Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa View Full Text


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Article Info

DATE

2021-01-13

AUTHORS

Jana Freff, Kathrin Schwarte, Lisa Bröker, Judith Bühlmeier, Isabelle Kraft, Dana Öztürk, Anke Hinney, Volker Arolt, Udo Dannlowski, Georg Romer, Bernhard T. Baune, Johannes Hebebrand, Manuel Föcker, Judith Alferink

ABSTRACT

Anorexia nervosa (AN) is a severe eating disorder and often associated with altered humoral immune responses. However, distinct B cell maturation stages in peripheral blood in adolescents with AN have not been characterized. Treatment effects and the relationship between clinical and B cell parameters are also not fully understood. Here we investigated the phenotype of circulating B cell subsets and the relationship with body composition in adolescents with AN before (T0, n = 24) and after 6 weeks (T1, n = 20) of treatment. Using multi-parameter flow cytometry, we found increased percentages of antigen-experienced B cells and plasmablasts in patients with AN compared to healthy controls (n = 20). In contrast, percentages of CD1d+CD5+ B cells and transitional B cells with immunoregulatory roles were reduced at T0 and T1. These B cell frequencies correlated positively with fat mass, fat mass index (FMI), free fat mass index, and body mass index standard deviation score. In addition, scavenger-like receptor CD5 expression levels were downregulated on transitional B cells and correlated with fat mass and FMI in AN. Our findings that regulatory B cell subgroups were reduced in AN and their strong relationship with body composition parameters point toward an impact of immunoregulatory B cells in the pathogenesis of AN. More... »

PAGES

1125

References to SciGraph publications

  • 2019-06-05. Risk factors for a low weight gain in the early stage of adolescent anorexia nervosa inpatient treatment: findings from a pilot study in EATING AND WEIGHT DISORDERS - STUDIES ON ANOREXIA, BULIMIA AND OBESITY
  • 2003-12-22. Intestinal permeability is decreased in anorexia nervosa in MOLECULAR PSYCHIATRY
  • 2016-05-18. Flow cytometry combined with viSNE for the analysis of microbial biofilms and detection of microplastics in NATURE COMMUNICATIONS
  • 2010-02-24. Body mass index percentiles for children and adolescents in Germany based on a nationally representative sample (KiGGS 2003–2006) in EUROPEAN JOURNAL OF CLINICAL NUTRITION
  • 1996-07. Role of leptin in the neuroendocrine response to fasting in NATURE
  • 2017-09-13. Altered B Cell Homeostasis in Patients with Major Depressive Disorder and Normalization of CD5 Surface Expression on Regulatory B Cells in Treatment Responders in JOURNAL OF NEUROIMMUNE PHARMACOLOGY
  • 2016-02-05. Leptin levels in patients with anorexia nervosa following day/inpatient treatment do not predict weight 1 year post-referral in EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
  • 2009-12. Adipose tissue lymphocytes: types and roles in JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
  • 2016-05-17. Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index in MOLECULAR PSYCHIATRY
  • 2017-01-31. Food matters: how the microbiome and gut–brain interaction might impact the development and course of anorexia nervosa in EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
  • 2017-09-22. Genetics of Anorexia Nervosa in CURRENT PSYCHIATRY REPORTS
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    http://scigraph.springernature.com/pub.10.1038/s41598-020-80693-4

    DOI

    http://dx.doi.org/10.1038/s41598-020-80693-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1134516793

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33441933


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