Human leukocyte antigen B*0702 is protective against ocular Stevens–Johnson syndrome/toxic epidermal necrolysis in the UK population View Full Text


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Article Info

DATE

2021-02-03

AUTHORS

Gibran F. Butt, Ali Hassan, Graham R. Wallace, Shigeru Kinoshita, Sajjad Ahmad, Mayumi Ueta, Saaeha Rauz

ABSTRACT

Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) are part of a disease continuum of vesiculobullous mucocutaneous reactions affecting the skin and mucous membranes including the ocular surface. Manifestations of disease range from mild dry eye to progressive conjunctival cicatrisation, limbal epithelial stem cell failure and corneal blindness. In Far Eastern and South East Asian populations where SJS/TEN is prevalent, numerous human leukocyte antigen (HLA) gene variants at the A, B and C loci have been identified as risk factors for developing SJS/TEN with severe ocular complications (SOC). By contrast, the incidence of SJS/TEN with SOC in European countries is relatively low. To date, ocular SJS/TEN risk altering alleles have not been widely investigated in European populations. In this study, we analysed the association of HLA -A, -B and -C alleles with SJS/TEN in 33 patients residing in the UK with age matched controls. The data showed statistically significant novel negative allele association with HLA-B*0702 and a trend with HLA-C*0702 in the patient group, indicating these alleles are protective. Further characterisation of protective and risk alleles in other ethnic groups is required to fully elucidate the putative role of these alleles in the susceptibility of SJS/TEN with or without severe ocular complications in patients in the UK. More... »

PAGES

2928

References to SciGraph publications

  • 2012-06-22. Incidence, presenting features, and diagnosis of cicatrising conjunctivitis in the United Kingdom in EYE
  • 2014-04-30. Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement in SCIENTIFIC REPORTS
  • 2019-11-07. Identification of HLA-A*02:06:01 as the primary disease susceptibility HLA allele in cold medicine-related Stevens-Johnson syndrome with severe ocular complications by high-resolution NGS-based HLA typing in SCIENTIFIC REPORTS
  • 2014-07-18. Strong association between hla-a*02:06 and acetaminophen-related stevens-johnson syndrome with severe mucosal involvements in the Japanese in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2014-08-07. Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications in SCIENTIFIC REPORTS
  • 2017-11-21. Association of Human Leukocyte Antigen Class 1 genes with Stevens Johnson Syndrome with severe ocular complications in an Indian population in SCIENTIFIC REPORTS
  • 2008-11-23. Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis in NATURE MEDICINE
  • 2015-10-19. Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: An Update in AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
  • 2014-07-18. HLA association with antipyretic analgesics-induced Stevens-Johnson Syndrome/toxic epidermal necrolysis with severe ocular surface complications in japanese patients in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2019-10-28. Association of HLA class I and II gene polymorphisms with acetaminophen-related Stevens–Johnson syndrome with severe ocular complications in Japanese individuals in HUMAN GENOME VARIATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-021-82400-3

    DOI

    http://dx.doi.org/10.1038/s41598-021-82400-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1135070339

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33536518


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    34 schema:description Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) are part of a disease continuum of vesiculobullous mucocutaneous reactions affecting the skin and mucous membranes including the ocular surface. Manifestations of disease range from mild dry eye to progressive conjunctival cicatrisation, limbal epithelial stem cell failure and corneal blindness. In Far Eastern and South East Asian populations where SJS/TEN is prevalent, numerous human leukocyte antigen (HLA) gene variants at the A, B and C loci have been identified as risk factors for developing SJS/TEN with severe ocular complications (SOC). By contrast, the incidence of SJS/TEN with SOC in European countries is relatively low. To date, ocular SJS/TEN risk altering alleles have not been widely investigated in European populations. In this study, we analysed the association of HLA -A, -B and -C alleles with SJS/TEN in 33 patients residing in the UK with age matched controls. The data showed statistically significant novel negative allele association with HLA-B*0702 and a trend with HLA-C*0702 in the patient group, indicating these alleles are protective. Further characterisation of protective and risk alleles in other ethnic groups is required to fully elucidate the putative role of these alleles in the susceptibility of SJS/TEN with or without severe ocular complications in patients in the UK.
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