Differential effects of D-cycloserine and amantadine on motor behavior and D2/3 receptor binding in the nigrostriatal and mesolimbic system of ... View Full Text


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Article Info

DATE

2019-11-06

AUTHORS

Susanne Nikolaus, Hans-Jörg Wittsack, Frithjof Wickrath, Anja Müller-Lutz, Hubertus Hautzel, Markus Beu, Christina Antke, Eduards Mamlins, Maria Angelica De Souza Silva, Joseph P. Huston, Gerald Antoch, Hans-Wilhelm Müller

ABSTRACT

D-cycloserine (DCS) and amantadine (AMA) act as partial NMDA receptor (R) agonist and antagonist, respectively. In the present study, we compared the effects of DCS and AMA on dopamine D2/3R binding in the brain of adult rats in relation to motor behavior. D2/3R binding was determined with small animal SPECT in baseline and after challenge with DCS (20 mg/kg) or AMA (40 mg/kg) with [123I]IBZM as radioligand. Immediately post-challenge, motor/exploratory behavior was assessed for 30 min in an open field. The regional binding potentials (ratios of the specifically bound compartments to the cerebellar reference region) were computed in baseline and post-challenge. DCS increased D2/3R binding in nucleus accumbens, substantia nigra/ventral tegmental area, thalamus, frontal, motor and parietal cortex as well as anterodorsal and posterior hippocampus, whereas AMA decreased D2/3R binding in nucleus accumbens, caudateputamen and thalamus. After DCS, ambulation and head-shoulder motility were decreased, while sitting was increased compared to vehicle and AMA. Moreover, DCS increased rearing relative to AMA. The regional elevations of D2/3R binding after DCS reflect a reduction of available dopamine throughout the mesolimbocortical system. In contrast, the reductions of D2/3R binding after AMA indicate increased dopamine in nucleus accumbens, caudateputamen and thalamus. Findings imply that, after DCS, nigrostriatal and mesolimbic dopamine levels are directly related to motor/exploratory activity, whereas an inverse relationship may be inferred for AMA. More... »

PAGES

16128

References to SciGraph publications

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  • Identifiers

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    http://scigraph.springernature.com/pub.10.1038/s41598-019-52185-7

    DOI

    http://dx.doi.org/10.1038/s41598-019-52185-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1122331313

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31695055


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