Molecular alterations and PD-L1 expression in non-ampullary duodenal adenocarcinoma: Associations among clinicopathological, immunophenotypic and molecular features View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-07-19

AUTHORS

Jiro Watari, Seiichiro Mitani, Chiyomi Ito, Katsuyuki Tozawa, Toshihiko Tomita, Tadayuki Oshima, Hirokazu Fukui, Shigenori Kadowaki, Seiji Natsume, Yoshiki Senda, Masahiro Tajika, Kazuo Hara, Yasushi Yatabe, Yasuhiro Shimizu, Kei Muro, Takeshi Morimoto, Seiichi Hirota, Kiron M. Das, Hiroto Miwa

ABSTRACT

Non-ampullary duodenal adenocarcinoma (NADC) is extremely rare. Little is known about its clinicopathological and molecular features or its management. Herein we retrospectively analyzed the cases of 32 NADC patients, focusing on microsatellite instability (MSI), genetic mutations, CpG island methylator phenotype (CIMP), and immunostaining including mucin phenotype and PD-L1 expression. The incidence of MSI, KRAS/BRAF/GNAS mutations and CIMP was 51.6%, 34.4%/3.1%/6.5% and 28.1%, respectively. PD-L1 expression was seen in 34.4% of patients. No significant associations between clinicopathological features and KRAS/BRAF/GNAS genetic mutations or CIMP were found. Histologically non-well-differentiated-type NADCs and those in the 1st portion of the duodenum were significantly associated with later stages (stages III–IV) (P = 0.006 and P = 0.003, respectively). Gastric-phenotype NADCs were frequently observed in the 1st portion and in late-stage patients; their cancer cells more frequently expressed PD-L1. Histologically, the non-well-differentiated type was an independent predictor of PD-L1 expression in cancer cells (OR 25.05, P = 0.04) and immune cells (OR 44.14, P = 0.02). Only late-stage disease (HR 12.23, P = 0.01) was a prognostic factor for worse overall survival in a Cox proportional hazards regression model. Our observation of high proportions of MSI and PD-L1 expression may prompt the consideration of immune checkpoint inhibitors as a new treatment option for NADCs. More... »

PAGES

10526

References to SciGraph publications

  • 2001-08-01. A phenotypic change of small intestinal epithelium to colonocytes in small intestinal adenomas and adenocarcinomas in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2017-10-17. Effects of long-term aspirin use on molecular alterations in precancerous gastric mucosa in patients with and without gastric cancer in SCIENTIFIC REPORTS
  • 2013-11-05. Small bowel adenocarcinoma phenotyping, a clinicobiological prognostic study in BRITISH JOURNAL OF CANCER
  • 2009-11-24. Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine in BRITISH JOURNAL OF CANCER
  • 2011-02-04. Genetics and epigenetics of small bowel adenocarcinoma: the interactions of CIN, MSI, and CIMP in MODERN PATHOLOGY
  • 2016-07-12. Characterisation of PD-L1-positive subsets of microsatellite-unstable colorectal cancers in BRITISH JOURNAL OF CANCER
  • 2013-07-30. Small bowel adenocarcinomas—existing evidence and evolving paradigms in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2018-09-25. Long-term effects of H. pylori eradication on epigenetic alterations related to gastric carcinogenesis in SCIENTIFIC REPORTS
  • 2013-01-04. Diagnostic value of DNA alteration: loss of heterozygosity or allelic imbalance—promising for molecular staging of prostate cancers in MEDICAL ONCOLOGY
  • 2015-03-24. Activating GNAS and KRAS mutations in gastric foveolar metaplasia, gastric heterotopia, and adenocarcinoma of the duodenum in BRITISH JOURNAL OF CANCER
  • 2015-12-15. Effects of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic treatment: analysis of molecular alterations by a randomised controlled trial in BRITISH JOURNAL OF CANCER
  • 2016-07-22. Patterns and prognostic relevance of PD-1 and PD-L1 expression in colorectal carcinoma in MODERN PATHOLOGY
  • Journal

    TITLE

    Scientific Reports

    ISSUE

    1

    VOLUME

    9

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-019-46167-y

    DOI

    http://dx.doi.org/10.1038/s41598-019-46167-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1118097789

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31324814


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adenocarcinoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "B7-H1 Antigen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromogranins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "CpG Islands", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Methylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA, Neoplasm", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Duodenal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "GTP-Binding Protein alpha Subunits, Gs", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genes, Neoplasm", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genes, ras", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kaplan-Meier Estimate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Microsatellite Instability", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phenotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proportional Hazards Models", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins B-raf", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272264.7", 
              "name": [
                "Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Watari", 
            "givenName": "Jiro", 
            "id": "sg:person.01177145244.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177145244.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410800.d", 
              "name": [
                "Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mitani", 
            "givenName": "Seiichiro", 
            "id": "sg:person.01305720353.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305720353.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272264.7", 
              "name": [
                "Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ito", 
            "givenName": "Chiyomi", 
            "id": "sg:person.016557126511.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016557126511.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272264.7", 
              "name": [
                "Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tozawa", 
            "givenName": "Katsuyuki", 
            "id": "sg:person.01137000423.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137000423.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272264.7", 
              "name": [
                "Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tomita", 
            "givenName": "Toshihiko", 
            "id": "sg:person.01340061160.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340061160.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272264.7", 
              "name": [
                "Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oshima", 
            "givenName": "Tadayuki", 
            "id": "sg:person.0723101126.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723101126.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272264.7", 
              "name": [
                "Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fukui", 
            "givenName": "Hirokazu", 
            "id": "sg:person.07372705062.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07372705062.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410800.d", 
              "name": [
                "Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kadowaki", 
            "givenName": "Shigenori", 
            "id": "sg:person.01333122366.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333122366.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410800.d", 
              "name": [
                "Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Natsume", 
            "givenName": "Seiji", 
            "id": "sg:person.0607004507.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607004507.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410800.d", 
              "name": [
                "Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Senda", 
            "givenName": "Yoshiki", 
            "id": "sg:person.01367456571.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367456571.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Endoscopy, Aichi Cancer Center Hospital, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410800.d", 
              "name": [
                "Department of Endoscopy, Aichi Cancer Center Hospital, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tajika", 
            "givenName": "Masahiro", 
            "id": "sg:person.01241316024.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241316024.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410800.d", 
              "name": [
                "Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hara", 
            "givenName": "Kazuo", 
            "id": "sg:person.01263636065.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263636065.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Molecular Diagnosis, Aichi Cancer Center Hospital, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410800.d", 
              "name": [
                "Department of Pathology and Molecular Diagnosis, Aichi Cancer Center Hospital, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yatabe", 
            "givenName": "Yasushi", 
            "id": "sg:person.01234607202.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234607202.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410800.d", 
              "name": [
                "Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shimizu", 
            "givenName": "Yasuhiro", 
            "id": "sg:person.015771736565.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015771736565.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410800.d", 
              "name": [
                "Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Muro", 
            "givenName": "Kei", 
            "id": "sg:person.0740500270.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740500270.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272264.7", 
              "name": [
                "Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Morimoto", 
            "givenName": "Takeshi", 
            "id": "sg:person.011273662612.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011273662612.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272264.7", 
              "name": [
                "Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hirota", 
            "givenName": "Seiichi", 
            "id": "sg:person.013156774212.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013156774212.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology and Hepatology, Departments of Medicine and Pathology, Robert Wood Johnson Medical School, Rutgers, Cancer Institute of New Jersey, New Brunswick, NJ, USA", 
              "id": "http://www.grid.ac/institutes/grid.430387.b", 
              "name": [
                "Division of Gastroenterology and Hepatology, Departments of Medicine and Pathology, Robert Wood Johnson Medical School, Rutgers, Cancer Institute of New Jersey, New Brunswick, NJ, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Das", 
            "givenName": "Kiron M.", 
            "id": "sg:person.011511544777.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011511544777.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272264.7", 
              "name": [
                "Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miwa", 
            "givenName": "Hiroto", 
            "id": "sg:person.0611747536.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611747536.16"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/s41598-018-32717-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107108093", 
              "https://doi.org/10.1038/s41598-018-32717-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-13842-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092170430", 
              "https://doi.org/10.1038/s41598-017-13842-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2013.132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053599458", 
              "https://doi.org/10.1038/nrclinonc.2013.132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2015.104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050485568", 
              "https://doi.org/10.1038/bjc.2015.104"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2015.418", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021770280", 
              "https://doi.org/10.1038/bjc.2015.418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2016.211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037442310", 
              "https://doi.org/10.1038/bjc.2016.211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12032-012-0391-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020695357", 
              "https://doi.org/10.1007/s12032-012-0391-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2001.04056.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027806508", 
              "https://doi.org/10.1111/j.1572-0241.2001.04056.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2013.677", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013589069", 
              "https://doi.org/10.1038/bjc.2013.677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2010.223", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001321209", 
              "https://doi.org/10.1038/modpathol.2010.223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2016.139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034870705", 
              "https://doi.org/10.1038/modpathol.2016.139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6605449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000280877", 
              "https://doi.org/10.1038/sj.bjc.6605449"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-07-19", 
        "datePublishedReg": "2019-07-19", 
        "description": "Non-ampullary duodenal adenocarcinoma (NADC) is extremely rare. Little is known about its clinicopathological and molecular features or its management. Herein we retrospectively analyzed the cases of 32 NADC patients, focusing on microsatellite instability (MSI), genetic mutations, CpG island methylator phenotype (CIMP), and immunostaining including mucin phenotype and PD-L1 expression. The incidence of MSI, KRAS/BRAF/GNAS mutations and CIMP was 51.6%, 34.4%/3.1%/6.5% and 28.1%, respectively. PD-L1 expression was seen in 34.4% of patients. No significant associations between clinicopathological features and KRAS/BRAF/GNAS genetic mutations or CIMP were found. Histologically non-well-differentiated-type NADCs and those in the 1st portion of the duodenum were significantly associated with later stages (stages III\u2013IV) (P\u2009=\u20090.006 and P\u2009=\u20090.003, respectively). Gastric-phenotype NADCs were frequently observed in the 1st portion and in late-stage patients; their cancer cells more frequently expressed PD-L1. Histologically, the non-well-differentiated type was an independent predictor of PD-L1 expression in cancer cells (OR 25.05, P\u2009=\u20090.04) and immune cells (OR 44.14, P\u2009=\u20090.02). Only late-stage disease (HR 12.23, P\u2009=\u20090.01) was a prognostic factor for worse overall survival in a Cox proportional hazards regression model. Our observation of high proportions of MSI and PD-L1 expression may prompt the consideration of immune checkpoint inhibitors as a new treatment option for NADCs.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41598-019-46167-y", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2497877", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "keywords": [
          "non-ampullary duodenal adenocarcinoma", 
          "PD-L1 expression", 
          "CpG island methylator phenotype", 
          "microsatellite instability", 
          "duodenal adenocarcinoma", 
          "Cox proportional hazards regression model", 
          "proportional hazards regression models", 
          "incidence of MSI", 
          "immune checkpoint inhibitors", 
          "cancer cells", 
          "late-stage patients", 
          "late-stage disease", 
          "worse overall survival", 
          "hazards regression models", 
          "new treatment options", 
          "genetic mutations", 
          "molecular features", 
          "checkpoint inhibitors", 
          "overall survival", 
          "PD-L1", 
          "independent predictors", 
          "prognostic factors", 
          "clinicopathological features", 
          "treatment options", 
          "immune cells", 
          "mucin phenotype", 
          "GNAS mutations", 
          "molecular alterations", 
          "significant association", 
          "patients", 
          "methylator phenotype", 
          "adenocarcinoma", 
          "regression models", 
          "higher proportion", 
          "expression", 
          "cells", 
          "association", 
          "mutations", 
          "phenotype", 
          "duodenum", 
          "later stages", 
          "incidence", 
          "disease", 
          "survival", 
          "predictors", 
          "inhibitors", 
          "alterations", 
          "options", 
          "proportion", 
          "management", 
          "factors", 
          "portion", 
          "cases", 
          "features", 
          "stage", 
          "types", 
          "Herein", 
          "observations", 
          "consideration", 
          "instability", 
          "model"
        ], 
        "name": "Molecular alterations and PD-L1 expression in non-ampullary duodenal adenocarcinoma: Associations among clinicopathological, immunophenotypic and molecular features", 
        "pagination": "10526", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1118097789"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-019-46167-y"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "31324814"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-019-46167-y", 
          "https://app.dimensions.ai/details/publication/pub.1118097789"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-10-01T06:45", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_799.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41598-019-46167-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-46167-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-46167-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-46167-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-46167-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    411 TRIPLES      21 PREDICATES      122 URIs      102 LITERALS      31 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-019-46167-y schema:about N16bf916b3c464a108ea8629e05f4a523
    2 N1a23453430a7435498a39750a4006fdb
    3 N30845daa92aa4cc7bcfe303df374d8c6
    4 N37c5575a16a647169076a12d7b8decc5
    5 N566356442560411e8223205d1f1bb64d
    6 N63a8725b290c4348ad4cf2a9fe53a99e
    7 N77170b843d49493f853fcb6fb623d962
    8 N7d1e3d99f18340e1be40815acf183500
    9 N7e2f8697320e42f7a7ba8c6bf0bb511e
    10 N8267846ae413482aabf2aab0f4c61fe7
    11 N8b3ee1dc53934904b116df8d24d9dead
    12 N8e3bc2abc68a48d9ba1a65db494c4e64
    13 N975e2d8840d84a4c9d92353bcc00a23b
    14 N9bd2725c4451418ca60e226a8f847543
    15 Na30cf56d5f184314ab02f8920ec06b92
    16 Na88bf87523334e7abbb01ea466768f93
    17 Naa1d387a46ff43cdbfbc9751f88e72d2
    18 Nad55ff7c9fdb47588aa991fe4636c4dd
    19 Nc3f7f99d9475425eacf971c74ac73503
    20 Ncf84e634a37a4b1fa611083accc40916
    21 Ndb31b11985be4aa89b5ddf87f2719e3d
    22 Ne9bb951cf14f477bae306fcbe8789819
    23 Nf04774787ae042c4bdb15325ebc8c6a0
    24 Nf84293f0bdb644e1bad142fe92a9833c
    25 anzsrc-for:11
    26 anzsrc-for:1112
    27 schema:author N5ad8fecd72b04d1d832f63e38324f6cb
    28 schema:citation sg:pub.10.1007/s12032-012-0391-9
    29 sg:pub.10.1038/bjc.2013.677
    30 sg:pub.10.1038/bjc.2015.104
    31 sg:pub.10.1038/bjc.2015.418
    32 sg:pub.10.1038/bjc.2016.211
    33 sg:pub.10.1038/modpathol.2010.223
    34 sg:pub.10.1038/modpathol.2016.139
    35 sg:pub.10.1038/nrclinonc.2013.132
    36 sg:pub.10.1038/s41598-017-13842-x
    37 sg:pub.10.1038/s41598-018-32717-3
    38 sg:pub.10.1038/sj.bjc.6605449
    39 sg:pub.10.1111/j.1572-0241.2001.04056.x
    40 schema:datePublished 2019-07-19
    41 schema:datePublishedReg 2019-07-19
    42 schema:description Non-ampullary duodenal adenocarcinoma (NADC) is extremely rare. Little is known about its clinicopathological and molecular features or its management. Herein we retrospectively analyzed the cases of 32 NADC patients, focusing on microsatellite instability (MSI), genetic mutations, CpG island methylator phenotype (CIMP), and immunostaining including mucin phenotype and PD-L1 expression. The incidence of MSI, KRAS/BRAF/GNAS mutations and CIMP was 51.6%, 34.4%/3.1%/6.5% and 28.1%, respectively. PD-L1 expression was seen in 34.4% of patients. No significant associations between clinicopathological features and KRAS/BRAF/GNAS genetic mutations or CIMP were found. Histologically non-well-differentiated-type NADCs and those in the 1st portion of the duodenum were significantly associated with later stages (stages III–IV) (P = 0.006 and P = 0.003, respectively). Gastric-phenotype NADCs were frequently observed in the 1st portion and in late-stage patients; their cancer cells more frequently expressed PD-L1. Histologically, the non-well-differentiated type was an independent predictor of PD-L1 expression in cancer cells (OR 25.05, P = 0.04) and immune cells (OR 44.14, P = 0.02). Only late-stage disease (HR 12.23, P = 0.01) was a prognostic factor for worse overall survival in a Cox proportional hazards regression model. Our observation of high proportions of MSI and PD-L1 expression may prompt the consideration of immune checkpoint inhibitors as a new treatment option for NADCs.
    43 schema:genre article
    44 schema:isAccessibleForFree true
    45 schema:isPartOf N19f6e12ebd0442ee9887a74b5e039fc7
    46 N3e76c57dad2842588b14d4d3f69dde0b
    47 sg:journal.1045337
    48 schema:keywords Cox proportional hazards regression model
    49 CpG island methylator phenotype
    50 GNAS mutations
    51 Herein
    52 PD-L1
    53 PD-L1 expression
    54 adenocarcinoma
    55 alterations
    56 association
    57 cancer cells
    58 cases
    59 cells
    60 checkpoint inhibitors
    61 clinicopathological features
    62 consideration
    63 disease
    64 duodenal adenocarcinoma
    65 duodenum
    66 expression
    67 factors
    68 features
    69 genetic mutations
    70 hazards regression models
    71 higher proportion
    72 immune cells
    73 immune checkpoint inhibitors
    74 incidence
    75 incidence of MSI
    76 independent predictors
    77 inhibitors
    78 instability
    79 late-stage disease
    80 late-stage patients
    81 later stages
    82 management
    83 methylator phenotype
    84 microsatellite instability
    85 model
    86 molecular alterations
    87 molecular features
    88 mucin phenotype
    89 mutations
    90 new treatment options
    91 non-ampullary duodenal adenocarcinoma
    92 observations
    93 options
    94 overall survival
    95 patients
    96 phenotype
    97 portion
    98 predictors
    99 prognostic factors
    100 proportion
    101 proportional hazards regression models
    102 regression models
    103 significant association
    104 stage
    105 survival
    106 treatment options
    107 types
    108 worse overall survival
    109 schema:name Molecular alterations and PD-L1 expression in non-ampullary duodenal adenocarcinoma: Associations among clinicopathological, immunophenotypic and molecular features
    110 schema:pagination 10526
    111 schema:productId N8c60876a12e543129862c4fe3fc88e57
    112 N8c8aa0a9e55a4305935994cea66d13b5
    113 N9be264d086ca42b9b4161d016e7e78a4
    114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1118097789
    115 https://doi.org/10.1038/s41598-019-46167-y
    116 schema:sdDatePublished 2022-10-01T06:45
    117 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    118 schema:sdPublisher Nf6195a84cdf445d78f2a74cffb875f1a
    119 schema:url https://doi.org/10.1038/s41598-019-46167-y
    120 sgo:license sg:explorer/license/
    121 sgo:sdDataset articles
    122 rdf:type schema:ScholarlyArticle
    123 N0758bff2fbbd42deaf0c34d7cac64a02 rdf:first sg:person.015771736565.08
    124 rdf:rest N2f9c61757edd444ca59dda113b2ec6ac
    125 N0e378390471145adb86beafef0e49f57 rdf:first sg:person.01263636065.82
    126 rdf:rest Nd49fc4b892094dd9860ea8c49b6d608b
    127 N16bf916b3c464a108ea8629e05f4a523 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Kaplan-Meier Estimate
    129 rdf:type schema:DefinedTerm
    130 N19f6e12ebd0442ee9887a74b5e039fc7 schema:volumeNumber 9
    131 rdf:type schema:PublicationVolume
    132 N1a23453430a7435498a39750a4006fdb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name DNA, Neoplasm
    134 rdf:type schema:DefinedTerm
    135 N1ef75731062c4e0a83fb71149f455d3b rdf:first sg:person.011511544777.20
    136 rdf:rest Ne10215f124c34c1e9b47b2926c20c26f
    137 N2a70b0c82aac4b048a3468290c244568 rdf:first sg:person.01137000423.01
    138 rdf:rest Nf3ae065fa3d348e790041ee1641d3855
    139 N2f9c61757edd444ca59dda113b2ec6ac rdf:first sg:person.0740500270.49
    140 rdf:rest Nc0b88f11beb14dfe93805698d6ec55be
    141 N30845daa92aa4cc7bcfe303df374d8c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Aged
    143 rdf:type schema:DefinedTerm
    144 N37c5575a16a647169076a12d7b8decc5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Phenotype
    146 rdf:type schema:DefinedTerm
    147 N3e76c57dad2842588b14d4d3f69dde0b schema:issueNumber 1
    148 rdf:type schema:PublicationIssue
    149 N566356442560411e8223205d1f1bb64d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Proportional Hazards Models
    151 rdf:type schema:DefinedTerm
    152 N5ad8fecd72b04d1d832f63e38324f6cb rdf:first sg:person.01177145244.29
    153 rdf:rest Ne89cf188bd264f2cade227dde4a5f09c
    154 N63a8725b290c4348ad4cf2a9fe53a99e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Duodenal Neoplasms
    156 rdf:type schema:DefinedTerm
    157 N664de93cd3154109906eeb4e1b1d3172 rdf:first sg:person.013156774212.80
    158 rdf:rest N1ef75731062c4e0a83fb71149f455d3b
    159 N73b7730636df46d193bab1476898d42d rdf:first sg:person.016557126511.88
    160 rdf:rest N2a70b0c82aac4b048a3468290c244568
    161 N77170b843d49493f853fcb6fb623d962 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Neoplasm Proteins
    163 rdf:type schema:DefinedTerm
    164 N79ae73d0a74a48e599c040f91fc26c54 rdf:first sg:person.01333122366.99
    165 rdf:rest Nc4faec5dd8cc4fafab534aae48c65317
    166 N7cf3f7aaf8834eb297450137091746f2 rdf:first sg:person.0723101126.27
    167 rdf:rest Naa7ea67086bc41fca1866349d28814f8
    168 N7d1e3d99f18340e1be40815acf183500 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Adenocarcinoma
    170 rdf:type schema:DefinedTerm
    171 N7e2f8697320e42f7a7ba8c6bf0bb511e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name GTP-Binding Protein alpha Subunits, Gs
    173 rdf:type schema:DefinedTerm
    174 N8267846ae413482aabf2aab0f4c61fe7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Chromogranins
    176 rdf:type schema:DefinedTerm
    177 N8b3ee1dc53934904b116df8d24d9dead schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name CpG Islands
    179 rdf:type schema:DefinedTerm
    180 N8c60876a12e543129862c4fe3fc88e57 schema:name doi
    181 schema:value 10.1038/s41598-019-46167-y
    182 rdf:type schema:PropertyValue
    183 N8c8aa0a9e55a4305935994cea66d13b5 schema:name dimensions_id
    184 schema:value pub.1118097789
    185 rdf:type schema:PropertyValue
    186 N8e3bc2abc68a48d9ba1a65db494c4e64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Genes, ras
    188 rdf:type schema:DefinedTerm
    189 N975e2d8840d84a4c9d92353bcc00a23b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name B7-H1 Antigen
    191 rdf:type schema:DefinedTerm
    192 N9bd2725c4451418ca60e226a8f847543 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Retrospective Studies
    194 rdf:type schema:DefinedTerm
    195 N9be264d086ca42b9b4161d016e7e78a4 schema:name pubmed_id
    196 schema:value 31324814
    197 rdf:type schema:PropertyValue
    198 Na30cf56d5f184314ab02f8920ec06b92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Proto-Oncogene Proteins B-raf
    200 rdf:type schema:DefinedTerm
    201 Na88bf87523334e7abbb01ea466768f93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name Prognosis
    203 rdf:type schema:DefinedTerm
    204 Naa1d387a46ff43cdbfbc9751f88e72d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name Female
    206 rdf:type schema:DefinedTerm
    207 Naa7ea67086bc41fca1866349d28814f8 rdf:first sg:person.07372705062.66
    208 rdf:rest N79ae73d0a74a48e599c040f91fc26c54
    209 Nad55ff7c9fdb47588aa991fe4636c4dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Genes, Neoplasm
    211 rdf:type schema:DefinedTerm
    212 Nc0b88f11beb14dfe93805698d6ec55be rdf:first sg:person.011273662612.03
    213 rdf:rest N664de93cd3154109906eeb4e1b1d3172
    214 Nc3f7f99d9475425eacf971c74ac73503 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Male
    216 rdf:type schema:DefinedTerm
    217 Nc4a7766508454a219feb125f853ad654 rdf:first sg:person.01241316024.37
    218 rdf:rest N0e378390471145adb86beafef0e49f57
    219 Nc4faec5dd8cc4fafab534aae48c65317 rdf:first sg:person.0607004507.20
    220 rdf:rest Nd2c4e2b7a26c43e886623eb64ab432ec
    221 Ncf84e634a37a4b1fa611083accc40916 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    222 schema:name Mutation
    223 rdf:type schema:DefinedTerm
    224 Nd2c4e2b7a26c43e886623eb64ab432ec rdf:first sg:person.01367456571.22
    225 rdf:rest Nc4a7766508454a219feb125f853ad654
    226 Nd49fc4b892094dd9860ea8c49b6d608b rdf:first sg:person.01234607202.62
    227 rdf:rest N0758bff2fbbd42deaf0c34d7cac64a02
    228 Ndb31b11985be4aa89b5ddf87f2719e3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    229 schema:name Humans
    230 rdf:type schema:DefinedTerm
    231 Ne10215f124c34c1e9b47b2926c20c26f rdf:first sg:person.0611747536.16
    232 rdf:rest rdf:nil
    233 Ne89cf188bd264f2cade227dde4a5f09c rdf:first sg:person.01305720353.18
    234 rdf:rest N73b7730636df46d193bab1476898d42d
    235 Ne9bb951cf14f477bae306fcbe8789819 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    236 schema:name Microsatellite Instability
    237 rdf:type schema:DefinedTerm
    238 Nf04774787ae042c4bdb15325ebc8c6a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    239 schema:name Middle Aged
    240 rdf:type schema:DefinedTerm
    241 Nf3ae065fa3d348e790041ee1641d3855 rdf:first sg:person.01340061160.83
    242 rdf:rest N7cf3f7aaf8834eb297450137091746f2
    243 Nf6195a84cdf445d78f2a74cffb875f1a schema:name Springer Nature - SN SciGraph project
    244 rdf:type schema:Organization
    245 Nf84293f0bdb644e1bad142fe92a9833c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    246 schema:name DNA Methylation
    247 rdf:type schema:DefinedTerm
    248 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    249 schema:name Medical and Health Sciences
    250 rdf:type schema:DefinedTerm
    251 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    252 schema:name Oncology and Carcinogenesis
    253 rdf:type schema:DefinedTerm
    254 sg:grant.2497877 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-46167-y
    255 rdf:type schema:MonetaryGrant
    256 sg:journal.1045337 schema:issn 2045-2322
    257 schema:name Scientific Reports
    258 schema:publisher Springer Nature
    259 rdf:type schema:Periodical
    260 sg:person.011273662612.03 schema:affiliation grid-institutes:grid.272264.7
    261 schema:familyName Morimoto
    262 schema:givenName Takeshi
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011273662612.03
    264 rdf:type schema:Person
    265 sg:person.01137000423.01 schema:affiliation grid-institutes:grid.272264.7
    266 schema:familyName Tozawa
    267 schema:givenName Katsuyuki
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137000423.01
    269 rdf:type schema:Person
    270 sg:person.011511544777.20 schema:affiliation grid-institutes:grid.430387.b
    271 schema:familyName Das
    272 schema:givenName Kiron M.
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011511544777.20
    274 rdf:type schema:Person
    275 sg:person.01177145244.29 schema:affiliation grid-institutes:grid.272264.7
    276 schema:familyName Watari
    277 schema:givenName Jiro
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177145244.29
    279 rdf:type schema:Person
    280 sg:person.01234607202.62 schema:affiliation grid-institutes:grid.410800.d
    281 schema:familyName Yatabe
    282 schema:givenName Yasushi
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234607202.62
    284 rdf:type schema:Person
    285 sg:person.01241316024.37 schema:affiliation grid-institutes:grid.410800.d
    286 schema:familyName Tajika
    287 schema:givenName Masahiro
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241316024.37
    289 rdf:type schema:Person
    290 sg:person.01263636065.82 schema:affiliation grid-institutes:grid.410800.d
    291 schema:familyName Hara
    292 schema:givenName Kazuo
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263636065.82
    294 rdf:type schema:Person
    295 sg:person.01305720353.18 schema:affiliation grid-institutes:grid.410800.d
    296 schema:familyName Mitani
    297 schema:givenName Seiichiro
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305720353.18
    299 rdf:type schema:Person
    300 sg:person.013156774212.80 schema:affiliation grid-institutes:grid.272264.7
    301 schema:familyName Hirota
    302 schema:givenName Seiichi
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013156774212.80
    304 rdf:type schema:Person
    305 sg:person.01333122366.99 schema:affiliation grid-institutes:grid.410800.d
    306 schema:familyName Kadowaki
    307 schema:givenName Shigenori
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333122366.99
    309 rdf:type schema:Person
    310 sg:person.01340061160.83 schema:affiliation grid-institutes:grid.272264.7
    311 schema:familyName Tomita
    312 schema:givenName Toshihiko
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340061160.83
    314 rdf:type schema:Person
    315 sg:person.01367456571.22 schema:affiliation grid-institutes:grid.410800.d
    316 schema:familyName Senda
    317 schema:givenName Yoshiki
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367456571.22
    319 rdf:type schema:Person
    320 sg:person.015771736565.08 schema:affiliation grid-institutes:grid.410800.d
    321 schema:familyName Shimizu
    322 schema:givenName Yasuhiro
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015771736565.08
    324 rdf:type schema:Person
    325 sg:person.016557126511.88 schema:affiliation grid-institutes:grid.272264.7
    326 schema:familyName Ito
    327 schema:givenName Chiyomi
    328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016557126511.88
    329 rdf:type schema:Person
    330 sg:person.0607004507.20 schema:affiliation grid-institutes:grid.410800.d
    331 schema:familyName Natsume
    332 schema:givenName Seiji
    333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607004507.20
    334 rdf:type schema:Person
    335 sg:person.0611747536.16 schema:affiliation grid-institutes:grid.272264.7
    336 schema:familyName Miwa
    337 schema:givenName Hiroto
    338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611747536.16
    339 rdf:type schema:Person
    340 sg:person.0723101126.27 schema:affiliation grid-institutes:grid.272264.7
    341 schema:familyName Oshima
    342 schema:givenName Tadayuki
    343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723101126.27
    344 rdf:type schema:Person
    345 sg:person.07372705062.66 schema:affiliation grid-institutes:grid.272264.7
    346 schema:familyName Fukui
    347 schema:givenName Hirokazu
    348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07372705062.66
    349 rdf:type schema:Person
    350 sg:person.0740500270.49 schema:affiliation grid-institutes:grid.410800.d
    351 schema:familyName Muro
    352 schema:givenName Kei
    353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740500270.49
    354 rdf:type schema:Person
    355 sg:pub.10.1007/s12032-012-0391-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020695357
    356 https://doi.org/10.1007/s12032-012-0391-9
    357 rdf:type schema:CreativeWork
    358 sg:pub.10.1038/bjc.2013.677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013589069
    359 https://doi.org/10.1038/bjc.2013.677
    360 rdf:type schema:CreativeWork
    361 sg:pub.10.1038/bjc.2015.104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050485568
    362 https://doi.org/10.1038/bjc.2015.104
    363 rdf:type schema:CreativeWork
    364 sg:pub.10.1038/bjc.2015.418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021770280
    365 https://doi.org/10.1038/bjc.2015.418
    366 rdf:type schema:CreativeWork
    367 sg:pub.10.1038/bjc.2016.211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037442310
    368 https://doi.org/10.1038/bjc.2016.211
    369 rdf:type schema:CreativeWork
    370 sg:pub.10.1038/modpathol.2010.223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001321209
    371 https://doi.org/10.1038/modpathol.2010.223
    372 rdf:type schema:CreativeWork
    373 sg:pub.10.1038/modpathol.2016.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034870705
    374 https://doi.org/10.1038/modpathol.2016.139
    375 rdf:type schema:CreativeWork
    376 sg:pub.10.1038/nrclinonc.2013.132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053599458
    377 https://doi.org/10.1038/nrclinonc.2013.132
    378 rdf:type schema:CreativeWork
    379 sg:pub.10.1038/s41598-017-13842-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1092170430
    380 https://doi.org/10.1038/s41598-017-13842-x
    381 rdf:type schema:CreativeWork
    382 sg:pub.10.1038/s41598-018-32717-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107108093
    383 https://doi.org/10.1038/s41598-018-32717-3
    384 rdf:type schema:CreativeWork
    385 sg:pub.10.1038/sj.bjc.6605449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000280877
    386 https://doi.org/10.1038/sj.bjc.6605449
    387 rdf:type schema:CreativeWork
    388 sg:pub.10.1111/j.1572-0241.2001.04056.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027806508
    389 https://doi.org/10.1111/j.1572-0241.2001.04056.x
    390 rdf:type schema:CreativeWork
    391 grid-institutes:grid.272264.7 schema:alternateName Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan
    392 Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    393 Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    394 schema:name Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan
    395 Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    396 Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    397 rdf:type schema:Organization
    398 grid-institutes:grid.410800.d schema:alternateName Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan
    399 Department of Endoscopy, Aichi Cancer Center Hospital, Nagoya, Japan
    400 Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    401 Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan
    402 Department of Pathology and Molecular Diagnosis, Aichi Cancer Center Hospital, Nagoya, Japan
    403 schema:name Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan
    404 Department of Endoscopy, Aichi Cancer Center Hospital, Nagoya, Japan
    405 Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    406 Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan
    407 Department of Pathology and Molecular Diagnosis, Aichi Cancer Center Hospital, Nagoya, Japan
    408 rdf:type schema:Organization
    409 grid-institutes:grid.430387.b schema:alternateName Division of Gastroenterology and Hepatology, Departments of Medicine and Pathology, Robert Wood Johnson Medical School, Rutgers, Cancer Institute of New Jersey, New Brunswick, NJ, USA
    410 schema:name Division of Gastroenterology and Hepatology, Departments of Medicine and Pathology, Robert Wood Johnson Medical School, Rutgers, Cancer Institute of New Jersey, New Brunswick, NJ, USA
    411 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...