Improvement of glymphatic–lymphatic drainage of beta-amyloid by focused ultrasound in Alzheimer’s disease model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-09-30

AUTHORS

Youngsun Lee, Yoori Choi, Eun-Joo Park, Seokjun Kwon, Hyun Kim, Jae Young Lee, Dong Soo Lee

ABSTRACT

Drainage of parenchymal waste through the lymphatic system maintains brain homeostasis. Age-related changes of glymphatic–lymphatic clearance lead to the accumulation beta-amyloid (Aβ) in dementia models. In this study, focused ultrasound treatment in combination with microbubbles (FUS-MB) improved Aβ drainage in early dementia model mice, 5XFAD. FUS-MB enhanced solute Aβ clearance from brain, but not plaques, to cerebrospinal fluid (CSF) space and then deep cervical lymph node (dCLN). dCLN ligation exaggerated memory impairment and progress of plaque formation and also the beneficial effects of FUS-MB upon Aβ removal through CSF-lymphatic routes. In this ligation model, FUS-MB improved memory despite accumulation of Aβ in CSF. In conclusion, FUS-MB enhances glymphatic–lymphatic clearance of Aβ mainly by increasing brain-to-CSF Aβ drainage. We suggest that FUS-MB can delay dementia progress in early period and benefits of FUS-MB depend on the effect of Aβ disposal through CSF-lymphatics. More... »

PAGES

16144

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-020-73151-8

DOI

http://dx.doi.org/10.1038/s41598-020-73151-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1131320681

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32999351


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