Hto, Tritiated Amino Acid Exposure and External Exposure Induce Differential Effects on Hematopoiesis and Iron Metabolism View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12-27

AUTHORS

Jean-Marc Bertho, Dimitri Kereselidze, Line Manens, Cécile Culeux, Victor Magneron, Joel Surette, Melinda Blimkie, Linsdey Bertrand, Heather Wyatt, Maâmar Souidi, Isabelle Dublineau, Nicholas Priest, Jean-René Jourdain

ABSTRACT

The increased potential for tritium releases from either nuclear reactors or from new facilities raises questions about the appropriateness of the current ICRP and WHO recommendations for tritium exposures to human populations. To study the potential toxicity of tritium as a function of dose, including at a regulatory level, mice were chronically exposed to tritium in drinking water at one of three concentrations, 10 kBq.l-1, 1 MBq.l-1 or 20 MBq.l-1. Tritium was administered as either HTO or as tritiated non-essential amino acids (TAA). After one month's exposure, a dose-dependent decrease in red blood cells (RBC) and iron deprivation was seen in all TAA exposed groups, but not in the HTO exposed groups. After eight months of exposure this RBC decrease was compensated by an increase in mean globular volume - suggesting the occurrence of an iron deficit-associated anemia. The analysis of hematopoiesis, of red blood cell retention in the spleen and of iron metabolism in the liver, the kidneys and the intestine suggested that the iron deficit was due to a decrease in iron absorption from the intestine. In contrast, mice exposed to external gamma irradiation at equivalent dose rates did not show any change in red blood cell numbers, white blood cell numbers or in the plasma iron concentration. These results showed that health effects only appeared following chronic exposure to concentrations of tritium above regulatory levels and the effects seen were dependent upon the speciation of tritium. More... »

PAGES

19919

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-56453-4

DOI

http://dx.doi.org/10.1038/s41598-019-56453-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1123685209

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31882739


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28 schema:description The increased potential for tritium releases from either nuclear reactors or from new facilities raises questions about the appropriateness of the current ICRP and WHO recommendations for tritium exposures to human populations. To study the potential toxicity of tritium as a function of dose, including at a regulatory level, mice were chronically exposed to tritium in drinking water at one of three concentrations, 10 kBq.l<sup>-1</sup>, 1 MBq.l<sup>-1</sup> or 20 MBq.l<sup>-1</sup>. Tritium was administered as either HTO or as tritiated non-essential amino acids (TAA). After one month's exposure, a dose-dependent decrease in red blood cells (RBC) and iron deprivation was seen in all TAA exposed groups, but not in the HTO exposed groups. After eight months of exposure this RBC decrease was compensated by an increase in mean globular volume - suggesting the occurrence of an iron deficit-associated anemia. The analysis of hematopoiesis, of red blood cell retention in the spleen and of iron metabolism in the liver, the kidneys and the intestine suggested that the iron deficit was due to a decrease in iron absorption from the intestine. In contrast, mice exposed to external gamma irradiation at equivalent dose rates did not show any change in red blood cell numbers, white blood cell numbers or in the plasma iron concentration. These results showed that health effects only appeared following chronic exposure to concentrations of tritium above regulatory levels and the effects seen were dependent upon the speciation of tritium.
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37 HTO
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39 Induce Differential Effects
40 MBq
41 RBC decrease
42 TAA
43 absorption
44 acid
45 acid exposure
46 amino acid exposure
47 amino acids
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50 anemia
51 appropriateness
52 blood cell numbers
53 blood cell retention
54 blood cells
55 cell number
56 cell retention
57 cells
58 changes
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60 concentration
61 concentration of tritium
62 contrast
63 current ICRP
64 decrease
65 deficit-associated anemia
66 deficits
67 deprivation
68 differential effects
69 dose
70 dose rate
71 dose-dependent decrease
72 drinking water
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75 exposure
76 external gamma irradiation
77 facilities
78 function
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80 gamma irradiation
81 group
82 health effects
83 hematopoiesis
84 human populations
85 increase
86 intestine
87 iron absorption
88 iron concentration
89 iron deficit
90 iron deficit-associated anemia
91 iron deprivation
92 iron metabolism
93 irradiation
94 kBq
95 kidney
96 levels
97 liver
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99 mice
100 months
101 months exposure
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103 new facilities
104 non-essential amino acids
105 nuclear reactors
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