Normalized power variance of eLORETA at high-convexity area predicts shunt response in idiopathic normal pressure hydrocephalus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-08-03

AUTHORS

Yasunori Aoki, Hiroaki Kazui, Ricardo Bruña, Roberto D. Pascual-Marqui, Kenji Yoshiyama, Tamiki Wada, Hideki Kanemoto, Yukiko Suzuki, Takashi Suehiro, Takuya Matsumoto, Kyosuke Kakeda, Masahiro Hata, Leonides Canuet, Ryouhei Ishii, Masao Iwase, Manabu Ikeda

ABSTRACT

Idiopathic normal pressure hydrocephalus (iNPH) is a neuropsychiatric disease characterized by gait disturbance, cognitive deterioration and urinary incontinence associated with excessive accumulation of cerebrospinal fluid (CSF) in the brain ventricles. These symptoms, in particular gait disturbance, can be potentially improved by shunt operation in the early stage of the disease, and the intervention associates with a worse outcome when performed late during the course of the disease. Despite the variable outcome of shunt operation, noninvasive presurgical prediction methods of shunt response have not been established yet. In the present study, we used normalized power variance (NPV), a sensitive measure of the instability of cortical electrical activity, to analyze cortical electrical activity derived from EEG data using exact-low-resolution-electromagnetic-tomography (eLORETA) in 15 shunt responders and 19 non-responders. We found that shunt responders showed significantly higher NPV values at high-convexity areas in beta frequency band than non-responders. In addition, using this difference, we could discriminate shunt responders from non-responders with leave-one-subject-out cross-validation accuracy of 67.6% (23/34) [positive predictive value of 61.1% (11/18) and negative predictive value of 75.0% (12/16)]. Our findings indicate that eLORETA-NPV can be a useful tool for noninvasive prediction of clinical response to shunt operation in patients with iNPH. More... »

PAGES

13054

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-020-70035-9

DOI

http://dx.doi.org/10.1038/s41598-020-70035-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1129833036

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32747671


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22 schema:description Idiopathic normal pressure hydrocephalus (iNPH) is a neuropsychiatric disease characterized by gait disturbance, cognitive deterioration and urinary incontinence associated with excessive accumulation of cerebrospinal fluid (CSF) in the brain ventricles. These symptoms, in particular gait disturbance, can be potentially improved by shunt operation in the early stage of the disease, and the intervention associates with a worse outcome when performed late during the course of the disease. Despite the variable outcome of shunt operation, noninvasive presurgical prediction methods of shunt response have not been established yet. In the present study, we used normalized power variance (NPV), a sensitive measure of the instability of cortical electrical activity, to analyze cortical electrical activity derived from EEG data using exact-low-resolution-electromagnetic-tomography (eLORETA) in 15 shunt responders and 19 non-responders. We found that shunt responders showed significantly higher NPV values at high-convexity areas in beta frequency band than non-responders. In addition, using this difference, we could discriminate shunt responders from non-responders with leave-one-subject-out cross-validation accuracy of 67.6% (23/34) [positive predictive value of 61.1% (11/18) and negative predictive value of 75.0% (12/16)]. Our findings indicate that eLORETA-NPV can be a useful tool for noninvasive prediction of clinical response to shunt operation in patients with iNPH.
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29 NPV values
30 accumulation
31 accuracy
32 activity
33 addition
34 area
35 associates
36 band
37 beta frequency bands
38 brain ventricles
39 cerebrospinal fluid
40 clinical response
41 cognitive deterioration
42 cortical electrical activity
43 course
44 cross-validation accuracy
45 data
46 deterioration
47 differences
48 disease
49 disturbances
50 early stages
51 electrical activity
52 excessive accumulation
53 findings
54 fluid
55 frequency band
56 gait disturbance
57 high-convexity area
58 higher NPV values
59 hydrocephalus
60 idiopathic normal pressure hydrocephalus
61 incontinence
62 instability
63 measures
64 method
65 neuropsychiatric diseases
66 noninvasive prediction
67 normal pressure hydrocephalus
68 normalized power variance
69 one-subject
70 operation
71 outcomes
72 patients
73 power variance
74 prediction
75 prediction method
76 present study
77 pressure hydrocephalus
78 responders
79 response
80 sensitive measure
81 shunt operation
82 shunt responders
83 shunt response
84 stage
85 study
86 symptoms
87 tomography
88 tool
89 urinary incontinence
90 useful tool
91 values
92 variable outcomes
93 variance
94 ventricle
95 worse outcomes
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