Association of PM2.5 exposure with hospitalization for cardiovascular disease in elderly individuals in Japan View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-05-10

AUTHORS

Toshiki Kaihara, Kihei Yoneyama, Michikazu Nakai, Takumi Higuma, Yoko Sumita, Yoshihiro Miyamoto, Mika Watanabe, Masaki Izumo, Yuki Ishibashi, Yasuhiro Tanabe, Tomoo Harada, Satoshi Yasuda, Hisao Ogawa, Yoshihiro J. Akashi

ABSTRACT

Although exposure to particulate matter with aerodynamic diameters ≤ 2.5 µm (PM2.5) influences cardiovascular disease (CVD), its association with CVD-related hospitalizations of super-aged patients in Japan remains uncertain. We investigated the relationship between short-term PM2.5 exposure and CVD-related hospitalizations, lengths of hospital stays, and medical expenses. We analyzed the Japanese national database of patients with CVD (835,405) admitted to acute-care hospitals between 2012 and 2014. Patients with planned hospitalizations and those with missing PM2.5 exposure data were excluded. We classified the included patients into five quintiles based on their PM2.5 exposure: PM-5, -4, -3, -2, and -1 groups, in descending order of concentration. Compared with the PM-1 group, the other groups had higher hospitalization rates. The PM-3, -4, and -5 groups exhibited increased hospitalization durations and medical expenses, compared with the PM-1 group. Interestingly, the hospitalization period was longer for the ≥ 90-year-old group than for the ≤ 64-year-old group, yet the medical expenses were lower for the former group. Short-term PM2.5 exposure is associated with increased CVD-related hospitalizations, hospitalization durations, and medical expenses. The effects of incident CVDs were more marked in elderly than in younger patients. National PM2.5 concentrations should be reduced and the public should be aware of the risks. More... »

PAGES

9897

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-021-89290-5

DOI

http://dx.doi.org/10.1038/s41598-021-89290-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1137878661

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33972608


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25 schema:description Although exposure to particulate matter with aerodynamic diameters ≤ 2.5 µm (PM2.5) influences cardiovascular disease (CVD), its association with CVD-related hospitalizations of super-aged patients in Japan remains uncertain. We investigated the relationship between short-term PM2.5 exposure and CVD-related hospitalizations, lengths of hospital stays, and medical expenses. We analyzed the Japanese national database of patients with CVD (835,405) admitted to acute-care hospitals between 2012 and 2014. Patients with planned hospitalizations and those with missing PM2.5 exposure data were excluded. We classified the included patients into five quintiles based on their PM2.5 exposure: PM-5, -4, -3, -2, and -1 groups, in descending order of concentration. Compared with the PM-1 group, the other groups had higher hospitalization rates. The PM-3, -4, and -5 groups exhibited increased hospitalization durations and medical expenses, compared with the PM-1 group. Interestingly, the hospitalization period was longer for the ≥ 90-year-old group than for the ≤ 64-year-old group, yet the medical expenses were lower for the former group. Short-term PM2.5 exposure is associated with increased CVD-related hospitalizations, hospitalization durations, and medical expenses. The effects of incident CVDs were more marked in elderly than in younger patients. National PM2.5 concentrations should be reduced and the public should be aware of the risks.
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34 PM-5
35 PM2.5 concentrations
36 PM2.5 exposure
37 Pm 3
38 acute care hospitals
39 aerodynamic diameter
40 aged patients
41 association
42 cardiovascular disease
43 concentration
44 data
45 database
46 diameter
47 disease
48 duration
49 effect
50 elderly individuals
51 expense
52 exposure
53 exposure data
54 former group
55 group
56 higher hospitalization rates
57 hospital
58 hospital stay
59 hospitalization
60 hospitalization duration
61 hospitalization period
62 hospitalization rates
63 incident cardiovascular disease
64 individuals
65 length
66 matter
67 medical expenses
68 national database
69 order
70 order of concentration
71 patients
72 period
73 public
74 quintile
75 rate
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77 risk
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