Maturational delay and asymmetric information flow of brain connectivity in SHR model of ADHD revealed by topological analysis of metabolic ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-02-21

AUTHORS

Seunggyun Ha, Hyekyoung Lee, Yoori Choi, Hyejin Kang, Se Jin Jeon, Jong Hoon Ryu, Hee Jin Kim, Jae Hoon Cheong, Seonhee Lim, Bung-Nyun Kim, Dong Soo Lee

ABSTRACT

Attention-deficit hyperactivity disorder (ADHD) is a complex brain development disorder characterized by hyperactivity/impulsivity and inattention. A major hypothesis of ADHD is a lag of maturation, which is supported mainly by anatomical studies evaluating cortical thickness. Here, we analyzed changes of topological characteristics of whole-brain metabolic connectivity in twelve SHR rats selected as ADHD-model rats by confirming behavior abnormalities using the marble burying test, open field test, and delay discounting task and 12 Wistar Kyoto rats as the control group, across development from 4 weeks old (childhood) and 6 weeks old (entry of puberty). A topological approach based on graph filtrations revealed a lag in the strengthening of limbic-cortical/subcortical connections in ADHD-model rats. This in turn related to impaired modularization of memory and reward-motivation associated regions. Using mathematical network analysis techniques such as single linkage hierarchical clustering and volume entropy, we observed left-lateralized connectivity in the ADHD-model rats at 6 weeks old. Our findings supported the maturational delay of metabolic connectivity in the SHR model of ADHD, and also suggested the possibility of impaired and compensative reconfiguration of information flow over the brain network. More... »

PAGES

3197

Journal

TITLE

Scientific Reports

ISSUE

1

VOLUME

10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-020-59921-4

DOI

http://dx.doi.org/10.1038/s41598-020-59921-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1125042225

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32081992


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35 schema:description Attention-deficit hyperactivity disorder (ADHD) is a complex brain development disorder characterized by hyperactivity/impulsivity and inattention. A major hypothesis of ADHD is a lag of maturation, which is supported mainly by anatomical studies evaluating cortical thickness. Here, we analyzed changes of topological characteristics of whole-brain metabolic connectivity in twelve SHR rats selected as ADHD-model rats by confirming behavior abnormalities using the marble burying test, open field test, and delay discounting task and 12 Wistar Kyoto rats as the control group, across development from 4 weeks old (childhood) and 6 weeks old (entry of puberty). A topological approach based on graph filtrations revealed a lag in the strengthening of limbic-cortical/subcortical connections in ADHD-model rats. This in turn related to impaired modularization of memory and reward-motivation associated regions. Using mathematical network analysis techniques such as single linkage hierarchical clustering and volume entropy, we observed left-lateralized connectivity in the ADHD-model rats at 6 weeks old. Our findings supported the maturational delay of metabolic connectivity in the SHR model of ADHD, and also suggested the possibility of impaired and compensative reconfiguration of information flow over the brain network.
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41 schema:keywords Kyoto rats
42 SHR model
43 SHR rats
44 Wistar-Kyoto rats
45 abnormalities
46 analysis
47 analysis techniques
48 anatomical study
49 approach
50 asymmetric information flow
51 attention deficit hyperactivity disorder
52 behavior abnormalities
53 brain connectivity
54 brain development disorders
55 brain networks
56 changes
57 characteristics
58 clustering
59 connection
60 connectivity
61 control group
62 cortical thickness
63 delay
64 development
65 development disorders
66 disorders
67 entropy
68 field tests
69 filtration
70 findings
71 flow
72 graph filtration
73 group
74 hierarchical clustering
75 hyperactivity disorder
76 hyperactivity/impulsivity
77 hypothesis
78 impulsivity
79 inattention
80 information flow
81 lag
82 major hypotheses
83 marble burying test
84 maturation
85 maturational delay
86 memory
87 metabolic connectivity
88 metabolic networks
89 model
90 modularization
91 network
92 network analysis techniques
93 open field test
94 possibility
95 rats
96 reconfiguration
97 region
98 single-linkage hierarchical clustering
99 strengthening
100 study
101 subcortical connections
102 task
103 technique
104 test
105 thickness
106 topological analysis
107 topological approach
108 topological characteristics
109 turn
110 volume entropy
111 weeks
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