A pilot clinical study of the therapeutic antibody against canine PD-1 for advanced spontaneous cancers in dogs View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-10-27

AUTHORS

Masaya Igase, Yuki Nemoto, Kazuhito Itamoto, Kenji Tani, Munekazu Nakaichi, Masashi Sakurai, Yusuke Sakai, Shunsuke Noguchi, Masahiro Kato, Toshihiro Tsukui, Takuya Mizuno

ABSTRACT

Inhibition of programmed death 1 (PD-1), expressed on activated T cells, can break through immune resistance and elicit durable responses in human melanoma as well as other types of cancers. Canine oral malignant melanoma is one of the most aggressive tumors bearing poor prognosis due to its high metastatic potency. However, there are few effective treatments for the advanced stages of melanoma in veterinary medicine. Only one previous study indicated the potential of the immune checkpoint inhibitor, anti-canine PD-L1 therapeutic antibody in dogs, and no anti-canine PD-1 therapeutic antibodies are currently available. Here, we developed two therapeutic antibodies, rat-dog chimeric and caninized anti-canine PD-1 monoclonal antibodies and evaluated in vitro functionality for these antibodies. Moreover, we conducted a pilot study to determine their safety profiles and clinical efficacy in spontaneously occurring canine cancers. In conclusion, the anti-canine PD-1 monoclonal antibody was relatively safe and effective in dogs with advanced oral malignant melanoma and other cancers. Thus, our study suggests that PD-1 blockade may be an attractive treatment option in canine cancers. More... »

PAGES

18311

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-020-75533-4

DOI

http://dx.doi.org/10.1038/s41598-020-75533-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1132047558

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33110170


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