Characterization and visualization of murine coagulation factor VIII-producing cells in vivo View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-07-21

AUTHORS

Morisada Hayakawa, Asuka Sakata, Hiroko Hayakawa, Hikari Matsumoto, Takafumi Hiramoto, Yuji Kashiwakura, Nemekhbayar Baatartsogt, Noriyoshi Fukushima, Yoichi Sakata, Katsue Suzuki-Inoue, Tsukasa Ohmori

ABSTRACT

Coagulation factors are produced from hepatocytes, whereas production of coagulation factor VIII (FVIII) from primary tissues and cell species is still controversial. Here, we tried to characterize primary FVIII-producing organ and cell species using genetically engineered mice, in which enhanced green fluorescent protein (EGFP) was expressed instead of the F8 gene. EGFP-positive FVIII-producing cells existed only in thin sinusoidal layer of the liver and characterized as CD31high, CD146high, and lymphatic vascular endothelial hyaluronan receptor 1 (Lyve1)+. EGFP-positive cells can be clearly distinguished from lymphatic endothelial cells in the expression profile of the podoplanin− and C-type lectin-like receptor-2 (CLEC-2)+. In embryogenesis, EGFP-positive cells began to emerge at E14.5 and subsequently increased according to liver maturation. Furthermore, plasma FVIII could be abolished by crossing F8 conditional deficient mice with Lyve1-Cre mice. In conclusion, in mice, FVIII is only produced from endothelial cells exhibiting CD31high, CD146high, Lyve1+, CLEC-2+, and podoplanin− in liver sinusoidal endothelial cells. More... »

PAGES

14824

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-021-94307-0

DOI

http://dx.doi.org/10.1038/s41598-021-94307-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1139828407

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34290295


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