The impact of muscle mass loss and deteriorating physical function on prognosis in patients receiving hemodialysis View Full Text


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Article Info

DATE

2021-11-16

AUTHORS

Mineaki Kitamura, Takahiro Takazono, Kosei Yamaguchi, Satoko Notomi, Kenji Sawase, Takashi Harada, Satoshi Funakoshi, Hiroshi Mukae, Tomoya Nishino

ABSTRACT

Muscle mass loss and worsening physical function are crucial issues in patients receiving hemodialysis (HD). However, few studies have investigated the association between temporal changes in muscle mass and physical function in a large number of HD patients. We examined 286 patients receiving HD (males, 58%; age, 66.8 ± 13.0 years) at a single center, and calculated the percent changes in psoas muscle mass index (%PMI) using computed tomography over two screenings, once per year (July 2011–June 2013). Physical function was evaluated using the Eastern Cooperative Oncology Group Performance Status (ECOG-PS) (range 0–4). The observation period was from July 2012 to June 2021. The median %PMI was -9.5%, and those with the lowest quartile of %PMI (< −20.5%) showed a significantly poor prognosis compared with other patients (p < 0.001). Multivariable logistic regression analysis revealed that these patients tended to have decreased physical function (ECOG-PS 2–4) [odds ratio (OR): 2.46, p < 0.001] and albumin levels (OR: 0.22, p = 0.007). Multiple-factor-adjusted Cox regression analyses showed that %PMI (hazard ratio: 0.99, p = 0.004) and each ECOG-PS stage (1–4 vs. 0) (p < 0.01) were associated with mortality. Augmenting physical activities in daily life and serum albumin levels should be considered to maintain muscle mass and improve the prognosis of patients receiving HD. More... »

PAGES

22290

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-021-01581-z

    DOI

    http://dx.doi.org/10.1038/s41598-021-01581-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1142592496

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34785712


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