Combined detection of lymphocyte clonality and MALT1 translocations in bronchoalveolar lavage fluid for diagnosing pulmonary lymphomas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-12-06

AUTHORS

Takashi Kido, Hiroshi Ishimoto, Hiroshi Ishii, Kanako Hara, Mutsumi Ozasa, Hiroki Kawabata, Toshinori Kawanami, Yu Suzuki, Hiroki Yoshikawa, Atsuko Hara, Noriho Sakamoto, Nobuhiro Matsumoto, Chiharu Yoshii, Junya Fukuoka, Masaki Fujita, Masamitsu Nakazato, Junichi Kadota, Hiroshi Mukae, Kazuhiro Yatera

ABSTRACT

Diagnosis of pulmonary lymphoma using small tissue samples is difficult and often requires surgical procedures; thus, a less invasive sampling method is desirable. We previously showed that pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma can be diagnosed by detecting MALT lymphoma translocation gene 1 (MALT1) translocations in bronchoalveolar lavage fluid (BALF) cells. Analysis of B-cell clonality based on immunoglobulin heavy chain (IGH) gene rearrangements was also reportedly useful for diagnosing pulmonary lymphoma. The aim of this prospective multicenter study was to evaluate the yet unknown diagnostic potential of combined detection of MALT1 translocations and clonality using BALF. We analyzed B- and T-cell clonality based on IGH and T-cell receptor (TCR) rearrangements together with MALT1 translocations using BALF of patients with clinically suspected pulmonary lymphomas. In total, 39 patients were evaluated and categorized into three groups: B-cell lymphoma, lymphoproliferative disorders, and other diseases. IGH rearrangement detection for B-cell lymphoma diagnosis exhibited sensitivity and specificity of 88.9% and 90.0%, respectively. TCR rearrangements were not observed in patients with B-cell lymphomas. The presence of IGH rearrangements together with the absence of TCR rearrangements indicated 96.0% specificity for the diagnosis of B-cell lymphoma. The sensitivity and specificity of MALT1 translocations for diagnosing MALT lymphoma were 28.6% and 100%, respectively. The combined detection of lymphocyte clonality and MALT1 translocations using BALF is suitable for screening and diagnosis of B-cell lymphomas. Analysis of specific genes such as MALT1 should improve the precision of B-cell lymphoma diagnosis. More... »

PAGES

23430

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-021-02861-4

DOI

http://dx.doi.org/10.1038/s41598-021-02861-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1143654635

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34873224


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Technology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1004", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Biotechnology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bronchoalveolar Lavage Fluid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Aberrations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Rearrangement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma, B-Cell, Marginal Zone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogene Proteins, Fusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sensitivity and Specificity", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan", 
            "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kido", 
        "givenName": "Takashi", 
        "id": "sg:person.01211346734.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211346734.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan", 
            "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishimoto", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01342450607.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342450607.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, Fukuoka University Hospital, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411556.2", 
          "name": [
            "Department of Respiratory Medicine, Fukuoka University Hospital, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishii", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01260304701.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260304701.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hara", 
        "givenName": "Kanako", 
        "id": "sg:person.0763624047.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763624047.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, 852-8501, Nagasaki, Japan", 
            "Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ozasa", 
        "givenName": "Mutsumi", 
        "id": "sg:person.07500003430.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07500003430.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawabata", 
        "givenName": "Hiroki", 
        "id": "sg:person.014214615040.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014214615040.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawanami", 
        "givenName": "Toshinori", 
        "id": "sg:person.0623556107.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623556107.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, Kokura Memorial Hospital, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415432.5", 
          "name": [
            "Department of Respiratory Medicine, Kokura Memorial Hospital, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Yu", 
        "id": "sg:person.010226631432.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010226631432.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine and Infectious Disease, Faculty of Medicine, Oita University, Yufu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412334.3", 
          "name": [
            "Department of Respiratory Medicine and Infectious Disease, Faculty of Medicine, Oita University, Yufu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshikawa", 
        "givenName": "Hiroki", 
        "id": "sg:person.0662564173.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662564173.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hara", 
        "givenName": "Atsuko", 
        "id": "sg:person.01111773607.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111773607.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakamoto", 
        "givenName": "Noriho", 
        "id": "sg:person.01057344215.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057344215.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Neurology, Respirology, Endocrinology and Metabolism, Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410849.0", 
          "name": [
            "Neurology, Respirology, Endocrinology and Metabolism, Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsumoto", 
        "givenName": "Nobuhiro", 
        "id": "sg:person.012676300422.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012676300422.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, Wakamatsu Hospital of the University of Occupational and Environmental Health, Japan, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Respiratory Medicine, Wakamatsu Hospital of the University of Occupational and Environmental Health, Japan, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshii", 
        "givenName": "Chiharu", 
        "id": "sg:person.01134663476.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134663476.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukuoka", 
        "givenName": "Junya", 
        "id": "sg:person.0616033724.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616033724.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, Fukuoka University Hospital, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411556.2", 
          "name": [
            "Department of Respiratory Medicine, Fukuoka University Hospital, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujita", 
        "givenName": "Masaki", 
        "id": "sg:person.01064431637.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064431637.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Neurology, Respirology, Endocrinology and Metabolism, Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410849.0", 
          "name": [
            "Neurology, Respirology, Endocrinology and Metabolism, Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakazato", 
        "givenName": "Masamitsu", 
        "id": "sg:person.0725136110.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725136110.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine and Infectious Disease, Faculty of Medicine, Oita University, Yufu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412334.3", 
          "name": [
            "Department of Respiratory Medicine and Infectious Disease, Faculty of Medicine, Oita University, Yufu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kadota", 
        "givenName": "Junichi", 
        "id": "sg:person.0646451302.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646451302.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan", 
            "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mukae", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01143125277.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143125277.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yatera", 
        "givenName": "Kazuhiro", 
        "id": "sg:person.01032646234.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032646234.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.leu.2403428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043506170", 
          "https://doi.org/10.1038/sj.leu.2403428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027716225", 
          "https://doi.org/10.1038/sj.leu.2403202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035768039", 
          "https://doi.org/10.1038/sj.leu.2403501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2404479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032286803", 
          "https://doi.org/10.1038/sj.leu.2404479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2404467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016386977", 
          "https://doi.org/10.1038/sj.leu.2404467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043782984", 
          "https://doi.org/10.1038/sj.onc.1203018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00277-009-0875-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009262540", 
          "https://doi.org/10.1007/s00277-009-0875-7"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-12-06", 
    "datePublishedReg": "2021-12-06", 
    "description": "Diagnosis of pulmonary lymphoma using small tissue samples is difficult and often requires surgical procedures; thus, a less invasive sampling method is desirable. We previously showed that pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma can be diagnosed by detecting MALT lymphoma translocation gene 1 (MALT1) translocations in bronchoalveolar lavage fluid (BALF) cells. Analysis of B-cell clonality based on immunoglobulin heavy chain (IGH) gene rearrangements was also reportedly useful for diagnosing pulmonary lymphoma. The aim of this prospective multicenter study was to evaluate the yet unknown diagnostic potential of combined detection of MALT1 translocations and clonality using BALF. We analyzed B- and T-cell clonality based on IGH and T-cell receptor (TCR) rearrangements together with MALT1 translocations using BALF of patients with clinically suspected pulmonary lymphomas. In total, 39 patients were evaluated and categorized into three groups: B-cell lymphoma, lymphoproliferative disorders, and other diseases. IGH rearrangement detection for B-cell lymphoma diagnosis exhibited sensitivity and specificity of 88.9% and 90.0%, respectively. TCR rearrangements were not observed in patients with B-cell lymphomas. The presence of IGH rearrangements together with the absence of TCR rearrangements indicated 96.0% specificity for the diagnosis of B-cell lymphoma. The sensitivity and specificity of MALT1 translocations for diagnosing MALT lymphoma were 28.6% and 100%, respectively. The combined detection of lymphocyte clonality and MALT1 translocations using BALF is suitable for screening and diagnosis of B-cell lymphomas. Analysis of specific genes such as MALT1 should improve the precision of B-cell lymphoma diagnosis.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-021-02861-4", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "keywords": [
      "B-cell lymphoma", 
      "MALT1 translocation", 
      "pulmonary lymphoma", 
      "B-cell lymphoma diagnosis", 
      "combined detection", 
      "lymphocyte clonality", 
      "lymphoma diagnosis", 
      "TCR rearrangements", 
      "bronchoalveolar lavage fluid cells", 
      "BALF of patients", 
      "prospective multicenter study", 
      "T-cell receptor rearrangements", 
      "immunoglobulin heavy chain gene rearrangement", 
      "bronchoalveolar lavage fluid", 
      "lymphoid tissue lymphoma", 
      "heavy chain gene rearrangement", 
      "T-cell clonality", 
      "B-cell clonality", 
      "chain gene rearrangement", 
      "tissue lymphoma", 
      "multicenter study", 
      "lymphoproliferative disorders", 
      "lavage fluid", 
      "MALT lymphoma", 
      "pulmonary mucosa", 
      "surgical procedures", 
      "receptor rearrangement", 
      "lymphoma", 
      "invasive sampling methods", 
      "BALF", 
      "patients", 
      "diagnosis", 
      "IgH rearrangements", 
      "tissue samples", 
      "gene rearrangements", 
      "diagnostic potential", 
      "small tissue samples", 
      "clonality", 
      "fluid cells", 
      "rearrangement detection", 
      "specificity", 
      "translocation", 
      "mucosa", 
      "specific genes", 
      "disease", 
      "disorders", 
      "MALT1", 
      "screening", 
      "sensitivity", 
      "IgH", 
      "cells", 
      "sampling method", 
      "group", 
      "aim", 
      "detection", 
      "absence", 
      "study", 
      "genes", 
      "rearrangement", 
      "procedure", 
      "analysis", 
      "presence", 
      "fluid", 
      "samples", 
      "potential", 
      "method", 
      "precision"
    ], 
    "name": "Combined detection of lymphocyte clonality and MALT1 translocations in bronchoalveolar lavage fluid for diagnosing pulmonary lymphomas", 
    "pagination": "23430", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1143654635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-021-02861-4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "34873224"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-021-02861-4", 
      "https://app.dimensions.ai/details/publication/pub.1143654635"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_896.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-021-02861-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-02861-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-02861-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-02861-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-021-02861-4'


 

This table displays all metadata directly associated to this object as RDF triples.

377 TRIPLES      21 PREDICATES      118 URIs      103 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-021-02861-4 schema:about N03b354775ad149b1a407bce96bd7bb54
2 N065833635c1843508e197aa7e0a5d4f3
3 N206c47b39b264f289543c4515cfc7f81
4 N287ddec66116462a8ffd7ed9facec5e6
5 N2931ef2fd00542908e2b3ac5ea7ff2d3
6 N2fa1e94332664becbf7a3b4574f506e8
7 N35c52c2269734505a1aaf57b215458d0
8 N3e66702cf53244299ea174e8e303a832
9 N4f9926215ab548c489fdd06c08a003f5
10 N5217d0f0d43f4eeebe5be109b8ecf233
11 N57b67e067e5540debaf6d6a577bfa754
12 N6fa60ccb19a8446aad8308b92edf19b5
13 N7185d5e07af349d892d59f19c4be60a2
14 N859fadcc723648eeb660df21ec53a419
15 N86fcd98aa39d45f8990ede9b4108b6a4
16 Nd272c6faf88d42fd8ca4a5e033bd23e1
17 Ne68acf8049b14d12a12ffb6d9cb3b135
18 Ne8ddace11a704b8ca575e6e6bee98a6c
19 Nf0894f84990345528ce59fb80fd10723
20 anzsrc-for:10
21 anzsrc-for:1004
22 schema:author N330c16f0613c460f933906299468020b
23 schema:citation sg:pub.10.1007/s00277-009-0875-7
24 sg:pub.10.1038/sj.leu.2403202
25 sg:pub.10.1038/sj.leu.2403428
26 sg:pub.10.1038/sj.leu.2403501
27 sg:pub.10.1038/sj.leu.2404467
28 sg:pub.10.1038/sj.leu.2404479
29 sg:pub.10.1038/sj.onc.1203018
30 schema:datePublished 2021-12-06
31 schema:datePublishedReg 2021-12-06
32 schema:description Diagnosis of pulmonary lymphoma using small tissue samples is difficult and often requires surgical procedures; thus, a less invasive sampling method is desirable. We previously showed that pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma can be diagnosed by detecting MALT lymphoma translocation gene 1 (MALT1) translocations in bronchoalveolar lavage fluid (BALF) cells. Analysis of B-cell clonality based on immunoglobulin heavy chain (IGH) gene rearrangements was also reportedly useful for diagnosing pulmonary lymphoma. The aim of this prospective multicenter study was to evaluate the yet unknown diagnostic potential of combined detection of MALT1 translocations and clonality using BALF. We analyzed B- and T-cell clonality based on IGH and T-cell receptor (TCR) rearrangements together with MALT1 translocations using BALF of patients with clinically suspected pulmonary lymphomas. In total, 39 patients were evaluated and categorized into three groups: B-cell lymphoma, lymphoproliferative disorders, and other diseases. IGH rearrangement detection for B-cell lymphoma diagnosis exhibited sensitivity and specificity of 88.9% and 90.0%, respectively. TCR rearrangements were not observed in patients with B-cell lymphomas. The presence of IGH rearrangements together with the absence of TCR rearrangements indicated 96.0% specificity for the diagnosis of B-cell lymphoma. The sensitivity and specificity of MALT1 translocations for diagnosing MALT lymphoma were 28.6% and 100%, respectively. The combined detection of lymphocyte clonality and MALT1 translocations using BALF is suitable for screening and diagnosis of B-cell lymphomas. Analysis of specific genes such as MALT1 should improve the precision of B-cell lymphoma diagnosis.
33 schema:genre article
34 schema:isAccessibleForFree true
35 schema:isPartOf N7db42b4b55b5479db34a89a532dab46b
36 Nc1fb43bd254148f2942c7d9ec3abf2f0
37 sg:journal.1045337
38 schema:keywords B-cell clonality
39 B-cell lymphoma
40 B-cell lymphoma diagnosis
41 BALF
42 BALF of patients
43 IgH
44 IgH rearrangements
45 MALT lymphoma
46 MALT1
47 MALT1 translocation
48 T-cell clonality
49 T-cell receptor rearrangements
50 TCR rearrangements
51 absence
52 aim
53 analysis
54 bronchoalveolar lavage fluid
55 bronchoalveolar lavage fluid cells
56 cells
57 chain gene rearrangement
58 clonality
59 combined detection
60 detection
61 diagnosis
62 diagnostic potential
63 disease
64 disorders
65 fluid
66 fluid cells
67 gene rearrangements
68 genes
69 group
70 heavy chain gene rearrangement
71 immunoglobulin heavy chain gene rearrangement
72 invasive sampling methods
73 lavage fluid
74 lymphocyte clonality
75 lymphoid tissue lymphoma
76 lymphoma
77 lymphoma diagnosis
78 lymphoproliferative disorders
79 method
80 mucosa
81 multicenter study
82 patients
83 potential
84 precision
85 presence
86 procedure
87 prospective multicenter study
88 pulmonary lymphoma
89 pulmonary mucosa
90 rearrangement
91 rearrangement detection
92 receptor rearrangement
93 samples
94 sampling method
95 screening
96 sensitivity
97 small tissue samples
98 specific genes
99 specificity
100 study
101 surgical procedures
102 tissue lymphoma
103 tissue samples
104 translocation
105 schema:name Combined detection of lymphocyte clonality and MALT1 translocations in bronchoalveolar lavage fluid for diagnosing pulmonary lymphomas
106 schema:pagination 23430
107 schema:productId N0d3038bc1d694a5099fa48ab89aafee5
108 Nade12836639846a09da0a29c3d8d38fd
109 Nc7e7d8c0e876415ebbead1919843b604
110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1143654635
111 https://doi.org/10.1038/s41598-021-02861-4
112 schema:sdDatePublished 2022-09-02T16:05
113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
114 schema:sdPublisher N9e93e239bace4b4d9ec129d8dab01d53
115 schema:url https://doi.org/10.1038/s41598-021-02861-4
116 sgo:license sg:explorer/license/
117 sgo:sdDataset articles
118 rdf:type schema:ScholarlyArticle
119 N03b354775ad149b1a407bce96bd7bb54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Bronchoalveolar Lavage Fluid
121 rdf:type schema:DefinedTerm
122 N065833635c1843508e197aa7e0a5d4f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Oncogene Proteins, Fusion
124 rdf:type schema:DefinedTerm
125 N0d3038bc1d694a5099fa48ab89aafee5 schema:name pubmed_id
126 schema:value 34873224
127 rdf:type schema:PropertyValue
128 N1001193b643049c78a5d806d5f95c8e8 rdf:first sg:person.0725136110.34
129 rdf:rest Nd2a4d2564f1d40e1a647e8d07026a4f5
130 N18eddade167a4b78b51e060d1dfb086a rdf:first sg:person.014214615040.96
131 rdf:rest Nfe4232258952411eb102e30bc1d29e8a
132 N206c47b39b264f289543c4515cfc7f81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Humans
134 rdf:type schema:DefinedTerm
135 N20f9a6a61d8f49088c3015e33db804b7 rdf:first sg:person.01134663476.54
136 rdf:rest Na4f761faa7b6485682cf4367bd6a346c
137 N22278c81bfb94b469cb12ed70ad3e188 rdf:first sg:person.01057344215.61
138 rdf:rest N29605746b5b54842a46c4cf41462f67c
139 N287ddec66116462a8ffd7ed9facec5e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Aged
141 rdf:type schema:DefinedTerm
142 N2931ef2fd00542908e2b3ac5ea7ff2d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Adult
144 rdf:type schema:DefinedTerm
145 N29605746b5b54842a46c4cf41462f67c rdf:first sg:person.012676300422.60
146 rdf:rest N20f9a6a61d8f49088c3015e33db804b7
147 N2fa1e94332664becbf7a3b4574f506e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
149 rdf:type schema:DefinedTerm
150 N330c16f0613c460f933906299468020b rdf:first sg:person.01211346734.05
151 rdf:rest Nfc5864f89f3c4a7094f6bc56f0f25912
152 N35c52c2269734505a1aaf57b215458d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Chromosome Aberrations
154 rdf:type schema:DefinedTerm
155 N3e66702cf53244299ea174e8e303a832 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Aged, 80 and over
157 rdf:type schema:DefinedTerm
158 N4e065073d29b404999acf72a8db1b837 rdf:first sg:person.0763624047.54
159 rdf:rest Ncbf6f48f6f1e4eb4b87ce07c9e69d28b
160 N4f9926215ab548c489fdd06c08a003f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Sensitivity and Specificity
162 rdf:type schema:DefinedTerm
163 N5217d0f0d43f4eeebe5be109b8ecf233 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Lymphocytes
165 rdf:type schema:DefinedTerm
166 N57b67e067e5540debaf6d6a577bfa754 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Lymphoma
168 rdf:type schema:DefinedTerm
169 N5d528a68b7094d50a30b648ca0537fca rdf:first sg:person.010226631432.41
170 rdf:rest Nad892886cc8f426d85f1a6231501d879
171 N6fa60ccb19a8446aad8308b92edf19b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Gene Rearrangement
173 rdf:type schema:DefinedTerm
174 N7185d5e07af349d892d59f19c4be60a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Lymphoma, B-Cell, Marginal Zone
176 rdf:type schema:DefinedTerm
177 N7db42b4b55b5479db34a89a532dab46b schema:volumeNumber 11
178 rdf:type schema:PublicationVolume
179 N859fadcc723648eeb660df21ec53a419 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Female
181 rdf:type schema:DefinedTerm
182 N86fcd98aa39d45f8990ede9b4108b6a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Immunoglobulins
184 rdf:type schema:DefinedTerm
185 N987cfce475cd4aa0aad29bbbffc036ad rdf:first sg:person.01143125277.28
186 rdf:rest Nc1f7de5515a944b7a1edc9fa7c72289a
187 N9b08e532972249d7bfa38dd947fd8323 rdf:first sg:person.01064431637.94
188 rdf:rest N1001193b643049c78a5d806d5f95c8e8
189 N9e93e239bace4b4d9ec129d8dab01d53 schema:name Springer Nature - SN SciGraph project
190 rdf:type schema:Organization
191 Na4f761faa7b6485682cf4367bd6a346c rdf:first sg:person.0616033724.80
192 rdf:rest N9b08e532972249d7bfa38dd947fd8323
193 Nad892886cc8f426d85f1a6231501d879 rdf:first sg:person.0662564173.80
194 rdf:rest Nd5e5c66702004751b55f9206c546cf00
195 Nade12836639846a09da0a29c3d8d38fd schema:name doi
196 schema:value 10.1038/s41598-021-02861-4
197 rdf:type schema:PropertyValue
198 Nc1f7de5515a944b7a1edc9fa7c72289a rdf:first sg:person.01032646234.50
199 rdf:rest rdf:nil
200 Nc1fb43bd254148f2942c7d9ec3abf2f0 schema:issueNumber 1
201 rdf:type schema:PublicationIssue
202 Nc7e7d8c0e876415ebbead1919843b604 schema:name dimensions_id
203 schema:value pub.1143654635
204 rdf:type schema:PropertyValue
205 Ncbf6f48f6f1e4eb4b87ce07c9e69d28b rdf:first sg:person.07500003430.07
206 rdf:rest N18eddade167a4b78b51e060d1dfb086a
207 Nd272c6faf88d42fd8ca4a5e033bd23e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Prospective Studies
209 rdf:type schema:DefinedTerm
210 Nd2a4d2564f1d40e1a647e8d07026a4f5 rdf:first sg:person.0646451302.55
211 rdf:rest N987cfce475cd4aa0aad29bbbffc036ad
212 Nd5e5c66702004751b55f9206c546cf00 rdf:first sg:person.01111773607.17
213 rdf:rest N22278c81bfb94b469cb12ed70ad3e188
214 Ne68acf8049b14d12a12ffb6d9cb3b135 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Lung Neoplasms
216 rdf:type schema:DefinedTerm
217 Ne8ddace11a704b8ca575e6e6bee98a6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Male
219 rdf:type schema:DefinedTerm
220 Nf056d02053904b86a93a830d10959720 rdf:first sg:person.01260304701.86
221 rdf:rest N4e065073d29b404999acf72a8db1b837
222 Nf0894f84990345528ce59fb80fd10723 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Middle Aged
224 rdf:type schema:DefinedTerm
225 Nfc5864f89f3c4a7094f6bc56f0f25912 rdf:first sg:person.01342450607.40
226 rdf:rest Nf056d02053904b86a93a830d10959720
227 Nfe4232258952411eb102e30bc1d29e8a rdf:first sg:person.0623556107.50
228 rdf:rest N5d528a68b7094d50a30b648ca0537fca
229 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
230 schema:name Technology
231 rdf:type schema:DefinedTerm
232 anzsrc-for:1004 schema:inDefinedTermSet anzsrc-for:
233 schema:name Medical Biotechnology
234 rdf:type schema:DefinedTerm
235 sg:journal.1045337 schema:issn 2045-2322
236 schema:name Scientific Reports
237 schema:publisher Springer Nature
238 rdf:type schema:Periodical
239 sg:person.010226631432.41 schema:affiliation grid-institutes:grid.415432.5
240 schema:familyName Suzuki
241 schema:givenName Yu
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010226631432.41
243 rdf:type schema:Person
244 sg:person.01032646234.50 schema:affiliation grid-institutes:grid.271052.3
245 schema:familyName Yatera
246 schema:givenName Kazuhiro
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032646234.50
248 rdf:type schema:Person
249 sg:person.01057344215.61 schema:affiliation grid-institutes:grid.174567.6
250 schema:familyName Sakamoto
251 schema:givenName Noriho
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057344215.61
253 rdf:type schema:Person
254 sg:person.01064431637.94 schema:affiliation grid-institutes:grid.411556.2
255 schema:familyName Fujita
256 schema:givenName Masaki
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064431637.94
258 rdf:type schema:Person
259 sg:person.01111773607.17 schema:affiliation grid-institutes:grid.174567.6
260 schema:familyName Hara
261 schema:givenName Atsuko
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111773607.17
263 rdf:type schema:Person
264 sg:person.01134663476.54 schema:affiliation grid-institutes:grid.271052.3
265 schema:familyName Yoshii
266 schema:givenName Chiharu
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134663476.54
268 rdf:type schema:Person
269 sg:person.01143125277.28 schema:affiliation grid-institutes:grid.174567.6
270 schema:familyName Mukae
271 schema:givenName Hiroshi
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143125277.28
273 rdf:type schema:Person
274 sg:person.01211346734.05 schema:affiliation grid-institutes:grid.174567.6
275 schema:familyName Kido
276 schema:givenName Takashi
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211346734.05
278 rdf:type schema:Person
279 sg:person.01260304701.86 schema:affiliation grid-institutes:grid.411556.2
280 schema:familyName Ishii
281 schema:givenName Hiroshi
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260304701.86
283 rdf:type schema:Person
284 sg:person.012676300422.60 schema:affiliation grid-institutes:grid.410849.0
285 schema:familyName Matsumoto
286 schema:givenName Nobuhiro
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012676300422.60
288 rdf:type schema:Person
289 sg:person.01342450607.40 schema:affiliation grid-institutes:grid.174567.6
290 schema:familyName Ishimoto
291 schema:givenName Hiroshi
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342450607.40
293 rdf:type schema:Person
294 sg:person.014214615040.96 schema:affiliation grid-institutes:grid.271052.3
295 schema:familyName Kawabata
296 schema:givenName Hiroki
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014214615040.96
298 rdf:type schema:Person
299 sg:person.0616033724.80 schema:affiliation grid-institutes:grid.174567.6
300 schema:familyName Fukuoka
301 schema:givenName Junya
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616033724.80
303 rdf:type schema:Person
304 sg:person.0623556107.50 schema:affiliation grid-institutes:grid.271052.3
305 schema:familyName Kawanami
306 schema:givenName Toshinori
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623556107.50
308 rdf:type schema:Person
309 sg:person.0646451302.55 schema:affiliation grid-institutes:grid.412334.3
310 schema:familyName Kadota
311 schema:givenName Junichi
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646451302.55
313 rdf:type schema:Person
314 sg:person.0662564173.80 schema:affiliation grid-institutes:grid.412334.3
315 schema:familyName Yoshikawa
316 schema:givenName Hiroki
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662564173.80
318 rdf:type schema:Person
319 sg:person.0725136110.34 schema:affiliation grid-institutes:grid.410849.0
320 schema:familyName Nakazato
321 schema:givenName Masamitsu
322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725136110.34
323 rdf:type schema:Person
324 sg:person.07500003430.07 schema:affiliation grid-institutes:grid.174567.6
325 schema:familyName Ozasa
326 schema:givenName Mutsumi
327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07500003430.07
328 rdf:type schema:Person
329 sg:person.0763624047.54 schema:affiliation grid-institutes:grid.271052.3
330 schema:familyName Hara
331 schema:givenName Kanako
332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763624047.54
333 rdf:type schema:Person
334 sg:pub.10.1007/s00277-009-0875-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009262540
335 https://doi.org/10.1007/s00277-009-0875-7
336 rdf:type schema:CreativeWork
337 sg:pub.10.1038/sj.leu.2403202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027716225
338 https://doi.org/10.1038/sj.leu.2403202
339 rdf:type schema:CreativeWork
340 sg:pub.10.1038/sj.leu.2403428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043506170
341 https://doi.org/10.1038/sj.leu.2403428
342 rdf:type schema:CreativeWork
343 sg:pub.10.1038/sj.leu.2403501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035768039
344 https://doi.org/10.1038/sj.leu.2403501
345 rdf:type schema:CreativeWork
346 sg:pub.10.1038/sj.leu.2404467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016386977
347 https://doi.org/10.1038/sj.leu.2404467
348 rdf:type schema:CreativeWork
349 sg:pub.10.1038/sj.leu.2404479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032286803
350 https://doi.org/10.1038/sj.leu.2404479
351 rdf:type schema:CreativeWork
352 sg:pub.10.1038/sj.onc.1203018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043782984
353 https://doi.org/10.1038/sj.onc.1203018
354 rdf:type schema:CreativeWork
355 grid-institutes:grid.174567.6 schema:alternateName Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
356 Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, 852-8501, Nagasaki, Japan
357 schema:name Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
358 Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, 852-8501, Nagasaki, Japan
359 Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
360 rdf:type schema:Organization
361 grid-institutes:grid.271052.3 schema:alternateName Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
362 Department of Respiratory Medicine, Wakamatsu Hospital of the University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
363 schema:name Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
364 Department of Respiratory Medicine, Wakamatsu Hospital of the University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
365 rdf:type schema:Organization
366 grid-institutes:grid.410849.0 schema:alternateName Neurology, Respirology, Endocrinology and Metabolism, Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
367 schema:name Neurology, Respirology, Endocrinology and Metabolism, Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
368 rdf:type schema:Organization
369 grid-institutes:grid.411556.2 schema:alternateName Department of Respiratory Medicine, Fukuoka University Hospital, Fukuoka, Japan
370 schema:name Department of Respiratory Medicine, Fukuoka University Hospital, Fukuoka, Japan
371 rdf:type schema:Organization
372 grid-institutes:grid.412334.3 schema:alternateName Department of Respiratory Medicine and Infectious Disease, Faculty of Medicine, Oita University, Yufu, Japan
373 schema:name Department of Respiratory Medicine and Infectious Disease, Faculty of Medicine, Oita University, Yufu, Japan
374 rdf:type schema:Organization
375 grid-institutes:grid.415432.5 schema:alternateName Department of Respiratory Medicine, Kokura Memorial Hospital, Kitakyushu, Japan
376 schema:name Department of Respiratory Medicine, Kokura Memorial Hospital, Kitakyushu, Japan
377 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...