Reappraisal of the prognostic value of Epstein-Barr virus status in monomorphic post-transplantation lymphoproliferative disorders–diffuse large B-cell lymphoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-02-03

AUTHORS

Jwa Hoon Kim, Hyungwoo Cho, Heungsup Sung, Ah Ra Jung, Yoon Sei Lee, Sang-wook Lee, Jin-Sook Ryu, Eun Jin Chae, Kyoung Won Kim, Jooryung Huh, Chan-Sik Park, Dok Hyun Yoon, Cheolwon Suh

ABSTRACT

The role of the Epstein-Barr virus (EBV) status in the blood for predicting survival in post-transplantation lymphoproliferative disorders–diffuse large B-cell lymphoma (PTLD–DLBCL) is unknown. We evaluated the prognostic values of pre-treatment EBV-encoded small RNA (EBER) detected with in situ hybridization in tissues and EBV DNA in the whole blood (WB) and plasma in 58 patients with monomorphic PTLD–DLBCL after solid organ transplantation. There were no significant differences in the rates of overall response, complete response, and survival according to EBER EBV and WB EBV status. In contrast, patients with positive plasma EBV DNA had significantly lower rates of overall response (60.0% vs. 94.4%, P = 0.043) and complete response (40.0% vs. 88.9%, P = 0.019) as well as worse progression-free survival (PFS) (P = 0.035) and overall survival (OS) (P = 0.039) compared with patients with negative plasma EBV DNA. In multivariate analysis, plasma EBV DNA positivity was a significantly unfavorable prognostic factor for PFS [hazard ratio (HR) 4.92, 95% confidence interval (CI) 1.22–19.86, P = 0.025] and OS (HR 4.48, 95% CI 1.14–17.63, P = 0.032). Despite small number of 6 patients with plasma EBV positivity, plasma EBV DNA positivity might be more prognostic for survival than EBER or WB EBV DNA positivity in patients with monomorphic PTLD–DLBCL. More... »

PAGES

2880

Journal

TITLE

Scientific Reports

ISSUE

1

VOLUME

11

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-021-82534-4

DOI

http://dx.doi.org/10.1038/s41598-021-82534-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1135062195

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33536508


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29 schema:description The role of the Epstein-Barr virus (EBV) status in the blood for predicting survival in post-transplantation lymphoproliferative disorders–diffuse large B-cell lymphoma (PTLD–DLBCL) is unknown. We evaluated the prognostic values of pre-treatment EBV-encoded small RNA (EBER) detected with in situ hybridization in tissues and EBV DNA in the whole blood (WB) and plasma in 58 patients with monomorphic PTLD–DLBCL after solid organ transplantation. There were no significant differences in the rates of overall response, complete response, and survival according to EBER EBV and WB EBV status. In contrast, patients with positive plasma EBV DNA had significantly lower rates of overall response (60.0% vs. 94.4%, P = 0.043) and complete response (40.0% vs. 88.9%, P = 0.019) as well as worse progression-free survival (PFS) (P = 0.035) and overall survival (OS) (P = 0.039) compared with patients with negative plasma EBV DNA. In multivariate analysis, plasma EBV DNA positivity was a significantly unfavorable prognostic factor for PFS [hazard ratio (HR) 4.92, 95% confidence interval (CI) 1.22–19.86, P = 0.025] and OS (HR 4.48, 95% CI 1.14–17.63, P = 0.032). Despite small number of 6 patients with plasma EBV positivity, plasma EBV DNA positivity might be more prognostic for survival than EBER or WB EBV DNA positivity in patients with monomorphic PTLD–DLBCL.
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36 schema:keywords B-cell lymphoma
37 DNA
38 DNA positivity
39 EBER
40 EBV
41 EBV DNA
42 EBV DNA positivity
43 EBV positivity
44 EBV status
45 Epstein-Barr virus status
46 RNA
47 analysis
48 blood
49 complete response
50 contrast
51 differences
52 factors
53 hybridization
54 large B-cell lymphoma
55 lower rates
56 lymphoma
57 multivariate analysis
58 number
59 organ transplantation
60 overall response
61 overall survival
62 patients
63 plasma EBV DNA
64 positive plasma EBV DNA
65 positivity
66 prognostic factors
67 prognostic value
68 progression-free survival
69 rate
70 reappraisal
71 response
72 role
73 significant differences
74 situ hybridization
75 small RNAs
76 small number
77 solid organ transplantation
78 status
79 survival
80 tissue
81 transplantation
82 unfavorable prognostic factor
83 values
84 virus status
85 whole blood
86 worse progression-free survival
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