Neutrophil extracellular traps are induced in a psoriasis model of interleukin-36 receptor antagonist-deficient mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-11-19

AUTHORS

Soichiro Watanabe, Yohei Iwata, Hidehiko Fukushima, Kenta Saito, Yoshihito Tanaka, Yurie Hasegawa, Masashi Akiyama, Kazumitsu Sugiura

ABSTRACT

Loss-of-function mutations in the interleukin (IL)-36 gene IL36RN are associated with psoriasis. The importance of neutrophil extracellular traps (NETs), web-like structures composed of neutrophil DNA, in the pathogenesis of psoriasis has been unclear. Here, we aimed to clarify the role of NET signaling in the deficiency of IL36 receptor antagonist (DITRA). We evaluated the severity of psoriasis-like lesions induced by imiquimod cream treatment in Il36rn-/- mice. The mRNA levels of psoriasis-related cytokines were measured via real-time reverse transcription polymerase chain reaction, and the effects of Cl-amidine, a peptidyl arginine deiminase 4 (PAD4) inhibitor, on psoriasis-like lesions were evaluated. PAD4 is a histone-modifying enzyme that is involved in NET formation. Psoriasis area and severity index scores, epidermal thickness, and infiltrated neutrophil counts were significantly increased in Il36rn-/- mice; NET formation was confirmed pathologically. Several cytokines and chemokines were upregulated in the skin lesions of Il36rn-/- mice and Cl-amidine treatment improved these psoriasis-like lesions. These results suggest that NET formation plays an important role in the pathology of psoriasis-like lesions in these mice and might represent a promising therapeutic target for DITRA. More... »

PAGES

20149

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-020-76864-y

DOI

http://dx.doi.org/10.1038/s41598-020-76864-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1132742002

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33214582


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Topical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Extracellular Traps", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Imiquimod", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macrophages, Peritoneal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Mutant Strains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neutrophils", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ornithine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Psoriasis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi 470-1192 Japan", 
          "id": "http://www.grid.ac/institutes/grid.256115.4", 
          "name": [
            "Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi 470-1192 Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watanabe", 
        "givenName": "Soichiro", 
        "id": "sg:person.015747560147.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015747560147.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi 470-1192 Japan", 
          "id": "http://www.grid.ac/institutes/grid.256115.4", 
          "name": [
            "Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi 470-1192 Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iwata", 
        "givenName": "Yohei", 
        "id": "sg:person.01105072301.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105072301.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi 470-1192 Japan", 
          "id": "http://www.grid.ac/institutes/grid.256115.4", 
          "name": [
            "Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi 470-1192 Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukushima", 
        "givenName": "Hidehiko", 
        "id": "sg:person.016371331524.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016371331524.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi 470-1192 Japan", 
          "id": "http://www.grid.ac/institutes/grid.256115.4", 
          "name": [
            "Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi 470-1192 Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saito", 
        "givenName": "Kenta", 
        "id": "sg:person.010115734317.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010115734317.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi 470-1192 Japan", 
          "id": "http://www.grid.ac/institutes/grid.256115.4", 
          "name": [
            "Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi 470-1192 Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tanaka", 
        "givenName": "Yoshihito", 
        "id": "sg:person.0663632224.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663632224.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi 470-1192 Japan", 
          "id": "http://www.grid.ac/institutes/grid.256115.4", 
          "name": [
            "Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi 470-1192 Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hasegawa", 
        "givenName": "Yurie", 
        "id": "sg:person.015202574307.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015202574307.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550 Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550 Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akiyama", 
        "givenName": "Masashi", 
        "id": "sg:person.013324706103.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013324706103.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi 470-1192 Japan", 
          "id": "http://www.grid.ac/institutes/grid.256115.4", 
          "name": [
            "Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi 470-1192 Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugiura", 
        "givenName": "Kazumitsu", 
        "id": "sg:person.0617007352.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617007352.91"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ni1110-973", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034689952", 
          "https://doi.org/10.1038/ni1110-973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.1959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051827328", 
          "https://doi.org/10.1038/nm.1959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-020-57550-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1124189622", 
          "https://doi.org/10.1038/s41598-020-57550-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri.2017.105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092131662", 
          "https://doi.org/10.1038/nri.2017.105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-020-71256-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1130659467", 
          "https://doi.org/10.1038/s41598-020-71256-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-019-56847-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1123950493", 
          "https://doi.org/10.1038/s41598-019-56847-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-016-0001-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085379182", 
          "https://doi.org/10.1038/s41598-016-0001-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.4294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084129242", 
          "https://doi.org/10.1038/nm.4294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41419-017-0012-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100155941", 
          "https://doi.org/10.1038/s41419-017-0012-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035817137", 
          "https://doi.org/10.1038/nmeth.2089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep31119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034212551", 
          "https://doi.org/10.1038/srep31119"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-11-19", 
    "datePublishedReg": "2020-11-19", 
    "description": "Loss-of-function mutations in the interleukin (IL)-36 gene IL36RN are associated with psoriasis. The importance of neutrophil extracellular traps (NETs), web-like structures composed of neutrophil DNA, in the pathogenesis of psoriasis has been unclear. Here, we aimed to clarify the role of NET signaling in the deficiency of IL36 receptor antagonist (DITRA). We evaluated the severity of psoriasis-like lesions induced by imiquimod cream treatment in Il36rn-/- mice. The mRNA levels of psoriasis-related cytokines were measured via real-time reverse transcription polymerase chain reaction, and the effects of Cl-amidine, a peptidyl arginine deiminase 4 (PAD4) inhibitor, on psoriasis-like lesions were evaluated. PAD4 is a histone-modifying enzyme that is involved in NET formation. Psoriasis area and severity index scores, epidermal thickness, and infiltrated neutrophil counts were significantly increased in Il36rn-/- mice; NET formation was confirmed pathologically. Several cytokines and chemokines were upregulated in the skin lesions of Il36rn-/- mice and Cl-amidine treatment improved these psoriasis-like lesions. These results suggest that NET formation plays an important role in the pathology of psoriasis-like lesions in these mice and might represent a promising therapeutic target for DITRA.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-020-76864-y", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7535111", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.9338224", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5856358", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "keywords": [
      "psoriasis-like lesions", 
      "neutrophil extracellular traps", 
      "NET formation", 
      "extracellular traps", 
      "role of NETs", 
      "imiquimod cream treatment", 
      "psoriasis-related cytokines", 
      "Cl-amidine treatment", 
      "Severity Index score", 
      "pathogenesis of psoriasis", 
      "real-time reverse transcription-polymerase chain reaction", 
      "reverse transcription-polymerase chain reaction", 
      "promising therapeutic target", 
      "transcription-polymerase chain reaction", 
      "Psoriasis Area", 
      "neutrophil count", 
      "psoriasis model", 
      "receptor antagonist", 
      "polymerase chain reaction", 
      "skin lesions", 
      "neutrophil DNA", 
      "IL36RN", 
      "therapeutic target", 
      "Cl-amidine", 
      "cream treatment", 
      "index score", 
      "epidermal thickness", 
      "lesions", 
      "mice", 
      "mRNA levels", 
      "chain reaction", 
      "psoriasis", 
      "function mutations", 
      "cytokines", 
      "treatment", 
      "interleukin", 
      "DITRA", 
      "chemokines", 
      "pathogenesis", 
      "antagonist", 
      "pathology", 
      "severity", 
      "important role", 
      "scores", 
      "inhibitors", 
      "web-like structure", 
      "role", 
      "deficiency", 
      "count", 
      "mutations", 
      "target", 
      "levels", 
      "PAD4", 
      "loss", 
      "effect", 
      "enzyme", 
      "DNA", 
      "formation", 
      "importance", 
      "area", 
      "results", 
      "reaction", 
      "model", 
      "thickness", 
      "traps", 
      "structure", 
      "gene IL36RN", 
      "IL36 receptor antagonist", 
      "peptidyl arginine deiminase 4 (PAD4) inhibitor", 
      "arginine deiminase 4 (PAD4) inhibitor", 
      "deiminase 4 (PAD4) inhibitor", 
      "interleukin-36 receptor antagonist-deficient mice", 
      "receptor antagonist-deficient mice", 
      "antagonist-deficient mice"
    ], 
    "name": "Neutrophil extracellular traps are induced in a psoriasis model of interleukin-36 receptor antagonist-deficient mice", 
    "pagination": "20149", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1132742002"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-020-76864-y"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "33214582"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-020-76864-y", 
      "https://app.dimensions.ai/details/publication/pub.1132742002"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_860.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-020-76864-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-76864-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-76864-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-76864-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-76864-y'


 

This table displays all metadata directly associated to this object as RDF triples.

301 TRIPLES      22 PREDICATES      127 URIs      108 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-020-76864-y schema:about N2299d469de5a455ebbc2029f4172aa5a
2 N30f87c6c81e6412c99fdedc48137066c
3 N3a94a1f01c3346dbb5d42dbc828f2cfd
4 N58f93b1e6a804c199386606fcb147a60
5 N701fb165ea634fb69f1aed34a82675d4
6 N8b3d4a837e7141259ac100b27a37eddd
7 N8d700c9ef4c8422e87efccdeefd60eba
8 Nbb7d1afe2a454ce1bae4bfdb60d4fb84
9 Nc955624ada1b4817a539fabe166fc808
10 Ndb5c5a59064142b2a0423f8b4dde5e4b
11 Ne9f63cd731f84948aadf21d6178e29b6
12 Nf3cc4b4fd8874c01a48db27ba637be91
13 Nf4f9042c1dca4220b5c14cfb7463f65f
14 Nfa1a47a440714682b204406cb46575d1
15 Nfa1c4523617048949f5e91ee4107f325
16 Nfdc302fe382a4a92b66bfeeeb1448d4a
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author Nf68cd9b0a6ad47c18910bc6d7c03dfd5
20 schema:citation sg:pub.10.1038/ni1110-973
21 sg:pub.10.1038/nm.1959
22 sg:pub.10.1038/nm.4294
23 sg:pub.10.1038/nmeth.2089
24 sg:pub.10.1038/nri.2017.105
25 sg:pub.10.1038/s41419-017-0012-9
26 sg:pub.10.1038/s41598-016-0001-8
27 sg:pub.10.1038/s41598-019-56847-4
28 sg:pub.10.1038/s41598-020-57550-5
29 sg:pub.10.1038/s41598-020-71256-8
30 sg:pub.10.1038/srep31119
31 schema:datePublished 2020-11-19
32 schema:datePublishedReg 2020-11-19
33 schema:description Loss-of-function mutations in the interleukin (IL)-36 gene IL36RN are associated with psoriasis. The importance of neutrophil extracellular traps (NETs), web-like structures composed of neutrophil DNA, in the pathogenesis of psoriasis has been unclear. Here, we aimed to clarify the role of NET signaling in the deficiency of IL36 receptor antagonist (DITRA). We evaluated the severity of psoriasis-like lesions induced by imiquimod cream treatment in Il36rn<sup>-/-</sup> mice. The mRNA levels of psoriasis-related cytokines were measured via real-time reverse transcription polymerase chain reaction, and the effects of Cl-amidine, a peptidyl arginine deiminase 4 (PAD4) inhibitor, on psoriasis-like lesions were evaluated. PAD4 is a histone-modifying enzyme that is involved in NET formation. Psoriasis area and severity index scores, epidermal thickness, and infiltrated neutrophil counts were significantly increased in Il36rn<sup>-/-</sup> mice; NET formation was confirmed pathologically. Several cytokines and chemokines were upregulated in the skin lesions of Il36rn<sup>-/-</sup> mice and Cl-amidine treatment improved these psoriasis-like lesions. These results suggest that NET formation plays an important role in the pathology of psoriasis-like lesions in these mice and might represent a promising therapeutic target for DITRA.
34 schema:genre article
35 schema:inLanguage en
36 schema:isAccessibleForFree true
37 schema:isPartOf N8d0624696d6149b78778c3c1d1761fac
38 Ne8eff2ad29af4e37a3eee08075b6ab45
39 sg:journal.1045337
40 schema:keywords Cl-amidine
41 Cl-amidine treatment
42 DITRA
43 DNA
44 IL36 receptor antagonist
45 IL36RN
46 NET formation
47 PAD4
48 Psoriasis Area
49 Severity Index score
50 antagonist
51 antagonist-deficient mice
52 area
53 arginine deiminase 4 (PAD4) inhibitor
54 chain reaction
55 chemokines
56 count
57 cream treatment
58 cytokines
59 deficiency
60 deiminase 4 (PAD4) inhibitor
61 effect
62 enzyme
63 epidermal thickness
64 extracellular traps
65 formation
66 function mutations
67 gene IL36RN
68 imiquimod cream treatment
69 importance
70 important role
71 index score
72 inhibitors
73 interleukin
74 interleukin-36 receptor antagonist-deficient mice
75 lesions
76 levels
77 loss
78 mRNA levels
79 mice
80 model
81 mutations
82 neutrophil DNA
83 neutrophil count
84 neutrophil extracellular traps
85 pathogenesis
86 pathogenesis of psoriasis
87 pathology
88 peptidyl arginine deiminase 4 (PAD4) inhibitor
89 polymerase chain reaction
90 promising therapeutic target
91 psoriasis
92 psoriasis model
93 psoriasis-like lesions
94 psoriasis-related cytokines
95 reaction
96 real-time reverse transcription-polymerase chain reaction
97 receptor antagonist
98 receptor antagonist-deficient mice
99 results
100 reverse transcription-polymerase chain reaction
101 role
102 role of NETs
103 scores
104 severity
105 skin lesions
106 structure
107 target
108 therapeutic target
109 thickness
110 transcription-polymerase chain reaction
111 traps
112 treatment
113 web-like structure
114 schema:name Neutrophil extracellular traps are induced in a psoriasis model of interleukin-36 receptor antagonist-deficient mice
115 schema:pagination 20149
116 schema:productId N0d0d212ac0d547f7b02c184b7802741f
117 N9b22aaa37cf8481f8930bdb2f331326a
118 Nef8b71c8fcc8497b92b8d639162d2a8f
119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132742002
120 https://doi.org/10.1038/s41598-020-76864-y
121 schema:sdDatePublished 2022-01-01T18:57
122 schema:sdLicense https://scigraph.springernature.com/explorer/license/
123 schema:sdPublisher N91c408cf6cab4a9ab457fa94054cf185
124 schema:url https://doi.org/10.1038/s41598-020-76864-y
125 sgo:license sg:explorer/license/
126 sgo:sdDataset articles
127 rdf:type schema:ScholarlyArticle
128 N095ecba96dd64d9caa23c3694860f799 rdf:first sg:person.013324706103.19
129 rdf:rest N5c82a1918c344398bf3a39628b0a3df1
130 N0d0d212ac0d547f7b02c184b7802741f schema:name dimensions_id
131 schema:value pub.1132742002
132 rdf:type schema:PropertyValue
133 N2299d469de5a455ebbc2029f4172aa5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Interleukin-1
135 rdf:type schema:DefinedTerm
136 N30f87c6c81e6412c99fdedc48137066c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Neutrophils
138 rdf:type schema:DefinedTerm
139 N36daafeb24ce45e0adc3e3cf00b42f41 rdf:first sg:person.01105072301.83
140 rdf:rest Ndb9c573a59cb466d8b8ebe75191c92fa
141 N3a94a1f01c3346dbb5d42dbc828f2cfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Mice, Inbred C57BL
143 rdf:type schema:DefinedTerm
144 N58f93b1e6a804c199386606fcb147a60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Cells, Cultured
146 rdf:type schema:DefinedTerm
147 N5c82a1918c344398bf3a39628b0a3df1 rdf:first sg:person.0617007352.91
148 rdf:rest rdf:nil
149 N701fb165ea634fb69f1aed34a82675d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Psoriasis
151 rdf:type schema:DefinedTerm
152 N8b3d4a837e7141259ac100b27a37eddd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Macrophages, Peritoneal
154 rdf:type schema:DefinedTerm
155 N8d0624696d6149b78778c3c1d1761fac schema:issueNumber 1
156 rdf:type schema:PublicationIssue
157 N8d700c9ef4c8422e87efccdeefd60eba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Mice, Mutant Strains
159 rdf:type schema:DefinedTerm
160 N91c408cf6cab4a9ab457fa94054cf185 schema:name Springer Nature - SN SciGraph project
161 rdf:type schema:Organization
162 N9b22aaa37cf8481f8930bdb2f331326a schema:name pubmed_id
163 schema:value 33214582
164 rdf:type schema:PropertyValue
165 Nb837a71cee5b4f7299bf94ccf1b2b785 rdf:first sg:person.010115734317.55
166 rdf:rest Ne278cea63c9b4b9396841d883ad139aa
167 Nbb7d1afe2a454ce1bae4bfdb60d4fb84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Extracellular Traps
169 rdf:type schema:DefinedTerm
170 Nc3d08ecbca2249908c0d3fbe1007d050 rdf:first sg:person.015202574307.92
171 rdf:rest N095ecba96dd64d9caa23c3694860f799
172 Nc955624ada1b4817a539fabe166fc808 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Imiquimod
174 rdf:type schema:DefinedTerm
175 Ndb5c5a59064142b2a0423f8b4dde5e4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Chemokines
177 rdf:type schema:DefinedTerm
178 Ndb9c573a59cb466d8b8ebe75191c92fa rdf:first sg:person.016371331524.42
179 rdf:rest Nb837a71cee5b4f7299bf94ccf1b2b785
180 Ne278cea63c9b4b9396841d883ad139aa rdf:first sg:person.0663632224.00
181 rdf:rest Nc3d08ecbca2249908c0d3fbe1007d050
182 Ne8eff2ad29af4e37a3eee08075b6ab45 schema:volumeNumber 10
183 rdf:type schema:PublicationVolume
184 Ne9f63cd731f84948aadf21d6178e29b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Male
186 rdf:type schema:DefinedTerm
187 Nef8b71c8fcc8497b92b8d639162d2a8f schema:name doi
188 schema:value 10.1038/s41598-020-76864-y
189 rdf:type schema:PropertyValue
190 Nf3cc4b4fd8874c01a48db27ba637be91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Administration, Topical
192 rdf:type schema:DefinedTerm
193 Nf4f9042c1dca4220b5c14cfb7463f65f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Cytokines
195 rdf:type schema:DefinedTerm
196 Nf68cd9b0a6ad47c18910bc6d7c03dfd5 rdf:first sg:person.015747560147.69
197 rdf:rest N36daafeb24ce45e0adc3e3cf00b42f41
198 Nfa1a47a440714682b204406cb46575d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Ornithine
200 rdf:type schema:DefinedTerm
201 Nfa1c4523617048949f5e91ee4107f325 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Disease Models, Animal
203 rdf:type schema:DefinedTerm
204 Nfdc302fe382a4a92b66bfeeeb1448d4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Animals
206 rdf:type schema:DefinedTerm
207 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
208 schema:name Medical and Health Sciences
209 rdf:type schema:DefinedTerm
210 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
211 schema:name Clinical Sciences
212 rdf:type schema:DefinedTerm
213 sg:grant.5856358 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-020-76864-y
214 rdf:type schema:MonetaryGrant
215 sg:grant.7535111 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-020-76864-y
216 rdf:type schema:MonetaryGrant
217 sg:grant.9338224 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-020-76864-y
218 rdf:type schema:MonetaryGrant
219 sg:journal.1045337 schema:issn 2045-2322
220 schema:name Scientific Reports
221 schema:publisher Springer Nature
222 rdf:type schema:Periodical
223 sg:person.010115734317.55 schema:affiliation grid-institutes:grid.256115.4
224 schema:familyName Saito
225 schema:givenName Kenta
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010115734317.55
227 rdf:type schema:Person
228 sg:person.01105072301.83 schema:affiliation grid-institutes:grid.256115.4
229 schema:familyName Iwata
230 schema:givenName Yohei
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105072301.83
232 rdf:type schema:Person
233 sg:person.013324706103.19 schema:affiliation grid-institutes:grid.27476.30
234 schema:familyName Akiyama
235 schema:givenName Masashi
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013324706103.19
237 rdf:type schema:Person
238 sg:person.015202574307.92 schema:affiliation grid-institutes:grid.256115.4
239 schema:familyName Hasegawa
240 schema:givenName Yurie
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015202574307.92
242 rdf:type schema:Person
243 sg:person.015747560147.69 schema:affiliation grid-institutes:grid.256115.4
244 schema:familyName Watanabe
245 schema:givenName Soichiro
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015747560147.69
247 rdf:type schema:Person
248 sg:person.016371331524.42 schema:affiliation grid-institutes:grid.256115.4
249 schema:familyName Fukushima
250 schema:givenName Hidehiko
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016371331524.42
252 rdf:type schema:Person
253 sg:person.0617007352.91 schema:affiliation grid-institutes:grid.256115.4
254 schema:familyName Sugiura
255 schema:givenName Kazumitsu
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617007352.91
257 rdf:type schema:Person
258 sg:person.0663632224.00 schema:affiliation grid-institutes:grid.256115.4
259 schema:familyName Tanaka
260 schema:givenName Yoshihito
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663632224.00
262 rdf:type schema:Person
263 sg:pub.10.1038/ni1110-973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034689952
264 https://doi.org/10.1038/ni1110-973
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/nm.1959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051827328
267 https://doi.org/10.1038/nm.1959
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/nm.4294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129242
270 https://doi.org/10.1038/nm.4294
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/nmeth.2089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035817137
273 https://doi.org/10.1038/nmeth.2089
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/nri.2017.105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092131662
276 https://doi.org/10.1038/nri.2017.105
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/s41419-017-0012-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100155941
279 https://doi.org/10.1038/s41419-017-0012-9
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/s41598-016-0001-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085379182
282 https://doi.org/10.1038/s41598-016-0001-8
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/s41598-019-56847-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1123950493
285 https://doi.org/10.1038/s41598-019-56847-4
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/s41598-020-57550-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1124189622
288 https://doi.org/10.1038/s41598-020-57550-5
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/s41598-020-71256-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1130659467
291 https://doi.org/10.1038/s41598-020-71256-8
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/srep31119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034212551
294 https://doi.org/10.1038/srep31119
295 rdf:type schema:CreativeWork
296 grid-institutes:grid.256115.4 schema:alternateName Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi 470-1192 Japan
297 schema:name Department of Dermatology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Toyoake, Aichi 470-1192 Japan
298 rdf:type schema:Organization
299 grid-institutes:grid.27476.30 schema:alternateName Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550 Japan
300 schema:name Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550 Japan
301 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...