JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiotensin II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelium, Vascular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infusions, Parenteral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intercellular Adhesion Molecule-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidative Stress", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Cell Adhesion Molecule-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Remodeling", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Posgrado en Biolog\u00eda Experimental, Universidad Aut\u00f3noma Metropolitana-Iztapalapa, 09640, Mexico City, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.7220.7", 
          "name": [
            "Facultad de Medicina, Universidad Aut\u00f3noma del Estado de Morelos, 62350, Cuernavaca, Morelos, Mexico", 
            "Posgrado en Biolog\u00eda Experimental, Universidad Aut\u00f3noma Metropolitana-Iztapalapa, 09640, Mexico City, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trejo-Moreno", 
        "givenName": "Celeste", 
        "id": "sg:person.015006506660.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015006506660.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, 62790, Xochitepec, Morelos, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.419157.f", 
          "name": [
            "Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, 62790, Xochitepec, Morelos, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jim\u00e9nez-Ferrer", 
        "givenName": "Enrique", 
        "id": "sg:person.0651356723.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651356723.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Facultad de Medicina, Universidad Aut\u00f3noma del Estado de Morelos, 62350, Cuernavaca, Morelos, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.412873.b", 
          "name": [
            "Facultad de Medicina, Universidad Aut\u00f3noma del Estado de Morelos, 62350, Cuernavaca, Morelos, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Castro-Mart\u00ednez", 
        "givenName": "Gabriela", 
        "id": "sg:person.010537754764.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010537754764.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departamento de Sistemas Biol\u00f3gicos, Universidad Aut\u00f3noma Metropolitana-Xochimilco, 04960, Mexico City, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.7220.7", 
          "name": [
            "Facultad de Medicina, Universidad Aut\u00f3noma del Estado de Morelos, 62350, Cuernavaca, Morelos, Mexico", 
            "Departamento de Sistemas Biol\u00f3gicos, Universidad Aut\u00f3noma Metropolitana-Xochimilco, 04960, Mexico City, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00e9ndez-Mart\u00ednez", 
        "givenName": "Marisol", 
        "id": "sg:person.015604067260.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015604067260.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centro de Investigaci\u00f3n en Din\u00e1mica Celular, Universidad Aut\u00f3noma del Estado de Morelos, 62209, Cuernavaca, Morelos, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.412873.b", 
          "name": [
            "Centro de Investigaci\u00f3n en Din\u00e1mica Celular, Universidad Aut\u00f3noma del Estado de Morelos, 62209, Cuernavaca, Morelos, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santana", 
        "givenName": "Mar\u00eda Ang\u00e9lica", 
        "id": "sg:person.01037246445.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037246445.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Facultad de Ciencias de la Salud, Universidad Panamericana, 03920, Mexico City, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.412242.3", 
          "name": [
            "Facultad de Medicina, Universidad Aut\u00f3noma del Estado de Morelos, 62350, Cuernavaca, Morelos, Mexico", 
            "Facultad de Ciencias de la Salud, Universidad Panamericana, 03920, Mexico City, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arrell\u00edn-Rosas", 
        "givenName": "Gerardo", 
        "id": "sg:person.011034120345.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011034120345.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510, Mexico City, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.9486.3", 
          "name": [
            "Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510, Mexico City, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pedraza-Chaverri", 
        "givenName": "Jos\u00e9", 
        "id": "sg:person.0675676240.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675676240.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510, Mexico City, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.9486.3", 
          "name": [
            "Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510, Mexico City, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Medina-Campos", 
        "givenName": "Omar Noel", 
        "id": "sg:person.01077774627.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077774627.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510, Mexico City, CP, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.9486.3", 
          "name": [
            "Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510, Mexico City, CP, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hern\u00e1ndez-T\u00e9llez", 
        "givenName": "Beatriz", 
        "id": "sg:person.01012624742.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012624742.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centro de Investigaci\u00f3n en Din\u00e1mica Celular, Universidad Aut\u00f3noma del Estado de Morelos, 62209, Cuernavaca, Morelos, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.412873.b", 
          "name": [
            "Centro de Investigaci\u00f3n en Din\u00e1mica Celular, Universidad Aut\u00f3noma del Estado de Morelos, 62209, Cuernavaca, Morelos, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ram\u00edrez-Pliego", 
        "givenName": "Oscar", 
        "id": "sg:person.01102512663.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102512663.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, 62790, Xochitepec, Morelos, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.419157.f", 
          "name": [
            "Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, 62790, Xochitepec, Morelos, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Herrera-Ruiz", 
        "givenName": "Maribel", 
        "id": "sg:person.0737564747.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737564747.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510, Mexico City, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.9486.3", 
          "name": [
            "Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510, Mexico City, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cervantes-Torres", 
        "givenName": "Jacquelynne", 
        "id": "sg:person.016460305427.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016460305427.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Facultad de Medicina, Universidad Aut\u00f3noma del Estado de Morelos, 62350, Cuernavaca, Morelos, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.412873.b", 
          "name": [
            "Facultad de Medicina, Universidad Aut\u00f3noma del Estado de Morelos, 62350, Cuernavaca, Morelos, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alvarado-Ojeda", 
        "givenName": "Zimri Aziel", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Facultad de Medicina, Universidad Aut\u00f3noma del Estado de Morelos, 62350, Cuernavaca, Morelos, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.412873.b", 
          "name": [
            "Facultad de Medicina, Universidad Aut\u00f3noma del Estado de Morelos, 62350, Cuernavaca, Morelos, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Costet-Mej\u00eda", 
        "givenName": "Alejandro", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510, Mexico City, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.9486.3", 
          "name": [
            "Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510, Mexico City, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fragoso", 
        "givenName": "Gladis", 
        "id": "sg:person.01013112462.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013112462.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Facultad de Medicina, Universidad Aut\u00f3noma del Estado de Morelos, 62350, Cuernavaca, Morelos, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.412873.b", 
          "name": [
            "Facultad de Medicina, Universidad Aut\u00f3noma del Estado de Morelos, 62350, Cuernavaca, Morelos, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rosas-Salgado", 
        "givenName": "Gabriela", 
        "id": "sg:person.01175454262.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175454262.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00395-019-0717-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1111406502", 
          "https://doi.org/10.1007/s00395-019-0717-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00395-008-0733-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016040736", 
          "https://doi.org/10.1007/s00395-008-0733-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41575-018-0009-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103856576", 
          "https://doi.org/10.1038/s41575-018-0009-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1020714518246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040670160", 
          "https://doi.org/10.1023/a:1020714518246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2840-5-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046060866", 
          "https://doi.org/10.1186/1475-2840-5-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12038-011-9097-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037356379", 
          "https://doi.org/10.1007/s12038-011-9097-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13577-018-0220-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107967670", 
          "https://doi.org/10.1007/s13577-018-0220-3"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-10-27", 
    "datePublishedReg": "2021-10-27", 
    "description": "Endothelial dysfunction (ED) is a key factor for the development of cardiovascular diseases. Due to its chronic, life-threatening nature, ED only can be studied experimentally in animal models. Therefore, this work was aimed to characterize a murine model of ED induced by a daily intraperitoneal administration of angiotensin II (AGII) for 10\u00a0weeks. Oxidative stress, inflammation, vascular remodeling, hypertension, and damage to various target organs were evaluated in treated animals. The results indicated that a chronic intraperitoneal administration of AGII increases the production of systemic soluble VCAM, ROS and ICAM-1 expression, and the production of TNF\u03b1, IL1\u03b2, IL17A, IL4, TGF\u03b2, and IL10 in the kidney, as well as blood pressure levels; it also promotes vascular remodeling and induces non-alcoholic fatty liver disease, glomerulosclerosis, and proliferative retinopathy. Therefore, the model herein proposed can be a representative model for ED; additionally, it is easy to implement, safe, rapid, and inexpensive.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-021-00676-x", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "keywords": [
      "endothelial dysfunction", 
      "chronic intraperitoneal administration", 
      "angiotensin II", 
      "intraperitoneal administration", 
      "vascular remodeling", 
      "murine model", 
      "non-alcoholic fatty liver disease", 
      "blood pressure levels", 
      "fatty liver disease", 
      "daily intraperitoneal administration", 
      "production of TNF\u03b1", 
      "ICAM-1 expression", 
      "life-threatening nature", 
      "soluble VCAM", 
      "proliferative retinopathy", 
      "liver disease", 
      "cardiovascular disease", 
      "target organs", 
      "animal models", 
      "oxidative stress", 
      "administration", 
      "dysfunction", 
      "disease", 
      "remodeling", 
      "pressure levels", 
      "hypertension", 
      "retinopathy", 
      "inflammation", 
      "IL17A", 
      "glomerulosclerosis", 
      "IL10", 
      "chronic", 
      "IL1\u03b2", 
      "TNF\u03b1", 
      "VCAM", 
      "IL4", 
      "kidney", 
      "weeks", 
      "TGF\u03b2", 
      "organs", 
      "animals", 
      "ROS", 
      "expression", 
      "damage", 
      "factors", 
      "levels", 
      "production", 
      "key factors", 
      "stress", 
      "development", 
      "model", 
      "results", 
      "representative model", 
      "characterization", 
      "nature", 
      "work"
    ], 
    "name": "Characterization of a murine model of endothelial dysfunction induced by chronic intraperitoneal administration of angiotensin II", 
    "pagination": "21193", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1142200209"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-021-00676-x"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "34707201"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-021-00676-x", 
      "https://app.dimensions.ai/details/publication/pub.1142200209"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_895.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-021-00676-x"
  }
]

Download the RDF metadata as:  json-ld nt turtle xml License info

This table displays all metadata directly associated to this object as RDF triples.

342 TRIPLES      22 PREDICATES      107 URIs      92 LITERALS      25 BLANK NODES