Pluripotent epigenetic regulator OBP-801 maintains filtering blebs in glaucoma filtration surgery model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-12-01

AUTHORS

Yuji Yamamoto, Atsushi Mukai, Toru Ikushima, Yasuo Urata, Shigeru Kinoshita, Junji Hamuro, Morio Ueno, Chie Sotozono

ABSTRACT

Inhibition of fibrosis is indispensable for maintaining filtering blebs after glaucoma filtration surgery (GFS). The purpose of this study was to investigate the ability of a pluripotent epigenetic regulator OBP-801 (OBP) to ameliorate extracellular matrix formation in a rabbit model of GFS. Rabbits that underwent GFS were treated with OBP. The gene expression profiles and intraocular pressure (IOP) were monitored until 30 postoperative days. The bleb tissues were evaluated for tissue fibrosis at 30 postoperative days. In in vitro models, OBP interfered the functions of diverse genes during the wound-healing process. In in vivo GFS models, the expressions of TGF-β3, MMP-2, TIMP-2 and 3, LOX, COL1A and SERPINH1 were significantly inhibited at 30 postoperative days in the OBP group compared with those in the vehicle control group. OBP treatment involving subconjunctival injection or eye drops showed no adverse effects, and reduced levels of α-SMA and collagen deposition at the surgical wound site. OBP maintained the long-lived bleb without scar formation, and IOP was lower at 30 postoperative days compared with the vehicle control group. These findings suggest that OBP is an effective and useful candidate low-molecular-weight agent for improving wound healing and surgical outcomes in a rabbit model of GFS. More... »

PAGES

20936

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-020-77811-7

DOI

http://dx.doi.org/10.1038/s41598-020-77811-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1132950415

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33262357


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blister", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cicatrix", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Collagen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epigenesis, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Filtering Surgery", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Enzymologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glaucoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intraocular Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myofibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptides, Cyclic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pluripotent Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Lysine 6-Oxidase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rabbits", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor beta2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wound Healing", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, 602-8566, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, 602-8566, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamamoto", 
        "givenName": "Yuji", 
        "id": "sg:person.013661171714.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013661171714.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, 602-8566, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, 602-8566, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mukai", 
        "givenName": "Atsushi", 
        "id": "sg:person.012134405525.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012134405525.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, 602-8566, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, 602-8566, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ikushima", 
        "givenName": "Toru", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oncolys BioPharma, Inc., 106-0032, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.459865.3", 
          "name": [
            "Oncolys BioPharma, Inc., 106-0032, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Urata", 
        "givenName": "Yasuo", 
        "id": "sg:person.01103016074.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103016074.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, 602-8566, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, 602-8566, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kinoshita", 
        "givenName": "Shigeru", 
        "id": "sg:person.01016754101.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016754101.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, 602-8566, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, 602-8566, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hamuro", 
        "givenName": "Junji", 
        "id": "sg:person.01236565401.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236565401.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, 602-8566, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, 602-8566, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ueno", 
        "givenName": "Morio", 
        "id": "sg:person.01074315450.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074315450.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, 602-8566, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, 602-8566, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sotozono", 
        "givenName": "Chie", 
        "id": "sg:person.0624777723.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624777723.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nm.2807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049248840", 
          "https://doi.org/10.1038/nm.2807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep35187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025699972", 
          "https://doi.org/10.1038/srep35187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-018-1722-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1110038029", 
          "https://doi.org/10.1007/s00109-018-1722-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-12-01", 
    "datePublishedReg": "2020-12-01", 
    "description": "Inhibition of fibrosis is indispensable for maintaining filtering blebs after glaucoma filtration surgery (GFS). The purpose of this study was to investigate the ability of a pluripotent epigenetic regulator OBP-801 (OBP) to ameliorate extracellular matrix formation in a rabbit model of GFS. Rabbits that underwent GFS were treated with OBP. The gene expression profiles and intraocular pressure (IOP) were monitored until 30 postoperative days. The bleb tissues were evaluated for tissue fibrosis at 30 postoperative days. In in vitro models, OBP interfered the functions of diverse genes during the wound-healing process. In in vivo GFS models, the expressions of TGF-\u03b23, MMP-2, TIMP-2 and 3, LOX, COL1A and SERPINH1 were significantly inhibited at 30 postoperative days in the OBP group compared with those in the vehicle control group. OBP treatment involving subconjunctival injection or eye drops showed no adverse effects, and reduced levels of \u03b1-SMA and collagen deposition at the surgical wound site. OBP maintained the long-lived bleb without scar formation, and IOP was lower at 30 postoperative days compared with the vehicle control group. These findings suggest that OBP is an effective and useful candidate low-molecular-weight agent for improving wound healing and surgical outcomes in a rabbit model of GFS.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-020-77811-7", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7536285", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.9209339", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "keywords": [
      "glaucoma filtration surgery", 
      "postoperative day", 
      "vehicle control group", 
      "intraocular pressure", 
      "OBP-801", 
      "control group", 
      "rabbit model", 
      "surgical wound site", 
      "inhibition of fibrosis", 
      "bleb tissues", 
      "subconjunctival injection", 
      "surgical outcomes", 
      "filtration surgery", 
      "eye drops", 
      "wound healing process", 
      "\u03b1-SMA", 
      "tissue fibrosis", 
      "collagen deposition", 
      "scar formation", 
      "MMP-2", 
      "TIMP-2", 
      "weight agents", 
      "surgery model", 
      "adverse effects", 
      "wound healing", 
      "TGF-\u03b23", 
      "reduced levels", 
      "gene expression profiles", 
      "fibrosis", 
      "wound site", 
      "extracellular matrix formation", 
      "days", 
      "blebs", 
      "expression profiles", 
      "group", 
      "useful candidate", 
      "matrix formation", 
      "surgery", 
      "rabbits", 
      "healing", 
      "outcomes", 
      "COL1A", 
      "treatment", 
      "injection", 
      "inhibition", 
      "tissue", 
      "SERPINH1", 
      "expression", 
      "agents", 
      "findings", 
      "LOX", 
      "levels", 
      "diverse genes", 
      "study", 
      "genes", 
      "OBPs", 
      "effect", 
      "profile", 
      "pressure", 
      "candidates", 
      "purpose", 
      "function", 
      "ability", 
      "model", 
      "sites", 
      "formation", 
      "drop", 
      "deposition", 
      "process", 
      "GFS model"
    ], 
    "name": "Pluripotent epigenetic regulator OBP-801 maintains filtering blebs in glaucoma filtration surgery model", 
    "pagination": "20936", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1132950415"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-020-77811-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "33262357"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-020-77811-7", 
      "https://app.dimensions.ai/details/publication/pub.1132950415"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T17:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_856.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-020-77811-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-77811-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-77811-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-77811-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-77811-7'


 

This table displays all metadata directly associated to this object as RDF triples.

283 TRIPLES      21 PREDICATES      119 URIs      108 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-020-77811-7 schema:about N141e5edb3fd84860ba945bc6ee3b86a8
2 N1637b07850a541bba3fb5c314c4bc56c
3 N25d2233298f14470a81fde2d3db5f0a9
4 N2986610e63b24e2eadd3e95de76b6648
5 N2d5b90c212804437bf90ebacafb07559
6 N3915a4ff3c434d8cb7483eff8ada7377
7 N426fcf2eefc1465e9725c1f379d18243
8 N5af835ac61134faeb35fac91f8c18c5b
9 N71ef9265b06c47b0b492492f2f4adf50
10 N7cd7ff784d004146996d51ed5d394988
11 N84fcecf389fa4567a5fa9e8eecee1815
12 N8c9ff84e5e7f4d71804c5ead5a030c34
13 N93cc4af0f0eb41be828a285469a0cc72
14 N98d2713fb93d417db4618a466b2ef6c9
15 Na5059b030ebc406aa12d8d9018be9d0f
16 Nb2f7890e6b9c4b00b130ce8601e301f3
17 Ncddc993a0e1a4812ae32c1a1f5de737b
18 Nd6261306b5f0469eb827914e0b816c5a
19 Nd715c456338f497b8eae9cf0e9fe7060
20 Nee6a0eade79c4a1f9bf54d4add78930f
21 Nfa7e2563b27748d4a47f606f03a5566c
22 anzsrc-for:11
23 anzsrc-for:1103
24 schema:author N3d789a75d40d40e8adb7844a8598aa84
25 schema:citation sg:pub.10.1007/s00109-018-1722-x
26 sg:pub.10.1038/nm.2807
27 sg:pub.10.1038/srep35187
28 schema:datePublished 2020-12-01
29 schema:datePublishedReg 2020-12-01
30 schema:description Inhibition of fibrosis is indispensable for maintaining filtering blebs after glaucoma filtration surgery (GFS). The purpose of this study was to investigate the ability of a pluripotent epigenetic regulator OBP-801 (OBP) to ameliorate extracellular matrix formation in a rabbit model of GFS. Rabbits that underwent GFS were treated with OBP. The gene expression profiles and intraocular pressure (IOP) were monitored until 30 postoperative days. The bleb tissues were evaluated for tissue fibrosis at 30 postoperative days. In in vitro models, OBP interfered the functions of diverse genes during the wound-healing process. In in vivo GFS models, the expressions of TGF-β3, MMP-2, TIMP-2 and 3, LOX, COL1A and SERPINH1 were significantly inhibited at 30 postoperative days in the OBP group compared with those in the vehicle control group. OBP treatment involving subconjunctival injection or eye drops showed no adverse effects, and reduced levels of α-SMA and collagen deposition at the surgical wound site. OBP maintained the long-lived bleb without scar formation, and IOP was lower at 30 postoperative days compared with the vehicle control group. These findings suggest that OBP is an effective and useful candidate low-molecular-weight agent for improving wound healing and surgical outcomes in a rabbit model of GFS.
31 schema:genre article
32 schema:isAccessibleForFree true
33 schema:isPartOf Nd33b4d8b84054f2ebfcb1bd1bab87907
34 Nf3b8486839864b45bd24a6bbd3d77760
35 sg:journal.1045337
36 schema:keywords COL1A
37 GFS model
38 LOX
39 MMP-2
40 OBP-801
41 OBPs
42 SERPINH1
43 TGF-β3
44 TIMP-2
45 ability
46 adverse effects
47 agents
48 bleb tissues
49 blebs
50 candidates
51 collagen deposition
52 control group
53 days
54 deposition
55 diverse genes
56 drop
57 effect
58 expression
59 expression profiles
60 extracellular matrix formation
61 eye drops
62 fibrosis
63 filtration surgery
64 findings
65 formation
66 function
67 gene expression profiles
68 genes
69 glaucoma filtration surgery
70 group
71 healing
72 inhibition
73 inhibition of fibrosis
74 injection
75 intraocular pressure
76 levels
77 matrix formation
78 model
79 outcomes
80 postoperative day
81 pressure
82 process
83 profile
84 purpose
85 rabbit model
86 rabbits
87 reduced levels
88 scar formation
89 sites
90 study
91 subconjunctival injection
92 surgery
93 surgery model
94 surgical outcomes
95 surgical wound site
96 tissue
97 tissue fibrosis
98 treatment
99 useful candidate
100 vehicle control group
101 weight agents
102 wound healing
103 wound healing process
104 wound site
105 α-SMA
106 schema:name Pluripotent epigenetic regulator OBP-801 maintains filtering blebs in glaucoma filtration surgery model
107 schema:pagination 20936
108 schema:productId N19a083642ff344279e42e1fd17896172
109 N5b7a15145c064a6eaf83be2c82354403
110 Nc4eb913d41844eb28a6d198b0902b9eb
111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132950415
112 https://doi.org/10.1038/s41598-020-77811-7
113 schema:sdDatePublished 2022-08-04T17:09
114 schema:sdLicense https://scigraph.springernature.com/explorer/license/
115 schema:sdPublisher N6ea97b01c5a9493ba63a60bdc5163a90
116 schema:url https://doi.org/10.1038/s41598-020-77811-7
117 sgo:license sg:explorer/license/
118 sgo:sdDataset articles
119 rdf:type schema:ScholarlyArticle
120 N0c3c1fdf05004520a95306d0eb679b4d rdf:first sg:person.01236565401.72
121 rdf:rest N8da162002b5545d68c76d06b91efca88
122 N141e5edb3fd84860ba945bc6ee3b86a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Tumor Necrosis Factor-alpha
124 rdf:type schema:DefinedTerm
125 N1637b07850a541bba3fb5c314c4bc56c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Pluripotent Stem Cells
127 rdf:type schema:DefinedTerm
128 N19a083642ff344279e42e1fd17896172 schema:name dimensions_id
129 schema:value pub.1132950415
130 rdf:type schema:PropertyValue
131 N21b75db583a541e1a65aabb9cf596b0e schema:affiliation grid-institutes:grid.272458.e
132 schema:familyName Ikushima
133 schema:givenName Toru
134 rdf:type schema:Person
135 N25d2233298f14470a81fde2d3db5f0a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Intraocular Pressure
137 rdf:type schema:DefinedTerm
138 N2986610e63b24e2eadd3e95de76b6648 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Disease Models, Animal
140 rdf:type schema:DefinedTerm
141 N2d5b90c212804437bf90ebacafb07559 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Epigenesis, Genetic
143 rdf:type schema:DefinedTerm
144 N3915a4ff3c434d8cb7483eff8ada7377 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Glaucoma
146 rdf:type schema:DefinedTerm
147 N3d789a75d40d40e8adb7844a8598aa84 rdf:first sg:person.013661171714.99
148 rdf:rest Nec579ff72aa74be08c546092f3901769
149 N426fcf2eefc1465e9725c1f379d18243 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Collagen
151 rdf:type schema:DefinedTerm
152 N4e72cffd05ce4cf194057ebe13872c3f rdf:first N21b75db583a541e1a65aabb9cf596b0e
153 rdf:rest Nda47bc1d82544000aa5491fedb807272
154 N5af835ac61134faeb35fac91f8c18c5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Gene Expression Regulation, Enzymologic
156 rdf:type schema:DefinedTerm
157 N5b7a15145c064a6eaf83be2c82354403 schema:name doi
158 schema:value 10.1038/s41598-020-77811-7
159 rdf:type schema:PropertyValue
160 N6ea97b01c5a9493ba63a60bdc5163a90 schema:name Springer Nature - SN SciGraph project
161 rdf:type schema:Organization
162 N71ef9265b06c47b0b492492f2f4adf50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Blister
164 rdf:type schema:DefinedTerm
165 N7cd7ff784d004146996d51ed5d394988 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Wound Healing
167 rdf:type schema:DefinedTerm
168 N84fcecf389fa4567a5fa9e8eecee1815 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Cicatrix
170 rdf:type schema:DefinedTerm
171 N8c9ff84e5e7f4d71804c5ead5a030c34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Rabbits
173 rdf:type schema:DefinedTerm
174 N8da162002b5545d68c76d06b91efca88 rdf:first sg:person.01074315450.48
175 rdf:rest Nd2e19f8d09d446c9b639119e7955fc32
176 N93cc4af0f0eb41be828a285469a0cc72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Fibrosis
178 rdf:type schema:DefinedTerm
179 N98d2713fb93d417db4618a466b2ef6c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Inflammation
181 rdf:type schema:DefinedTerm
182 Na5059b030ebc406aa12d8d9018be9d0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Filtering Surgery
184 rdf:type schema:DefinedTerm
185 Nb2f7890e6b9c4b00b130ce8601e301f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Peptides, Cyclic
187 rdf:type schema:DefinedTerm
188 Nc4eb913d41844eb28a6d198b0902b9eb schema:name pubmed_id
189 schema:value 33262357
190 rdf:type schema:PropertyValue
191 Ncddc993a0e1a4812ae32c1a1f5de737b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Myofibroblasts
193 rdf:type schema:DefinedTerm
194 Nd2e19f8d09d446c9b639119e7955fc32 rdf:first sg:person.0624777723.12
195 rdf:rest rdf:nil
196 Nd33b4d8b84054f2ebfcb1bd1bab87907 schema:volumeNumber 10
197 rdf:type schema:PublicationVolume
198 Nd6261306b5f0469eb827914e0b816c5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Disease Progression
200 rdf:type schema:DefinedTerm
201 Nd715c456338f497b8eae9cf0e9fe7060 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Protein-Lysine 6-Oxidase
203 rdf:type schema:DefinedTerm
204 Nda47bc1d82544000aa5491fedb807272 rdf:first sg:person.01103016074.35
205 rdf:rest Nde5730d8b44d42b784753ef17824d027
206 Nde5730d8b44d42b784753ef17824d027 rdf:first sg:person.01016754101.20
207 rdf:rest N0c3c1fdf05004520a95306d0eb679b4d
208 Nec579ff72aa74be08c546092f3901769 rdf:first sg:person.012134405525.77
209 rdf:rest N4e72cffd05ce4cf194057ebe13872c3f
210 Nee6a0eade79c4a1f9bf54d4add78930f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Animals
212 rdf:type schema:DefinedTerm
213 Nf3b8486839864b45bd24a6bbd3d77760 schema:issueNumber 1
214 rdf:type schema:PublicationIssue
215 Nfa7e2563b27748d4a47f606f03a5566c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Transforming Growth Factor beta2
217 rdf:type schema:DefinedTerm
218 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
219 schema:name Medical and Health Sciences
220 rdf:type schema:DefinedTerm
221 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
222 schema:name Clinical Sciences
223 rdf:type schema:DefinedTerm
224 sg:grant.7536285 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-020-77811-7
225 rdf:type schema:MonetaryGrant
226 sg:grant.9209339 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-020-77811-7
227 rdf:type schema:MonetaryGrant
228 sg:journal.1045337 schema:issn 2045-2322
229 schema:name Scientific Reports
230 schema:publisher Springer Nature
231 rdf:type schema:Periodical
232 sg:person.01016754101.20 schema:affiliation grid-institutes:grid.272458.e
233 schema:familyName Kinoshita
234 schema:givenName Shigeru
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016754101.20
236 rdf:type schema:Person
237 sg:person.01074315450.48 schema:affiliation grid-institutes:grid.272458.e
238 schema:familyName Ueno
239 schema:givenName Morio
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074315450.48
241 rdf:type schema:Person
242 sg:person.01103016074.35 schema:affiliation grid-institutes:grid.459865.3
243 schema:familyName Urata
244 schema:givenName Yasuo
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103016074.35
246 rdf:type schema:Person
247 sg:person.012134405525.77 schema:affiliation grid-institutes:grid.272458.e
248 schema:familyName Mukai
249 schema:givenName Atsushi
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012134405525.77
251 rdf:type schema:Person
252 sg:person.01236565401.72 schema:affiliation grid-institutes:grid.272458.e
253 schema:familyName Hamuro
254 schema:givenName Junji
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236565401.72
256 rdf:type schema:Person
257 sg:person.013661171714.99 schema:affiliation grid-institutes:grid.272458.e
258 schema:familyName Yamamoto
259 schema:givenName Yuji
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013661171714.99
261 rdf:type schema:Person
262 sg:person.0624777723.12 schema:affiliation grid-institutes:grid.272458.e
263 schema:familyName Sotozono
264 schema:givenName Chie
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624777723.12
266 rdf:type schema:Person
267 sg:pub.10.1007/s00109-018-1722-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1110038029
268 https://doi.org/10.1007/s00109-018-1722-x
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/nm.2807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049248840
271 https://doi.org/10.1038/nm.2807
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/srep35187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025699972
274 https://doi.org/10.1038/srep35187
275 rdf:type schema:CreativeWork
276 grid-institutes:grid.272458.e schema:alternateName Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, 602-8566, Kyoto, Japan
277 Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, 602-8566, Kyoto, Japan
278 schema:name Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, 602-8566, Kyoto, Japan
279 Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, 602-8566, Kyoto, Japan
280 rdf:type schema:Organization
281 grid-institutes:grid.459865.3 schema:alternateName Oncolys BioPharma, Inc., 106-0032, Tokyo, Japan
282 schema:name Oncolys BioPharma, Inc., 106-0032, Tokyo, Japan
283 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...