Ontology type: schema:ScholarlyArticle Open Access: True
2021-08-02
AUTHORSMelanie Haidegger, Markus Kneihsl, Kurt Niederkorn, Hannes Deutschmann, Harald Mangge, Christian Vetta, Michael Augustin, Gerit Wünsch, Simon Fandler-Höfler, Susanna Horner, Christian Enzinger, Thomas Gattringer
ABSTRACTIn-stent restenosis (ISR) represents a major complication after stenting of intracranial artery stenosis (ICAS). Biomarkers derived from routine blood sampling including C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) have been associated with progressive atherosclerosis. We investigated the role of CRP, NLR, PLR and MPV on the development of intracranial ISR and recurrent stroke risk. We retrospectively included all patients who had undergone stenting of symptomatic ICAS at our university hospital between 2005 and 2016. ISR (≥ 50% stenosis) was diagnosed by regular Duplex sonography follow-up studies and confirmed by digital subtraction angiography or computed tomography angiography (mean follow-up duration: 5 years). Laboratory parameters were documented before stenting, at the time of restenosis and at last clinical follow-up. Of 115 patients (mean age: 73 ± 13 years; female: 34%), 38 (33%) developed ISR. The assessed laboratory parameters did not differ between patients with ISR and those without (p > 0.1). While ISR was associated with the occurrence of recurrent ischemic stroke (p = 0.003), CRP, NLR, PLR and MPV were not predictive of such events (p > 0.1). Investigated blood biomarkers of progressive atherosclerosis were not predictive for the occurrence of ISR or recurrent ischemic stroke after ICAS stenting during a 5-year follow-up. More... »
PAGES15599
http://scigraph.springernature.com/pub.10.1038/s41598-021-95135-y
DOIhttp://dx.doi.org/10.1038/s41598-021-95135-y
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1140121450
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/34341413
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Cardiorespiratory Medicine and Haematology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Atherosclerosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biomarkers",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Brain Ischemia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Constriction, Pathologic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Coronary Restenosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Disease Progression",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Intracranial Arterial Diseases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Platelet Aggregation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Risk Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Stents",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria",
"id": "http://www.grid.ac/institutes/grid.11598.34",
"name": [
"Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria"
],
"type": "Organization"
},
"familyName": "Haidegger",
"givenName": "Melanie",
"id": "sg:person.011273727157.99",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011273727157.99"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria",
"id": "http://www.grid.ac/institutes/grid.11598.34",
"name": [
"Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria"
],
"type": "Organization"
},
"familyName": "Kneihsl",
"givenName": "Markus",
"id": "sg:person.01000066375.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000066375.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria",
"id": "http://www.grid.ac/institutes/grid.11598.34",
"name": [
"Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria"
],
"type": "Organization"
},
"familyName": "Niederkorn",
"givenName": "Kurt",
"id": "sg:person.01077070465.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077070465.34"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria",
"id": "http://www.grid.ac/institutes/grid.11598.34",
"name": [
"Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria"
],
"type": "Organization"
},
"familyName": "Deutschmann",
"givenName": "Hannes",
"id": "sg:person.0627672706.64",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627672706.64"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria",
"id": "http://www.grid.ac/institutes/grid.11598.34",
"name": [
"Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria"
],
"type": "Organization"
},
"familyName": "Mangge",
"givenName": "Harald",
"id": "sg:person.01117005177.86",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117005177.86"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria",
"id": "http://www.grid.ac/institutes/grid.11598.34",
"name": [
"Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria"
],
"type": "Organization"
},
"familyName": "Vetta",
"givenName": "Christian",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria",
"id": "http://www.grid.ac/institutes/grid.11598.34",
"name": [
"Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria"
],
"type": "Organization"
},
"familyName": "Augustin",
"givenName": "Michael",
"id": "sg:person.0726727242.55",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726727242.55"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria",
"id": "http://www.grid.ac/institutes/grid.11598.34",
"name": [
"Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria"
],
"type": "Organization"
},
"familyName": "W\u00fcnsch",
"givenName": "Gerit",
"id": "sg:person.01230465144.84",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230465144.84"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria",
"id": "http://www.grid.ac/institutes/grid.11598.34",
"name": [
"Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria"
],
"type": "Organization"
},
"familyName": "Fandler-H\u00f6fler",
"givenName": "Simon",
"id": "sg:person.010066415137.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010066415137.46"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria",
"id": "http://www.grid.ac/institutes/grid.11598.34",
"name": [
"Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria"
],
"type": "Organization"
},
"familyName": "Horner",
"givenName": "Susanna",
"id": "sg:person.01274372374.55",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274372374.55"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria",
"id": "http://www.grid.ac/institutes/grid.11598.34",
"name": [
"Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria",
"Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria"
],
"type": "Organization"
},
"familyName": "Enzinger",
"givenName": "Christian",
"id": "sg:person.0617665673.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617665673.78"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria",
"id": "http://www.grid.ac/institutes/grid.11598.34",
"name": [
"Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria",
"Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria"
],
"type": "Organization"
},
"familyName": "Gattringer",
"givenName": "Thomas",
"id": "sg:person.0777034006.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777034006.05"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/s41598-018-25058-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103682670",
"https://doi.org/10.1038/s41598-018-25058-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12872-018-0812-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103739462",
"https://doi.org/10.1186/s12872-018-0812-6"
],
"type": "CreativeWork"
}
],
"datePublished": "2021-08-02",
"datePublishedReg": "2021-08-02",
"description": "In-stent restenosis (ISR) represents a major complication after stenting of intracranial artery stenosis (ICAS). Biomarkers derived from routine blood sampling including C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) have been associated with progressive atherosclerosis. We investigated the role of CRP, NLR, PLR and MPV on the development of intracranial ISR and recurrent stroke risk. We retrospectively included all patients who had undergone stenting of symptomatic ICAS at our university hospital between 2005 and 2016. ISR (\u2265\u200950% stenosis) was diagnosed by regular Duplex sonography follow-up studies and confirmed by digital subtraction angiography or computed tomography angiography (mean follow-up duration: 5\u00a0years). Laboratory parameters were documented before stenting, at the time of restenosis and at last clinical follow-up. Of 115 patients (mean age: 73\u2009\u00b1\u200913\u00a0years; female: 34%), 38 (33%) developed ISR. The assessed laboratory parameters did not differ between patients with ISR and those without (p\u2009>\u20090.1). While ISR was associated with the occurrence of recurrent ischemic stroke (p\u2009=\u20090.003), CRP, NLR, PLR and MPV were not predictive of such events (p\u2009>\u20090.1). Investigated blood biomarkers of progressive atherosclerosis were not predictive for the occurrence of ISR or recurrent ischemic stroke after ICAS stenting during a 5-year follow-up.",
"genre": "article",
"id": "sg:pub.10.1038/s41598-021-95135-y",
"inLanguage": "en",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1045337",
"issn": [
"2045-2322"
],
"name": "Scientific Reports",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "11"
}
],
"keywords": [
"intracranial artery stenosis",
"C-reactive protein",
"symptomatic intracranial artery stenosis",
"recurrent ischemic stroke",
"progressive atherosclerosis",
"ischemic stroke",
"laboratory parameters",
"artery stenosis",
"lymphocyte ratio",
"blood biomarkers",
"role of CRP",
"recurrent stroke risk",
"occurrence of ISR",
"routine blood sampling",
"time of restenosis",
"stroke risk",
"major complications",
"University Hospital",
"tomography angiography",
"platelet volume",
"stent restenosis",
"blood sampling",
"atherosclerosis",
"patients",
"restenosis",
"biomarkers",
"stenting",
"stenosis",
"digital subtraction",
"NLR",
"stroke",
"MPV",
"PLR",
"ISR",
"complications",
"angiography",
"hospital",
"neutrophils",
"follow",
"platelets",
"risk",
"occurrence",
"protein",
"study",
"role",
"ratio",
"events",
"volume",
"such events",
"development",
"sampling",
"time",
"parameters",
"subtraction"
],
"name": "Blood biomarkers of progressive atherosclerosis and restenosis after stenting of symptomatic intracranial artery stenosis",
"pagination": "15599",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1140121450"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41598-021-95135-y"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"34341413"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41598-021-95135-y",
"https://app.dimensions.ai/details/publication/pub.1140121450"
],
"sdDataset": "articles",
"sdDatePublished": "2022-06-01T22:25",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_923.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/s41598-021-95135-y"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-95135-y'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-95135-y'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-95135-y'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-95135-y'
This table displays all metadata directly associated to this object as RDF triples.
261 TRIPLES
22 PREDICATES
96 URIs
86 LITERALS
21 BLANK NODES