Targeting oxytocin receptor (Oxtr)-expressing neurons in the lateral septum to restore social novelty in autism spectrum disorder mouse models View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-12-17

AUTHORS

Machi Horiai, Ayano Otsuka, Shizu Hidema, Yuichi Hiraoka, Ryotaro Hayashi, Shinji Miyazaki, Tamio Furuse, Hiroaki Mizukami, Ryoichi Teruyama, Masaru Tamura, Haruhiko Bito, Yuko Maejima, Kenju Shimomura, Katsuhiko Nishimori

ABSTRACT

Autism spectrum disorder (ASD) is a continuum of neurodevelopmental disorders and needs new therapeutic approaches. Recently, oxytocin (OXT) showed potential as the first anti-ASD drug. Many reports have described the efficacy of intranasal OXT therapy to improve the core symptoms of patients with ASD; however, the underlying neurobiological mechanism remains unknown. The OXT/oxytocin receptor (OXTR) system, through the lateral septum (LS), contributes to social behavior, which is disrupted in ASD. Therefore, we selectively express hM3Dq in OXTR-expressing (OXTR+) neurons in the LS to investigate this effect in ASD mouse models developed by environmental and genetic cues. In mice that received valproic acid (environmental cue), we demonstrated successful recovery of impaired social memory with three-chamber test after OXTR+ neuron activation in the LS. Application of a similar strategy to Nl3R451C knock-in mice (genetic cue) also caused successful recovery of impaired social memory in single field test. OXTR+ neurons in the LS, which are activated by social stimuli, are projected to the CA1 region of the hippocampus. This study identified a candidate mechanism for improving core symptoms of ASD by artificial activation of DREADDs, as a simulation of OXT administration to activate OXTR+ neurons in the LS. More... »

PAGES

22173

References to SciGraph publications

  • 1988-11. GABA-containing neurons in the septum control inhibitory interneurons in the hippocampus in NATURE
  • 2004-07-07. Behavioral Alterations in Rats Prenatally Exposed to Valproic Acid: Animal Model of Autism in NEUROPSYCHOPHARMACOLOGY
  • 2014-02-23. The hippocampal CA2 region is essential for social memory in NATURE
  • 2014-06-26. Brain Oxytocin in Social Fear Conditioning and Its Extinction: Involvement of the Lateral Septum in NEUROPSYCHOPHARMACOLOGY
  • 2017-03-15. Bidirectional Control of Anxiety-Related Behaviors in Mice: Role of Inputs Arising from the Ventral Hippocampus to the Lateral Septum and Medial Prefrontal Cortex in NEUROPSYCHOPHARMACOLOGY
  • 2009-02-03. Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety in PSYCHOPHARMACOLOGY
  • 2009-06. Common circuit defect of excitatory-inhibitory balance in mouse models of autism in JOURNAL OF NEURODEVELOPMENTAL DISORDERS
  • 2013-07-21. Fear-enhancing effects of septal oxytocin receptors in NATURE NEUROSCIENCE
  • 2015-03-24. Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury in ACTA NEUROPATHOLOGICA COMMUNICATIONS
  • 2003-03-31. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism in NATURE GENETICS
  • 2017-10-03. A novel system for tracking social preference dynamics in mice reveals sex- and strain-specific characteristics in MOLECULAR AUTISM
  • 2007-05-16. Abnormal Fear Conditioning and Amygdala Processing in an Animal Model of Autism in NEUROPSYCHOPHARMACOLOGY
  • 2013-11-28. Role of oxytocin receptors in modulation of fear by social memory in PSYCHOPHARMACOLOGY
  • 2017-12-08. Hippocampal oxytocin receptors are necessary for discrimination of social stimuli in NATURE COMMUNICATIONS
  • 2015-03-31. Double Dissociation of the Roles of Metabotropic Glutamate Receptor 5 and Oxytocin Receptor in Discrete Social Behaviors in NEUROPSYCHOPHARMACOLOGY
  • 2013-09-13. Pax6-Dependent Cortical Glutamatergic Neuronal Differentiation Regulates Autism-Like Behavior in Prenatally Valproic Acid-Exposed Rat Offspring in MOLECULAR NEUROBIOLOGY
  • 2009-04. The anatomy of memory: an interactive overview of the parahippocampal–hippocampal network in NATURE REVIEWS NEUROSCIENCE
  • 2013-07-14. Functional labeling of neurons and their projections using the synthetic activity–dependent promoter E-SARE in NATURE METHODS
  • Journal

    TITLE

    Scientific Reports

    ISSUE

    1

    VOLUME

    10

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-020-79109-0

    DOI

    http://dx.doi.org/10.1038/s41598-020-79109-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1133580692

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33335150


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anxiety", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Autism Spectrum Disorder", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Behavior, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Models, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fluorescent Antibody Technique", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Knockout", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Targeted Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neurons", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pyramidal Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Oxytocin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Septum of Brain", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Social Behavior", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki-Aza-Aoba, Aoba-ku, 980-0845, Sendai, Miyagi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki-Aza-Aoba, Aoba-ku, 980-0845, Sendai, Miyagi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Horiai", 
            "givenName": "Machi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Obesity and Internal Inflammation, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411582.b", 
              "name": [
                "Department of Obesity and Internal Inflammation, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Otsuka", 
            "givenName": "Ayano", 
            "id": "sg:person.01045745577.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045745577.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411582.b", 
              "name": [
                "Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki-Aza-Aoba, Aoba-ku, 980-0845, Sendai, Miyagi, Japan", 
                "Department of Obesity and Internal Inflammation, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan", 
                "Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hidema", 
            "givenName": "Shizu", 
            "id": "sg:person.01147370103.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147370103.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory for Molecular Neuroscience Medical Research Institute, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.265073.5", 
              "name": [
                "Laboratory for Molecular Neuroscience Medical Research Institute, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hiraoka", 
            "givenName": "Yuichi", 
            "id": "sg:person.01136640226.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136640226.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Innovation Center, Nippon Flour Mills Co., Ltd., 5-1-3 Midorigaoka, 243-0041, Atsugi, Kanagawa, Japan", 
              "id": "http://www.grid.ac/institutes/grid.471412.5", 
              "name": [
                "Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki-Aza-Aoba, Aoba-ku, 980-0845, Sendai, Miyagi, Japan", 
                "Innovation Center, Nippon Flour Mills Co., Ltd., 5-1-3 Midorigaoka, 243-0041, Atsugi, Kanagawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hayashi", 
            "givenName": "Ryotaro", 
            "id": "sg:person.01125300044.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125300044.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki-Aza-Aoba, Aoba-ku, 980-0845, Sendai, Miyagi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki-Aza-Aoba, Aoba-ku, 980-0845, Sendai, Miyagi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miyazaki", 
            "givenName": "Shinji", 
            "id": "sg:person.0647450163.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647450163.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Technology and Development Team for Mouse Phenotype Analysis, Japan Mouse Clinic, RIKEN BioResouce Reserch Center (BRC), 3-1-1 Koyadai, 305-0074, Tsukuba, Ibaraki, Japan", 
              "id": "http://www.grid.ac/institutes/grid.7597.c", 
              "name": [
                "Technology and Development Team for Mouse Phenotype Analysis, Japan Mouse Clinic, RIKEN BioResouce Reserch Center (BRC), 3-1-1 Koyadai, 305-0074, Tsukuba, Ibaraki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Furuse", 
            "givenName": "Tamio", 
            "id": "sg:person.0634371603.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634371603.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Genetic Therapeutics, Center for Medicine, Jichi Medical University, 329-0498, Shimotsuke, Tochigi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410804.9", 
              "name": [
                "Division of Genetic Therapeutics, Center for Medicine, Jichi Medical University, 329-0498, Shimotsuke, Tochigi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mizukami", 
            "givenName": "Hiroaki", 
            "id": "sg:person.0613664001.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613664001.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biological Sciences, Louisiana State University, 70803, Baton Rouge, LA, USA", 
              "id": "http://www.grid.ac/institutes/grid.64337.35", 
              "name": [
                "Department of Biological Sciences, Louisiana State University, 70803, Baton Rouge, LA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Teruyama", 
            "givenName": "Ryoichi", 
            "id": "sg:person.01041356334.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041356334.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Technology and Development Team for Mouse Phenotype Analysis, Japan Mouse Clinic, RIKEN BioResouce Reserch Center (BRC), 3-1-1 Koyadai, 305-0074, Tsukuba, Ibaraki, Japan", 
              "id": "http://www.grid.ac/institutes/grid.7597.c", 
              "name": [
                "Technology and Development Team for Mouse Phenotype Analysis, Japan Mouse Clinic, RIKEN BioResouce Reserch Center (BRC), 3-1-1 Koyadai, 305-0074, Tsukuba, Ibaraki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tamura", 
            "givenName": "Masaru", 
            "id": "sg:person.01142306011.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142306011.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, 113-0033, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, 113-0033, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bito", 
            "givenName": "Haruhiko", 
            "id": "sg:person.01236552226.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236552226.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411582.b", 
              "name": [
                "Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maejima", 
            "givenName": "Yuko", 
            "id": "sg:person.0677121374.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677121374.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411582.b", 
              "name": [
                "Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shimomura", 
            "givenName": "Kenju", 
            "id": "sg:person.01220434613.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220434613.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411582.b", 
              "name": [
                "Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki-Aza-Aoba, Aoba-ku, 980-0845, Sendai, Miyagi, Japan", 
                "Department of Obesity and Internal Inflammation, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan", 
                "Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nishimori", 
            "givenName": "Katsuhiko", 
            "id": "sg:person.01151605507.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151605507.23"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sj.npp.1300518", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049034130", 
              "https://doi.org/10.1038/sj.npp.1300518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00213-009-1466-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003670684", 
              "https://doi.org/10.1007/s00213-009-1466-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn2614", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016525767", 
              "https://doi.org/10.1038/nrn2614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/336170a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021927311", 
              "https://doi.org/10.1038/336170a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2559", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020352117", 
              "https://doi.org/10.1038/nmeth.2559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-013-8535-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003836732", 
              "https://doi.org/10.1007/s12035-013-8535-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2017.56", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084129531", 
              "https://doi.org/10.1038/npp.2017.56"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11689-009-9023-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003067301", 
              "https://doi.org/10.1007/s11689-009-9023-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2015.81", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025468764", 
              "https://doi.org/10.1038/npp.2015.81"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-017-02173-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1093156833", 
              "https://doi.org/10.1038/s41467-017-02173-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044165099", 
              "https://doi.org/10.1038/nature13028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.npp.1301453", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006608502", 
              "https://doi.org/10.1038/sj.npp.1301453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13229-017-0169-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092057009", 
              "https://doi.org/10.1186/s13229-017-0169-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.3465", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018701779", 
              "https://doi.org/10.1038/nn.3465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2014.156", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003531885", 
              "https://doi.org/10.1038/npp.2014.156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00213-013-3356-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000837373", 
              "https://doi.org/10.1007/s00213-013-3356-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40478-015-0198-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002960074", 
              "https://doi.org/10.1186/s40478-015-0198-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038973206", 
              "https://doi.org/10.1038/ng1136"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2020-12-17", 
        "datePublishedReg": "2020-12-17", 
        "description": "Autism spectrum disorder (ASD) is a continuum of neurodevelopmental disorders and needs new therapeutic approaches. Recently, oxytocin (OXT) showed potential as the first anti-ASD drug. Many reports have described the efficacy of intranasal OXT therapy to improve the core symptoms of patients with ASD; however, the underlying neurobiological mechanism remains unknown. The OXT/oxytocin receptor (OXTR) system, through the lateral septum (LS), contributes to social behavior, which is disrupted in ASD. Therefore, we selectively express hM3Dq in OXTR-expressing (OXTR+) neurons in the LS to investigate this effect in ASD mouse models developed by environmental and genetic cues. In mice that received valproic acid (environmental cue), we demonstrated successful recovery of impaired social memory with three-chamber test after OXTR+ neuron activation in the LS. Application of a similar strategy to Nl3R451C knock-in mice (genetic cue) also caused successful recovery of impaired social memory in single field test. OXTR+ neurons in the LS, which are activated by social stimuli, are projected to the CA1 region of the hippocampus. This study identified a candidate mechanism for improving core symptoms of ASD by artificial activation of DREADDs, as a simulation of OXT administration to activate OXTR+ neurons in the LS.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41598-020-79109-0", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.8428517", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.9199853", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5852051", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "keywords": [
          "lateral septum", 
          "impaired social memory", 
          "mouse model", 
          "core symptoms", 
          "autism spectrum disorder", 
          "three-chamber test", 
          "new therapeutic approaches", 
          "ASD mouse models", 
          "oxytocin receptor system", 
          "underlying neurobiological mechanisms", 
          "CA1 region", 
          "therapeutic approaches", 
          "OXT administration", 
          "valproic acid", 
          "oxytocin receptor", 
          "receptor system", 
          "successful recovery", 
          "neurobiological mechanisms", 
          "neurons", 
          "neurodevelopmental disorders", 
          "social novelty", 
          "symptoms", 
          "artificial activation", 
          "neuron activation", 
          "mice", 
          "oxytocin", 
          "disorders", 
          "septum", 
          "candidate mechanism", 
          "spectrum disorder", 
          "activation", 
          "patients", 
          "hippocampus", 
          "DREADDs", 
          "therapy", 
          "administration", 
          "social stimuli", 
          "receptors", 
          "drugs", 
          "efficacy", 
          "single field test", 
          "recovery", 
          "report", 
          "OXTR", 
          "test", 
          "stimuli", 
          "genetic cues", 
          "mechanism", 
          "social memory", 
          "similar strategies", 
          "social behavior", 
          "study", 
          "effect", 
          "acid", 
          "memory", 
          "field tests", 
          "strategies", 
          "cues", 
          "potential", 
          "model", 
          "region", 
          "continuum", 
          "approach", 
          "system", 
          "behavior", 
          "applications", 
          "novelty", 
          "simulations"
        ], 
        "name": "Targeting oxytocin receptor (Oxtr)-expressing neurons in the lateral septum to restore social novelty in autism spectrum disorder mouse models", 
        "pagination": "22173", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1133580692"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-020-79109-0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "33335150"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-020-79109-0", 
          "https://app.dimensions.ai/details/publication/pub.1133580692"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-09-02T16:05", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_842.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41598-020-79109-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-79109-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-79109-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-79109-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-79109-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    381 TRIPLES      21 PREDICATES      126 URIs      100 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-020-79109-0 schema:about N1cb92273644a431a8482a1a1c3266474
    2 N1e41e330b41847499a7ab8fd868510d4
    3 N3de6d1f7b1b54974809f06333633c78d
    4 N5c21ffef484d4b37860a91ea6704b6e3
    5 N5d1ed5c5051b410abcfffd39deec79af
    6 N5dd4500b3d2f45be80e989a7ce95be6a
    7 N5f6073ed1a6148fc89602083a50f34c3
    8 N632443bff2dc4325a127a7b56275d18f
    9 N645d1bf1d6fa4dbb9e0f24dcfc1ef429
    10 N65660e85a70a481794ead0806b2f89d8
    11 Nc28cf7b4b1e44ac7b47c0897ef60cff8
    12 Nc6eb61f7306546d780f83f7756505082
    13 Nd8b26f6728214e77896be87c04a83e0c
    14 Ned56cc11853546579e1af5dc186b0c52
    15 Nfabcdb7e29c14b7e81e6bd5d74d54bf1
    16 anzsrc-for:11
    17 anzsrc-for:1109
    18 schema:author Nd1b28e2efcd04c2a84dcf028420087a3
    19 schema:citation sg:pub.10.1007/s00213-009-1466-y
    20 sg:pub.10.1007/s00213-013-3356-6
    21 sg:pub.10.1007/s11689-009-9023-x
    22 sg:pub.10.1007/s12035-013-8535-2
    23 sg:pub.10.1038/336170a0
    24 sg:pub.10.1038/nature13028
    25 sg:pub.10.1038/ng1136
    26 sg:pub.10.1038/nmeth.2559
    27 sg:pub.10.1038/nn.3465
    28 sg:pub.10.1038/npp.2014.156
    29 sg:pub.10.1038/npp.2015.81
    30 sg:pub.10.1038/npp.2017.56
    31 sg:pub.10.1038/nrn2614
    32 sg:pub.10.1038/s41467-017-02173-0
    33 sg:pub.10.1038/sj.npp.1300518
    34 sg:pub.10.1038/sj.npp.1301453
    35 sg:pub.10.1186/s13229-017-0169-1
    36 sg:pub.10.1186/s40478-015-0198-y
    37 schema:datePublished 2020-12-17
    38 schema:datePublishedReg 2020-12-17
    39 schema:description Autism spectrum disorder (ASD) is a continuum of neurodevelopmental disorders and needs new therapeutic approaches. Recently, oxytocin (OXT) showed potential as the first anti-ASD drug. Many reports have described the efficacy of intranasal OXT therapy to improve the core symptoms of patients with ASD; however, the underlying neurobiological mechanism remains unknown. The OXT/oxytocin receptor (OXTR) system, through the lateral septum (LS), contributes to social behavior, which is disrupted in ASD. Therefore, we selectively express hM3Dq in OXTR-expressing (OXTR+) neurons in the LS to investigate this effect in ASD mouse models developed by environmental and genetic cues. In mice that received valproic acid (environmental cue), we demonstrated successful recovery of impaired social memory with three-chamber test after OXTR+ neuron activation in the LS. Application of a similar strategy to Nl3R451C knock-in mice (genetic cue) also caused successful recovery of impaired social memory in single field test. OXTR+ neurons in the LS, which are activated by social stimuli, are projected to the CA1 region of the hippocampus. This study identified a candidate mechanism for improving core symptoms of ASD by artificial activation of DREADDs, as a simulation of OXT administration to activate OXTR+ neurons in the LS.
    40 schema:genre article
    41 schema:isAccessibleForFree true
    42 schema:isPartOf N304e7dd0f3924faba3a3dbe5b38b14a3
    43 N55dca3a9a46746ba8527fc771f16629e
    44 sg:journal.1045337
    45 schema:keywords ASD mouse models
    46 CA1 region
    47 DREADDs
    48 OXT administration
    49 OXTR
    50 acid
    51 activation
    52 administration
    53 applications
    54 approach
    55 artificial activation
    56 autism spectrum disorder
    57 behavior
    58 candidate mechanism
    59 continuum
    60 core symptoms
    61 cues
    62 disorders
    63 drugs
    64 effect
    65 efficacy
    66 field tests
    67 genetic cues
    68 hippocampus
    69 impaired social memory
    70 lateral septum
    71 mechanism
    72 memory
    73 mice
    74 model
    75 mouse model
    76 neurobiological mechanisms
    77 neurodevelopmental disorders
    78 neuron activation
    79 neurons
    80 new therapeutic approaches
    81 novelty
    82 oxytocin
    83 oxytocin receptor
    84 oxytocin receptor system
    85 patients
    86 potential
    87 receptor system
    88 receptors
    89 recovery
    90 region
    91 report
    92 septum
    93 similar strategies
    94 simulations
    95 single field test
    96 social behavior
    97 social memory
    98 social novelty
    99 social stimuli
    100 spectrum disorder
    101 stimuli
    102 strategies
    103 study
    104 successful recovery
    105 symptoms
    106 system
    107 test
    108 therapeutic approaches
    109 therapy
    110 three-chamber test
    111 underlying neurobiological mechanisms
    112 valproic acid
    113 schema:name Targeting oxytocin receptor (Oxtr)-expressing neurons in the lateral septum to restore social novelty in autism spectrum disorder mouse models
    114 schema:pagination 22173
    115 schema:productId N062f44af76134454b14c303a25984e51
    116 N12c554c1f9e04ba5a52ff8b6acc74f51
    117 Ne11adffeb8b4461c93d1bd66d4c5f971
    118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1133580692
    119 https://doi.org/10.1038/s41598-020-79109-0
    120 schema:sdDatePublished 2022-09-02T16:05
    121 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    122 schema:sdPublisher N8d4ab15ae6d849baae058cfaa73535f7
    123 schema:url https://doi.org/10.1038/s41598-020-79109-0
    124 sgo:license sg:explorer/license/
    125 sgo:sdDataset articles
    126 rdf:type schema:ScholarlyArticle
    127 N062f44af76134454b14c303a25984e51 schema:name pubmed_id
    128 schema:value 33335150
    129 rdf:type schema:PropertyValue
    130 N06fb1748579c446ebbba41aaa1dafadb schema:affiliation grid-institutes:grid.69566.3a
    131 schema:familyName Horiai
    132 schema:givenName Machi
    133 rdf:type schema:Person
    134 N087abd9b78e6467fa7ced21570ceb3fc rdf:first sg:person.01147370103.20
    135 rdf:rest Nce4a019fe06846c3b4c4f4d4eaf38e9c
    136 N0965d7a2674d4da190fca802c44fd357 rdf:first sg:person.01236552226.13
    137 rdf:rest Nf14839129407435780718cca42c95b08
    138 N0c09215b31dc47b8b26a46d20fc436c3 rdf:first sg:person.01045745577.48
    139 rdf:rest N087abd9b78e6467fa7ced21570ceb3fc
    140 N0eb422abea3e4d4aa57dac7450972513 rdf:first sg:person.0613664001.27
    141 rdf:rest N1f3ed0273f754b549d297a046831d614
    142 N12c554c1f9e04ba5a52ff8b6acc74f51 schema:name doi
    143 schema:value 10.1038/s41598-020-79109-0
    144 rdf:type schema:PropertyValue
    145 N1c28037d1fc84b3eb1a44bf559ab78c0 rdf:first sg:person.01220434613.22
    146 rdf:rest Nbd874c0f31b8491cba10f7baf8929510
    147 N1cb92273644a431a8482a1a1c3266474 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Gene Expression
    149 rdf:type schema:DefinedTerm
    150 N1e41e330b41847499a7ab8fd868510d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Autism Spectrum Disorder
    152 rdf:type schema:DefinedTerm
    153 N1f3ed0273f754b549d297a046831d614 rdf:first sg:person.01041356334.24
    154 rdf:rest Nbc4521b33d4848b3b9271cdf386f01d4
    155 N304e7dd0f3924faba3a3dbe5b38b14a3 schema:issueNumber 1
    156 rdf:type schema:PublicationIssue
    157 N3de6d1f7b1b54974809f06333633c78d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Septum of Brain
    159 rdf:type schema:DefinedTerm
    160 N55dca3a9a46746ba8527fc771f16629e schema:volumeNumber 10
    161 rdf:type schema:PublicationVolume
    162 N5c21ffef484d4b37860a91ea6704b6e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Animals
    164 rdf:type schema:DefinedTerm
    165 N5d1ed5c5051b410abcfffd39deec79af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Social Behavior
    167 rdf:type schema:DefinedTerm
    168 N5dd4500b3d2f45be80e989a7ce95be6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Anxiety
    170 rdf:type schema:DefinedTerm
    171 N5f6073ed1a6148fc89602083a50f34c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Mice
    173 rdf:type schema:DefinedTerm
    174 N632443bff2dc4325a127a7b56275d18f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Molecular Targeted Therapy
    176 rdf:type schema:DefinedTerm
    177 N645d1bf1d6fa4dbb9e0f24dcfc1ef429 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Disease Models, Animal
    179 rdf:type schema:DefinedTerm
    180 N65660e85a70a481794ead0806b2f89d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Neurons
    182 rdf:type schema:DefinedTerm
    183 N8d4ab15ae6d849baae058cfaa73535f7 schema:name Springer Nature - SN SciGraph project
    184 rdf:type schema:Organization
    185 N9080639b7afd4558b08ce7869fda9f79 rdf:first sg:person.0647450163.26
    186 rdf:rest N9fd71612bf9843fb9c41ed08706d6f13
    187 N9a289c2f8dbb451ab2934987ad2d9064 rdf:first sg:person.01125300044.17
    188 rdf:rest N9080639b7afd4558b08ce7869fda9f79
    189 N9fd71612bf9843fb9c41ed08706d6f13 rdf:first sg:person.0634371603.10
    190 rdf:rest N0eb422abea3e4d4aa57dac7450972513
    191 Nbc4521b33d4848b3b9271cdf386f01d4 rdf:first sg:person.01142306011.77
    192 rdf:rest N0965d7a2674d4da190fca802c44fd357
    193 Nbd874c0f31b8491cba10f7baf8929510 rdf:first sg:person.01151605507.23
    194 rdf:rest rdf:nil
    195 Nc28cf7b4b1e44ac7b47c0897ef60cff8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Mice, Knockout
    197 rdf:type schema:DefinedTerm
    198 Nc6eb61f7306546d780f83f7756505082 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Fluorescent Antibody Technique
    200 rdf:type schema:DefinedTerm
    201 Nce4a019fe06846c3b4c4f4d4eaf38e9c rdf:first sg:person.01136640226.18
    202 rdf:rest N9a289c2f8dbb451ab2934987ad2d9064
    203 Nd1b28e2efcd04c2a84dcf028420087a3 rdf:first N06fb1748579c446ebbba41aaa1dafadb
    204 rdf:rest N0c09215b31dc47b8b26a46d20fc436c3
    205 Nd8b26f6728214e77896be87c04a83e0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Pyramidal Cells
    207 rdf:type schema:DefinedTerm
    208 Ne11adffeb8b4461c93d1bd66d4c5f971 schema:name dimensions_id
    209 schema:value pub.1133580692
    210 rdf:type schema:PropertyValue
    211 Ned56cc11853546579e1af5dc186b0c52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Receptors, Oxytocin
    213 rdf:type schema:DefinedTerm
    214 Nf14839129407435780718cca42c95b08 rdf:first sg:person.0677121374.34
    215 rdf:rest N1c28037d1fc84b3eb1a44bf559ab78c0
    216 Nfabcdb7e29c14b7e81e6bd5d74d54bf1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    217 schema:name Behavior, Animal
    218 rdf:type schema:DefinedTerm
    219 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    220 schema:name Medical and Health Sciences
    221 rdf:type schema:DefinedTerm
    222 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    223 schema:name Neurosciences
    224 rdf:type schema:DefinedTerm
    225 sg:grant.5852051 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-020-79109-0
    226 rdf:type schema:MonetaryGrant
    227 sg:grant.8428517 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-020-79109-0
    228 rdf:type schema:MonetaryGrant
    229 sg:grant.9199853 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-020-79109-0
    230 rdf:type schema:MonetaryGrant
    231 sg:journal.1045337 schema:issn 2045-2322
    232 schema:name Scientific Reports
    233 schema:publisher Springer Nature
    234 rdf:type schema:Periodical
    235 sg:person.01041356334.24 schema:affiliation grid-institutes:grid.64337.35
    236 schema:familyName Teruyama
    237 schema:givenName Ryoichi
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041356334.24
    239 rdf:type schema:Person
    240 sg:person.01045745577.48 schema:affiliation grid-institutes:grid.411582.b
    241 schema:familyName Otsuka
    242 schema:givenName Ayano
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045745577.48
    244 rdf:type schema:Person
    245 sg:person.01125300044.17 schema:affiliation grid-institutes:grid.471412.5
    246 schema:familyName Hayashi
    247 schema:givenName Ryotaro
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125300044.17
    249 rdf:type schema:Person
    250 sg:person.01136640226.18 schema:affiliation grid-institutes:grid.265073.5
    251 schema:familyName Hiraoka
    252 schema:givenName Yuichi
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136640226.18
    254 rdf:type schema:Person
    255 sg:person.01142306011.77 schema:affiliation grid-institutes:grid.7597.c
    256 schema:familyName Tamura
    257 schema:givenName Masaru
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142306011.77
    259 rdf:type schema:Person
    260 sg:person.01147370103.20 schema:affiliation grid-institutes:grid.411582.b
    261 schema:familyName Hidema
    262 schema:givenName Shizu
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147370103.20
    264 rdf:type schema:Person
    265 sg:person.01151605507.23 schema:affiliation grid-institutes:grid.411582.b
    266 schema:familyName Nishimori
    267 schema:givenName Katsuhiko
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151605507.23
    269 rdf:type schema:Person
    270 sg:person.01220434613.22 schema:affiliation grid-institutes:grid.411582.b
    271 schema:familyName Shimomura
    272 schema:givenName Kenju
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220434613.22
    274 rdf:type schema:Person
    275 sg:person.01236552226.13 schema:affiliation grid-institutes:grid.26999.3d
    276 schema:familyName Bito
    277 schema:givenName Haruhiko
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236552226.13
    279 rdf:type schema:Person
    280 sg:person.0613664001.27 schema:affiliation grid-institutes:grid.410804.9
    281 schema:familyName Mizukami
    282 schema:givenName Hiroaki
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613664001.27
    284 rdf:type schema:Person
    285 sg:person.0634371603.10 schema:affiliation grid-institutes:grid.7597.c
    286 schema:familyName Furuse
    287 schema:givenName Tamio
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634371603.10
    289 rdf:type schema:Person
    290 sg:person.0647450163.26 schema:affiliation grid-institutes:grid.69566.3a
    291 schema:familyName Miyazaki
    292 schema:givenName Shinji
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647450163.26
    294 rdf:type schema:Person
    295 sg:person.0677121374.34 schema:affiliation grid-institutes:grid.411582.b
    296 schema:familyName Maejima
    297 schema:givenName Yuko
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677121374.34
    299 rdf:type schema:Person
    300 sg:pub.10.1007/s00213-009-1466-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1003670684
    301 https://doi.org/10.1007/s00213-009-1466-y
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1007/s00213-013-3356-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000837373
    304 https://doi.org/10.1007/s00213-013-3356-6
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1007/s11689-009-9023-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003067301
    307 https://doi.org/10.1007/s11689-009-9023-x
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1007/s12035-013-8535-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003836732
    310 https://doi.org/10.1007/s12035-013-8535-2
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/336170a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021927311
    313 https://doi.org/10.1038/336170a0
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/nature13028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044165099
    316 https://doi.org/10.1038/nature13028
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/ng1136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038973206
    319 https://doi.org/10.1038/ng1136
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/nmeth.2559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020352117
    322 https://doi.org/10.1038/nmeth.2559
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1038/nn.3465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018701779
    325 https://doi.org/10.1038/nn.3465
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/npp.2014.156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003531885
    328 https://doi.org/10.1038/npp.2014.156
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/npp.2015.81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025468764
    331 https://doi.org/10.1038/npp.2015.81
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/npp.2017.56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129531
    334 https://doi.org/10.1038/npp.2017.56
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/nrn2614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016525767
    337 https://doi.org/10.1038/nrn2614
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/s41467-017-02173-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093156833
    340 https://doi.org/10.1038/s41467-017-02173-0
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/sj.npp.1300518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049034130
    343 https://doi.org/10.1038/sj.npp.1300518
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/sj.npp.1301453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006608502
    346 https://doi.org/10.1038/sj.npp.1301453
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1186/s13229-017-0169-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092057009
    349 https://doi.org/10.1186/s13229-017-0169-1
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1186/s40478-015-0198-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1002960074
    352 https://doi.org/10.1186/s40478-015-0198-y
    353 rdf:type schema:CreativeWork
    354 grid-institutes:grid.265073.5 schema:alternateName Laboratory for Molecular Neuroscience Medical Research Institute, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan
    355 schema:name Laboratory for Molecular Neuroscience Medical Research Institute, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan
    356 rdf:type schema:Organization
    357 grid-institutes:grid.26999.3d schema:alternateName Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, 113-0033, Tokyo, Japan
    358 schema:name Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, 113-0033, Tokyo, Japan
    359 rdf:type schema:Organization
    360 grid-institutes:grid.410804.9 schema:alternateName Division of Genetic Therapeutics, Center for Medicine, Jichi Medical University, 329-0498, Shimotsuke, Tochigi, Japan
    361 schema:name Division of Genetic Therapeutics, Center for Medicine, Jichi Medical University, 329-0498, Shimotsuke, Tochigi, Japan
    362 rdf:type schema:Organization
    363 grid-institutes:grid.411582.b schema:alternateName Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan
    364 Department of Obesity and Internal Inflammation, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan
    365 schema:name Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan
    366 Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki-Aza-Aoba, Aoba-ku, 980-0845, Sendai, Miyagi, Japan
    367 Department of Obesity and Internal Inflammation, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan
    368 rdf:type schema:Organization
    369 grid-institutes:grid.471412.5 schema:alternateName Innovation Center, Nippon Flour Mills Co., Ltd., 5-1-3 Midorigaoka, 243-0041, Atsugi, Kanagawa, Japan
    370 schema:name Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki-Aza-Aoba, Aoba-ku, 980-0845, Sendai, Miyagi, Japan
    371 Innovation Center, Nippon Flour Mills Co., Ltd., 5-1-3 Midorigaoka, 243-0041, Atsugi, Kanagawa, Japan
    372 rdf:type schema:Organization
    373 grid-institutes:grid.64337.35 schema:alternateName Department of Biological Sciences, Louisiana State University, 70803, Baton Rouge, LA, USA
    374 schema:name Department of Biological Sciences, Louisiana State University, 70803, Baton Rouge, LA, USA
    375 rdf:type schema:Organization
    376 grid-institutes:grid.69566.3a schema:alternateName Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki-Aza-Aoba, Aoba-ku, 980-0845, Sendai, Miyagi, Japan
    377 schema:name Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki-Aza-Aoba, Aoba-ku, 980-0845, Sendai, Miyagi, Japan
    378 rdf:type schema:Organization
    379 grid-institutes:grid.7597.c schema:alternateName Technology and Development Team for Mouse Phenotype Analysis, Japan Mouse Clinic, RIKEN BioResouce Reserch Center (BRC), 3-1-1 Koyadai, 305-0074, Tsukuba, Ibaraki, Japan
    380 schema:name Technology and Development Team for Mouse Phenotype Analysis, Japan Mouse Clinic, RIKEN BioResouce Reserch Center (BRC), 3-1-1 Koyadai, 305-0074, Tsukuba, Ibaraki, Japan
    381 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...