Resveratrol improves motor function in patients with muscular dystrophies: an open-label, single-arm, phase IIa study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-11-25

AUTHORS

Kentaro Kawamura, Shinobu Fukumura, Koki Nikaido, Nobutada Tachi, Naoki Kozuka, Tsugumi Seino, Kingya Hatakeyama, Mitsuru Mori, Yoichi M. Ito, Akiyoshi Takami, Shiro Hinotsu, Atsushi Kuno, Yukihiko Kawasaki, Yoshiyuki Horio, Hiroyuki Tsutsumi

ABSTRACT

Muscular dystrophies (MDs) are inherited disorders characterized by progressive muscle weakness. Previously, we have shown that resveratrol (3,5,4′-trihydroxy-trans-stilbene), an antioxidant and an activator of the protein deacetylase SIRT1, decreases muscular and cardiac oxidative damage and improves pathophysiological conditions in animal MD models. To determine whether resveratrol provides therapeutic benefits to patients with MDs, an open-label, single-arm, phase IIa trial of resveratrol was conducted in 11 patients with Duchenne, Becker or Fukuyama MD. The daily dose of resveratrol was 500 mg/day, which was increased every 8 weeks to 1000 and then 1500 mg/day. Primary outcomes were motor function, evaluated by a motor function measure (MFM) scale, muscular strength, monitored with quantitative muscle testing (QMT), and serum creatine kinase (CK) levels. Adverse effects and tolerability were evaluated as secondary outcomes. Despite the advanced medical conditions of the patients, the mean MFM scores increased significantly from 34.6 to 38.4 after 24 weeks of medication. A twofold increase was found in the mean QMT scores of scapula elevation and shoulder abduction. Mean CK levels decreased considerably by 34%. Diarrhoea and abdominal pain was noted in six and three patients, respectively. Resveratrol may provide some benefit to MD patients. More... »

PAGES

20585

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-020-77197-6

DOI

http://dx.doi.org/10.1038/s41598-020-77197-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1132921697

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33239684


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antioxidants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Creatine Kinase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Japan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Motor Activity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle Strength", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle Weakness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscular Dystrophies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Resveratrol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stilbenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Sapporo Medical University School of Medicine, 060-8543, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Pediatrics, Sapporo Medical University School of Medicine, 060-8543, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawamura", 
        "givenName": "Kentaro", 
        "id": "sg:person.014720546717.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014720546717.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Sapporo Medical University School of Medicine, 060-8543, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Pediatrics, Sapporo Medical University School of Medicine, 060-8543, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukumura", 
        "givenName": "Shinobu", 
        "id": "sg:person.01106055736.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106055736.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Sapporo Medical University School of Medicine, 060-8543, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Pediatrics, Sapporo Medical University School of Medicine, 060-8543, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nikaido", 
        "givenName": "Koki", 
        "id": "sg:person.01007323604.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007323604.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Faculty of Health Science, Hokkaido Chitose College of Rehabilitation, 066-0055, Chitose, Japan", 
          "id": "http://www.grid.ac/institutes/grid.505710.6", 
          "name": [
            "Faculty of Health Science, Hokkaido Chitose College of Rehabilitation, 066-0055, Chitose, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tachi", 
        "givenName": "Nobutada", 
        "id": "sg:person.01032152371.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032152371.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physical Therapy, Sapporo Medical University School of Health Sciences, 060-8556, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Physical Therapy, Sapporo Medical University School of Health Sciences, 060-8556, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kozuka", 
        "givenName": "Naoki", 
        "id": "sg:person.01155053337.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155053337.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physical Therapy, Sapporo Medical University School of Health Sciences, 060-8556, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Physical Therapy, Sapporo Medical University School of Health Sciences, 060-8556, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seino", 
        "givenName": "Tsugumi", 
        "id": "sg:person.011563314571.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011563314571.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Sapporo Medical University School of Medicine, 060-8543, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Pediatrics, Sapporo Medical University School of Medicine, 060-8543, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hatakeyama", 
        "givenName": "Kingya", 
        "id": "sg:person.07463634315.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07463634315.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Faculty of Health Science, Hokkaido Chitose College of Rehabilitation, 066-0055, Chitose, Japan", 
          "id": "http://www.grid.ac/institutes/grid.505710.6", 
          "name": [
            "Faculty of Health Science, Hokkaido Chitose College of Rehabilitation, 066-0055, Chitose, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mori", 
        "givenName": "Mitsuru", 
        "id": "sg:person.010755731132.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010755731132.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biostatistics Division, Clinical Research and Medical Innovation Center, Hokkaido University Hospital, 060-8648, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412167.7", 
          "name": [
            "Biostatistics Division, Clinical Research and Medical Innovation Center, Hokkaido University Hospital, 060-8648, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ito", 
        "givenName": "Yoichi M.", 
        "id": "sg:person.013170625662.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013170625662.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, 480-1195, Nagakute, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411234.1", 
          "name": [
            "Division of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, 480-1195, Nagakute, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takami", 
        "givenName": "Akiyoshi", 
        "id": "sg:person.0577702220.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577702220.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biostatistics, Sapporo Medical University School of Medicine, 060-8556, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Biostatistics, Sapporo Medical University School of Medicine, 060-8556, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hinotsu", 
        "givenName": "Shiro", 
        "id": "sg:person.0674557451.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674557451.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology, Sapporo Medical University School of Medicine, 060-8556, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Pharmacology, Sapporo Medical University School of Medicine, 060-8556, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuno", 
        "givenName": "Atsushi", 
        "id": "sg:person.01006661246.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006661246.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Sapporo Medical University School of Medicine, 060-8543, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Pediatrics, Sapporo Medical University School of Medicine, 060-8543, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawasaki", 
        "givenName": "Yukihiko", 
        "id": "sg:person.0650137105.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650137105.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology, Sapporo Medical University School of Medicine, 060-8556, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Pharmacology, Sapporo Medical University School of Medicine, 060-8556, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horio", 
        "givenName": "Yoshiyuki", 
        "id": "sg:person.01353564646.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353564646.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Sapporo Medical University School of Medicine, 060-8543, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Pediatrics, Sapporo Medical University School of Medicine, 060-8543, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsutsumi", 
        "givenName": "Hiroyuki", 
        "id": "sg:person.01351137664.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351137664.61"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature00904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051586568", 
          "https://doi.org/10.1038/nature00904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/28653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046686728", 
          "https://doi.org/10.1038/28653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01960", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037301833", 
          "https://doi.org/10.1038/nature01960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-018-33930-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107670629", 
          "https://doi.org/10.1038/s41598-018-33930-w"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-019-02315-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1112158342", 
          "https://doi.org/10.1007/s00262-019-02315-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm.2016.93", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038682840", 
          "https://doi.org/10.1038/nrm.2016.93"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-11-25", 
    "datePublishedReg": "2020-11-25", 
    "description": "Muscular dystrophies (MDs) are inherited disorders characterized by progressive muscle weakness. Previously, we have shown that resveratrol (3,5,4\u2032-trihydroxy-trans-stilbene), an antioxidant and an activator of the protein deacetylase SIRT1, decreases muscular and cardiac oxidative damage and improves pathophysiological conditions in animal MD models. To determine whether resveratrol provides therapeutic benefits to patients with MDs, an open-label, single-arm, phase IIa trial of resveratrol was conducted in 11 patients with Duchenne, Becker or Fukuyama MD. The daily dose of resveratrol was 500\u00a0mg/day, which was increased every 8\u00a0weeks to 1000 and then 1500\u00a0mg/day. Primary outcomes were motor function, evaluated by a motor function measure (MFM) scale, muscular strength, monitored with quantitative muscle testing (QMT), and serum creatine kinase (CK) levels. Adverse effects and tolerability were evaluated as secondary outcomes. Despite the advanced medical conditions of the patients, the mean MFM scores increased significantly from 34.6 to 38.4 after 24\u00a0weeks of medication. A twofold increase was found in the mean QMT scores of scapula elevation and shoulder abduction. Mean CK levels decreased considerably by 34%. Diarrhoea and abdominal pain was noted in six and three patients, respectively. Resveratrol may provide some benefit to MD patients.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-020-77197-6", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5866945", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7535173", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7533795", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "keywords": [
      "quantitative muscle testing", 
      "muscular dystrophy", 
      "motor function", 
      "Motor Function Measure Scale", 
      "serum creatine kinase levels", 
      "advanced medical conditions", 
      "phase IIa trial", 
      "phase IIa study", 
      "weeks of medication", 
      "creatine kinase levels", 
      "progressive muscle weakness", 
      "cardiac oxidative damage", 
      "Fukuyama muscular dystrophy", 
      "protein deacetylase SIRT1", 
      "MFM scores", 
      "scapula elevation", 
      "abdominal pain", 
      "IIa trial", 
      "Secondary outcomes", 
      "IIa study", 
      "daily dose", 
      "primary outcome", 
      "muscle testing", 
      "MDS patients", 
      "muscle weakness", 
      "kinase levels", 
      "medical conditions", 
      "shoulder abduction", 
      "therapeutic benefit", 
      "patients", 
      "CK levels", 
      "muscular strength", 
      "pathophysiological conditions", 
      "adverse effects", 
      "deacetylase SIRT1", 
      "resveratrol", 
      "measure scale", 
      "oxidative damage", 
      "twofold increase", 
      "weeks", 
      "dystrophy", 
      "outcomes", 
      "scores", 
      "days", 
      "tolerability", 
      "medications", 
      "pain", 
      "diarrhea", 
      "dose", 
      "SIRT1", 
      "trials", 
      "disorders", 
      "levels", 
      "abduction", 
      "benefits", 
      "elevation", 
      "antioxidants", 
      "Duchenne", 
      "activator", 
      "damage", 
      "function", 
      "testing", 
      "study", 
      "weakness", 
      "increase", 
      "effect", 
      "conditions", 
      "scale", 
      "model", 
      "strength", 
      "Becker", 
      "MD model"
    ], 
    "name": "Resveratrol improves motor function in patients with muscular dystrophies: an open-label, single-arm, phase IIa study", 
    "pagination": "20585", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1132921697"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-020-77197-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "33239684"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-020-77197-6", 
      "https://app.dimensions.ai/details/publication/pub.1132921697"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T21:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_857.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-020-77197-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-77197-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-77197-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-77197-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-77197-6'


 

This table displays all metadata directly associated to this object as RDF triples.

339 TRIPLES      21 PREDICATES      119 URIs      105 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-020-77197-6 schema:about N157e23939d6f40598ea03e25d45374d6
2 N2084b9cbe6ad40d7b1328e89381efec0
3 N26b6c3e1840546d789b62db1e4e25a01
4 N31a8f17a47d94e8a9a7539e3788af55c
5 N442bf7f12620474ca646282121a3f62f
6 N510674afcba84340a35aa17c93bbbe3c
7 N712458f82d814cc18e7cd4965feec1a7
8 N724fc401f68049b3b8a4be21808cefbe
9 N861cfcabee1449a2844209f44b4041a7
10 N8ab348f175754a8f8bd415ff5520916c
11 N8b0415de9d0348198d1b6b6c3bc26686
12 Nde930eadb0c14a709438628b68caebfb
13 Ne0249b660e27402baaffd69c77a33617
14 Ne9ada21e06844d5fbad0952fc7eb4d96
15 Neda6b6dfebc147fe82efd1d40aa00f20
16 Nfd46b545a1ec41cf8bfe15c379740022
17 anzsrc-for:11
18 anzsrc-for:1109
19 schema:author N0eaff58726814eb7bf83fe5ec90916dd
20 schema:citation sg:pub.10.1007/s00262-019-02315-x
21 sg:pub.10.1038/28653
22 sg:pub.10.1038/nature00904
23 sg:pub.10.1038/nature01960
24 sg:pub.10.1038/nrm.2016.93
25 sg:pub.10.1038/s41598-018-33930-w
26 schema:datePublished 2020-11-25
27 schema:datePublishedReg 2020-11-25
28 schema:description Muscular dystrophies (MDs) are inherited disorders characterized by progressive muscle weakness. Previously, we have shown that resveratrol (3,5,4′-trihydroxy-trans-stilbene), an antioxidant and an activator of the protein deacetylase SIRT1, decreases muscular and cardiac oxidative damage and improves pathophysiological conditions in animal MD models. To determine whether resveratrol provides therapeutic benefits to patients with MDs, an open-label, single-arm, phase IIa trial of resveratrol was conducted in 11 patients with Duchenne, Becker or Fukuyama MD. The daily dose of resveratrol was 500 mg/day, which was increased every 8 weeks to 1000 and then 1500 mg/day. Primary outcomes were motor function, evaluated by a motor function measure (MFM) scale, muscular strength, monitored with quantitative muscle testing (QMT), and serum creatine kinase (CK) levels. Adverse effects and tolerability were evaluated as secondary outcomes. Despite the advanced medical conditions of the patients, the mean MFM scores increased significantly from 34.6 to 38.4 after 24 weeks of medication. A twofold increase was found in the mean QMT scores of scapula elevation and shoulder abduction. Mean CK levels decreased considerably by 34%. Diarrhoea and abdominal pain was noted in six and three patients, respectively. Resveratrol may provide some benefit to MD patients.
29 schema:genre article
30 schema:isAccessibleForFree true
31 schema:isPartOf N2c18c92bc26643eeaa2d7d99ef22e287
32 N8b7ea7dd202e4a0192f6b53ea940c926
33 sg:journal.1045337
34 schema:keywords Becker
35 CK levels
36 Duchenne
37 Fukuyama muscular dystrophy
38 IIa study
39 IIa trial
40 MD model
41 MDS patients
42 MFM scores
43 Motor Function Measure Scale
44 SIRT1
45 Secondary outcomes
46 abdominal pain
47 abduction
48 activator
49 advanced medical conditions
50 adverse effects
51 antioxidants
52 benefits
53 cardiac oxidative damage
54 conditions
55 creatine kinase levels
56 daily dose
57 damage
58 days
59 deacetylase SIRT1
60 diarrhea
61 disorders
62 dose
63 dystrophy
64 effect
65 elevation
66 function
67 increase
68 kinase levels
69 levels
70 measure scale
71 medical conditions
72 medications
73 model
74 motor function
75 muscle testing
76 muscle weakness
77 muscular dystrophy
78 muscular strength
79 outcomes
80 oxidative damage
81 pain
82 pathophysiological conditions
83 patients
84 phase IIa study
85 phase IIa trial
86 primary outcome
87 progressive muscle weakness
88 protein deacetylase SIRT1
89 quantitative muscle testing
90 resveratrol
91 scale
92 scapula elevation
93 scores
94 serum creatine kinase levels
95 shoulder abduction
96 strength
97 study
98 testing
99 therapeutic benefit
100 tolerability
101 trials
102 twofold increase
103 weakness
104 weeks
105 weeks of medication
106 schema:name Resveratrol improves motor function in patients with muscular dystrophies: an open-label, single-arm, phase IIa study
107 schema:pagination 20585
108 schema:productId N84f0c7af92324e6594ff193c6d4a5d6e
109 N97f67a34f0ac42d98abed2c8c58bfbb2
110 Ndd3fb2c7558047e8a24c1766043e5481
111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132921697
112 https://doi.org/10.1038/s41598-020-77197-6
113 schema:sdDatePublished 2022-11-24T21:05
114 schema:sdLicense https://scigraph.springernature.com/explorer/license/
115 schema:sdPublisher N07504de804184262bc4aee870677c683
116 schema:url https://doi.org/10.1038/s41598-020-77197-6
117 sgo:license sg:explorer/license/
118 sgo:sdDataset articles
119 rdf:type schema:ScholarlyArticle
120 N07504de804184262bc4aee870677c683 schema:name Springer Nature - SN SciGraph project
121 rdf:type schema:Organization
122 N0eaff58726814eb7bf83fe5ec90916dd rdf:first sg:person.014720546717.75
123 rdf:rest N45bbe4046cdb43bb9c95315fc47b391c
124 N157e23939d6f40598ea03e25d45374d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Stilbenes
126 rdf:type schema:DefinedTerm
127 N1b1f85bc86964290a978e5c4e66f1d42 rdf:first sg:person.01353564646.43
128 rdf:rest Nb8601018caf94e8092623f70132f2157
129 N1fd87d8c3cbb49378d34aebfe2a4d177 rdf:first sg:person.010755731132.52
130 rdf:rest N68f825d7987745d0acb788713305f5d2
131 N2084b9cbe6ad40d7b1328e89381efec0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Muscle Weakness
133 rdf:type schema:DefinedTerm
134 N26b6c3e1840546d789b62db1e4e25a01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Humans
136 rdf:type schema:DefinedTerm
137 N2c18c92bc26643eeaa2d7d99ef22e287 schema:volumeNumber 10
138 rdf:type schema:PublicationVolume
139 N31a8f17a47d94e8a9a7539e3788af55c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Motor Activity
141 rdf:type schema:DefinedTerm
142 N3b96f45c741e4c6bb200ac03fad03c8e rdf:first sg:person.01155053337.28
143 rdf:rest N7ac37bbfbc9e4dfda5cbe877b6364ec6
144 N3c9987ebb9004767a972fcabb39af8f3 rdf:first sg:person.01007323604.46
145 rdf:rest N3f2cdb9aabb5482eacd7e2d11574c90a
146 N3f2cdb9aabb5482eacd7e2d11574c90a rdf:first sg:person.01032152371.11
147 rdf:rest N3b96f45c741e4c6bb200ac03fad03c8e
148 N442bf7f12620474ca646282121a3f62f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Adult
150 rdf:type schema:DefinedTerm
151 N45bbe4046cdb43bb9c95315fc47b391c rdf:first sg:person.01106055736.04
152 rdf:rest N3c9987ebb9004767a972fcabb39af8f3
153 N50488e0796a244e1a3d417041642f880 rdf:first sg:person.0577702220.98
154 rdf:rest Ne050939021dc402291b3e937a8897b39
155 N510674afcba84340a35aa17c93bbbe3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Creatine Kinase
157 rdf:type schema:DefinedTerm
158 N52942485be034c93aeba2d86582240a9 rdf:first sg:person.01006661246.06
159 rdf:rest N658b648c680d44ff8b793f367223735d
160 N658b648c680d44ff8b793f367223735d rdf:first sg:person.0650137105.16
161 rdf:rest N1b1f85bc86964290a978e5c4e66f1d42
162 N68f825d7987745d0acb788713305f5d2 rdf:first sg:person.013170625662.23
163 rdf:rest N50488e0796a244e1a3d417041642f880
164 N712458f82d814cc18e7cd4965feec1a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Resveratrol
166 rdf:type schema:DefinedTerm
167 N724fc401f68049b3b8a4be21808cefbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Adolescent
169 rdf:type schema:DefinedTerm
170 N7ac37bbfbc9e4dfda5cbe877b6364ec6 rdf:first sg:person.011563314571.68
171 rdf:rest Nd6cd2bc8c2c746e296b211484cdee5e2
172 N84f0c7af92324e6594ff193c6d4a5d6e schema:name dimensions_id
173 schema:value pub.1132921697
174 rdf:type schema:PropertyValue
175 N861cfcabee1449a2844209f44b4041a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Female
177 rdf:type schema:DefinedTerm
178 N8ab348f175754a8f8bd415ff5520916c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Young Adult
180 rdf:type schema:DefinedTerm
181 N8b0415de9d0348198d1b6b6c3bc26686 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Japan
183 rdf:type schema:DefinedTerm
184 N8b7ea7dd202e4a0192f6b53ea940c926 schema:issueNumber 1
185 rdf:type schema:PublicationIssue
186 N97f67a34f0ac42d98abed2c8c58bfbb2 schema:name pubmed_id
187 schema:value 33239684
188 rdf:type schema:PropertyValue
189 Nb8601018caf94e8092623f70132f2157 rdf:first sg:person.01351137664.61
190 rdf:rest rdf:nil
191 Nd6cd2bc8c2c746e296b211484cdee5e2 rdf:first sg:person.07463634315.94
192 rdf:rest N1fd87d8c3cbb49378d34aebfe2a4d177
193 Ndd3fb2c7558047e8a24c1766043e5481 schema:name doi
194 schema:value 10.1038/s41598-020-77197-6
195 rdf:type schema:PropertyValue
196 Nde930eadb0c14a709438628b68caebfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Male
198 rdf:type schema:DefinedTerm
199 Ne0249b660e27402baaffd69c77a33617 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Child
201 rdf:type schema:DefinedTerm
202 Ne050939021dc402291b3e937a8897b39 rdf:first sg:person.0674557451.44
203 rdf:rest N52942485be034c93aeba2d86582240a9
204 Ne9ada21e06844d5fbad0952fc7eb4d96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Antioxidants
206 rdf:type schema:DefinedTerm
207 Neda6b6dfebc147fe82efd1d40aa00f20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Muscular Dystrophies
209 rdf:type schema:DefinedTerm
210 Nfd46b545a1ec41cf8bfe15c379740022 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Muscle Strength
212 rdf:type schema:DefinedTerm
213 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
214 schema:name Medical and Health Sciences
215 rdf:type schema:DefinedTerm
216 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
217 schema:name Neurosciences
218 rdf:type schema:DefinedTerm
219 sg:grant.5866945 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-020-77197-6
220 rdf:type schema:MonetaryGrant
221 sg:grant.7533795 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-020-77197-6
222 rdf:type schema:MonetaryGrant
223 sg:grant.7535173 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-020-77197-6
224 rdf:type schema:MonetaryGrant
225 sg:journal.1045337 schema:issn 2045-2322
226 schema:name Scientific Reports
227 schema:publisher Springer Nature
228 rdf:type schema:Periodical
229 sg:person.01006661246.06 schema:affiliation grid-institutes:grid.263171.0
230 schema:familyName Kuno
231 schema:givenName Atsushi
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006661246.06
233 rdf:type schema:Person
234 sg:person.01007323604.46 schema:affiliation grid-institutes:grid.263171.0
235 schema:familyName Nikaido
236 schema:givenName Koki
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007323604.46
238 rdf:type schema:Person
239 sg:person.01032152371.11 schema:affiliation grid-institutes:grid.505710.6
240 schema:familyName Tachi
241 schema:givenName Nobutada
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032152371.11
243 rdf:type schema:Person
244 sg:person.010755731132.52 schema:affiliation grid-institutes:grid.505710.6
245 schema:familyName Mori
246 schema:givenName Mitsuru
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010755731132.52
248 rdf:type schema:Person
249 sg:person.01106055736.04 schema:affiliation grid-institutes:grid.263171.0
250 schema:familyName Fukumura
251 schema:givenName Shinobu
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106055736.04
253 rdf:type schema:Person
254 sg:person.01155053337.28 schema:affiliation grid-institutes:grid.263171.0
255 schema:familyName Kozuka
256 schema:givenName Naoki
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155053337.28
258 rdf:type schema:Person
259 sg:person.011563314571.68 schema:affiliation grid-institutes:grid.263171.0
260 schema:familyName Seino
261 schema:givenName Tsugumi
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011563314571.68
263 rdf:type schema:Person
264 sg:person.013170625662.23 schema:affiliation grid-institutes:grid.412167.7
265 schema:familyName Ito
266 schema:givenName Yoichi M.
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013170625662.23
268 rdf:type schema:Person
269 sg:person.01351137664.61 schema:affiliation grid-institutes:grid.263171.0
270 schema:familyName Tsutsumi
271 schema:givenName Hiroyuki
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351137664.61
273 rdf:type schema:Person
274 sg:person.01353564646.43 schema:affiliation grid-institutes:grid.263171.0
275 schema:familyName Horio
276 schema:givenName Yoshiyuki
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353564646.43
278 rdf:type schema:Person
279 sg:person.014720546717.75 schema:affiliation grid-institutes:grid.263171.0
280 schema:familyName Kawamura
281 schema:givenName Kentaro
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014720546717.75
283 rdf:type schema:Person
284 sg:person.0577702220.98 schema:affiliation grid-institutes:grid.411234.1
285 schema:familyName Takami
286 schema:givenName Akiyoshi
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577702220.98
288 rdf:type schema:Person
289 sg:person.0650137105.16 schema:affiliation grid-institutes:grid.263171.0
290 schema:familyName Kawasaki
291 schema:givenName Yukihiko
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650137105.16
293 rdf:type schema:Person
294 sg:person.0674557451.44 schema:affiliation grid-institutes:grid.263171.0
295 schema:familyName Hinotsu
296 schema:givenName Shiro
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674557451.44
298 rdf:type schema:Person
299 sg:person.07463634315.94 schema:affiliation grid-institutes:grid.263171.0
300 schema:familyName Hatakeyama
301 schema:givenName Kingya
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07463634315.94
303 rdf:type schema:Person
304 sg:pub.10.1007/s00262-019-02315-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1112158342
305 https://doi.org/10.1007/s00262-019-02315-x
306 rdf:type schema:CreativeWork
307 sg:pub.10.1038/28653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046686728
308 https://doi.org/10.1038/28653
309 rdf:type schema:CreativeWork
310 sg:pub.10.1038/nature00904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051586568
311 https://doi.org/10.1038/nature00904
312 rdf:type schema:CreativeWork
313 sg:pub.10.1038/nature01960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037301833
314 https://doi.org/10.1038/nature01960
315 rdf:type schema:CreativeWork
316 sg:pub.10.1038/nrm.2016.93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038682840
317 https://doi.org/10.1038/nrm.2016.93
318 rdf:type schema:CreativeWork
319 sg:pub.10.1038/s41598-018-33930-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1107670629
320 https://doi.org/10.1038/s41598-018-33930-w
321 rdf:type schema:CreativeWork
322 grid-institutes:grid.263171.0 schema:alternateName Department of Biostatistics, Sapporo Medical University School of Medicine, 060-8556, Sapporo, Japan
323 Department of Pediatrics, Sapporo Medical University School of Medicine, 060-8543, Sapporo, Japan
324 Department of Pharmacology, Sapporo Medical University School of Medicine, 060-8556, Sapporo, Japan
325 Department of Physical Therapy, Sapporo Medical University School of Health Sciences, 060-8556, Sapporo, Japan
326 schema:name Department of Biostatistics, Sapporo Medical University School of Medicine, 060-8556, Sapporo, Japan
327 Department of Pediatrics, Sapporo Medical University School of Medicine, 060-8543, Sapporo, Japan
328 Department of Pharmacology, Sapporo Medical University School of Medicine, 060-8556, Sapporo, Japan
329 Department of Physical Therapy, Sapporo Medical University School of Health Sciences, 060-8556, Sapporo, Japan
330 rdf:type schema:Organization
331 grid-institutes:grid.411234.1 schema:alternateName Division of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, 480-1195, Nagakute, Japan
332 schema:name Division of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, 480-1195, Nagakute, Japan
333 rdf:type schema:Organization
334 grid-institutes:grid.412167.7 schema:alternateName Biostatistics Division, Clinical Research and Medical Innovation Center, Hokkaido University Hospital, 060-8648, Sapporo, Japan
335 schema:name Biostatistics Division, Clinical Research and Medical Innovation Center, Hokkaido University Hospital, 060-8648, Sapporo, Japan
336 rdf:type schema:Organization
337 grid-institutes:grid.505710.6 schema:alternateName Faculty of Health Science, Hokkaido Chitose College of Rehabilitation, 066-0055, Chitose, Japan
338 schema:name Faculty of Health Science, Hokkaido Chitose College of Rehabilitation, 066-0055, Chitose, Japan
339 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...