Prognostic impact of polypharmacy by drug essentiality in patients on hemodialysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-12-20

AUTHORS

Mineaki Kitamura, Kosei Yamaguchi, Yuki Ota, Satoko Notomi, Maya Komine, Rika Etoh, Takashi Harada, Satoshi Funakoshi, Hiroshi Mukae, Tomoya Nishino

ABSTRACT

Although polypharmacy is common among patients on hemodialysis (HD), its association with prognosis remains unclear. This study aimed to elucidate the association between the number of prescribed medicines and all-cause mortality in patients on HD, accounting for essential medicines (i.e., antihypertensives, antidiabetic medicines, and statins) and non-essential medicines. We evaluated 339 patients who underwent maintenance HD at Nagasaki Renal Center between July 2011 and June 2012 and followed up until June 2021. After adjusting for patient characteristics, the number of regularly prescribed medicines (10.0 ± 4.0) was not correlated with prognosis (hazard ratio [HR]: 1.01, 95% confidence interval [CI] 0.97–1.05, p = 0.60). However, the number of non-essential medicines (7.9 ± 3.6) was correlated with prognosis (HR: 1.06, 95% CI 1.01–1.10, p = 0.009). Adjusting for patient characteristics, patients who were prescribed more than 10 non-essential medicines were found to have a significantly higher probability of mortality than those prescribed less than five non-essential medicines, with a relative risk of 2.01 (p = 0.004). In conclusion, polypharmacy of non-essential medicines increases the risk of all-cause mortality in patients on HD. As such, prescribing essential medicines should be prioritized, and the clinical relevance of each medicine should be reviewed by physicians and pharmacists. More... »

PAGES

24238

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-021-03772-0

DOI

http://dx.doi.org/10.1038/s41598-021-03772-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1144027994

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34930934


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