Factors influencing therapy choice and clinical outcome in cerebral venous sinus thrombosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-12-10

AUTHORS

Dagmar Krajíčková, Jiří Král, Roman Herzig, Ľudovít Klzo, Antonín Krajina, Jaroslav Havelka, Libor Šimůnek, Oldřich Vyšata, Tran Van Quang, Michal Bar, Martin Vališ

ABSTRACT

We aimed was to assess the factors influencing therapy choice and clinical outcome after 3–4 months in patients with cerebral venous sinus thrombosis (CVST). In a retrospective, bi-centric study, the set consisted of 82 consecutive CVST patients (61 females; mean age 33.5 ± 15.7 years). Following data were collected: baseline characteristics, presence of gender-specific risk factors (GSRF), location and extent of venous sinus impairment, clinical presentation, type of treatment, recanalization, presence of parenchymal lesions, and clinical outcome after 3–4 months (assessed using the modified Rankin Scale [mRS], with excellent outcome defined as mRS 0–1). Multivariate logistic regression analysis was used for statistical evaluation. After 3–4 months, complete recovery was achieved in 41 (50%) and excellent clinical outcome in 67 (81.7%) patients. Female sex (OR 0.11; p = 0.0189) and presence of focal neurologic deficit (OR 0.16; p = 0.0165) were identified as significant independent negative predictors and, the presence of GSRF (OR 15.63; p = 0.0011) as significant independent positive predictor of excellent clinical outcome. In conclusion, in our CVST patients, the presence of GSRF was associated with excellent clinical outcome, while the female sex itself was associated with poorer clinical outcome. More... »

PAGES

21633

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URI

http://scigraph.springernature.com/pub.10.1038/s41598-020-78434-8

DOI

http://dx.doi.org/10.1038/s41598-020-78434-8

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https://app.dimensions.ai/details/publication/pub.1133368881

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33303787


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