Prognostic value of cardio-hepatic-skeletal muscle syndrome in patients with heart failure View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-02-12

AUTHORS

Takumi Noda, Kentaro Kamiya, Nobuaki Hamazaki, Kohei Nozaki, Takafumi Ichikawa, Takeshi Nakamura, Masashi Yamashita, Shota Uchida, Emi Maekawa, Jennifer L. Reed, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Junya Ako

ABSTRACT

Although heart failure (HF) and liver dysfunction often coexist because of complex cardiohepatic interactions, the association between liver dysfunction and physical dysfunction, and between coexistence of both and prognosis in HF patients remains unclear. We reviewed 895 patients with HF (mean age, 69.4 ± 14.2 years) who underwent liver function test using model for end-stage liver disease excluding international normalized ratio (MELD-XI) score and physical function test (grip strength, leg strength, gait speed, and 6-min walking distance [6MWD]). In the multiple regression analysis, MELD-XI score was independently associated with lower grip strength, leg strength, gait speed, and 6MWD (all P < 0.001). One hundred thirty deaths occurred over a median follow-up period of 1.67 years (interquartile range: 0.62–3.04). For all-cause mortality, patients with high MELD-XI scores and reduced physical functions were found to have a significantly higher mortality risk even after adjusting for several covariates (grip strength, hazard ratio [HR]: 3.80, P < 0.001; leg strength, HR: 4.65, P < 0.001; gait speed, HR: 2.49, P = 0.001, and 6MWD, HR: 5.48, P < 0.001). Liver dysfunction was correlated with reduced physical function. Moreover, the coexistence of lower physical function and liver dysfunction considerably affected prognosis in patients with HF. More... »

PAGES

3715

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-020-80641-2

DOI

http://dx.doi.org/10.1038/s41598-020-80641-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1135332790

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33580115


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36 coexistence
37 covariates
38 death
39 disease
40 dysfunction
41 end-stage liver disease
42 failure
43 follow
44 function
45 function tests
46 gait speed
47 grip strength
48 heart failure
49 high MELD-XI score
50 higher mortality risk
51 interaction
52 international normalized ratio (MELD-XI) score
53 leg strength
54 liver disease
55 liver dysfunction
56 liver function tests
57 low grip strength
58 low physical function
59 median follow
60 model
61 mortality
62 mortality risk
63 multiple regression analysis
64 muscle syndrome
65 patients
66 period
67 physical dysfunction
68 physical function
69 physical function tests
70 prognosis
71 prognostic value
72 ratio scores
73 regression analysis
74 risk
75 scores
76 speed
77 strength
78 syndrome
79 test
80 values
81 years
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