Subclinical cardiac impairment relates to traditional pulmonary function test parameters and lung volume as derived from whole-body MRI in a ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-08-09

AUTHORS

Ricarda von Krüchten, Roberto Lorbeer, Christopher Schuppert, Corinna Storz, Blerim Mujaj, Holger Schulz, Hans-Ulrich Kauczor, Annette Peters, Fabian Bamberg, Stefan Karrasch, Christopher L. Schlett

ABSTRACT

To evaluate the relationship of cardiac function, including time-volume-curves, with lung volumes derived from pulmonary function tests (PFT) and MRI in subjects without cardiovascular diseases. 216 subjects underwent whole-body MRI and spirometry as part of the KORA-FF4 cohort study. Lung volumes derived semi-automatically using an in-house algorithm. Forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and residual volume were measured. Cardiac parameters derived from Cine-SSFP-sequence using cvi42, while left ventricle (LV) time-volume-curves were evaluated using pyHeart. Linear regression analyses assessed the relationships of cardiac parameters with PFT and MRI-based lung volumes. Mean age was 56.3 ± 9.2 years (57% males). LV and right ventricular (RV) end-diastolic-, end-systolic-, stroke volume, LV peak ejection- and early/late diastolic filling rate were associated with FEV1, FVC, and residual volume (excluding late diastolic filling rate with FEV1, LV end-systolic/stroke volume and RV end-diastolic/end-systolic volumes with residual volume). In contrast, LV end-diastolic volume (ß = − 0.14, p = 0.01), early diastolic filling rate (ß = − 0.11, p = 0.04), and LV/RV stroke volume (ß = − 0.14, p = 0.01; ß = − 0.11, p = 0.01) were inversely associated with MRI-based lung volume. Subclinical cardiac impairment was associated with reduced FEV1, FVC, and residual volume. Cardiac parameters decreased with increasing MRI-based lung volume contrasting the results of PFT. More... »

PAGES

16173

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-021-95655-7

DOI

http://dx.doi.org/10.1038/s41598-021-95655-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1140287302

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34373570


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Forced Expiratory Volume", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Volume Measurements", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiratory Function Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vital Capacity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Whole Body Imaging", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Diagnostic and Interventional Radiology, Medical Center, University of Freiburg, Hugstetter Stra\u00dfe 55, 79106, Freiburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5963.9", 
          "name": [
            "Department of Diagnostic and Interventional Radiology, Medical Center, University of Freiburg, Hugstetter Stra\u00dfe 55, 79106, Freiburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "von Kr\u00fcchten", 
        "givenName": "Ricarda", 
        "id": "sg:person.013612572324.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013612572324.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Ludwig-Maximilians-University Hospital, Marchioninistra\u00dfe 15, 81377, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411095.8", 
          "name": [
            "Department of Radiology, Ludwig-Maximilians-University Hospital, Marchioninistra\u00dfe 15, 81377, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lorbeer", 
        "givenName": "Roberto", 
        "id": "sg:person.01345170100.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345170100.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Translational Lung Research Center Heidelberg, Member of the German Center of Lung Research (DZL), Im Neuenheimer Feld 156, 69120, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany", 
            "Translational Lung Research Center Heidelberg, Member of the German Center of Lung Research (DZL), Im Neuenheimer Feld 156, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schuppert", 
        "givenName": "Christopher", 
        "id": "sg:person.015512655264.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015512655264.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neuroradiology, Medical Center, University of Freiburg, Breisacher Stra\u00dfe 64, 79106, Freiburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5963.9", 
          "name": [
            "Department of Neuroradiology, Medical Center, University of Freiburg, Breisacher Stra\u00dfe 64, 79106, Freiburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Storz", 
        "givenName": "Corinna", 
        "id": "sg:person.015542554445.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015542554445.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Diagnostic and Interventional Radiology, Medical Center, University of Freiburg, Hugstetter Stra\u00dfe 55, 79106, Freiburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5963.9", 
          "name": [
            "Department of Diagnostic and Interventional Radiology, Medical Center, University of Freiburg, Hugstetter Stra\u00dfe 55, 79106, Freiburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mujaj", 
        "givenName": "Blerim", 
        "id": "sg:person.010053356357.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010053356357.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Member of the German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M), Max-Lebsche-Platz 31, 81377, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.452624.3", 
          "name": [
            "Institute of Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Ingolst\u00e4dter Landstra\u00dfe 1, 85764, Neuherberg, Germany", 
            "Member of the German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M), Max-Lebsche-Platz 31, 81377, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schulz", 
        "givenName": "Holger", 
        "id": "sg:person.0637527306.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637527306.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Translational Lung Research Center Heidelberg, Member of the German Center of Lung Research (DZL), Im Neuenheimer Feld 156, 69120, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany", 
            "Translational Lung Research Center Heidelberg, Member of the German Center of Lung Research (DZL), Im Neuenheimer Feld 156, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kauczor", 
        "givenName": "Hans-Ulrich", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Ingolst\u00e4dter Landstra\u00dfe 1, 85764, Neuherberg, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Institute of Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Ingolst\u00e4dter Landstra\u00dfe 1, 85764, Neuherberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peters", 
        "givenName": "Annette", 
        "id": "sg:person.01117072553.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117072553.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Diagnostic and Interventional Radiology, Medical Center, University of Freiburg, Hugstetter Stra\u00dfe 55, 79106, Freiburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5963.9", 
          "name": [
            "Department of Diagnostic and Interventional Radiology, Medical Center, University of Freiburg, Hugstetter Stra\u00dfe 55, 79106, Freiburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bamberg", 
        "givenName": "Fabian", 
        "id": "sg:person.016655046437.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016655046437.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Member of the German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M), Max-Lebsche-Platz 31, 81377, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.452624.3", 
          "name": [
            "Institute of Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Ingolst\u00e4dter Landstra\u00dfe 1, 85764, Neuherberg, Germany", 
            "Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, Ludwig-Maximilians-University Hospital, Ziemssenstra\u00dfe 1, 80336, Munich, Germany", 
            "Member of the German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M), Max-Lebsche-Platz 31, 81377, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karrasch", 
        "givenName": "Stefan", 
        "id": "sg:person.0721677441.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721677441.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Diagnostic and Interventional Radiology, Medical Center, University of Freiburg, Hugstetter Stra\u00dfe 55, 79106, Freiburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5963.9", 
          "name": [
            "Department of Diagnostic and Interventional Radiology, Medical Center, University of Freiburg, Hugstetter Stra\u00dfe 55, 79106, Freiburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schlett", 
        "givenName": "Christopher L.", 
        "id": "sg:person.01310221613.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310221613.07"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/s12968-017-0327-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083735060", 
          "https://doi.org/10.1186/s12968-017-0327-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00330-018-5659-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106365989", 
          "https://doi.org/10.1007/s00330-018-5659-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12350-010-9334-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038243686", 
          "https://doi.org/10.1007/s12350-010-9334-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1465-9921-7-53", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028727095", 
          "https://doi.org/10.1186/1465-9921-7-53"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-08-09", 
    "datePublishedReg": "2021-08-09", 
    "description": "To evaluate the relationship of cardiac function, including time-volume-curves, with lung volumes derived from pulmonary function tests (PFT) and MRI in subjects without cardiovascular diseases. 216 subjects underwent whole-body MRI and spirometry as part of the KORA-FF4 cohort study. Lung volumes derived semi-automatically using an in-house algorithm. Forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and residual volume were measured. Cardiac parameters derived from Cine-SSFP-sequence using cvi42, while left ventricle (LV) time-volume-curves were evaluated using pyHeart. Linear regression analyses assessed the relationships of cardiac parameters with PFT and MRI-based lung volumes. Mean age was 56.3\u2009\u00b1\u20099.2\u00a0years (57% males). LV and right ventricular (RV) end-diastolic-, end-systolic-, stroke volume, LV peak ejection- and early/late diastolic filling rate were associated with FEV1, FVC, and residual volume (excluding late diastolic filling rate with FEV1, LV end-systolic/stroke volume and RV end-diastolic/end-systolic volumes with residual volume). In contrast, LV end-diastolic volume (\u00df\u2009=\u2009\u2212\u20090.14, p\u2009=\u20090.01), early diastolic filling rate (\u00df\u2009=\u2009\u2212\u20090.11, p\u2009=\u20090.04), and LV/RV stroke volume (\u00df\u2009=\u2009\u2212\u20090.14, p\u2009=\u20090.01; \u00df\u2009=\u2009\u2212\u20090.11, p\u2009=\u20090.01) were inversely associated with MRI-based lung volume. Subclinical cardiac impairment was associated with reduced FEV1, FVC, and residual volume. Cardiac parameters decreased with increasing MRI-based lung volume contrasting the results of PFT.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-021-95655-7", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4834956", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "keywords": [
      "pulmonary function tests", 
      "subclinical cardiac impairment", 
      "diastolic filling rate", 
      "lung volume", 
      "whole-body MRI", 
      "residual volume", 
      "cardiac parameters", 
      "left ventricle", 
      "cohort study", 
      "cardiac impairment", 
      "right ventricular", 
      "stroke volume", 
      "results of PFTs", 
      "late diastolic filling rate", 
      "early diastolic filling rate", 
      "population-based cohort study", 
      "pulmonary function test parameters", 
      "LV end-diastolic volume", 
      "RV stroke volume", 
      "end-diastolic volume", 
      "expiratory volume", 
      "function tests", 
      "vital capacity", 
      "mean age", 
      "cardiac function", 
      "cardiovascular disease", 
      "peak ejection", 
      "linear regression analysis", 
      "filling rate", 
      "MRI", 
      "FEV1", 
      "FVC", 
      "regression analysis", 
      "impairment", 
      "subjects", 
      "spirometry", 
      "ventricular", 
      "cvi42", 
      "ventricle", 
      "disease", 
      "age", 
      "volume", 
      "study", 
      "rate", 
      "house algorithm", 
      "years", 
      "relationship", 
      "test parameters", 
      "curves", 
      "test", 
      "contrast", 
      "function", 
      "analysis", 
      "parameters", 
      "results", 
      "capacity", 
      "part", 
      "sequence", 
      "ejection", 
      "algorithm"
    ], 
    "name": "Subclinical cardiac impairment relates to traditional pulmonary function test parameters and lung volume as derived from whole-body MRI in a population-based cohort study", 
    "pagination": "16173", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1140287302"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-021-95655-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "34373570"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-021-95655-7", 
      "https://app.dimensions.ai/details/publication/pub.1140287302"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_913.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-021-95655-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-95655-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-95655-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-95655-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-95655-7'


 

This table displays all metadata directly associated to this object as RDF triples.

280 TRIPLES      21 PREDICATES      103 URIs      91 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-021-95655-7 schema:about N24140be671b54b15b5dc6e61a33605c6
2 N29a9cc8fb91942809734b923b7d2abfa
3 N5370145daf9541228a0c97d9aff684f1
4 N5c1726dc2e934b62b057db5a9d00504b
5 N66d4f0b02e864103b246abdece421b82
6 N6921afb6db3b4a29af9ac852028eccc3
7 N7934bff2d65c4de68dd42817ae65e54e
8 N82508cdf8a534eaf81f1fbf543fb7514
9 N86d47550ef8f4e3281f31f243c13cc56
10 N905b06ff30f0472a8c5d4d81ee56ee0b
11 Nb88c41b4eae241bca9f84f0d8a62e007
12 Nbeeb7bb9a41c45ef8c77ec9b4d2a85ec
13 Nc83f3c2fd6744783b17d14d6d9c02785
14 Nfb0c52bc8f264c1aa0857f281c7ef53e
15 anzsrc-for:11
16 anzsrc-for:1102
17 schema:author Nc41e5906feb14b0c98d7c93dc8478dac
18 schema:citation sg:pub.10.1007/s00330-018-5659-9
19 sg:pub.10.1007/s12350-010-9334-z
20 sg:pub.10.1186/1465-9921-7-53
21 sg:pub.10.1186/s12968-017-0327-9
22 schema:datePublished 2021-08-09
23 schema:datePublishedReg 2021-08-09
24 schema:description To evaluate the relationship of cardiac function, including time-volume-curves, with lung volumes derived from pulmonary function tests (PFT) and MRI in subjects without cardiovascular diseases. 216 subjects underwent whole-body MRI and spirometry as part of the KORA-FF4 cohort study. Lung volumes derived semi-automatically using an in-house algorithm. Forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and residual volume were measured. Cardiac parameters derived from Cine-SSFP-sequence using cvi42, while left ventricle (LV) time-volume-curves were evaluated using pyHeart. Linear regression analyses assessed the relationships of cardiac parameters with PFT and MRI-based lung volumes. Mean age was 56.3 ± 9.2 years (57% males). LV and right ventricular (RV) end-diastolic-, end-systolic-, stroke volume, LV peak ejection- and early/late diastolic filling rate were associated with FEV1, FVC, and residual volume (excluding late diastolic filling rate with FEV1, LV end-systolic/stroke volume and RV end-diastolic/end-systolic volumes with residual volume). In contrast, LV end-diastolic volume (ß = − 0.14, p = 0.01), early diastolic filling rate (ß = − 0.11, p = 0.04), and LV/RV stroke volume (ß = − 0.14, p = 0.01; ß = − 0.11, p = 0.01) were inversely associated with MRI-based lung volume. Subclinical cardiac impairment was associated with reduced FEV1, FVC, and residual volume. Cardiac parameters decreased with increasing MRI-based lung volume contrasting the results of PFT.
25 schema:genre article
26 schema:isAccessibleForFree true
27 schema:isPartOf N16f1f17b710a48aab2ad6dabcfa9e513
28 N4bf91e6083564dc4a69842e54de209cb
29 sg:journal.1045337
30 schema:keywords FEV1
31 FVC
32 LV end-diastolic volume
33 MRI
34 RV stroke volume
35 age
36 algorithm
37 analysis
38 capacity
39 cardiac function
40 cardiac impairment
41 cardiac parameters
42 cardiovascular disease
43 cohort study
44 contrast
45 curves
46 cvi42
47 diastolic filling rate
48 disease
49 early diastolic filling rate
50 ejection
51 end-diastolic volume
52 expiratory volume
53 filling rate
54 function
55 function tests
56 house algorithm
57 impairment
58 late diastolic filling rate
59 left ventricle
60 linear regression analysis
61 lung volume
62 mean age
63 parameters
64 part
65 peak ejection
66 population-based cohort study
67 pulmonary function test parameters
68 pulmonary function tests
69 rate
70 regression analysis
71 relationship
72 residual volume
73 results
74 results of PFTs
75 right ventricular
76 sequence
77 spirometry
78 stroke volume
79 study
80 subclinical cardiac impairment
81 subjects
82 test
83 test parameters
84 ventricle
85 ventricular
86 vital capacity
87 volume
88 whole-body MRI
89 years
90 schema:name Subclinical cardiac impairment relates to traditional pulmonary function test parameters and lung volume as derived from whole-body MRI in a population-based cohort study
91 schema:pagination 16173
92 schema:productId N4dcd082facde4c46b2bf0b4f607701c3
93 N933a94dd707e48f2bba165a251ad89ec
94 Nc0e8261c76064c0faf35dcc349309206
95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1140287302
96 https://doi.org/10.1038/s41598-021-95655-7
97 schema:sdDatePublished 2022-10-01T06:48
98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
99 schema:sdPublisher N951724285a3a4fcbaeffd6428092e033
100 schema:url https://doi.org/10.1038/s41598-021-95655-7
101 sgo:license sg:explorer/license/
102 sgo:sdDataset articles
103 rdf:type schema:ScholarlyArticle
104 N019466e562724c78909c786912366bc2 schema:affiliation grid-institutes:grid.5253.1
105 schema:familyName Kauczor
106 schema:givenName Hans-Ulrich
107 rdf:type schema:Person
108 N16f1f17b710a48aab2ad6dabcfa9e513 schema:issueNumber 1
109 rdf:type schema:PublicationIssue
110 N1f3bee65a8ab4bea811141b5b149db34 rdf:first sg:person.0721677441.98
111 rdf:rest N882d221bff564d2db64979f4933f5a3f
112 N24140be671b54b15b5dc6e61a33605c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Forced Expiratory Volume
114 rdf:type schema:DefinedTerm
115 N29a9cc8fb91942809734b923b7d2abfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Female
117 rdf:type schema:DefinedTerm
118 N2f32c1a786d9474ab78a2e8c5f09c544 rdf:first sg:person.015512655264.55
119 rdf:rest Nab834e2b90ca49c385ec561894cf22dc
120 N4bf91e6083564dc4a69842e54de209cb schema:volumeNumber 11
121 rdf:type schema:PublicationVolume
122 N4dcd082facde4c46b2bf0b4f607701c3 schema:name dimensions_id
123 schema:value pub.1140287302
124 rdf:type schema:PropertyValue
125 N5370145daf9541228a0c97d9aff684f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Humans
127 rdf:type schema:DefinedTerm
128 N537cc30a0f2341beb128d7a208e1821f rdf:first N019466e562724c78909c786912366bc2
129 rdf:rest Nb5d9a239828b477aa7e738cc602dfe26
130 N5c1726dc2e934b62b057db5a9d00504b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Male
132 rdf:type schema:DefinedTerm
133 N5d1213df39fb4393b7031e203a240f30 rdf:first sg:person.01345170100.56
134 rdf:rest N2f32c1a786d9474ab78a2e8c5f09c544
135 N66d4f0b02e864103b246abdece421b82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Cohort Studies
137 rdf:type schema:DefinedTerm
138 N6921afb6db3b4a29af9ac852028eccc3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Aged
140 rdf:type schema:DefinedTerm
141 N7934bff2d65c4de68dd42817ae65e54e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Heart
143 rdf:type schema:DefinedTerm
144 N82508cdf8a534eaf81f1fbf543fb7514 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Respiratory Function Tests
146 rdf:type schema:DefinedTerm
147 N86d47550ef8f4e3281f31f243c13cc56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Magnetic Resonance Imaging
149 rdf:type schema:DefinedTerm
150 N882d221bff564d2db64979f4933f5a3f rdf:first sg:person.01310221613.07
151 rdf:rest rdf:nil
152 N905b06ff30f0472a8c5d4d81ee56ee0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Vital Capacity
154 rdf:type schema:DefinedTerm
155 N933a94dd707e48f2bba165a251ad89ec schema:name pubmed_id
156 schema:value 34373570
157 rdf:type schema:PropertyValue
158 N951724285a3a4fcbaeffd6428092e033 schema:name Springer Nature - SN SciGraph project
159 rdf:type schema:Organization
160 Na69ef0b3f1d3475ab77d19d6b93814ad rdf:first sg:person.016655046437.33
161 rdf:rest N1f3bee65a8ab4bea811141b5b149db34
162 Nab834e2b90ca49c385ec561894cf22dc rdf:first sg:person.015542554445.78
163 rdf:rest Nfc05b45c3b044904990551f590273b0c
164 Nb5d9a239828b477aa7e738cc602dfe26 rdf:first sg:person.01117072553.44
165 rdf:rest Na69ef0b3f1d3475ab77d19d6b93814ad
166 Nb88c41b4eae241bca9f84f0d8a62e007 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Adult
168 rdf:type schema:DefinedTerm
169 Nbeeb7bb9a41c45ef8c77ec9b4d2a85ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Whole Body Imaging
171 rdf:type schema:DefinedTerm
172 Nc0e8261c76064c0faf35dcc349309206 schema:name doi
173 schema:value 10.1038/s41598-021-95655-7
174 rdf:type schema:PropertyValue
175 Nc41e5906feb14b0c98d7c93dc8478dac rdf:first sg:person.013612572324.22
176 rdf:rest N5d1213df39fb4393b7031e203a240f30
177 Nc83f3c2fd6744783b17d14d6d9c02785 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Middle Aged
179 rdf:type schema:DefinedTerm
180 Nea9c3648bb3b4d4798b02ee3431e5efe rdf:first sg:person.0637527306.80
181 rdf:rest N537cc30a0f2341beb128d7a208e1821f
182 Nfb0c52bc8f264c1aa0857f281c7ef53e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Lung Volume Measurements
184 rdf:type schema:DefinedTerm
185 Nfc05b45c3b044904990551f590273b0c rdf:first sg:person.010053356357.36
186 rdf:rest Nea9c3648bb3b4d4798b02ee3431e5efe
187 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
188 schema:name Medical and Health Sciences
189 rdf:type schema:DefinedTerm
190 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
191 schema:name Cardiorespiratory Medicine and Haematology
192 rdf:type schema:DefinedTerm
193 sg:grant.4834956 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-021-95655-7
194 rdf:type schema:MonetaryGrant
195 sg:journal.1045337 schema:issn 2045-2322
196 schema:name Scientific Reports
197 schema:publisher Springer Nature
198 rdf:type schema:Periodical
199 sg:person.010053356357.36 schema:affiliation grid-institutes:grid.5963.9
200 schema:familyName Mujaj
201 schema:givenName Blerim
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010053356357.36
203 rdf:type schema:Person
204 sg:person.01117072553.44 schema:affiliation grid-institutes:None
205 schema:familyName Peters
206 schema:givenName Annette
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117072553.44
208 rdf:type schema:Person
209 sg:person.01310221613.07 schema:affiliation grid-institutes:grid.5963.9
210 schema:familyName Schlett
211 schema:givenName Christopher L.
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310221613.07
213 rdf:type schema:Person
214 sg:person.01345170100.56 schema:affiliation grid-institutes:grid.411095.8
215 schema:familyName Lorbeer
216 schema:givenName Roberto
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345170100.56
218 rdf:type schema:Person
219 sg:person.013612572324.22 schema:affiliation grid-institutes:grid.5963.9
220 schema:familyName von Krüchten
221 schema:givenName Ricarda
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013612572324.22
223 rdf:type schema:Person
224 sg:person.015512655264.55 schema:affiliation grid-institutes:grid.5253.1
225 schema:familyName Schuppert
226 schema:givenName Christopher
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015512655264.55
228 rdf:type schema:Person
229 sg:person.015542554445.78 schema:affiliation grid-institutes:grid.5963.9
230 schema:familyName Storz
231 schema:givenName Corinna
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015542554445.78
233 rdf:type schema:Person
234 sg:person.016655046437.33 schema:affiliation grid-institutes:grid.5963.9
235 schema:familyName Bamberg
236 schema:givenName Fabian
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016655046437.33
238 rdf:type schema:Person
239 sg:person.0637527306.80 schema:affiliation grid-institutes:grid.452624.3
240 schema:familyName Schulz
241 schema:givenName Holger
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637527306.80
243 rdf:type schema:Person
244 sg:person.0721677441.98 schema:affiliation grid-institutes:grid.452624.3
245 schema:familyName Karrasch
246 schema:givenName Stefan
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721677441.98
248 rdf:type schema:Person
249 sg:pub.10.1007/s00330-018-5659-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106365989
250 https://doi.org/10.1007/s00330-018-5659-9
251 rdf:type schema:CreativeWork
252 sg:pub.10.1007/s12350-010-9334-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1038243686
253 https://doi.org/10.1007/s12350-010-9334-z
254 rdf:type schema:CreativeWork
255 sg:pub.10.1186/1465-9921-7-53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028727095
256 https://doi.org/10.1186/1465-9921-7-53
257 rdf:type schema:CreativeWork
258 sg:pub.10.1186/s12968-017-0327-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083735060
259 https://doi.org/10.1186/s12968-017-0327-9
260 rdf:type schema:CreativeWork
261 grid-institutes:None schema:alternateName Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany
262 schema:name Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany
263 rdf:type schema:Organization
264 grid-institutes:grid.411095.8 schema:alternateName Department of Radiology, Ludwig-Maximilians-University Hospital, Marchioninistraße 15, 81377, Munich, Germany
265 schema:name Department of Radiology, Ludwig-Maximilians-University Hospital, Marchioninistraße 15, 81377, Munich, Germany
266 rdf:type schema:Organization
267 grid-institutes:grid.452624.3 schema:alternateName Member of the German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M), Max-Lebsche-Platz 31, 81377, Munich, Germany
268 schema:name Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, Ludwig-Maximilians-University Hospital, Ziemssenstraße 1, 80336, Munich, Germany
269 Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany
270 Member of the German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M), Max-Lebsche-Platz 31, 81377, Munich, Germany
271 rdf:type schema:Organization
272 grid-institutes:grid.5253.1 schema:alternateName Translational Lung Research Center Heidelberg, Member of the German Center of Lung Research (DZL), Im Neuenheimer Feld 156, 69120, Heidelberg, Germany
273 schema:name Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
274 Translational Lung Research Center Heidelberg, Member of the German Center of Lung Research (DZL), Im Neuenheimer Feld 156, 69120, Heidelberg, Germany
275 rdf:type schema:Organization
276 grid-institutes:grid.5963.9 schema:alternateName Department of Diagnostic and Interventional Radiology, Medical Center, University of Freiburg, Hugstetter Straße 55, 79106, Freiburg, Germany
277 Department of Neuroradiology, Medical Center, University of Freiburg, Breisacher Straße 64, 79106, Freiburg, Germany
278 schema:name Department of Diagnostic and Interventional Radiology, Medical Center, University of Freiburg, Hugstetter Straße 55, 79106, Freiburg, Germany
279 Department of Neuroradiology, Medical Center, University of Freiburg, Breisacher Straße 64, 79106, Freiburg, Germany
280 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...