The interplay between Mn and Fe in Deinococcus radiodurans triggers cellular protection during paraquat-induced oxidative stress View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-11-20

AUTHORS

Sandra P. Santos, Yang Yang, Margarida T. G. Rosa, Mafalda A. A. Rodrigues, Claire Bouthier De La Tour, Suzanne Sommer, Miguel Teixeira, Maria A. Carrondo, Peter Cloetens, Isabel A. Abreu, Célia V. Romão

ABSTRACT

The bacterium Deinococcus radiodurans is highly resistant to several stress conditions, such as radiation. According to several reports, manganese plays a crucial role in stress protection, and a high Mn/Fe ratio is essential in this process. However, mobilization of manganese and iron, and the role of DNA-binding-proteins-under-starved-conditions during oxidative-stress remained open questions. We used synchrotron-based X-ray fluorescence imaging at nano-resolution to follow element-relocalization upon stress, and its dependency on the presence of Dps proteins, using dps knockout mutants. We show that manganese, calcium, and phosphorus are mobilized from rich-element regions that resemble electron-dense granules towards the cytosol and the cellular membrane, in a Dps-dependent way. Moreover, iron delocalizes from the septum region to the cytoplasm affecting cell division, specifically in the septum formation. These mechanisms are orchestrated by Dps1 and Dps2, which play a crucial role in metal homeostasis, and are associated with the D. radiodurans tolerance against reactive oxygen species. More... »

PAGES

17217

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-53140-2

DOI

http://dx.doi.org/10.1038/s41598-019-53140-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1122747581

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31748604


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54 high Mn/Fe ratio
55 homeostasis
56 interplay
57 iron
58 knockout mutants
59 manganese
60 mechanism
61 membrane
62 metal homeostasis
63 mobilization
64 mobilization of manganese
65 mutants
66 open question
67 oxidative stress
68 oxygen species
69 paraquat-induced oxidative stress
70 phosphorus
71 presence
72 process
73 protection
74 protein
75 questions
76 radiation
77 radiodurans
78 radiodurans tolerance
79 ratio
80 ray fluorescence
81 reactive oxygen species
82 region
83 report
84 rich-element regions
85 role
86 septum formation
87 septum region
88 species
89 stress
90 stress conditions
91 stress protection
92 tolerance
93 way
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