Comparison between male and female breast cancer survival using propensity score matching analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-06-02

AUTHORS

Serena Scomersi, Fabiola Giudici, Giuseppe Cacciatore, Pasquale Losurdo, Stefano Fracon, Sara Cortinovis, Rita Ceccherini, Fabrizio Zanconati, Maura Tonutti, Marina Bortul

ABSTRACT

Male breast cancer (MBC) is a rare disease. The few studies on MBC reported conflicting data regarding survival outcomes compared to women. This study has two objectives: to describe the characteristics of a single-cohort of MBC and to compare overall survival (OS) and disease-free survival (DFS) between men and women using the propensity score matching (PSM) analysis. We considered MBC patients (n = 40) diagnosed between January 2004 and May 2019. Clinical, pathological, oncological and follow-up data were analyzed. Univariate analysis was performed to determine the prognostic factors on OS and DFS for MBC. We selected female patients with BC (n = 2678). To minimize the effect of the imbalance of the prognostic factors between the two cohorts, the PSM method (1:3 ratio) was applied and differences in survival between the two groups were assessed. The average age of MBC patients was 73 years. The 5-year OS and DFS rates were 76.7% and 72.2% respectively. The prognostic factors that significantly influenced OS and DFS were tumor size and lymph node status. After the PSM, 5 year-OS was similar between MBC and FBC (72.9% vs 72.3%, p = 0.70) while we found a worse DFS for MBC (72.2% vs 91.4%, p = 0.03). Our data confirmed previous reported MBC characteristics: we found a higher risk of recurrence in MBC compared to FMC but similar OS. MBC and FMC are different entities and studies are needed to understand its epidemiology and guide its management. More... »

PAGES

11639

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-021-91131-4

DOI

http://dx.doi.org/10.1038/s41598-021-91131-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1138517148

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34079019


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31 schema:description Male breast cancer (MBC) is a rare disease. The few studies on MBC reported conflicting data regarding survival outcomes compared to women. This study has two objectives: to describe the characteristics of a single-cohort of MBC and to compare overall survival (OS) and disease-free survival (DFS) between men and women using the propensity score matching (PSM) analysis. We considered MBC patients (n = 40) diagnosed between January 2004 and May 2019. Clinical, pathological, oncological and follow-up data were analyzed. Univariate analysis was performed to determine the prognostic factors on OS and DFS for MBC. We selected female patients with BC (n = 2678). To minimize the effect of the imbalance of the prognostic factors between the two cohorts, the PSM method (1:3 ratio) was applied and differences in survival between the two groups were assessed. The average age of MBC patients was 73 years. The 5-year OS and DFS rates were 76.7% and 72.2% respectively. The prognostic factors that significantly influenced OS and DFS were tumor size and lymph node status. After the PSM, 5 year-OS was similar between MBC and FBC (72.9% vs 72.3%, p = 0.70) while we found a worse DFS for MBC (72.2% vs 91.4%, p  = 0.03). Our data confirmed previous reported MBC characteristics: we found a higher risk of recurrence in MBC compared to FMC but similar OS. MBC and FMC are different entities and studies are needed to understand its epidemiology and guide its management.
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39 DFS rates
40 FBC
41 FMC
42 MBC patients
43 PSM
44 PSM method
45 age
46 analysis
47 average age
48 breast cancer
49 breast cancer survival
50 cancer
51 cancer survival
52 characteristics
53 cohort
54 comparison
55 data
56 differences
57 different entities
58 disease
59 disease-free survival
60 effect
61 entities
62 epidemiology
63 factors
64 female breast cancer survival
65 female patients
66 group
67 high risk
68 imbalance
69 lymph node status
70 male breast cancer
71 management
72 men
73 method
74 node status
75 objective
76 outcomes
77 overall survival
78 patients
79 prognostic factors
80 propensity score
81 rare disease
82 rate
83 recurrence
84 risk
85 scores
86 similar OS
87 size
88 status
89 study
90 survival
91 survival outcomes
92 tumor size
93 univariate analysis
94 women
95 worse disease-free survival
96 year OS
97 years
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