Evaluation of Candida peritonitis with underlying peritoneal fibrosis and efficacy of micafungin in murine models of intra-abdominal candidiasis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-06-27

AUTHORS

Nobuyuki Ashizawa, Taiga Miyazaki, Shinichi Abe, Takahiro Takazono, Tomomi Saijo, Yoko Obata, Shintaro Shimamura, Kazuko Yamamoto, Yoshifumi Imamura, Takehiko Koji, Tomoya Nishino, Koichi Izumikawa, Katsunori Yanagihara, Shigeru Kohno, Hiroshi Mukae

ABSTRACT

Candida peritonitis is a crucial disease, however the optimal antifungal therapy regimen has not been clearly defined. Peritoneal fibrosis (PF) can be caused by abdominal surgery, intra-abdominal infection, and malignant diseases, and is also widely recognized as a crucial complication of long-term peritoneal dialysis. However, the influence of PF on Candida peritonitis prognosis remains unknown. Here, we evaluated the severity of Candida peritonitis within the context of PF and the efficacy of micafungin using mice. A PF mouse model was generated by intraperitoneally administering chlorhexidine gluconate. Candida peritonitis, induced by intraperitoneal inoculation of Candida albicans, was treated with a 7-day consecutive subcutaneous administration of micafungin. Candida infection caused a higher mortality rate in the PF mice compared with the control mice on day 7. Proliferative Candida invasion into the peritoneum and intra-abdominal organs was confirmed pathologically only in the PF mice. However, all mice in both groups treated with micafungin survived until day 20. Micafungin treatment tends to suppress inflammatory cytokines in the plasma 12 h after infection in both groups. Our results suggest that PF enhances early mortality in Candida peritonitis. Prompt initiation and sufficient doses of micafungin had good efficacy for Candida peritonitis, irrespective of the underlying PF. More... »

PAGES

9331

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-45776-x

DOI

http://dx.doi.org/10.1038/s41598-019-45776-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1117495675

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31249356


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24 schema:description Candida peritonitis is a crucial disease, however the optimal antifungal therapy regimen has not been clearly defined. Peritoneal fibrosis (PF) can be caused by abdominal surgery, intra-abdominal infection, and malignant diseases, and is also widely recognized as a crucial complication of long-term peritoneal dialysis. However, the influence of PF on Candida peritonitis prognosis remains unknown. Here, we evaluated the severity of Candida peritonitis within the context of PF and the efficacy of micafungin using mice. A PF mouse model was generated by intraperitoneally administering chlorhexidine gluconate. Candida peritonitis, induced by intraperitoneal inoculation of Candida albicans, was treated with a 7-day consecutive subcutaneous administration of micafungin. Candida infection caused a higher mortality rate in the PF mice compared with the control mice on day 7. Proliferative Candida invasion into the peritoneum and intra-abdominal organs was confirmed pathologically only in the PF mice. However, all mice in both groups treated with micafungin survived until day 20. Micafungin treatment tends to suppress inflammatory cytokines in the plasma 12 h after infection in both groups. Our results suggest that PF enhances early mortality in Candida peritonitis. Prompt initiation and sufficient doses of micafungin had good efficacy for Candida peritonitis, irrespective of the underlying PF.
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30 schema:keywords Candida
31 Candida albicans
32 Candida infections
33 Candida invasion
34 Candida peritonitis
35 PF mice
36 PF mouse model
37 abdominal surgery
38 administration
39 albicans
40 better efficacy
41 candidiasis
42 chlorhexidine gluconate
43 complications
44 context
45 control mice
46 crucial complication
47 crucial diseases
48 cytokines
49 day 20
50 day 7
51 dialysis
52 disease
53 doses
54 early mortality
55 efficacy
56 efficacy of micafungin
57 evaluation
58 fibrosis
59 gluconate
60 group
61 high mortality rate
62 infection
63 inflammatory cytokines
64 influence
65 initiation
66 inoculation
67 intra-abdominal candidiasis
68 intra-abdominal infections
69 intra-abdominal organs
70 intraperitoneal inoculation
71 invasion
72 long-term peritoneal dialysis
73 malignant disease
74 micafungin
75 micafungin treatment
76 mice
77 model
78 mortality
79 mortality rate
80 mouse model
81 murine model
82 organs
83 peritoneal dialysis
84 peritoneal fibrosis
85 peritoneum
86 peritonitis
87 plasma 12
88 prognosis
89 prompt initiation
90 rate
91 regimen
92 results
93 severity
94 subcutaneous administration
95 sufficient doses
96 surgery
97 therapy regimen
98 treatment
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