Impact of HLA class I allele-level mismatch on viral infection within 100 days after cord blood transplantation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-12-03

AUTHORS

Tomoki Iemura, Yasuyuki Arai, Junya Kanda, Toshio Kitawaki, Masakatsu Hishizawa, Tadakazu Kondo, Kouhei Yamashita, Akifumi Takaori-Kondo

ABSTRACT

Viral infection is more frequently reported in cord blood transplantation (CBT) than in transplantation of other stem cell sources, but its precise mechanism related to antiviral host defenses has not been elucidated yet. To evaluate the effect of human leukocyte antigen (HLA) class I allele-level incompatibility on viral infection in CBT, we conducted a single-center retrospective study. Total 94 patients were included, and viral infections were detected in 32 patients (34%) within 100 days after CBT. HLA-C mismatches in graft-versus-host direction showed a significantly higher incidence of viral infection (hazard ratio (HR), 3.67; p = 0.01), while mismatches in HLA-A, -B, or -DRB1 were not significant. Overall HLA class I mismatch was also a significant risk factor and the predictor of post-CBT viral infection (≥ 3 mismatches, HR 2.38, p = 0.02), probably due to the insufficient cytotoxic T cell recognition and dendritic cell priming. Patients with viral infection had significantly worse overall survival (52.7% vs. 72.1%; p = 0.02), and higher non-relapse mortality (29.3% vs. 9.8%; p = 0.01) at 5 years. Our findings suggest that appropriate graft selection as well as prophylaxis and early intervention for viral infection in such high-risk patients with ≥ 3 HLA class I allele-level mismatches, including HLA-C, may improve CBT outcomes. More... »

PAGES

21150

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-020-78259-5

DOI

http://dx.doi.org/10.1038/s41598-020-78259-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1132950974

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33273656


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cord Blood Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histocompatibility Antigens Class I", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Incidence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multivariate Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recurrence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Virus Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iemura", 
        "givenName": "Tomoki", 
        "id": "sg:person.016341550740.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016341550740.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Laboratory Medicine, Graduate School of Medicine, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
            "Department of Clinical Laboratory Medicine, Graduate School of Medicine, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arai", 
        "givenName": "Yasuyuki", 
        "id": "sg:person.0632351344.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632351344.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kanda", 
        "givenName": "Junya", 
        "id": "sg:person.01100640630.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100640630.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kitawaki", 
        "givenName": "Toshio", 
        "id": "sg:person.0617700541.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617700541.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hishizawa", 
        "givenName": "Masakatsu", 
        "id": "sg:person.01133351543.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133351543.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kondo", 
        "givenName": "Tadakazu", 
        "id": "sg:person.0666225507.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666225507.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamashita", 
        "givenName": "Kouhei", 
        "id": "sg:person.0700464544.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700464544.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takaori-Kondo", 
        "givenName": "Akifumi", 
        "id": "sg:person.0743352217.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743352217.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bmt.2015.162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036041636", 
          "https://doi.org/10.1038/bmt.2015.162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12878-016-0050-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042830042", 
          "https://doi.org/10.1186/s12878-016-0050-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2013.235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018618056", 
          "https://doi.org/10.1038/bmt.2013.235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00277-014-2222-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009467187", 
          "https://doi.org/10.1007/s00277-014-2222-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41409-018-0369-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1108038512", 
          "https://doi.org/10.1038/s41409-018-0369-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2012.244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028358194", 
          "https://doi.org/10.1038/bmt.2012.244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1703270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038624434", 
          "https://doi.org/10.1038/sj.bmt.1703270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2017.175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091081783", 
          "https://doi.org/10.1038/bmt.2017.175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2012.180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053094923", 
          "https://doi.org/10.1038/bmt.2012.180"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-12-03", 
    "datePublishedReg": "2020-12-03", 
    "description": "Viral infection is more frequently reported in cord blood transplantation (CBT) than in transplantation of other stem cell sources, but its precise mechanism related to antiviral host defenses has not been elucidated yet. To evaluate the effect of human leukocyte antigen (HLA) class I allele-level incompatibility on viral infection in CBT, we conducted a single-center retrospective study. Total 94 patients were included, and viral infections were detected in 32 patients (34%) within 100\u00a0days after CBT. HLA-C mismatches in graft-versus-host direction showed a significantly higher incidence of viral infection (hazard ratio (HR), 3.67; p\u2009=\u20090.01), while mismatches in HLA-A, -B, or -DRB1 were not significant. Overall HLA class I mismatch was also a significant risk factor and the predictor of post-CBT viral infection (\u2265\u20093 mismatches, HR 2.38, p\u2009=\u20090.02), probably due to the insufficient cytotoxic T cell recognition and dendritic cell priming. Patients with viral infection had significantly worse overall survival (52.7% vs. 72.1%; p\u2009=\u20090.02), and higher non-relapse mortality (29.3% vs. 9.8%; p\u2009=\u20090.01) at 5\u00a0years. Our findings suggest that appropriate graft selection as well as prophylaxis and early intervention for viral infection in such high-risk patients with \u2265\u20093 HLA class I allele-level mismatches, including HLA-C, may improve CBT outcomes.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-020-78259-5", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8421189", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "keywords": [
      "cord blood transplantation", 
      "viral infection", 
      "blood transplantation", 
      "HLA class I mismatches", 
      "higher non-relapse mortality", 
      "single-center retrospective study", 
      "such high-risk patients", 
      "cytotoxic T cell recognition", 
      "HLA-C mismatches", 
      "dendritic cell priming", 
      "non-relapse mortality", 
      "appropriate graft selection", 
      "high-risk patients", 
      "worse overall survival", 
      "significant risk factors", 
      "T cell recognition", 
      "antiviral host defense", 
      "stem cell source", 
      "overall survival", 
      "host direction", 
      "cell priming", 
      "retrospective study", 
      "graft selection", 
      "risk factors", 
      "high incidence", 
      "early intervention", 
      "patients", 
      "host defense", 
      "infection", 
      "transplantation", 
      "CBT outcome", 
      "precise mechanism", 
      "cell recognition", 
      "cell source", 
      "HLA", 
      "days", 
      "prophylaxis", 
      "graft", 
      "DRB1", 
      "mortality", 
      "incidence", 
      "survival", 
      "intervention", 
      "outcomes", 
      "predictors", 
      "priming", 
      "years", 
      "findings", 
      "factors", 
      "study", 
      "effect", 
      "defense", 
      "mechanism", 
      "impact", 
      "recognition", 
      "mismatch", 
      "selection", 
      "incompatibility", 
      "source", 
      "direction"
    ], 
    "name": "Impact of HLA class I allele-level mismatch on viral infection within 100 days after cord blood transplantation", 
    "pagination": "21150", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1132950974"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-020-78259-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "33273656"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-020-78259-5", 
      "https://app.dimensions.ai/details/publication/pub.1132950974"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_850.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-020-78259-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-78259-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-78259-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-78259-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-78259-5'


 

This table displays all metadata directly associated to this object as RDF triples.

273 TRIPLES      21 PREDICATES      110 URIs      93 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-020-78259-5 schema:about N050c9adc49134716a695dc9d6c99bf05
2 N1b912f9cccdc452191727d0f8861dcdd
3 N3dc3900f9990444e8ac6e8c79aa26dc8
4 N6047febfcc5c4a96b1f2d02ff2860a21
5 N66d0e0345178420f801b1ccd5d40bff6
6 N72b24aa93cff4c3bbfb0ae5ba3831864
7 N7d328fc92e58423f88ec78eb5b2f6acf
8 N7fdfad70b9c84a8a9b1d756933bf1f28
9 N8a10f1e19d174cfc97f3b0a7b43a087b
10 N91a509e1353a4770b2d4cacb74b796b5
11 Na2a8356d01004b6a8459e1a1b049acc1
12 Na7800560014e439b9f85816c94adcafb
13 Naccc70f951614ac1bbb80c316ed89596
14 Nbb2f4dc781e64d279f3adb7ef5cf447a
15 Nc21329090e8b4bdea218a8cbb8c62ed0
16 Nf5f22ffad4704b1f9d742b0c95a463e8
17 anzsrc-for:11
18 anzsrc-for:1107
19 schema:author Nccb062cfe0be4611b9b58f4d59779c8b
20 schema:citation sg:pub.10.1007/s00277-014-2222-x
21 sg:pub.10.1038/bmt.2012.180
22 sg:pub.10.1038/bmt.2012.244
23 sg:pub.10.1038/bmt.2013.235
24 sg:pub.10.1038/bmt.2015.162
25 sg:pub.10.1038/bmt.2017.175
26 sg:pub.10.1038/s41409-018-0369-0
27 sg:pub.10.1038/sj.bmt.1703270
28 sg:pub.10.1186/s12878-016-0050-z
29 schema:datePublished 2020-12-03
30 schema:datePublishedReg 2020-12-03
31 schema:description Viral infection is more frequently reported in cord blood transplantation (CBT) than in transplantation of other stem cell sources, but its precise mechanism related to antiviral host defenses has not been elucidated yet. To evaluate the effect of human leukocyte antigen (HLA) class I allele-level incompatibility on viral infection in CBT, we conducted a single-center retrospective study. Total 94 patients were included, and viral infections were detected in 32 patients (34%) within 100 days after CBT. HLA-C mismatches in graft-versus-host direction showed a significantly higher incidence of viral infection (hazard ratio (HR), 3.67; p = 0.01), while mismatches in HLA-A, -B, or -DRB1 were not significant. Overall HLA class I mismatch was also a significant risk factor and the predictor of post-CBT viral infection (≥ 3 mismatches, HR 2.38, p = 0.02), probably due to the insufficient cytotoxic T cell recognition and dendritic cell priming. Patients with viral infection had significantly worse overall survival (52.7% vs. 72.1%; p = 0.02), and higher non-relapse mortality (29.3% vs. 9.8%; p = 0.01) at 5 years. Our findings suggest that appropriate graft selection as well as prophylaxis and early intervention for viral infection in such high-risk patients with ≥ 3 HLA class I allele-level mismatches, including HLA-C, may improve CBT outcomes.
32 schema:genre article
33 schema:isAccessibleForFree true
34 schema:isPartOf N37df20cb2fbd4ddfbdaeba09e22040fd
35 Nfffe2e4e0e9049e6af32aede9e61e404
36 sg:journal.1045337
37 schema:keywords CBT outcome
38 DRB1
39 HLA
40 HLA class I mismatches
41 HLA-C mismatches
42 T cell recognition
43 antiviral host defense
44 appropriate graft selection
45 blood transplantation
46 cell priming
47 cell recognition
48 cell source
49 cord blood transplantation
50 cytotoxic T cell recognition
51 days
52 defense
53 dendritic cell priming
54 direction
55 early intervention
56 effect
57 factors
58 findings
59 graft
60 graft selection
61 high incidence
62 high-risk patients
63 higher non-relapse mortality
64 host defense
65 host direction
66 impact
67 incidence
68 incompatibility
69 infection
70 intervention
71 mechanism
72 mismatch
73 mortality
74 non-relapse mortality
75 outcomes
76 overall survival
77 patients
78 precise mechanism
79 predictors
80 priming
81 prophylaxis
82 recognition
83 retrospective study
84 risk factors
85 selection
86 significant risk factors
87 single-center retrospective study
88 source
89 stem cell source
90 study
91 such high-risk patients
92 survival
93 transplantation
94 viral infection
95 worse overall survival
96 years
97 schema:name Impact of HLA class I allele-level mismatch on viral infection within 100 days after cord blood transplantation
98 schema:pagination 21150
99 schema:productId N589263a7f55444a797235e46bdcba530
100 N9629ee3c095b4c42b0ebb8a5ce363bab
101 Nd7f2055ee82745c783bb2c5b8aeea64f
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132950974
103 https://doi.org/10.1038/s41598-020-78259-5
104 schema:sdDatePublished 2022-12-01T06:40
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher N3c8a4d1fe8f34109a9197ae3e458e474
107 schema:url https://doi.org/10.1038/s41598-020-78259-5
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N050c9adc49134716a695dc9d6c99bf05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Middle Aged
113 rdf:type schema:DefinedTerm
114 N0911f35067274db7b9e5ad5f55646ced rdf:first sg:person.0666225507.36
115 rdf:rest Nfaf5836f5e324dc1baee39a3189a5bb0
116 N0d63bf9bb91c4bc68e41ca36c4b8feed rdf:first sg:person.0743352217.37
117 rdf:rest rdf:nil
118 N1b912f9cccdc452191727d0f8861dcdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Recurrence
120 rdf:type schema:DefinedTerm
121 N37df20cb2fbd4ddfbdaeba09e22040fd schema:issueNumber 1
122 rdf:type schema:PublicationIssue
123 N3c8a4d1fe8f34109a9197ae3e458e474 schema:name Springer Nature - SN SciGraph project
124 rdf:type schema:Organization
125 N3dc3900f9990444e8ac6e8c79aa26dc8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Cord Blood Stem Cell Transplantation
127 rdf:type schema:DefinedTerm
128 N4ebd102bc7ff4e41901c2a3df49205a6 rdf:first sg:person.01133351543.21
129 rdf:rest N0911f35067274db7b9e5ad5f55646ced
130 N589263a7f55444a797235e46bdcba530 schema:name dimensions_id
131 schema:value pub.1132950974
132 rdf:type schema:PropertyValue
133 N6047febfcc5c4a96b1f2d02ff2860a21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Young Adult
135 rdf:type schema:DefinedTerm
136 N66d0e0345178420f801b1ccd5d40bff6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Virus Diseases
138 rdf:type schema:DefinedTerm
139 N72b24aa93cff4c3bbfb0ae5ba3831864 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Multivariate Analysis
141 rdf:type schema:DefinedTerm
142 N7d19b9e7eaec4604824c6964b9b6beee rdf:first sg:person.0632351344.47
143 rdf:rest Ndfc7bc15d1684e8a8d8a7f8757afcf01
144 N7d328fc92e58423f88ec78eb5b2f6acf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Alleles
146 rdf:type schema:DefinedTerm
147 N7fdfad70b9c84a8a9b1d756933bf1f28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Incidence
149 rdf:type schema:DefinedTerm
150 N8a10f1e19d174cfc97f3b0a7b43a087b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Aged
152 rdf:type schema:DefinedTerm
153 N91a509e1353a4770b2d4cacb74b796b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Adult
155 rdf:type schema:DefinedTerm
156 N939ae27fae974d618263ae558ae17d76 rdf:first sg:person.0617700541.45
157 rdf:rest N4ebd102bc7ff4e41901c2a3df49205a6
158 N9629ee3c095b4c42b0ebb8a5ce363bab schema:name pubmed_id
159 schema:value 33273656
160 rdf:type schema:PropertyValue
161 Na2a8356d01004b6a8459e1a1b049acc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Male
163 rdf:type schema:DefinedTerm
164 Na7800560014e439b9f85816c94adcafb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Humans
166 rdf:type schema:DefinedTerm
167 Naccc70f951614ac1bbb80c316ed89596 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Histocompatibility Antigens Class I
169 rdf:type schema:DefinedTerm
170 Nbb2f4dc781e64d279f3adb7ef5cf447a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Female
172 rdf:type schema:DefinedTerm
173 Nc21329090e8b4bdea218a8cbb8c62ed0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Treatment Outcome
175 rdf:type schema:DefinedTerm
176 Nccb062cfe0be4611b9b58f4d59779c8b rdf:first sg:person.016341550740.13
177 rdf:rest N7d19b9e7eaec4604824c6964b9b6beee
178 Nd7f2055ee82745c783bb2c5b8aeea64f schema:name doi
179 schema:value 10.1038/s41598-020-78259-5
180 rdf:type schema:PropertyValue
181 Ndfc7bc15d1684e8a8d8a7f8757afcf01 rdf:first sg:person.01100640630.10
182 rdf:rest N939ae27fae974d618263ae558ae17d76
183 Nf5f22ffad4704b1f9d742b0c95a463e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Risk Factors
185 rdf:type schema:DefinedTerm
186 Nfaf5836f5e324dc1baee39a3189a5bb0 rdf:first sg:person.0700464544.66
187 rdf:rest N0d63bf9bb91c4bc68e41ca36c4b8feed
188 Nfffe2e4e0e9049e6af32aede9e61e404 schema:volumeNumber 10
189 rdf:type schema:PublicationVolume
190 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
191 schema:name Medical and Health Sciences
192 rdf:type schema:DefinedTerm
193 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
194 schema:name Immunology
195 rdf:type schema:DefinedTerm
196 sg:grant.8421189 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-020-78259-5
197 rdf:type schema:MonetaryGrant
198 sg:journal.1045337 schema:issn 2045-2322
199 schema:name Scientific Reports
200 schema:publisher Springer Nature
201 rdf:type schema:Periodical
202 sg:person.01100640630.10 schema:affiliation grid-institutes:grid.258799.8
203 schema:familyName Kanda
204 schema:givenName Junya
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100640630.10
206 rdf:type schema:Person
207 sg:person.01133351543.21 schema:affiliation grid-institutes:grid.258799.8
208 schema:familyName Hishizawa
209 schema:givenName Masakatsu
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133351543.21
211 rdf:type schema:Person
212 sg:person.016341550740.13 schema:affiliation grid-institutes:grid.258799.8
213 schema:familyName Iemura
214 schema:givenName Tomoki
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016341550740.13
216 rdf:type schema:Person
217 sg:person.0617700541.45 schema:affiliation grid-institutes:grid.258799.8
218 schema:familyName Kitawaki
219 schema:givenName Toshio
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617700541.45
221 rdf:type schema:Person
222 sg:person.0632351344.47 schema:affiliation grid-institutes:grid.258799.8
223 schema:familyName Arai
224 schema:givenName Yasuyuki
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632351344.47
226 rdf:type schema:Person
227 sg:person.0666225507.36 schema:affiliation grid-institutes:grid.258799.8
228 schema:familyName Kondo
229 schema:givenName Tadakazu
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666225507.36
231 rdf:type schema:Person
232 sg:person.0700464544.66 schema:affiliation grid-institutes:grid.258799.8
233 schema:familyName Yamashita
234 schema:givenName Kouhei
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700464544.66
236 rdf:type schema:Person
237 sg:person.0743352217.37 schema:affiliation grid-institutes:grid.258799.8
238 schema:familyName Takaori-Kondo
239 schema:givenName Akifumi
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743352217.37
241 rdf:type schema:Person
242 sg:pub.10.1007/s00277-014-2222-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009467187
243 https://doi.org/10.1007/s00277-014-2222-x
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/bmt.2012.180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053094923
246 https://doi.org/10.1038/bmt.2012.180
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/bmt.2012.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028358194
249 https://doi.org/10.1038/bmt.2012.244
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/bmt.2013.235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018618056
252 https://doi.org/10.1038/bmt.2013.235
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/bmt.2015.162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036041636
255 https://doi.org/10.1038/bmt.2015.162
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/bmt.2017.175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091081783
258 https://doi.org/10.1038/bmt.2017.175
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/s41409-018-0369-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1108038512
261 https://doi.org/10.1038/s41409-018-0369-0
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/sj.bmt.1703270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038624434
264 https://doi.org/10.1038/sj.bmt.1703270
265 rdf:type schema:CreativeWork
266 sg:pub.10.1186/s12878-016-0050-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1042830042
267 https://doi.org/10.1186/s12878-016-0050-z
268 rdf:type schema:CreativeWork
269 grid-institutes:grid.258799.8 schema:alternateName Department of Clinical Laboratory Medicine, Graduate School of Medicine, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan
270 Department of Hematology and Oncology, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan
271 schema:name Department of Clinical Laboratory Medicine, Graduate School of Medicine, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan
272 Department of Hematology and Oncology, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan
273 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...