Comparison between male and female breast cancer survival using propensity score matching analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-06-02

AUTHORS

Serena Scomersi, Fabiola Giudici, Giuseppe Cacciatore, Pasquale Losurdo, Stefano Fracon, Sara Cortinovis, Rita Ceccherini, Fabrizio Zanconati, Maura Tonutti, Marina Bortul

ABSTRACT

Male breast cancer (MBC) is a rare disease. The few studies on MBC reported conflicting data regarding survival outcomes compared to women. This study has two objectives: to describe the characteristics of a single-cohort of MBC and to compare overall survival (OS) and disease-free survival (DFS) between men and women using the propensity score matching (PSM) analysis. We considered MBC patients (n = 40) diagnosed between January 2004 and May 2019. Clinical, pathological, oncological and follow-up data were analyzed. Univariate analysis was performed to determine the prognostic factors on OS and DFS for MBC. We selected female patients with BC (n = 2678). To minimize the effect of the imbalance of the prognostic factors between the two cohorts, the PSM method (1:3 ratio) was applied and differences in survival between the two groups were assessed. The average age of MBC patients was 73 years. The 5-year OS and DFS rates were 76.7% and 72.2% respectively. The prognostic factors that significantly influenced OS and DFS were tumor size and lymph node status. After the PSM, 5 year-OS was similar between MBC and FBC (72.9% vs 72.3%, p = 0.70) while we found a worse DFS for MBC (72.2% vs 91.4%, p = 0.03). Our data confirmed previous reported MBC characteristics: we found a higher risk of recurrence in MBC compared to FMC but similar OS. MBC and FMC are different entities and studies are needed to understand its epidemiology and guide its management. More... »

PAGES

11639

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-021-91131-4

DOI

http://dx.doi.org/10.1038/s41598-021-91131-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1138517148

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34079019


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31 schema:description Male breast cancer (MBC) is a rare disease. The few studies on MBC reported conflicting data regarding survival outcomes compared to women. This study has two objectives: to describe the characteristics of a single-cohort of MBC and to compare overall survival (OS) and disease-free survival (DFS) between men and women using the propensity score matching (PSM) analysis. We considered MBC patients (n = 40) diagnosed between January 2004 and May 2019. Clinical, pathological, oncological and follow-up data were analyzed. Univariate analysis was performed to determine the prognostic factors on OS and DFS for MBC. We selected female patients with BC (n = 2678). To minimize the effect of the imbalance of the prognostic factors between the two cohorts, the PSM method (1:3 ratio) was applied and differences in survival between the two groups were assessed. The average age of MBC patients was 73 years. The 5-year OS and DFS rates were 76.7% and 72.2% respectively. The prognostic factors that significantly influenced OS and DFS were tumor size and lymph node status. After the PSM, 5 year-OS was similar between MBC and FBC (72.9% vs 72.3%, p = 0.70) while we found a worse DFS for MBC (72.2% vs 91.4%, p  = 0.03). Our data confirmed previous reported MBC characteristics: we found a higher risk of recurrence in MBC compared to FMC but similar OS. MBC and FMC are different entities and studies are needed to understand its epidemiology and guide its management.
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39 DFS rates
40 FBC
41 FMC
42 MBC characteristics
43 MBC patients
44 PSM
45 PSM method
46 age
47 analysis
48 average age
49 breast cancer
50 breast cancer survival
51 cancer
52 cancer survival
53 characteristics
54 cohort
55 comparison
56 data
57 differences
58 different entities
59 disease
60 disease-free survival
61 effect
62 entities
63 epidemiology
64 factors
65 female breast cancer survival
66 female patients
67 group
68 high risk
69 imbalance
70 lymph node status
71 male breast cancer
72 management
73 men
74 method
75 node status
76 objective
77 outcomes
78 overall survival
79 patients
80 prognostic factors
81 propensity score
82 rare disease
83 rate
84 recurrence
85 risk
86 scores
87 similar OS
88 size
89 status
90 study
91 survival
92 survival outcomes
93 tumor size
94 univariate analysis
95 women
96 worse disease-free survival
97 year OS
98 years
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