Optimal value of CA19-9 determined by KRAS-mutated circulating tumor DNA contributes to the prediction of prognosis in pancreatic cancer patients View Full Text


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Article Info

DATE

2021-10-21

AUTHORS

Fumiaki Watanabe, Koichi Suzuki, Sawako Tamaki, Iku Abe, Yuhei Endo, Yuji Takayama, Hideki Ishikawa, Nao Kakizawa, Masaaki Saito, Kazushige Futsuhara, Hiroshi Noda, Fumio Konishi, Toshiki Rikiyama

ABSTRACT

Despite the acceptance of carbohydrate antigen 19-9 (CA19-9) as a valuable predictor for the prognosis of pancreatic ductal adenocarcinoma (PDAC), its cutoff value remains controversial. Our previous study showed a significant correlation between CA19-9 levels and the presence of KRAS-mutated ctDNA in the blood of patients with PDAC. Based on this correlation, we investigated the optimal cutoff value of CA19-9 before surgery. Continuous CA19-9 values and KRAS-mutated ctDNAs were monitored in 22 patients with unresectable PDAC who underwent chemotherapy between 2015 and 2017. Receiver operating characteristic curve analysis identified 949.7 U/mL of CA19-9 as the cutoff value corresponding to the presence of KRAS-mutated ctDNA. The median value of CA19-9 was 221.1 U/mL. Subsequently, these values were verified for their prognostic values of recurrence-free survival (RFS) and overall survival (OS) in 60 patients who underwent surgery between 2005 and 2013. Multivariate analysis revealed that 949.7 U/mL of CA19-9 was an independent risk factor for OS and RFS in these patients (P = 0.001 and P = 0.010, respectively), along with lymph node metastasis (P = 0.008 and P = 0.017), unlike the median CA19-9 level (P = 0.150 and P = 0.210). The optimal CA19-9 level contributes to the prediction of prognosis in patients with PDAC before surgery. More... »

PAGES

20797

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-021-00060-9

    DOI

    http://dx.doi.org/10.1038/s41598-021-00060-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1142033109

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34675229


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    326 grid-institutes:grid.416093.9 schema:alternateName Department of Surgery, Saitama Medical Center, Jichi Medical University, 1-847, Amanuma-cho, 330-8503, Omiya-ku, Saitama, Japan
    327 schema:name Department of Surgery, Saitama Medical Center, Jichi Medical University, 1-847, Amanuma-cho, 330-8503, Omiya-ku, Saitama, Japan
    328 rdf:type schema:Organization
     




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