Very-long-chain fatty acid metabolic capacity of 17-beta-hydroxysteroid dehydrogenase type 12 (HSD17B12) promotes replication of hepatitis C virus and related flaviviruses View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-03-04

AUTHORS

Bassim Mohamed, Clément Mazeaud, Martin Baril, Donald Poirier, Aïssatou Aïcha Sow, Laurent Chatel-Chaix, Vladimir Titorenko, Daniel Lamarre

ABSTRACT

Flaviviridae infections represent a major global health burden. By deciphering mechanistic aspects of hepatitis C virus (HCV)-host interactions, one could discover common strategy for inhibiting the replication of related flaviviruses. By elucidating the HCV interactome, we identified the 17-beta-hydroxysteroid dehydrogenase type 12 (HSD17B12) as a human hub of the very-long-chain fatty acid (VLCFA) synthesis pathway and core interactor. Here we show that HSD17B12 knockdown (KD) impairs HCV replication and reduces virion production. Mechanistically, depletion of HSD17B12 induces alterations in VLCFA-containing lipid species and a drastic reduction of lipid droplets (LDs) that play a critical role in virus assembly. Oleic acid supplementation rescues viral RNA replication and production of infectious particles in HSD17B12 depleted cells, supporting a specific role of VLCFA in HCV life cycle. Furthermore, the small-molecule HSD17B12 inhibitor, INH-12, significantly reduces replication and infectious particle production of HCV as well as dengue virus and Zika virus revealing a conserved requirement across Flaviviridae virus family. Overall, the data provide a strong rationale for the advanced evaluation of HSD17B12 inhibition as a promising broad-spectrum antiviral strategy for the treatment of Flaviviridae infections. More... »

PAGES

4040

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-020-61051-w

DOI

http://dx.doi.org/10.1038/s41598-020-61051-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1125348903

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32132633


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "17-Hydroxysteroid Dehydrogenases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chlorocebus aethiops", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HeLa Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hep G2 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepacivirus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oleic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vero Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Virus Replication", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Pharmacology Department, Medical Research Division, National Research Centre, Cairo, Egypt", 
          "id": "http://www.grid.ac/institutes/grid.419725.c", 
          "name": [
            "Centre de Recherche du CHUM (CRCHUM) et Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Canada", 
            "Pharmacology Department, Medical Research Division, National Research Centre, Cairo, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mohamed", 
        "givenName": "Bassim", 
        "id": "sg:person.0625255750.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625255750.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut National de la Recherche Scientifique, Centre Armand-Frappier Sant\u00e9 Biotechnologie, Universit\u00e9 du Qu\u00e9bec, Laval, Canada", 
          "id": "http://www.grid.ac/institutes/grid.418084.1", 
          "name": [
            "Institut National de la Recherche Scientifique, Centre Armand-Frappier Sant\u00e9 Biotechnologie, Universit\u00e9 du Qu\u00e9bec, Laval, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mazeaud", 
        "givenName": "Cl\u00e9ment", 
        "id": "sg:person.015753311337.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015753311337.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre de Recherche du CHUM (CRCHUM) et Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Canada", 
          "id": "http://www.grid.ac/institutes/grid.14848.31", 
          "name": [
            "Centre de Recherche du CHUM (CRCHUM) et Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baril", 
        "givenName": "Martin", 
        "id": "sg:person.01223023160.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223023160.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre de recherche du CHU de Qu\u00e9bec et Facult\u00e9 de m\u00e9decine, Universit\u00e9 Laval, Qu\u00e9bec, Canada", 
          "id": "http://www.grid.ac/institutes/grid.411081.d", 
          "name": [
            "Centre de recherche du CHU de Qu\u00e9bec et Facult\u00e9 de m\u00e9decine, Universit\u00e9 Laval, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Poirier", 
        "givenName": "Donald", 
        "id": "sg:person.01256006667.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256006667.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut National de la Recherche Scientifique, Centre Armand-Frappier Sant\u00e9 Biotechnologie, Universit\u00e9 du Qu\u00e9bec, Laval, Canada", 
          "id": "http://www.grid.ac/institutes/grid.418084.1", 
          "name": [
            "Institut National de la Recherche Scientifique, Centre Armand-Frappier Sant\u00e9 Biotechnologie, Universit\u00e9 du Qu\u00e9bec, Laval, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sow", 
        "givenName": "A\u00efssatou A\u00efcha", 
        "id": "sg:person.015153433423.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015153433423.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut National de la Recherche Scientifique, Centre Armand-Frappier Sant\u00e9 Biotechnologie, Universit\u00e9 du Qu\u00e9bec, Laval, Canada", 
          "id": "http://www.grid.ac/institutes/grid.418084.1", 
          "name": [
            "Institut National de la Recherche Scientifique, Centre Armand-Frappier Sant\u00e9 Biotechnologie, Universit\u00e9 du Qu\u00e9bec, Laval, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chatel-Chaix", 
        "givenName": "Laurent", 
        "id": "sg:person.01170474457.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170474457.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Concordia University, Montr\u00e9al, Canada", 
          "id": "http://www.grid.ac/institutes/grid.410319.e", 
          "name": [
            "Concordia University, Montr\u00e9al, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Titorenko", 
        "givenName": "Vladimir", 
        "id": "sg:person.01237376277.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237376277.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Case Western Reserve University, 2103 Cornell Road, 44106, Cleveland, Ohio, USA", 
          "id": "http://www.grid.ac/institutes/grid.67105.35", 
          "name": [
            "Centre de Recherche du CHUM (CRCHUM) et Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Canada", 
            "Department of Pathology, Case Western Reserve University, 2103 Cornell Road, 44106, Cleveland, Ohio, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lamarre", 
        "givenName": "Daniel", 
        "id": "sg:person.0576725703.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576725703.72"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature02099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031742663", 
          "https://doi.org/10.1038/nature02099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4939-1363-3_21", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016309865", 
          "https://doi.org/10.1007/978-1-4939-1363-3_21"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042875201", 
          "https://doi.org/10.1038/nm1268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-981-10-8684-7_3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105193859", 
          "https://doi.org/10.1007/978-981-10-8684-7_3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro.2016.60", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004040117", 
          "https://doi.org/10.1038/nrmicro.2016.60"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021798602", 
          "https://doi.org/10.1038/nature11288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013173208", 
          "https://doi.org/10.1038/ncb1631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015293498", 
          "https://doi.org/10.1038/nature10719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep04549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013057519", 
          "https://doi.org/10.1038/srep04549"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-03-04", 
    "datePublishedReg": "2020-03-04", 
    "description": "Flaviviridae infections represent a major global health burden. By deciphering mechanistic aspects of hepatitis C virus (HCV)-host interactions, one could discover common strategy for inhibiting the replication of related flaviviruses. By elucidating the HCV interactome, we identified the 17-beta-hydroxysteroid dehydrogenase type 12 (HSD17B12) as a human hub of the very-long-chain fatty acid (VLCFA) synthesis pathway and core interactor. Here we show that HSD17B12 knockdown (KD) impairs HCV replication and reduces virion production. Mechanistically, depletion of HSD17B12 induces alterations in VLCFA-containing lipid species and a drastic reduction of lipid droplets (LDs) that play a critical role in virus assembly. Oleic acid supplementation rescues viral RNA replication and production of infectious particles in HSD17B12 depleted cells, supporting a specific role of VLCFA in HCV life cycle. Furthermore, the small-molecule HSD17B12 inhibitor, INH-12, significantly reduces replication and infectious particle production of HCV as well as dengue virus and Zika virus revealing a conserved requirement across Flaviviridae virus family. Overall, the data provide a strong rationale for the advanced evaluation of HSD17B12 inhibition as a promising broad-spectrum antiviral strategy for the treatment of Flaviviridae infections.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-020-61051-w", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "keywords": [
      "hepatitis C virus", 
      "C virus", 
      "related flaviviruses", 
      "Flaviviridae infections", 
      "major global health burden", 
      "global health burden", 
      "HCV life cycle", 
      "lipid droplets", 
      "Flaviviridae virus family", 
      "type 12", 
      "oleic acid supplementation", 
      "infectious particle production", 
      "HCV replication", 
      "health burden", 
      "acid supplementation", 
      "broad-spectrum antiviral strategy", 
      "Zika virus", 
      "dengue virus", 
      "strong rationale", 
      "antiviral strategies", 
      "viral RNA replication", 
      "virion production", 
      "infectious particles", 
      "virus", 
      "infection", 
      "flaviviruses", 
      "HSD17B12", 
      "RNA replication", 
      "host interactions", 
      "metabolic capacity", 
      "lipid species", 
      "virus families", 
      "specific role", 
      "critical role", 
      "VLCFA", 
      "HCV", 
      "fatty acid synthesis pathway", 
      "virus assembly", 
      "replication", 
      "advanced evaluation", 
      "supplementation", 
      "treatment", 
      "burden", 
      "inhibitors", 
      "inhibition", 
      "alterations", 
      "role", 
      "synthesis pathway", 
      "cells", 
      "pathway", 
      "rationale", 
      "depletion", 
      "strategies", 
      "evaluation", 
      "common strategy", 
      "production", 
      "reduction", 
      "family", 
      "drastic reduction", 
      "data", 
      "interactome", 
      "life cycle", 
      "interactors", 
      "capacity", 
      "cycle", 
      "aspects", 
      "mechanistic aspects", 
      "interaction", 
      "hub", 
      "species", 
      "requirements", 
      "particle production", 
      "droplets", 
      "assembly", 
      "particles"
    ], 
    "name": "Very-long-chain fatty acid metabolic capacity of 17-beta-hydroxysteroid dehydrogenase type 12 (HSD17B12) promotes replication of hepatitis C virus and related flaviviruses", 
    "pagination": "4040", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1125348903"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-020-61051-w"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "32132633"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-020-61051-w", 
      "https://app.dimensions.ai/details/publication/pub.1125348903"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:41", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_867.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-020-61051-w"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-61051-w'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-61051-w'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-61051-w'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-020-61051-w'


 

This table displays all metadata directly associated to this object as RDF triples.

281 TRIPLES      21 PREDICATES      120 URIs      103 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-020-61051-w schema:about N229734c2a1444e53aac84fce66a9cf89
2 N6191829cc79447e58194f89abb2564fa
3 N64e412f6ad6c4eadbe41c1c361e9c4c8
4 N7bc16209dd9c4f629f4d6d1f7adaa980
5 N839e8fa701c64e2b9ef07af325729786
6 N9a581be93eee46dbb5999e8bf01c3758
7 N9ed6d5182e0943fd8efb432379ab524e
8 N9f6a11da5d4d4384a75369b3bb124226
9 Nb0a84d081fa24d46a0453e810f4497c2
10 Ndbf8ffc6c2c74db9ac14e6e15571a26f
11 Ne73c84bab9ff4c07872b64df0c6403ea
12 anzsrc-for:11
13 anzsrc-for:1108
14 schema:author N30d924a4e7654e34afde18323ffc6533
15 schema:citation sg:pub.10.1007/978-1-4939-1363-3_21
16 sg:pub.10.1007/978-981-10-8684-7_3
17 sg:pub.10.1038/nature02099
18 sg:pub.10.1038/nature10719
19 sg:pub.10.1038/nature11288
20 sg:pub.10.1038/ncb1631
21 sg:pub.10.1038/nm1268
22 sg:pub.10.1038/nrmicro.2016.60
23 sg:pub.10.1038/srep04549
24 schema:datePublished 2020-03-04
25 schema:datePublishedReg 2020-03-04
26 schema:description Flaviviridae infections represent a major global health burden. By deciphering mechanistic aspects of hepatitis C virus (HCV)-host interactions, one could discover common strategy for inhibiting the replication of related flaviviruses. By elucidating the HCV interactome, we identified the 17-beta-hydroxysteroid dehydrogenase type 12 (HSD17B12) as a human hub of the very-long-chain fatty acid (VLCFA) synthesis pathway and core interactor. Here we show that HSD17B12 knockdown (KD) impairs HCV replication and reduces virion production. Mechanistically, depletion of HSD17B12 induces alterations in VLCFA-containing lipid species and a drastic reduction of lipid droplets (LDs) that play a critical role in virus assembly. Oleic acid supplementation rescues viral RNA replication and production of infectious particles in HSD17B12 depleted cells, supporting a specific role of VLCFA in HCV life cycle. Furthermore, the small-molecule HSD17B12 inhibitor, INH-12, significantly reduces replication and infectious particle production of HCV as well as dengue virus and Zika virus revealing a conserved requirement across Flaviviridae virus family. Overall, the data provide a strong rationale for the advanced evaluation of HSD17B12 inhibition as a promising broad-spectrum antiviral strategy for the treatment of Flaviviridae infections.
27 schema:genre article
28 schema:isAccessibleForFree true
29 schema:isPartOf N658df3f67b204b28928cbdeed1cc9325
30 N84df4a7ab61e464bac201a4c06dfe4ee
31 sg:journal.1045337
32 schema:keywords C virus
33 Flaviviridae infections
34 Flaviviridae virus family
35 HCV
36 HCV life cycle
37 HCV replication
38 HSD17B12
39 RNA replication
40 VLCFA
41 Zika virus
42 acid supplementation
43 advanced evaluation
44 alterations
45 antiviral strategies
46 aspects
47 assembly
48 broad-spectrum antiviral strategy
49 burden
50 capacity
51 cells
52 common strategy
53 critical role
54 cycle
55 data
56 dengue virus
57 depletion
58 drastic reduction
59 droplets
60 evaluation
61 family
62 fatty acid synthesis pathway
63 flaviviruses
64 global health burden
65 health burden
66 hepatitis C virus
67 host interactions
68 hub
69 infection
70 infectious particle production
71 infectious particles
72 inhibition
73 inhibitors
74 interaction
75 interactome
76 interactors
77 life cycle
78 lipid droplets
79 lipid species
80 major global health burden
81 mechanistic aspects
82 metabolic capacity
83 oleic acid supplementation
84 particle production
85 particles
86 pathway
87 production
88 rationale
89 reduction
90 related flaviviruses
91 replication
92 requirements
93 role
94 species
95 specific role
96 strategies
97 strong rationale
98 supplementation
99 synthesis pathway
100 treatment
101 type 12
102 viral RNA replication
103 virion production
104 virus
105 virus assembly
106 virus families
107 schema:name Very-long-chain fatty acid metabolic capacity of 17-beta-hydroxysteroid dehydrogenase type 12 (HSD17B12) promotes replication of hepatitis C virus and related flaviviruses
108 schema:pagination 4040
109 schema:productId N7af5d16aa3e64b25814986091b2ede95
110 N8d47bc417bd7437e97f571ed436fd7b5
111 Nd8e7ebbd677a4417847ac7624b679c49
112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1125348903
113 https://doi.org/10.1038/s41598-020-61051-w
114 schema:sdDatePublished 2022-12-01T06:41
115 schema:sdLicense https://scigraph.springernature.com/explorer/license/
116 schema:sdPublisher N3cb2675de9384774b2888c7262ee8103
117 schema:url https://doi.org/10.1038/s41598-020-61051-w
118 sgo:license sg:explorer/license/
119 sgo:sdDataset articles
120 rdf:type schema:ScholarlyArticle
121 N0dae9dba02004529be30973f9ae94912 rdf:first sg:person.015153433423.23
122 rdf:rest Ndf244497d0b541779df715ca7a091acb
123 N229734c2a1444e53aac84fce66a9cf89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name HeLa Cells
125 rdf:type schema:DefinedTerm
126 N30d924a4e7654e34afde18323ffc6533 rdf:first sg:person.0625255750.90
127 rdf:rest Ndf4122928f7c4005a2ca9a5f05e042de
128 N3cb2675de9384774b2888c7262ee8103 schema:name Springer Nature - SN SciGraph project
129 rdf:type schema:Organization
130 N5b3f00c9fbf04d8d8593e80675d6c3a4 rdf:first sg:person.01256006667.03
131 rdf:rest N0dae9dba02004529be30973f9ae94912
132 N6191829cc79447e58194f89abb2564fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Animals
134 rdf:type schema:DefinedTerm
135 N64e412f6ad6c4eadbe41c1c361e9c4c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Oleic Acid
137 rdf:type schema:DefinedTerm
138 N658df3f67b204b28928cbdeed1cc9325 schema:issueNumber 1
139 rdf:type schema:PublicationIssue
140 N69e319632b7d4c4e9c5d3f010032184e rdf:first sg:person.0576725703.72
141 rdf:rest rdf:nil
142 N7af5d16aa3e64b25814986091b2ede95 schema:name doi
143 schema:value 10.1038/s41598-020-61051-w
144 rdf:type schema:PropertyValue
145 N7bc16209dd9c4f629f4d6d1f7adaa980 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Virus Replication
147 rdf:type schema:DefinedTerm
148 N839e8fa701c64e2b9ef07af325729786 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Hep G2 Cells
150 rdf:type schema:DefinedTerm
151 N84df4a7ab61e464bac201a4c06dfe4ee schema:volumeNumber 10
152 rdf:type schema:PublicationVolume
153 N8d47bc417bd7437e97f571ed436fd7b5 schema:name pubmed_id
154 schema:value 32132633
155 rdf:type schema:PropertyValue
156 N9a581be93eee46dbb5999e8bf01c3758 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Vero Cells
158 rdf:type schema:DefinedTerm
159 N9ed6d5182e0943fd8efb432379ab524e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Hepacivirus
161 rdf:type schema:DefinedTerm
162 N9f6a11da5d4d4384a75369b3bb124226 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Hepatitis C
164 rdf:type schema:DefinedTerm
165 Nb0a84d081fa24d46a0453e810f4497c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name 17-Hydroxysteroid Dehydrogenases
167 rdf:type schema:DefinedTerm
168 Nb32821ba64ff4e67b5bd79339ab897ab rdf:first sg:person.01237376277.18
169 rdf:rest N69e319632b7d4c4e9c5d3f010032184e
170 Nd8e7ebbd677a4417847ac7624b679c49 schema:name dimensions_id
171 schema:value pub.1125348903
172 rdf:type schema:PropertyValue
173 Ndbf8ffc6c2c74db9ac14e6e15571a26f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Chlorocebus aethiops
175 rdf:type schema:DefinedTerm
176 Ndf244497d0b541779df715ca7a091acb rdf:first sg:person.01170474457.93
177 rdf:rest Nb32821ba64ff4e67b5bd79339ab897ab
178 Ndf4122928f7c4005a2ca9a5f05e042de rdf:first sg:person.015753311337.05
179 rdf:rest Ne3f01820231e49c0a95855cce17f0d18
180 Ne3f01820231e49c0a95855cce17f0d18 rdf:first sg:person.01223023160.94
181 rdf:rest N5b3f00c9fbf04d8d8593e80675d6c3a4
182 Ne73c84bab9ff4c07872b64df0c6403ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Humans
184 rdf:type schema:DefinedTerm
185 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
186 schema:name Medical and Health Sciences
187 rdf:type schema:DefinedTerm
188 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
189 schema:name Medical Microbiology
190 rdf:type schema:DefinedTerm
191 sg:journal.1045337 schema:issn 2045-2322
192 schema:name Scientific Reports
193 schema:publisher Springer Nature
194 rdf:type schema:Periodical
195 sg:person.01170474457.93 schema:affiliation grid-institutes:grid.418084.1
196 schema:familyName Chatel-Chaix
197 schema:givenName Laurent
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170474457.93
199 rdf:type schema:Person
200 sg:person.01223023160.94 schema:affiliation grid-institutes:grid.14848.31
201 schema:familyName Baril
202 schema:givenName Martin
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223023160.94
204 rdf:type schema:Person
205 sg:person.01237376277.18 schema:affiliation grid-institutes:grid.410319.e
206 schema:familyName Titorenko
207 schema:givenName Vladimir
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237376277.18
209 rdf:type schema:Person
210 sg:person.01256006667.03 schema:affiliation grid-institutes:grid.411081.d
211 schema:familyName Poirier
212 schema:givenName Donald
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256006667.03
214 rdf:type schema:Person
215 sg:person.015153433423.23 schema:affiliation grid-institutes:grid.418084.1
216 schema:familyName Sow
217 schema:givenName Aïssatou Aïcha
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015153433423.23
219 rdf:type schema:Person
220 sg:person.015753311337.05 schema:affiliation grid-institutes:grid.418084.1
221 schema:familyName Mazeaud
222 schema:givenName Clément
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015753311337.05
224 rdf:type schema:Person
225 sg:person.0576725703.72 schema:affiliation grid-institutes:grid.67105.35
226 schema:familyName Lamarre
227 schema:givenName Daniel
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576725703.72
229 rdf:type schema:Person
230 sg:person.0625255750.90 schema:affiliation grid-institutes:grid.419725.c
231 schema:familyName Mohamed
232 schema:givenName Bassim
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625255750.90
234 rdf:type schema:Person
235 sg:pub.10.1007/978-1-4939-1363-3_21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016309865
236 https://doi.org/10.1007/978-1-4939-1363-3_21
237 rdf:type schema:CreativeWork
238 sg:pub.10.1007/978-981-10-8684-7_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105193859
239 https://doi.org/10.1007/978-981-10-8684-7_3
240 rdf:type schema:CreativeWork
241 sg:pub.10.1038/nature02099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031742663
242 https://doi.org/10.1038/nature02099
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/nature10719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015293498
245 https://doi.org/10.1038/nature10719
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/nature11288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021798602
248 https://doi.org/10.1038/nature11288
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/ncb1631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013173208
251 https://doi.org/10.1038/ncb1631
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/nm1268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042875201
254 https://doi.org/10.1038/nm1268
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/nrmicro.2016.60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004040117
257 https://doi.org/10.1038/nrmicro.2016.60
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/srep04549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013057519
260 https://doi.org/10.1038/srep04549
261 rdf:type schema:CreativeWork
262 grid-institutes:grid.14848.31 schema:alternateName Centre de Recherche du CHUM (CRCHUM) et Faculté de Médecine, Université de Montréal, Montréal, Canada
263 schema:name Centre de Recherche du CHUM (CRCHUM) et Faculté de Médecine, Université de Montréal, Montréal, Canada
264 rdf:type schema:Organization
265 grid-institutes:grid.410319.e schema:alternateName Concordia University, Montréal, Canada
266 schema:name Concordia University, Montréal, Canada
267 rdf:type schema:Organization
268 grid-institutes:grid.411081.d schema:alternateName Centre de recherche du CHU de Québec et Faculté de médecine, Université Laval, Québec, Canada
269 schema:name Centre de recherche du CHU de Québec et Faculté de médecine, Université Laval, Québec, Canada
270 rdf:type schema:Organization
271 grid-institutes:grid.418084.1 schema:alternateName Institut National de la Recherche Scientifique, Centre Armand-Frappier Santé Biotechnologie, Université du Québec, Laval, Canada
272 schema:name Institut National de la Recherche Scientifique, Centre Armand-Frappier Santé Biotechnologie, Université du Québec, Laval, Canada
273 rdf:type schema:Organization
274 grid-institutes:grid.419725.c schema:alternateName Pharmacology Department, Medical Research Division, National Research Centre, Cairo, Egypt
275 schema:name Centre de Recherche du CHUM (CRCHUM) et Faculté de Médecine, Université de Montréal, Montréal, Canada
276 Pharmacology Department, Medical Research Division, National Research Centre, Cairo, Egypt
277 rdf:type schema:Organization
278 grid-institutes:grid.67105.35 schema:alternateName Department of Pathology, Case Western Reserve University, 2103 Cornell Road, 44106, Cleveland, Ohio, USA
279 schema:name Centre de Recherche du CHUM (CRCHUM) et Faculté de Médecine, Université de Montréal, Montréal, Canada
280 Department of Pathology, Case Western Reserve University, 2103 Cornell Road, 44106, Cleveland, Ohio, USA
281 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...