91 subtle distinctions
92 system
93 thermoneutrality
94 unusual phenotype
95 variability
96 variable food intake
97 weight
98 weight phenotype
99 wild-type littermates
100 schema:name Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity
101 schema:pagination 17571
102 schema:productId N02b210d3f4bf41809f593b77c8807ca0
103 N9ec884d5f02b4a46a9f77d6fcabe1ce0
104 Nd410903d60d143d1b36cdcef9eb884d1
105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1140836614
106 https://doi.org/10.1038/s41598-021-96278-8
107 schema:sdDatePublished 2022-05-20T07:38
108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
109 schema:sdPublisher Nd240d97ca401494fafe32395b01f2946
110 schema:url https://doi.org/10.1038/s41598-021-96278-8
111 sgo:license sg:explorer/license/
112 sgo:sdDataset articles
113 rdf:type schema:ScholarlyArticle
114 N00b300601f1d46d5a2d616911070917d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Mice, Knockout
116 rdf:type schema:DefinedTerm
117 N01cb7b50a17e41a99cffea168a09796e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Eating
119 rdf:type schema:DefinedTerm
120 N02b210d3f4bf41809f593b77c8807ca0 schema:name dimensions_id
121 schema:value pub.1140836614
122 rdf:type schema:PropertyValue
123 N05bde5b451fc47bc8110f80384fe0b3e rdf:first sg:person.01174243661.19
124 rdf:rest N1c1c425dce71490b9ed06db2f263c32f
125 N167aa411bfd7415fb3e44bd5993eaafa rdf:first sg:person.011517226430.40
126 rdf:rest Nb61d1480ef9c42f0bde5a3fbe089a2c1
127 N1c1c425dce71490b9ed06db2f263c32f rdf:first sg:person.0735210650.57
128 rdf:rest N4c61324a42924529bebf59416e0ba9e1
129 N25828b62031844cb800cd00b3dd5efae schema:volumeNumber 11
130 rdf:type schema:PublicationVolume
131 N310c1967d0934390892f227f67c280a9 rdf:first sg:person.07711435224.39
132 rdf:rest Nf5f600d646a341d1b46a789fbed7cce1
133 N323aa1ef79124d55a3dcb73697bec806 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Energy Metabolism
135 rdf:type schema:DefinedTerm
136 N333391f87dc64b56bb9356dcaa9ca5c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Obesity
138 rdf:type schema:DefinedTerm
139 N39117a1b435d48dca8229270da0de698 schema:affiliation grid-institutes:grid.5335.0
140 schema:familyName Tung
141 schema:givenName Y. C. Loraine
142 rdf:type schema:Person
143 N49d1e14c91a94a208086ef3ba7959cad rdf:first sg:person.015024501017.64
144 rdf:rest N51380f869f784146bd4eb4d9cc534a62
145 N4ba36c5a5ab54c0eb6a0ec350ee827d7 rdf:first sg:person.01100200445.54
146 rdf:rest N310c1967d0934390892f227f67c280a9
147 N4c61324a42924529bebf59416e0ba9e1 rdf:first sg:person.0720051327.04
148 rdf:rest N49d1e14c91a94a208086ef3ba7959cad
149 N51380f869f784146bd4eb4d9cc534a62 rdf:first sg:person.0672333020.12
150 rdf:rest Nd523377112514f7b9b8f0ef48f6f108d
151 N53c1cd6fa57940cfb574895aaf517152 rdf:first sg:person.01276760410.78
152 rdf:rest Na00952c8d3df4023811eeb5aa0be062a
153 N5948c2870fda42e2bfdcdd8ca5de2fa4 rdf:first sg:person.015537336047.86
154 rdf:rest N63bf64e740c542f3ac2ed1313f2d726c
155 N5d91fe1c5f7a4ca498e8fedb83bfe52d rdf:first sg:person.012627067243.10
156 rdf:rest Nf44b569615e04dc5b4c504eb3eaf3fe1
157 N617cd1f8d19e447db54e45b1afb69cf5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Animals
159 rdf:type schema:DefinedTerm
160 N63bf64e740c542f3ac2ed1313f2d726c rdf:first sg:person.011167132472.47
161 rdf:rest N81bdc78f295d44378af069e9b0e13d3e
162 N646baf335a0e4c9f9f26e47092cfa7d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Body Weight
164 rdf:type schema:DefinedTerm
165 N66bee9fe054b4c2980539e548aab353a schema:issueNumber 1
166 rdf:type schema:PublicationIssue
167 N69e1d8847b0446fcac2de12d09809433 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Female
169 rdf:type schema:DefinedTerm
170 N779298dba2ed4f65afdb342de6032462 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Biomarkers
172 rdf:type schema:DefinedTerm
173 N78d0477970094cd18c7bf18eaa8db992 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Diet, High-Fat
175 rdf:type schema:DefinedTerm
176 N81bdc78f295d44378af069e9b0e13d3e rdf:first sg:person.01313026263.33
177 rdf:rest N05bde5b451fc47bc8110f80384fe0b3e
178 N885b665d7b564b3984b19a157f9b17ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Male
180 rdf:type schema:DefinedTerm
181 N96b9277541d34ac9af6d2cf119c09a9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Mice, Inbred C57BL
183 rdf:type schema:DefinedTerm
184 N9ec884d5f02b4a46a9f77d6fcabe1ce0 schema:name doi
185 schema:value 10.1038/s41598-021-96278-8
186 rdf:type schema:PropertyValue
187 Na00952c8d3df4023811eeb5aa0be062a rdf:first sg:person.0656362133.52
188 rdf:rest N4ba36c5a5ab54c0eb6a0ec350ee827d7
189 Naa7e7bea601842c3ae68d86303e10f5e rdf:first N39117a1b435d48dca8229270da0de698
190 rdf:rest N167aa411bfd7415fb3e44bd5993eaafa
191 Nb61d1480ef9c42f0bde5a3fbe089a2c1 rdf:first sg:person.011726766221.03
192 rdf:rest Nbfdcecde39a64d2b858d4197a814e35a
193 Nbfdcecde39a64d2b858d4197a814e35a rdf:first sg:person.01341630244.43
194 rdf:rest N5948c2870fda42e2bfdcdd8ca5de2fa4
195 Nd06f9c004a444b74b5ed159c7b8c688b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Membrane Proteins
197 rdf:type schema:DefinedTerm
198 Nd240d97ca401494fafe32395b01f2946 schema:name Springer Nature - SN SciGraph project
199 rdf:type schema:Organization
200 Nd410903d60d143d1b36cdcef9eb884d1 schema:name pubmed_id
201 schema:value 34475432
202 rdf:type schema:PropertyValue
203 Nd523377112514f7b9b8f0ef48f6f108d rdf:first sg:person.01056713204.62
204 rdf:rest N53c1cd6fa57940cfb574895aaf517152
205 Ne1747708702842d59ad59d96a039b219 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Gene Expression Profiling
207 rdf:type schema:DefinedTerm
208 Ne645e8bb5abc4980a424f681b6551342 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Nerve Tissue Proteins
210 rdf:type schema:DefinedTerm
211 Nf44b569615e04dc5b4c504eb3eaf3fe1 rdf:first sg:person.01177257654.32
212 rdf:rest Naa7e7bea601842c3ae68d86303e10f5e
213 Nf5f600d646a341d1b46a789fbed7cce1 rdf:first sg:person.01002656510.36
214 rdf:rest rdf:nil
215 Nfd6cb97e72a04abf883d0444041f0018 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Mice
217 rdf:type schema:DefinedTerm
218 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
219 schema:name Medical and Health Sciences
220 rdf:type schema:DefinedTerm
221 anzsrc-for:1111 schema:inDefinedTermSet anzsrc-for:
222 schema:name Nutrition and Dietetics
223 rdf:type schema:DefinedTerm
224 sg:grant.2752738 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-021-96278-8
225 rdf:type schema:MonetaryGrant
226 sg:grant.2762296 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-021-96278-8
227 rdf:type schema:MonetaryGrant
228 sg:grant.2783446 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-021-96278-8
229 rdf:type schema:MonetaryGrant
230 sg:grant.3559965 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-021-96278-8
231 rdf:type schema:MonetaryGrant
232 sg:grant.3560056 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-021-96278-8
233 rdf:type schema:MonetaryGrant
234 sg:grant.3560141 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-021-96278-8
235 rdf:type schema:MonetaryGrant
236 sg:grant.5141564 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-021-96278-8
237 rdf:type schema:MonetaryGrant
238 sg:grant.7159916 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-021-96278-8
239 rdf:type schema:MonetaryGrant
240 sg:grant.8469512 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-021-96278-8
241 rdf:type schema:MonetaryGrant
242 sg:grant.8470187 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-021-96278-8
243 rdf:type schema:MonetaryGrant
244 sg:grant.8470215 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-021-96278-8
245 rdf:type schema:MonetaryGrant
246 sg:grant.8470218 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-021-96278-8
247 rdf:type schema:MonetaryGrant
248 sg:grant.9462536 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-021-96278-8
249 rdf:type schema:MonetaryGrant
250 sg:journal.1045337 schema:issn 2045-2322
251 schema:name Scientific Reports
252 schema:publisher Springer Nature
253 rdf:type schema:Periodical
254 sg:person.01002656510.36 schema:affiliation grid-institutes:grid.5335.0
255 schema:familyName Coll
256 schema:givenName Anthony P.
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002656510.36
258 rdf:type schema:Person
259 sg:person.01056713204.62 schema:affiliation grid-institutes:grid.120073.7
260 schema:familyName Farooqi
261 schema:givenName I. Sadaf
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056713204.62
263 rdf:type schema:Person
264 sg:person.01100200445.54 schema:affiliation grid-institutes:grid.5335.0
265 schema:familyName Reimann
266 schema:givenName Frank
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100200445.54
268 rdf:type schema:Person
269 sg:person.011167132472.47 schema:affiliation grid-institutes:grid.5335.0
270 schema:familyName Lam
271 schema:givenName Brian Y. H.
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011167132472.47
273 rdf:type schema:Person
274 sg:person.011517226430.40 schema:affiliation grid-institutes:grid.120073.7
275 schema:familyName Lawler
276 schema:givenName Katherine
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011517226430.40
278 rdf:type schema:Person
279 sg:person.011726766221.03 schema:affiliation grid-institutes:grid.417885.7
280 schema:familyName Larraufie
281 schema:givenName Pierre
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011726766221.03
283 rdf:type schema:Person
284 sg:person.01174243661.19 schema:affiliation grid-institutes:grid.5335.0
285 schema:familyName Ma
286 schema:givenName Marcella K. L.
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174243661.19
288 rdf:type schema:Person
289 sg:person.01177257654.32 schema:affiliation grid-institutes:grid.5335.0
290 schema:familyName Rimmington
291 schema:givenName Debra
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177257654.32
293 rdf:type schema:Person
294 sg:person.012627067243.10 schema:affiliation grid-institutes:grid.5335.0
295 schema:familyName Cimino
296 schema:givenName Irene
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012627067243.10
298 rdf:type schema:Person
299 sg:person.01276760410.78 schema:affiliation grid-institutes:grid.251017.0
300 schema:familyName Pospisilik
301 schema:givenName J. Andrew
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276760410.78
303 rdf:type schema:Person
304 sg:person.01313026263.33 schema:affiliation grid-institutes:grid.251017.0
305 schema:familyName Fagnocchi
306 schema:givenName Luca
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313026263.33
308 rdf:type schema:Person
309 sg:person.01341630244.43 schema:affiliation grid-institutes:grid.5335.0
310 schema:familyName Kay
311 schema:givenName Richard G.
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341630244.43
313 rdf:type schema:Person
314 sg:person.015024501017.64 schema:affiliation grid-institutes:grid.5335.0
315 schema:familyName Vidal-Puig
316 schema:givenName Antonio
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015024501017.64
318 rdf:type schema:Person
319 sg:person.015537336047.86 schema:affiliation grid-institutes:grid.5335.0
320 schema:familyName Virtue
321 schema:givenName Samuel
322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015537336047.86
323 rdf:type schema:Person
324 sg:person.0656362133.52 schema:affiliation grid-institutes:grid.5335.0
325 schema:familyName Gribble
326 schema:givenName Fiona M.
327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656362133.52
328 rdf:type schema:Person
329 sg:person.0672333020.12 schema:affiliation grid-institutes:grid.5335.0
330 schema:familyName Yeo
331 schema:givenName Giles S. H.
332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672333020.12
333 rdf:type schema:Person
334 sg:person.0720051327.04 schema:affiliation grid-institutes:grid.5335.0
335 schema:familyName Zvetkova
336 schema:givenName Ilona
337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720051327.04
338 rdf:type schema:Person
339 sg:person.0735210650.57 schema:affiliation grid-institutes:grid.5335.0
340 schema:familyName Saudek
341 schema:givenName Vladimir
342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735210650.57
343 rdf:type schema:Person
344 sg:person.07711435224.39 schema:affiliation grid-institutes:grid.5335.0
345 schema:familyName O’Rahilly
346 schema:givenName Stephen
347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07711435224.39
348 rdf:type schema:Person
349 sg:pub.10.1007/s00018-019-03197-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1117735071
350 https://doi.org/10.1007/s00018-019-03197-z
351 rdf:type schema:CreativeWork
352 sg:pub.10.1007/s00441-015-2325-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046771375
353 https://doi.org/10.1007/s00441-015-2325-2
354 rdf:type schema:CreativeWork
355 sg:pub.10.1038/nature07181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047418703
356 https://doi.org/10.1038/nature07181
357 rdf:type schema:CreativeWork
358 sg:pub.10.1038/nmeth.1806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042536830
359 https://doi.org/10.1038/nmeth.1806
360 rdf:type schema:CreativeWork
361 sg:pub.10.1038/s42255-018-0028-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111675771
362 https://doi.org/10.1038/s42255-018-0028-1
363 rdf:type schema:CreativeWork
364 sg:pub.10.1186/1471-2105-9-559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020312314
365 https://doi.org/10.1186/1471-2105-9-559
366 rdf:type schema:CreativeWork
367 sg:pub.10.1186/s13059-014-0550-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015222646
368 https://doi.org/10.1186/s13059-014-0550-8
369 rdf:type schema:CreativeWork
370 grid-institutes:grid.120073.7 schema:alternateName University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust‑MRC Institute of Metabolic Science, Addenbrooke’s Hospital, CB2 0SL, Cambridge, UK
371 schema:name University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust‑MRC Institute of Metabolic Science, Addenbrooke’s Hospital, CB2 0SL, Cambridge, UK
372 rdf:type schema:Organization
373 grid-institutes:grid.251017.0 schema:alternateName Department of Epigenetics, Van Andel Institute, 49503, Grand Rapids, MI, USA
374 schema:name Department of Epigenetics, Van Andel Institute, 49503, Grand Rapids, MI, USA
375 rdf:type schema:Organization
376 grid-institutes:grid.417885.7 schema:alternateName Université Paris-Saclay, AgroParisTech, INRAE, UMR PNCA, 75005, Paris, France
377 schema:name MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital, CB2 0SL, Cambridge, UK
378 Université Paris-Saclay, AgroParisTech, INRAE, UMR PNCA, 75005, Paris, France
379 rdf:type schema:Organization
380 grid-institutes:grid.5335.0 schema:alternateName MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital, CB2 0SL, Cambridge, UK
381 schema:name MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital, CB2 0SL, Cambridge, UK
382 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...