A randomized sham-controlled trial on the effect of continuous positive airway pressure treatment on gait control in severe obstructive sleep ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-04-29

AUTHORS

Sébastien Baillieul, Bernard Wuyam, Dominic Pérennou, Renaud Tamisier, Sébastien Bailly, Meriem Benmerad, Céline Piscicelli, Thibault Le Roux-Mallouf, Samuel Vergès, Jean-Louis Pépin

ABSTRACT

To determine the effect of continuous positive airway pressure (CPAP), the gold standard treatment for obstructive sleep apnea syndrome (OSAS), on gait control in severe OSAS patients. We conducted a randomized, double-blind, parallel-group, sham-controlled monocentric study in Grenoble Alpes University Hospital, France. Gait parameters were recorded under single and dual-task conditions using a visuo-verbal cognitive task (Stroop test), before and after the 8-week intervention period. Stride-time variability, a marker of gait control, was the primary study endpoint. Changes in the determinants of gait control were the main secondary outcomes. ClinicalTrials.gov Identifier: (NCT02345694). 24 patients [median (Q1; Q3)]: age: 59.5 (46.3; 66.8) years, 87.5% male, body mass index: 28.2 (24.7; 29.8) kg. m−2, apnea–hypopnea index: 51.6 (35.0; 61.4) events/h were randomized to be treated by effective CPAP (n = 12) or by sham-CPAP (n = 12). A complete case analysis was performed, using a mixed linear regression model. CPAP elicited no significant improvement in stride-time variability compared to sham-CPAP. No difference was found regarding the determinants of gait control. This study is the first RCT to investigate the effects of CPAP on gait control. Eight weeks of CPAP treatment did not improve gait control in severe non-obese OSAS patients. These results substantiate the complex OSAS-neurocognitive function relationship. More... »

PAGES

9329

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-021-88642-5

DOI

http://dx.doi.org/10.1038/s41598-021-88642-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1137605961

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33927278


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62 function relationships
63 gait control
64 gait parameters
65 gold standard treatment
66 hospital
67 identifiers
68 improvement
69 index
70 intervention period
71 linear regression models
72 main secondary outcomes
73 males
74 markers
75 mass index
76 mixed linear regression models
77 model
78 monocentric study
79 non-obese OSAS patients
80 obstructive sleep apnea patients
81 obstructive sleep apnea syndrome
82 outcomes
83 parameters
84 patients
85 period
86 positive airway pressure
87 positive airway pressure treatment
88 pressure
89 pressure treatment
90 primary study endpoint
91 randomized sham-controlled trial
92 regression models
93 relationship
94 results
95 severe OSAS patients
96 severe obstructive sleep apnea patients
97 sham CPAP
98 sham-controlled trial
99 significant improvement
100 sleep apnea patients
101 sleep apnea syndrome
102 standard treatment
103 stride time variability
104 study
105 study endpoint
106 syndrome
107 task
108 treatment
109 trials
110 variability
111 weeks
112 years
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