Opioid drug use in emergency and adverse outcomes among patients with chronic obstructive pulmonary disease: a multicenter observational study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-03-19

AUTHORS

Damien Viglino, Raoul Daoust, Sebastien Bailly, Caroline Faivre-Pierret, Isma Charif, Matthieu Roustit, Jean Paquet, Guillaume Debaty, Jean-Louis Pépin, Maxime Maignan, Jean-Marc Chauny

ABSTRACT

There is still debate as to the safety of non-palliative opioid administration to chronic obstructive pulmonary disease (COPD) patients punctually treated for an acute complaint. All patients over 40 presenting at two university hospital emergency departments (Montréal Qc, Grenoble Fr) from March 2008 to September 2014 with dyspnea, abdominal pain or trauma were retrieved, and COPD patients were selected. Our primary endpoint was a composite criterion including invasive ventilation and death. Comparisons between visits in which opioid drugs were prescribed and those without opioids were performed using an inverse probability of treatment and censoring weight (IPTCW) estimator to adjust for baseline confounders. A survival weighted Cox model was used. 7799 visits by COPD patients were identified, corresponding to 4173 unique patients. Opioid drug prescription was reported in 1317 (16.9%) visits. After applying IPCTW weighting, opioid prescription was found to be associated with the composite criterion of poor clinical outcomes (HR = 4.73 (2.94; 7.61), p < 0.01). When taken separately, this association remained significant for invasive ventilation and death, but not for NIV. All sensitivity analyses confirmed the association, except for patients with trauma or abdominal pain as the main complaint. This excess risk is observed whatever the route of administration. More... »

PAGES

5038

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-020-61887-2

DOI

http://dx.doi.org/10.1038/s41598-020-61887-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1125754080

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32193505


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Analgesics, Opioid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Emergency Service, Hospital", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multicenter Studies as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Palliative Care", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prescriptions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pulmonary Disease, Chronic Obstructive", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "INSERM U1042, HP2 Laboratory, Grenoble-Alpes University, Grenoble, France", 
          "id": "http://www.grid.ac/institutes/grid.450307.5", 
          "name": [
            "Emergency Department and Mobile Intensive Care Unit, Grenoble Alpes University Hospital, Grenoble, France", 
            "INSERM U1042, HP2 Laboratory, Grenoble-Alpes University, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Viglino", 
        "givenName": "Damien", 
        "id": "sg:person.01121270332.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121270332.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Emergency Medicine, Research Centre, Sacr\u00e9-Coeur Hospital of Montreal, Montreal, Quebec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.414056.2", 
          "name": [
            "Department of Emergency Medicine, Research Centre, Sacr\u00e9-Coeur Hospital of Montreal, Montreal, Quebec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Daoust", 
        "givenName": "Raoul", 
        "id": "sg:person.0576552462.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576552462.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology and Sleep, Grenoble Alpes University Hospital, Grenoble, France", 
          "id": "http://www.grid.ac/institutes/grid.410529.b", 
          "name": [
            "INSERM U1042, HP2 Laboratory, Grenoble-Alpes University, Grenoble, France", 
            "Department of Physiology and Sleep, Grenoble Alpes University Hospital, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bailly", 
        "givenName": "Sebastien", 
        "id": "sg:person.01125634305.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125634305.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emergency Department and Mobile Intensive Care Unit, Grenoble Alpes University Hospital, Grenoble, France", 
          "id": "http://www.grid.ac/institutes/grid.410529.b", 
          "name": [
            "Emergency Department and Mobile Intensive Care Unit, Grenoble Alpes University Hospital, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Faivre-Pierret", 
        "givenName": "Caroline", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "INSERM U1042, HP2 Laboratory, Grenoble-Alpes University, Grenoble, France", 
          "id": "http://www.grid.ac/institutes/grid.450307.5", 
          "name": [
            "INSERM U1042, HP2 Laboratory, Grenoble-Alpes University, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Charif", 
        "givenName": "Isma", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Clinical Pharmacology Department, INSERM CIC1406, Grenoble Alpes University Hospital, Grenoble, France", 
          "id": "http://www.grid.ac/institutes/grid.410529.b", 
          "name": [
            "INSERM U1042, HP2 Laboratory, Grenoble-Alpes University, Grenoble, France", 
            "Clinical Pharmacology Department, INSERM CIC1406, Grenoble Alpes University Hospital, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roustit", 
        "givenName": "Matthieu", 
        "id": "sg:person.01225611327.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225611327.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Emergency Medicine, Research Centre, Sacr\u00e9-Coeur Hospital of Montreal, Montreal, Quebec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.414056.2", 
          "name": [
            "Department of Emergency Medicine, Research Centre, Sacr\u00e9-Coeur Hospital of Montreal, Montreal, Quebec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paquet", 
        "givenName": "Jean", 
        "id": "sg:person.0576671510.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576671510.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emergency Department and Mobile Intensive Care Unit, Grenoble Alpes University Hospital, Grenoble, France", 
          "id": "http://www.grid.ac/institutes/grid.410529.b", 
          "name": [
            "Emergency Department and Mobile Intensive Care Unit, Grenoble Alpes University Hospital, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Debaty", 
        "givenName": "Guillaume", 
        "id": "sg:person.01220232430.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220232430.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology and Sleep, Grenoble Alpes University Hospital, Grenoble, France", 
          "id": "http://www.grid.ac/institutes/grid.410529.b", 
          "name": [
            "INSERM U1042, HP2 Laboratory, Grenoble-Alpes University, Grenoble, France", 
            "Department of Physiology and Sleep, Grenoble Alpes University Hospital, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "P\u00e9pin", 
        "givenName": "Jean-Louis", 
        "id": "sg:person.01177006343.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177006343.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "INSERM U1042, HP2 Laboratory, Grenoble-Alpes University, Grenoble, France", 
          "id": "http://www.grid.ac/institutes/grid.450307.5", 
          "name": [
            "Emergency Department and Mobile Intensive Care Unit, Grenoble Alpes University Hospital, Grenoble, France", 
            "INSERM U1042, HP2 Laboratory, Grenoble-Alpes University, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maignan", 
        "givenName": "Maxime", 
        "id": "sg:person.01120615246.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120615246.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Emergency Medicine, Research Centre, Sacr\u00e9-Coeur Hospital of Montreal, Montreal, Quebec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.414056.2", 
          "name": [
            "Department of Emergency Medicine, Research Centre, Sacr\u00e9-Coeur Hospital of Montreal, Montreal, Quebec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chauny", 
        "givenName": "Jean-Marc", 
        "id": "sg:person.0754120747.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754120747.38"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00134-015-3919-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015365558", 
          "https://doi.org/10.1007/s00134-015-3919-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-006-0447-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035879747", 
          "https://doi.org/10.1007/s00134-006-0447-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1741-7015-11-181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010506925", 
          "https://doi.org/10.1186/1741-7015-11-181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11136-013-0515-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048325997", 
          "https://doi.org/10.1007/s11136-013-0515-5"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-03-19", 
    "datePublishedReg": "2020-03-19", 
    "description": "There is still debate as to the safety of non-palliative opioid administration to chronic obstructive pulmonary disease (COPD) patients punctually treated for an acute complaint. All patients over 40 presenting at two university hospital emergency departments (Montr\u00e9al Qc, Grenoble Fr) from March 2008 to September 2014 with dyspnea, abdominal pain or trauma were retrieved, and COPD patients were selected. Our primary endpoint was a composite criterion including invasive ventilation and death. Comparisons between visits in which opioid drugs were prescribed and those without opioids were performed using an inverse probability of treatment and censoring weight (IPTCW) estimator to adjust for baseline confounders. A survival weighted Cox model was used. 7799 visits by COPD patients were identified, corresponding to 4173 unique patients. Opioid drug prescription was reported in 1317 (16.9%) visits. After applying IPCTW weighting, opioid prescription was found to be associated with the composite criterion of poor clinical outcomes (HR\u2009=\u20094.73 (2.94; 7.61), p\u2009<\u20090.01). When taken separately, this association remained significant for invasive ventilation and death, but not for NIV. All sensitivity analyses confirmed the association, except for patients with trauma or abdominal pain as the main complaint. This excess risk is observed whatever the route of administration.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-020-61887-2", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "keywords": [
      "abdominal pain", 
      "invasive ventilation", 
      "COPD patients", 
      "chronic obstructive pulmonary disease patients", 
      "obstructive pulmonary disease patients", 
      "university hospital emergency department", 
      "chronic obstructive pulmonary disease", 
      "opioid drug prescriptions", 
      "multicenter observational study", 
      "pulmonary disease patients", 
      "obstructive pulmonary disease", 
      "opioid drug use", 
      "poor clinical outcome", 
      "hospital emergency department", 
      "route of administration", 
      "composite criterion", 
      "opioid administration", 
      "primary endpoint", 
      "opioid prescriptions", 
      "pulmonary disease", 
      "clinical outcomes", 
      "acute complaints", 
      "baseline confounders", 
      "unique patients", 
      "emergency department", 
      "opioid drugs", 
      "adverse outcomes", 
      "disease patients", 
      "main complaint", 
      "excess risk", 
      "drug prescriptions", 
      "observational study", 
      "Cox model", 
      "patients", 
      "drug use", 
      "inverse probability", 
      "visits", 
      "pain", 
      "complaints", 
      "trauma", 
      "administration", 
      "ventilation", 
      "death", 
      "outcomes", 
      "prescription", 
      "association", 
      "dyspnea", 
      "opioids", 
      "confounders", 
      "disease", 
      "endpoint", 
      "drugs", 
      "survival", 
      "NIV", 
      "treatment", 
      "risk", 
      "criteria", 
      "emergency", 
      "Department", 
      "safety", 
      "sensitivity analysis", 
      "study", 
      "use", 
      "comparison", 
      "analysis", 
      "route", 
      "probability", 
      "model", 
      "weighting", 
      "weight estimator", 
      "estimator"
    ], 
    "name": "Opioid drug use in emergency and adverse outcomes among patients with chronic obstructive pulmonary disease: a multicenter observational study", 
    "pagination": "5038", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1125754080"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-020-61887-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "32193505"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-020-61887-2", 
      "https://app.dimensions.ai/details/publication/pub.1125754080"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_859.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-020-61887-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-61887-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-61887-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-61887-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-61887-2'


 

This table displays all metadata directly associated to this object as RDF triples.

287 TRIPLES      21 PREDICATES      115 URIs      103 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-020-61887-2 schema:about N18060feda6774ecd89e92961528bf7af
2 N1cbc98966724483880f3210dbdfb0edd
3 N2c692a83a9374bd8ada4c529ce85c7a3
4 N2d98dd126abf4213ac473f98d0ef78e7
5 N35205b4171334c2f881ba9ecb74b319a
6 N44439f383f2541828952d03757ee55e3
7 N5335f67ab0404e60b4f673eda5ff3599
8 N616083d4db7e42a995fc4a35bc20fccb
9 N71dedc700344475ea531e5b035f92d67
10 N77779b4d57bd4468a8efa021103a06e9
11 N7d669fed6c1347b891a2dde95ecbfb50
12 N891dbabef9294b86a6a8de843e828fce
13 Nadc4ab5482dd4dbdb748fa3b7891caa7
14 Nd04d753996404e6493c6a7154525151c
15 Ndeab507a28564a7d8dbcae02805577e6
16 anzsrc-for:11
17 anzsrc-for:1102
18 schema:author N8ebc8286192a44f39aea6303577f74a0
19 schema:citation sg:pub.10.1007/s00134-006-0447-4
20 sg:pub.10.1007/s00134-015-3919-6
21 sg:pub.10.1007/s11136-013-0515-5
22 sg:pub.10.1186/1741-7015-11-181
23 schema:datePublished 2020-03-19
24 schema:datePublishedReg 2020-03-19
25 schema:description There is still debate as to the safety of non-palliative opioid administration to chronic obstructive pulmonary disease (COPD) patients punctually treated for an acute complaint. All patients over 40 presenting at two university hospital emergency departments (Montréal Qc, Grenoble Fr) from March 2008 to September 2014 with dyspnea, abdominal pain or trauma were retrieved, and COPD patients were selected. Our primary endpoint was a composite criterion including invasive ventilation and death. Comparisons between visits in which opioid drugs were prescribed and those without opioids were performed using an inverse probability of treatment and censoring weight (IPTCW) estimator to adjust for baseline confounders. A survival weighted Cox model was used. 7799 visits by COPD patients were identified, corresponding to 4173 unique patients. Opioid drug prescription was reported in 1317 (16.9%) visits. After applying IPCTW weighting, opioid prescription was found to be associated with the composite criterion of poor clinical outcomes (HR = 4.73 (2.94; 7.61), p < 0.01). When taken separately, this association remained significant for invasive ventilation and death, but not for NIV. All sensitivity analyses confirmed the association, except for patients with trauma or abdominal pain as the main complaint. This excess risk is observed whatever the route of administration.
26 schema:genre article
27 schema:isAccessibleForFree true
28 schema:isPartOf N87ba8bfd51ed478983002870c87197ec
29 Nb1b7e5461ac6494cb7433784a7ad5ba7
30 sg:journal.1045337
31 schema:keywords COPD patients
32 Cox model
33 Department
34 NIV
35 abdominal pain
36 acute complaints
37 administration
38 adverse outcomes
39 analysis
40 association
41 baseline confounders
42 chronic obstructive pulmonary disease
43 chronic obstructive pulmonary disease patients
44 clinical outcomes
45 comparison
46 complaints
47 composite criterion
48 confounders
49 criteria
50 death
51 disease
52 disease patients
53 drug prescriptions
54 drug use
55 drugs
56 dyspnea
57 emergency
58 emergency department
59 endpoint
60 estimator
61 excess risk
62 hospital emergency department
63 invasive ventilation
64 inverse probability
65 main complaint
66 model
67 multicenter observational study
68 observational study
69 obstructive pulmonary disease
70 obstructive pulmonary disease patients
71 opioid administration
72 opioid drug prescriptions
73 opioid drug use
74 opioid drugs
75 opioid prescriptions
76 opioids
77 outcomes
78 pain
79 patients
80 poor clinical outcome
81 prescription
82 primary endpoint
83 probability
84 pulmonary disease
85 pulmonary disease patients
86 risk
87 route
88 route of administration
89 safety
90 sensitivity analysis
91 study
92 survival
93 trauma
94 treatment
95 unique patients
96 university hospital emergency department
97 use
98 ventilation
99 visits
100 weight estimator
101 weighting
102 schema:name Opioid drug use in emergency and adverse outcomes among patients with chronic obstructive pulmonary disease: a multicenter observational study
103 schema:pagination 5038
104 schema:productId N187da1a35c7f4826ab13de0b9d1f58c1
105 N4db95fe2809945ea974a84768f58fe31
106 N819689c5be604db28a7c499cb01f16e8
107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1125754080
108 https://doi.org/10.1038/s41598-020-61887-2
109 schema:sdDatePublished 2022-09-02T16:04
110 schema:sdLicense https://scigraph.springernature.com/explorer/license/
111 schema:sdPublisher Nc9af0c4cca4040cba01ff83b850ecfec
112 schema:url https://doi.org/10.1038/s41598-020-61887-2
113 sgo:license sg:explorer/license/
114 sgo:sdDataset articles
115 rdf:type schema:ScholarlyArticle
116 N1568f6c40bf54a148e00a8ab21fc135c rdf:first sg:person.01225611327.59
117 rdf:rest N87cf9247f27348bfb152f1bd68446832
118 N18060feda6774ecd89e92961528bf7af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Male
120 rdf:type schema:DefinedTerm
121 N187da1a35c7f4826ab13de0b9d1f58c1 schema:name dimensions_id
122 schema:value pub.1125754080
123 rdf:type schema:PropertyValue
124 N1cbc98966724483880f3210dbdfb0edd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Pulmonary Disease, Chronic Obstructive
126 rdf:type schema:DefinedTerm
127 N276c5debedff408796f9dd47e4c17906 rdf:first sg:person.01220232430.18
128 rdf:rest Ne411cdf66992467896126948bf1e718f
129 N2c692a83a9374bd8ada4c529ce85c7a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Retrospective Studies
131 rdf:type schema:DefinedTerm
132 N2d98dd126abf4213ac473f98d0ef78e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Age Factors
134 rdf:type schema:DefinedTerm
135 N35205b4171334c2f881ba9ecb74b319a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Humans
137 rdf:type schema:DefinedTerm
138 N44439f383f2541828952d03757ee55e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Emergency Service, Hospital
140 rdf:type schema:DefinedTerm
141 N4db95fe2809945ea974a84768f58fe31 schema:name doi
142 schema:value 10.1038/s41598-020-61887-2
143 rdf:type schema:PropertyValue
144 N5335f67ab0404e60b4f673eda5ff3599 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Palliative Care
146 rdf:type schema:DefinedTerm
147 N55a9dbc8b6b04511bd29c1848aaa50c0 rdf:first sg:person.0754120747.38
148 rdf:rest rdf:nil
149 N5f344788adab43998a86eb5ffe06cc7d rdf:first sg:person.01120615246.81
150 rdf:rest N55a9dbc8b6b04511bd29c1848aaa50c0
151 N616083d4db7e42a995fc4a35bc20fccb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Prescriptions
153 rdf:type schema:DefinedTerm
154 N622a625d243c46cea977feeb43604d77 schema:affiliation grid-institutes:grid.450307.5
155 schema:familyName Charif
156 schema:givenName Isma
157 rdf:type schema:Person
158 N71dedc700344475ea531e5b035f92d67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Pain
160 rdf:type schema:DefinedTerm
161 N77779b4d57bd4468a8efa021103a06e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Female
163 rdf:type schema:DefinedTerm
164 N7d669fed6c1347b891a2dde95ecbfb50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Aged
166 rdf:type schema:DefinedTerm
167 N7e6604b7bf474eb89bbe0688cbb20739 rdf:first sg:person.0576552462.02
168 rdf:rest N8c87f427b3b44d18b19662ff5c0ffb7b
169 N819689c5be604db28a7c499cb01f16e8 schema:name pubmed_id
170 schema:value 32193505
171 rdf:type schema:PropertyValue
172 N8723a177edf24b6289053e9ea5d75ff6 rdf:first Nf20cfe77d03044aaa64651450620b95d
173 rdf:rest Naa3f981cd4034a1c9a0b6a21d03c1f79
174 N87ba8bfd51ed478983002870c87197ec schema:volumeNumber 10
175 rdf:type schema:PublicationVolume
176 N87cf9247f27348bfb152f1bd68446832 rdf:first sg:person.0576671510.21
177 rdf:rest N276c5debedff408796f9dd47e4c17906
178 N891dbabef9294b86a6a8de843e828fce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Risk
180 rdf:type schema:DefinedTerm
181 N8c87f427b3b44d18b19662ff5c0ffb7b rdf:first sg:person.01125634305.00
182 rdf:rest N8723a177edf24b6289053e9ea5d75ff6
183 N8ebc8286192a44f39aea6303577f74a0 rdf:first sg:person.01121270332.39
184 rdf:rest N7e6604b7bf474eb89bbe0688cbb20739
185 Naa3f981cd4034a1c9a0b6a21d03c1f79 rdf:first N622a625d243c46cea977feeb43604d77
186 rdf:rest N1568f6c40bf54a148e00a8ab21fc135c
187 Nadc4ab5482dd4dbdb748fa3b7891caa7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Prognosis
189 rdf:type schema:DefinedTerm
190 Nb1b7e5461ac6494cb7433784a7ad5ba7 schema:issueNumber 1
191 rdf:type schema:PublicationIssue
192 Nc9af0c4cca4040cba01ff83b850ecfec schema:name Springer Nature - SN SciGraph project
193 rdf:type schema:Organization
194 Nd04d753996404e6493c6a7154525151c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Multicenter Studies as Topic
196 rdf:type schema:DefinedTerm
197 Ndeab507a28564a7d8dbcae02805577e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Analgesics, Opioid
199 rdf:type schema:DefinedTerm
200 Ne411cdf66992467896126948bf1e718f rdf:first sg:person.01177006343.55
201 rdf:rest N5f344788adab43998a86eb5ffe06cc7d
202 Nf20cfe77d03044aaa64651450620b95d schema:affiliation grid-institutes:grid.410529.b
203 schema:familyName Faivre-Pierret
204 schema:givenName Caroline
205 rdf:type schema:Person
206 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
207 schema:name Medical and Health Sciences
208 rdf:type schema:DefinedTerm
209 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
210 schema:name Cardiorespiratory Medicine and Haematology
211 rdf:type schema:DefinedTerm
212 sg:journal.1045337 schema:issn 2045-2322
213 schema:name Scientific Reports
214 schema:publisher Springer Nature
215 rdf:type schema:Periodical
216 sg:person.01120615246.81 schema:affiliation grid-institutes:grid.450307.5
217 schema:familyName Maignan
218 schema:givenName Maxime
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120615246.81
220 rdf:type schema:Person
221 sg:person.01121270332.39 schema:affiliation grid-institutes:grid.450307.5
222 schema:familyName Viglino
223 schema:givenName Damien
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121270332.39
225 rdf:type schema:Person
226 sg:person.01125634305.00 schema:affiliation grid-institutes:grid.410529.b
227 schema:familyName Bailly
228 schema:givenName Sebastien
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125634305.00
230 rdf:type schema:Person
231 sg:person.01177006343.55 schema:affiliation grid-institutes:grid.410529.b
232 schema:familyName Pépin
233 schema:givenName Jean-Louis
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177006343.55
235 rdf:type schema:Person
236 sg:person.01220232430.18 schema:affiliation grid-institutes:grid.410529.b
237 schema:familyName Debaty
238 schema:givenName Guillaume
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220232430.18
240 rdf:type schema:Person
241 sg:person.01225611327.59 schema:affiliation grid-institutes:grid.410529.b
242 schema:familyName Roustit
243 schema:givenName Matthieu
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225611327.59
245 rdf:type schema:Person
246 sg:person.0576552462.02 schema:affiliation grid-institutes:grid.414056.2
247 schema:familyName Daoust
248 schema:givenName Raoul
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576552462.02
250 rdf:type schema:Person
251 sg:person.0576671510.21 schema:affiliation grid-institutes:grid.414056.2
252 schema:familyName Paquet
253 schema:givenName Jean
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576671510.21
255 rdf:type schema:Person
256 sg:person.0754120747.38 schema:affiliation grid-institutes:grid.414056.2
257 schema:familyName Chauny
258 schema:givenName Jean-Marc
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754120747.38
260 rdf:type schema:Person
261 sg:pub.10.1007/s00134-006-0447-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035879747
262 https://doi.org/10.1007/s00134-006-0447-4
263 rdf:type schema:CreativeWork
264 sg:pub.10.1007/s00134-015-3919-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015365558
265 https://doi.org/10.1007/s00134-015-3919-6
266 rdf:type schema:CreativeWork
267 sg:pub.10.1007/s11136-013-0515-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048325997
268 https://doi.org/10.1007/s11136-013-0515-5
269 rdf:type schema:CreativeWork
270 sg:pub.10.1186/1741-7015-11-181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010506925
271 https://doi.org/10.1186/1741-7015-11-181
272 rdf:type schema:CreativeWork
273 grid-institutes:grid.410529.b schema:alternateName Clinical Pharmacology Department, INSERM CIC1406, Grenoble Alpes University Hospital, Grenoble, France
274 Department of Physiology and Sleep, Grenoble Alpes University Hospital, Grenoble, France
275 Emergency Department and Mobile Intensive Care Unit, Grenoble Alpes University Hospital, Grenoble, France
276 schema:name Clinical Pharmacology Department, INSERM CIC1406, Grenoble Alpes University Hospital, Grenoble, France
277 Department of Physiology and Sleep, Grenoble Alpes University Hospital, Grenoble, France
278 Emergency Department and Mobile Intensive Care Unit, Grenoble Alpes University Hospital, Grenoble, France
279 INSERM U1042, HP2 Laboratory, Grenoble-Alpes University, Grenoble, France
280 rdf:type schema:Organization
281 grid-institutes:grid.414056.2 schema:alternateName Department of Emergency Medicine, Research Centre, Sacré-Coeur Hospital of Montreal, Montreal, Quebec, Canada
282 schema:name Department of Emergency Medicine, Research Centre, Sacré-Coeur Hospital of Montreal, Montreal, Quebec, Canada
283 rdf:type schema:Organization
284 grid-institutes:grid.450307.5 schema:alternateName INSERM U1042, HP2 Laboratory, Grenoble-Alpes University, Grenoble, France
285 schema:name Emergency Department and Mobile Intensive Care Unit, Grenoble Alpes University Hospital, Grenoble, France
286 INSERM U1042, HP2 Laboratory, Grenoble-Alpes University, Grenoble, France
287 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...